Pooled safety analysis of two phase 3 studies investigating trifluridine/tipiracil plus bevacizumab in patients with metastatic colorectal cancer by Julien Taieb, Marwan Fakih, Gabor Liposits, Gerald W. Prager, Eric Van Cutsem, Fortunato Ciardiello, Nadia Amellal, Elizabeth Calleja, Mei Liu, Lucas Roby, Josep Tabernero, Thierry André

“…FTD/TPI plus bevacizumab showed good tolerability in the phase 3 SOLSTICE (first-line) and SUNLIGHT (later-line) trials. …”
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Assessment of Patient Satisfaction and Acceptance of Acupuncture as an Alternative Therapy in Dental Practice by Tapas K. Sarkar, Divya Pandya, Mohit Sharma, Sandip Kulavi, Priyanka Dausage, Anwesha Banerjee

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A randomized controlled trial on the effect of smartphone-based mental health application among outpatients with depressive and anxiety symptoms: A pilot study in Malaysia by Sharon Tan, Mohammad Ayob Bin Ismail, Tuti Iryani Mohd Daud, Rozita Hod, Norfazilah Ahmad

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Effects of Manual Acupuncture Versus Sham Acupuncture in patients with Post-Stroke Depression: A Randomized Clinical Trial by Conghui Wei, Jinling Chen, Qu Yang, Jingjing Xu, Qingsong Li, Fulin Li, Yu Liu, Jun Luo

“…Methods From October 28, 2022 to May 16, 2023, this single-center, single-blind, randomized clinical trial was conducted at the Second Affiliated Hospital of Nanchang University. …”
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An empowerment programme to improve diet quality during pregnancy – the Power 4 a Healthy Pregnancy cluster randomised controlled trial by Renske M. van Lonkhuijzen, Jeanne H. M. de Vries, Elske Brouwer-Brolsma, Susanne Cremers, Janine P. M. Faessen, Edith J. M. Feskens, Annemarie Wagemakers

“…This study lays the foundation for future empowerment-based interventions in maternal health contexts. Trial registration International Clinical Trial Registry Platform NL-OMON23191, date of registration: 19/05/2021.…”
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Upper Extremity Function following Transradial Percutaneous Coronary Intervention: Results of the ARCUS Trial by Eva M. Zwaan, Elena S. Cheung, Alexander J. J. IJsselmuiden, Carlo A. J. Holtzer, Ton A. R. Schreuders, Marcel J. M Kofflard, J. Henk Coert

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Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials by Yi Sun, Bowen Zhang, Xiuhua Jia, Shiqi Ling, Juan Deng

“…Results. 1045 eyes in 18 randomized controlled trials (RCTs) enrolled. Overall, the pooled estimate showed a statistically significant effect of bevacizumab on the reduction of recurrence (RR 0.74, 95% CI 0.56–0.97, P=0.03). …”
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The Effects of Yoga on Patients with Parkinson’s Disease: A Meta-Analysis of Randomized Controlled Trials by Mengke Ban, Xuejing Yue, Pengyu Dou, Ping Zhang

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Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials by Stefano Marini, Domenico De Berardis, Federica Vellante, Rita Santacroce, Laura Orsolini, Alessandro Valchera, Gabriella Girinelli, Alessandro Carano, Michele Fornaro, Francesco Gambi, Giovanni Martinotti, Massimo Di Giannantonio

“…Celecoxib showed beneficial effects mostly in early stages of schizophrenia. …”
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The Effect of Probiotics on Childhood Constipation: A Randomized Controlled Double Blind Clinical Trial by M. Sadeghzadeh, A. Rabieefar, P. Khoshnevisasl, N. Mousavinasab, K. Eftekhari

“…In this placebo controlled trial, fifty-six children aged 4–12 years with constipation received randomly lactulose plus Protexin or lactulose plus placebo daily for four weeks. …”
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Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database by C. Quarracino, F. Capani, F. Capani, M. Otero-Losada, G. E. Rodríguez, S. Pérez-Lloret, S. Pérez-Lloret

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Long-term engagement in smoking cessation campaign: A mixed methods randomized trial. by Robert Schwartz, Tracey Borland, Maaz Shahid, Karen Kuzmich, Michael Chaiton

“…The intervention also allows for real-time learning to support campaign development.<h4>Trial registration</h4>ISRCTN94797633.…”
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The effect of dexmedetomidine vs. atracurium on intubation condition in children - a randomized clinical trial by Mohammad Alipour, Samira Ghanei, Shahrzad Sheikh, Masoud Ghanei, Ahmad Nemati, Shabnam Niroumand

“…Decreased heart rate and less coughing were observed when using dexmedetomidine. This trial was registered retrospectively in the Iranian Clinical Trials Registry at 2021-24-05 ( https://www.irct.ir/ ), and its registration number is IRCT20201028049177N1.…”
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Effect of Artificial Intelligence Helpfulness and Uncertainty on Cognitive Interactions with Pharmacists: Randomized Controlled Trial by Chuan-Ching Tsai, Jin Yong Kim, Qiyuan Chen, Brigid Rowell, X Jessie Yang, Raed Kontar, Megan Whitaker, Corey Lester

“…Transparency in AI is needed in “black box” systems, but showing more information can add a cognitive burden. …”
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Efficacy of Unsupervised YouTube Dance Exercise for Patients With Hypertension: Randomized Controlled Trial by Mizuki Sakairi, Taiju Miyagami, Hiroki Tabata, Naotake Yanagisawa, Mizue Saita, Mai Suzuki, Kazutoshi Fujibayashi, Hiroshi Fukuda, Toshio Naito

“…MethodsThis nonblind, double-arm, randomized controlled trial was conducted at Juntendo University, Tokyo, from April to December 2023. …”
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Reactive agility training to prevent frailty in older adults – a randomized controlled trial. by Eric Lichtenstein, Martin Keller, Ralf Roth, Sebastian Ludyga, Oliver Faude

“…Neither strength, explosiveness, and balance parameters, nor physical well-being and fear of falling data showed notable between-group differences (d < 0.2). …”
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Overview of Novel Antipsychotic Drugs: State of the Art, New Mechanisms, and Clinical Aspects of Promising Compounds by Letizia Biso, Marco Carli, Marco Scarselli, Biancamaria Longoni

“…Moreover, in the past few decades, discoveries in the pathophysiology of psychotic disorders have opened the way for experimenting with novel compounds that have alternative mechanisms of action, with some of them showing promising results in early trials. The scope of this review was to summarize the novel antipsychotics developed, their current experimental status, and their mechanisms of action. …”
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A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical tria... by Floriane Jochum, Madeleine Doll, Anne-Sophie Hamy, Lou Donval, Paul Gougis, Élise Dumas, Lise Lecointre, Thomas Gaillard, Fabien Reyal, Fabrice Lecuru, Cherif Akladios, Enora Laas

“…Findings: Our nationwide cohorts included 7108 cervical cancer and 23,090 ovarian cancer patients treated across 596 centres. The LACC trial led to a 14.1% reduction in radical hysterectomies by MIS (275 fewer surgeries; 95% CI: −407 to −140), with academic centres showing 27.9% reduction compared to 2.5% increase in nonacademic centres. …”
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The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial by Catherine M. Mewborn, Cutter A. Lindbergh, B. Randy Hammond, Lisa M. Renzi-Hammond, L. Stephen Miller

“…We hypothesized that the supplement group would increase, maintain, or show attenuated loss in hypothesized regions-of-interest (ROIs) while the placebo group would show age-related declines in brain structural integrity over the course of the trial. …”
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Efficient Model Order Reduction for the Dynamics of Nonlinear Multilayer Sheet Structures with Trial Vector Derivatives by Wolfgang Witteveen, Florian Pichler

“…In the present contribution, the method of trial vector derivatives is applied and extended in order to obtain a-priori trial vectors for the model reduction which are suitable for determining the nonlinearities in the joints of the reduced system. …”
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