The Effect of External Cold and Vibration on Infiltration-Induced Pain in Children: A Randomized Clinical Trial by Reihaneh Faghihian, Mona Esmaeili, Hossein Asadi, Mohammad Hossein Nikbakht, Fateme Shadmanfar, Mehdi Jafarzadeh

“…The FLACC score was significantly lower in the BUZZY group than in the cold-alone group, but the Wong–Baker scale and heart rate did not show a significant difference between the two groups. …”
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Systematic Review of Randomized Clinical Trials on Safety and Efficacy of Pharmacological and Nonpharmacological Treatments for Retinitis Pigmentosa by Marta Sacchetti, Flavio Mantelli, Daniela Merlo, Alessandro Lambiase

“…All treatments proved safe but did not show significant benefit on visual function. Long term supplementation with vitamin A showed a significantly slower decline rate in electroretinogram amplitude. …”
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The role of footwear in improving running economy: a systematic review with meta-analysis of controlled trials by Liya Xu, Yifan Wang, Xu Wen

“…Compared with barefoot running, minimalist running did not show a beneficial effect (SMD = 0.37 [95% CI − 0.07, 0.81], P = 0.10) on RE. …”
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Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

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Phage Cocktail Alleviates Bacterial Canker of Kiwifruit by Modulating Bacterial Community Structure in Field Trial by Ran Hu, Xiaohan Xu, Yajun Jia, Cancan Zhu, Lin Wang, Minxin Song, Qian Xu, Mian Xia, Xiaoqing He, Yi Jin

“…In this study, the field trial results showed that phage cocktail could significantly reduce the incidence of bacterial canker in kiwifruit. …”
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Using a clinical decision support system to reduce excess driving pressure: the ALARM trial by Ursula Burger-Klepp, Mathias Maleczek, Robin Ristl, Bettina Kroyer, Marcus Raudner, Claus G. Krenn, Roman Ullrich

“…Methods A prospective cohort trial was conducted in patients at risk of ARDS admitted to an intensive care unit (ICU). …”
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Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) by Kazutaka Aonuma, Kenji Ando, Kengo Kusano, Toru Asai, Koichi Inoue, Yukihiro Inamura, Takanori Ikeda, Takeshi Mitsuhashi, Toyoaki Murohara, Nobuhiro Nishii, Akihiko Nogami, Wataru Shimizu, Caroline Beaudoint, Torri Simon, Torsten Kayser, Hussin Azlan, Ngarmukos Tachapong, Joseph Yat‐Sun Chan, Valentina Kutyifa, Yasushi Sakata, For the HINODE Investigators

“…Propensity‐matched HV cohorts showed comparable VA (P = 0.61) and mortality rates (P = 0.29) for HINODE and MADIT‐RIT. …”
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Determining First Aid Knowledge and Skills Retention with Laypeople: A Randomized Controlled Trial in Nepal

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Evaluating the Effectiveness of Amarantha and Chlorhexidine Mouthwashes in Chronic Generalized Gingivitis: A Randomized Clinical Trial by Swapna Ediga, Ruchi Gulati, Heeralal Chokotiya, Meet Modi, Vasundhra Sethi, Sagar Kumar Kashyap

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Mobile Health App as an Auxiliary Tool in Management of Atopic Dermatitis in Children: Randomized Controlled Trial by Alex Zvulunov, Stepan Lenevich, Natalia Migacheva

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A prospective pragmatic evaluation of automatic trial matching tools in a molecular tumor board by Lilia Gueguen, Louise Olgiati, Clément Brutti-Mairesse, Alric Sans, Vincent Le Texier, Loic Verlingue

“…Each patient had 2.19 trials proposed on average, and 38% had no trials suggested. …”
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Periodontal Therapy as an Adjunct to Pulmonary Rehabilitation in Chronic Respiratory Diseases: A Randomized Controlled Trial by Anuj S. Parihar, Neha Khare, Sneha Bayyapu, Maninderjit Kaur, Deepak Kochar, Rashmi Laddha

“…Objective: This randomized controlled trial (RCT) assessed the impact of periodontal therapy combined with PR on lung function, quality of life, and systemic inflammation in CRD patients. …”
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Effectiveness of Mobilization with Movement on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials by Gidey Gomera Weleslassie, Melaku Hailu Temesgen, Abayneh Alamer, Gebrerufael Solomon Tsegay, Teklehaimanot Tekle Hailemariam, Haimanot Melese

“…Osteoarthritis is becoming a global major cause of pain and functional disability worldwide, especially in the elderly population. Nowadays, evidence shows that mobilization with movement (MWM) has a beneficial effect on knee osteoarthritis subjects. …”
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Non-inferiority of minimally invasive rotational cutting in granulomatous mastitis treatment: a comparative trial by Fuman Zhang, Chengyi Li, Xinquan Wu, Kali Miao, Zhe Zhang, Jing Zhang

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The effect of Snoezelen intervention on problem behaviors in children with cerebral palsy: A randomized controlled trial by Mina Kim, Sook-Hee Yi, Jee-Sun Lee, Ji-Young Lee, Yun-Tae Hwang, Jeong-Soo Kim

“…The unique protocol ID for this trial is SRH2018R-01. A randomized controlled trial with 28 children (aged 2–5 years) with CP was conducted. …”
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Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials by Carolina Sandoval Salinas, Andrés L. González Rangel, Juan G. Cataño Cataño, Juan C. Fuentes Pachón, Juan S. Castillo Londoño

“…However, some differences in patient-related outcomes favor the newer methods. Larger trials are required.…”
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Feasibility and accuracy of continuous intraabdominal pressure monitoring with a capsular device in human pilot trial by Chien-Hung Liao, David A. Spain, Chih-Chi Chen, Chi-Tung Cheng, Wei-Cheng Lin, Dong-Ru Ho, Heng-Fu Lin, Fausto Catena

“…However, capsule measurements showed excellent correlation with intravesical IAP measurements, with an intraclass correlation coefficient of 0.916 (95% CI: 0.8821–0.9320). …”
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Efficacy of aquatic exercises on balance in children with sickle cell anemia: A randomized controlled trial by Omar Abd El-Hameed Abd El-Fattah Ghetas, Azza Abd El-Aziz Abd El-Hady, El-Sayed Ali Shaheen Ali, Amira El-Sayed El-Bagalaty

“…A randomized controlled trial was conducted. Sixty children with mild sickle cell anemia and poor balance from both sexes (35 boys and 25 girls) participated in this study. …”
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Effectiveness of a training program for the acquisition of motor milestones in infants: a randomized clinical trial by Luis Fernández-Sola, Beatriz Cano-Díez, Yessica Pons-Solaz, Begoña Vera-Egido, Sergio Moreno-González

“…Results The initial baseline assessment showed no statistical differences between groups (p > 0,05). …”
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Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial by Djawid Hashemi, Ludwig Dettmann, Tobias D. Trippel, Volker Holzendorf, Johannes Petutschnigg, Rolf Wachter, Gerd Hasenfuß, Burkert Pieske, Antonia Zapf, Frank Edelmann

“…Methods and results The aldosterone receptor blockade in diastolic HF trial is a multicentre, prospective, randomized, double‐blind, placebo‐controlled trial conducted between March 2007 and April 2011 at 10 sites in Germany and Austria that included 422 ambulatory patients [mean age: 67 years (standard deviation: 8); 52% women]. …”
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