YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…YAP1 is a novel negative biomarker of ICIs treatment in EGFR-mutant NSCLC population. Clinical Trials. This trial is registered with NCT03513666.…”
Get full text

Cost-effectiveness analysis of pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in the Chinese healthcare system by Wenwang Lang, Yulong He, Changchun Hou, Hua Li, Qinling Jiang, Liuyong Mei

“…The purpose of this study was to assess its cost-effectiveness.Materials and methodsA Markov state-transition model was constructed using data from the IND227 phase 3 randomized clinical trial. Utility values for health states were taken from the IND227 trial, and direct medical costs were from the pertinent literature and local pricing data. …”
Get full text

Matching-Adjusted Indirect Comparison of the Efficacy at Week 32 of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis by Tiago Torres, Anne Sohrt Petersen, Ulla Ivens, Albert Bosch Vilaro, John Stinson, José Manuel Carrascosa

“…Methods An unanchored matching-adjusted indirect comparison was conducted using individual patient data (IPD) from the ECZTRA 3 tralokinumab trial and aggregate data from the LIBERTY AD CHRONOS dupilumab trial. …”
Get full text

Optimasi Keamanan Web Server Terhadap Serangan Brute-Force Menggunakan Penetration Testing by Fahmi Fachri

“…The results of the study show that there are three categories of weaknesses, 5 vulnerabilities at the High level, 164 vulnerabilities at the Medium level, 52 vulnerabilities at the Low level. …”
Get full text

The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers by Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Carsten Watzl, Edmund Wascher, Stephan Getzmann

“…These parameters should be considered when assessing the risk for developing burnout and validating the diagnosis of burnout. Trial registration: ClinicalTrials.gov NCT05155397; https://clinicaltrials.gov/ct2/show/NCT05155397.…”
Get full text

Relationships between multiple patient safety outcomes and healthcare and hospital-related risk factors in colorectal resection cases: cross-sectional evidence from a nationwide sa... by Ralf Kuhlen, Jochen Schmitt, Felix Walther, Martin Roessler, Peter Scriba, Maria Eberlein-Gonska, Olaf Schoffer

“…Hospital variables like volume, ownership or localisation did not show consistent relationships to patient safety outcomes.Trial registration number ISRCTN10188560.…”
Get full text

Transcranial photobiomodulation for reducing symptoms of autism spectrum disorder and modulating brain electrophysiology in children aged 2–7: an open label study by Yuli Fradkin, Joaquin A. Anguera, Alexander J. Simon, Luis De Taboada, Eugenia Steingold

“…No moderate or severe side effects were reported.ConclusionThis study supports the potential of tPBM as a safe and effective treatment for ASD, and it suggests that EEG measurements may serve as a useful biomarker for future research. Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT04660552…”
Get full text

Low-Protein Diet Supplemented with Keto Acids Is Associated with Suppression of Small-Solute Peritoneal Transport Rate in Peritoneal Dialysis Patients by Na Jiang, Jiaqi Qian, Aiwu Lin, Wei Fang, Weiming Zhang, Liou Cao, Qin Wang, Zhaohui Ni, Qiang Yao

“…We investigate whether low-protein diet would show benefits in suppressing peritoneal transport rate in peritoneal dialysis (PD) patients. …”
Get full text

Development of a machine learning model related to explore the association between heavy metal exposure and alveolar bone loss among US adults utilizing SHAP: a study based on NHAN... by Jiayi Chen

“…Conclusion In this study, RF showed superior performance compared with the other five algorithms. …”
Get full text

Effectiveness of digital health applications on the quality of life in patients with overweight or obesity: a systematic review by Melanie Mäder, Tonio Schönfelder, Ria Heinrich, Carsta Militzer-Horstmann, Patrick Timpel

“…As potentially eligible trials had to demonstrate effectiveness, only randomized controlled trials (RCT) were included as the minimum evidence standard. …”
Get full text

Utility of Consumer-Grade Wearable Devices for Inferring Physical and Mental Health Outcomes in Severe Mental Illness: Systematic Review by Lamiece Hassan, Alyssa Milton, Chelsea Sawyer, Alexander J Casson, John Torous, Alan Davies, Bernalyn Ruiz-Yu, Joseph Firth

“…MethodsWe conducted a systematic review of the following databases: Cochrane Central Register of Controlled Trials, Technology Assessment, AMED (Allied and Complementary Medicine), APA PsycINFO, Embase, MEDLINE(R), and IEEE XPlore. …”
Get full text

Biological and psychosocial factors associated with the persistence of pruritus symptoms: protocol for a prospective, exploratory observational study in Germany (individual project... by Sonja Ständer, Stefan W Schneider, Gudrun Schneider, Stefan Kahnert, Manuel Pedro Pereira, Christian Mess, Volker Huck, Konstantin Agelopoulos, Gina Frank

“…Findings will be disseminated through peer-reviewed publications, scientific conferences and involvement of relevant stakeholders, patients and the lay public.Trial registration number DRKS00026646.…”
Get full text

Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation by Douglas W. Barrett, Roger E. Davis, Jennifer E. Siegel-Ramsay, Amy Bichlmeier, Jorge R. C. Almeida, F. Gonzalez-Lima

“…To confirm TILS efficacy, a sham-controlled, double-blinded randomized trial is needed.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT05354895.…”
Get full text

Effect of Pulsed Electric Field on the Cations Removal from Salt-Affected Soils to Optimize Energy Use Efficiency in Reclamation by Ahmed Abou-Shady

“…The pulsed 25% strategy of the OFF time showed an improvement in current passing at the longest interval of 120 min; the pulsed 50% strategy of the OFF time showed an improvement in current passing at the shorter and longer intervals of 15, 60, and 120 min; however, the interval of 30 min had a negative effect. …”
Get full text

El crimen y los procesos de los Sucesos de Casas Viejas. Los campesinos y la insidia política by José Luis Gutiérrez Molina

“…Both at the time and after, the protagonists, victims, were relegates to the background, because of the political consequences and because they were sees as people without political consciousness. The text shows this vision through the trial proceedings that led to 26 peasants before a military court in June 1934, in particular the allegations of the lawyer who, despite withdrawnness, maintained the idea of a secondary role of the anarchists.…”
Get full text

Les fourches sont-elles vraiment patibulaires ? Les fourches et leur contraire à partir de quelques exemples languedociens by Vincent Challet

“…Every study of the gallows must take in consideration a broader analysis of the communication system established between justice and persons subjects to trial in a given territory. Signs of a seignorial domination, the gallows constitue a strong visual symbol and play, in many places, a role as a boundary marker, whose function needs to be revived from time to time by a real hanging. …”
Get full text

Les sacs à procès du parlement de Flandre : constitution et conservation d’une source exceptionnelle by Sabrina Michel

“…However, undertaking an analysis of the procedural files leaves the question of the constitution of these bags at the time of the trial, but also that of their conservation after the judicial phase. …”
Get full text

Égalité, complémentarité, concurrence. La violence entre les “sexes” au Sénégal à l’épreuve du “genre” by Giovanna Cavatorta

“…Thanks to the analysis of a trial for conjugal violence, the essay discusses the stakes of power that are brought to light by its genderization. …”
Get full text

Oxytocin as a physiological correlate of dyadic music therapy relationships — a randomized crossover pilot study by Paula Kristin Busse, Lutz Neugebauer, Götz Kaschubowski, Dennis Anheyer, Dennis Anheyer, Dennis Anheyer, Thomas Ostermann

“…Between-group comparison and within-group comparisons showed no significant changes in oxytocin levels. …”
Get full text

Identifying Who Benefits the Most from a Community Health Worker-Led Multicomponent Intervention for Hypertension by Meng Pan, Andrea Beratarrechea, Rosana Poggio, Hua He, Chung-Shiuan Chen, Jing Chen, Vilma Irazola, Adolfo Rubinstein, Jiang He, Katherine T. Mills

“…This secondary analysis used data from HCPIA, a successful 18-month cluster-randomized trial in 18 health centers with 1,432 low-income hypertensive patients in Argentina. …”
Get full text