Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

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The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: a systematic review and meta-analysis by Felicity S. E. Spencer, Richard J. Elsworthy, Leigh Breen, Jon R. B. Bishop, Connor Dunleavy, Sarah Aldred

“…Randomised controlled trials have investigated whether the strongest genetic risk factor for Alzheimer’s disease, APOE4, impacts the effectiveness of exercise on health. …”
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Phage Cocktail Alleviates Bacterial Canker of Kiwifruit by Modulating Bacterial Community Structure in Field Trial by Ran Hu, Xiaohan Xu, Yajun Jia, Cancan Zhu, Lin Wang, Minxin Song, Qian Xu, Mian Xia, Xiaoqing He, Yi Jin

“…In this study, the field trial results showed that phage cocktail could significantly reduce the incidence of bacterial canker in kiwifruit. …”
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Using a clinical decision support system to reduce excess driving pressure: the ALARM trial by Ursula Burger-Klepp, Mathias Maleczek, Robin Ristl, Bettina Kroyer, Marcus Raudner, Claus G. Krenn, Roman Ullrich

“…Methods A prospective cohort trial was conducted in patients at risk of ARDS admitted to an intensive care unit (ICU). …”
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Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) by Kazutaka Aonuma, Kenji Ando, Kengo Kusano, Toru Asai, Koichi Inoue, Yukihiro Inamura, Takanori Ikeda, Takeshi Mitsuhashi, Toyoaki Murohara, Nobuhiro Nishii, Akihiko Nogami, Wataru Shimizu, Caroline Beaudoint, Torri Simon, Torsten Kayser, Hussin Azlan, Ngarmukos Tachapong, Joseph Yat‐Sun Chan, Valentina Kutyifa, Yasushi Sakata, For the HINODE Investigators

“…Propensity‐matched HV cohorts showed comparable VA (P = 0.61) and mortality rates (P = 0.29) for HINODE and MADIT‐RIT. …”
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Determining First Aid Knowledge and Skills Retention with Laypeople: A Randomized Controlled Trial in Nepal

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Mobile Health App as an Auxiliary Tool in Management of Atopic Dermatitis in Children: Randomized Controlled Trial by Alex Zvulunov, Stepan Lenevich, Natalia Migacheva

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A prospective pragmatic evaluation of automatic trial matching tools in a molecular tumor board by Lilia Gueguen, Louise Olgiati, Clément Brutti-Mairesse, Alric Sans, Vincent Le Texier, Loic Verlingue

“…Each patient had 2.19 trials proposed on average, and 38% had no trials suggested. …”
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Effectiveness of Mobilization with Movement on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials by Gidey Gomera Weleslassie, Melaku Hailu Temesgen, Abayneh Alamer, Gebrerufael Solomon Tsegay, Teklehaimanot Tekle Hailemariam, Haimanot Melese

“…Osteoarthritis is becoming a global major cause of pain and functional disability worldwide, especially in the elderly population. Nowadays, evidence shows that mobilization with movement (MWM) has a beneficial effect on knee osteoarthritis subjects. …”
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The effect of Snoezelen intervention on problem behaviors in children with cerebral palsy: A randomized controlled trial by Mina Kim, Sook-Hee Yi, Jee-Sun Lee, Ji-Young Lee, Yun-Tae Hwang, Jeong-Soo Kim

“…The unique protocol ID for this trial is SRH2018R-01. A randomized controlled trial with 28 children (aged 2–5 years) with CP was conducted. …”
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Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials by Carolina Sandoval Salinas, Andrés L. González Rangel, Juan G. Cataño Cataño, Juan C. Fuentes Pachón, Juan S. Castillo Londoño

“…However, some differences in patient-related outcomes favor the newer methods. Larger trials are required.…”
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Feasibility and accuracy of continuous intraabdominal pressure monitoring with a capsular device in human pilot trial by Chien-Hung Liao, David A. Spain, Chih-Chi Chen, Chi-Tung Cheng, Wei-Cheng Lin, Dong-Ru Ho, Heng-Fu Lin, Fausto Catena

“…However, capsule measurements showed excellent correlation with intravesical IAP measurements, with an intraclass correlation coefficient of 0.916 (95% CI: 0.8821–0.9320). …”
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Efficacy of aquatic exercises on balance in children with sickle cell anemia: A randomized controlled trial by Omar Abd El-Hameed Abd El-Fattah Ghetas, Azza Abd El-Aziz Abd El-Hady, El-Sayed Ali Shaheen Ali, Amira El-Sayed El-Bagalaty

“…A randomized controlled trial was conducted. Sixty children with mild sickle cell anemia and poor balance from both sexes (35 boys and 25 girls) participated in this study. …”
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Effectiveness of a training program for the acquisition of motor milestones in infants: a randomized clinical trial by Luis Fernández-Sola, Beatriz Cano-Díez, Yessica Pons-Solaz, Begoña Vera-Egido, Sergio Moreno-González

“…Results The initial baseline assessment showed no statistical differences between groups (p > 0,05). …”
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Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial by Djawid Hashemi, Ludwig Dettmann, Tobias D. Trippel, Volker Holzendorf, Johannes Petutschnigg, Rolf Wachter, Gerd Hasenfuß, Burkert Pieske, Antonia Zapf, Frank Edelmann

“…Methods and results The aldosterone receptor blockade in diastolic HF trial is a multicentre, prospective, randomized, double‐blind, placebo‐controlled trial conducted between March 2007 and April 2011 at 10 sites in Germany and Austria that included 422 ambulatory patients [mean age: 67 years (standard deviation: 8); 52% women]. …”
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Comparative Evaluation of the Effectiveness of Manual and Electric Toothbrushes in Blind Children: A Randomised Controlled Trial by PS Thanalakshme, R Ramesh

“…Results: Over the course of six months, the study showed that manual toothbrushes were superior to electronic toothbrushes in enhancing oral health in blind children. …”
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Donafenib combined with sintilimab for advanced hepatocellular carcinoma: a single arm phase II trial by Xiaoyang Hong, Yongjian Guo, Wenbo Shi, Kangshun Zhu, Licong Liang, Liteng Lin, Ye Chen, Jingwen Zhou, Jingjun Huang, Jiabai Huang, Yaozhu Wu, Wensou Huang, Mingyue Cai

“…Methods This was a single-center, single-arm phase II trial recruiting patients with BCLC stage C HCC. …”
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The effect of oxytocin, sublingual, and intrauterine misoprostol on blood loss in cesarean delivery: A randomized clinical trial by Mahdieh Masoumzadeh, Vahideh Rahmani, Manizheh Sayyah-Melli, Anis Sani

“…Results: The baseline characteristics showed no significant differences among the groups. …”
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Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials by Aidibai Simayi, Liguo Zhu, Hui Jin

“…The pooled OR of SAEs of women and infants did not show a statistical difference; the pooled ORs were 1.26 (95% CI: 0.78, 2.05); P=0.35) and 0.61 (95% CI: 0.37, 1.01); p=0.053), respectively. …”
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A Randomized Controlled Clinical Trial of Lifestyle Intervention and Pioglitazone for Normalization of Glucose Status in Chinese with Prediabetes by Yingying Luo, Hongyuan Wang, Xianghai Zhou, Cuiqing Chang, Wei Chen, Xiaohui Guo, Jinkui Yang, Linong Ji, Sanjoy K. Paul

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