Niacin alters ruminal microbial composition and metabolites in sheep fed a high-concentrate diet by Zhiqiang Cheng, Jiancheng Liu, Yingying Yu, Wentao Liu, Xiaobin Li, Fengming Li, Changjiang Zang, Kailun Yang

“…Ruminal fluid samples were collected from all trial sheep on days 34 and 35. The results showed that (1) the dry matter feed intake of the NA group was higher than that of the CON group (p < 0.05). (2) The ruminal pH of the NA was significantly higher than that of the CON group at 3, 5, and 7 h after feeding (p < 0.01). …”
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Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study by Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz

“…Clinical Trial Registrationclinicaltrials.gov, Identifier, database (NCT02716259).…”
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Positive end-expiratory pressure and risk of postoperative pulmonary complications in patients living at high altitudes and undergoing surgery at low altitudes: a single-centre, re... by Zhuoning Li, Kaixi Shang, Zongjing Xia, Xiaoli Ye, Chongcong Gong

“…Prospective longitudinal studies are needed to further investigate perioperative lung protection ventilation strategies for patients from high altitudes.Trial registration number Chinese Clinical Trial Registry (ChiCTR2100044260).…”
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Movement therapy in advanced heart failure assisted by a lightweight wearable robot: a feasibility pilot study by Isabell Anna Just, Denis Fries, Sina Loewe, Volkmar Falk, Nikola Cesarovic, Frank Edelmann, Anna Feuerstein, Florian L. Haufe, Michele Xiloyannis, Robert Riener, Felix Schoenrath

“…The results are highly encouraging to further pursue this innovative approach in rehabilitation programmes. This trial was registered at ClinicalTrials.gov: NCT04839133.…”
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The utilization of seagrass and macroalgae substrate for settlement of sandfish Holothuria scabra larvae by Lisa Fajar Indriana, , Marjuky, Sitti Hilyana

“…After 13 days experimental period, the survival of H. scabra larvae showed significantly different among substrates treatment. …”
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Risk factors for the delayed discharge from anesthesia intensive care unit: a single-center retrospective study by Yue Qian, Jing Hao, Wei Zhu, Yan Yang, Zhuan-yun Zhang, Lu-yang Zhou, Xiao-ping Gu, Zheng-liang Ma, Yu-e Sun

“…The nomogram model exhibits excellent performance. Trial registration The single-center retrospective study was approved by the Ethics Committee of Nanjing Drum Tower Hospital (No. 2021-563-01, Data: 22 November 2021) and registered on the Chinese Clinical Trial Registry (No. …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Objective Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)).Methods Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. …”
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Design and Performance Research of Flexible Drill Pipe Joint Based on Bionic Theory by Chuanliu Wang, Pei Ju

“…Based on the principle of engineering bionics, the spine structure and kinematic behavior characteristics of cheetah were studied; the bionic design and trial production of drill pipe joints were carried out. …”
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Promising role of voxelotor in managing sickle cell disease in children: a narrative review by Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua

“…Preclinical studies suggested that voxelotor effectively treats SCD and sickle cell anemia (SCA). In a phase III trial, voxelotor-treated patients showed significantly elevated hemoglobin levels (>1 g/dL from baseline) compared to placebo-treated patients. …”
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Evolutionary Prediction of Soil Loss from Observed Rainstorm Parameters in an Erosion Watershed Using Genetic Programming by Kennedy C. Onyelowe, Ahmed M. Ebid, Light Nwobia

“…The performance evaluation of the three models showed that trial 3 with the highest parametric permutation, i.e., that included the influence of all the studied parameters showed the least error of 0.1 and the maximum coefficient of determination (R2) of 0.97 and as such is the most efficient, robust, and applicable GP model to predict the soil loss value.…”
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Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MI... by Fiona McNicholas, Dieter Wolke, Jason Madan, Jatinder Singh, Federico Fiori, Paramala Santosh, Jane Warwick, Helena Tuomainen, Swaran Singh, Laura Adams, Mathilde Mastroianni, Natalie Heaney, Kate Lievesley, Ilyas Sagar-Ouriaghli, Giovanni Allibrio, Rebecca Appleton, Nikolina Davidović, Giovanni de Girolamo, Gwen Dieleman, Katarina Dodig-Ćurković, Tomislav Franić, Charlotte Gatherer, Suzanne Gerritsen, Elisa Gheza, Lidia Manenti, Athanasios Maras, Francesco Margari, Adriana Pastore, Moli Paul, Diane Purper-Ouakil, Francesco Rinaldi, Vehbi Sakar, Ulrike Schulze, Giulia Signorini, Cathy Street, Priya Tah, Sabine Tremmery, Amanda Tuffrey, Frank Verhulst, Anna Wilson

“…The main results of the cohort study with the nested cluster randomised trial are not reported.Conclusion The TRAM is a reliable instrument for assessing transition readiness and appropriateness. …”
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The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity by Mustafa Sibai, Sergi Cervilla, Daniela Grases, Eva Musulen, Rossana Lazcano, Chia-Kuei Mo, Veronica Davalos, Arola Fortian, Adrià Bernat, Margarita Romeo, Collin Tokheim, Jordi Barretina, Alexander J. Lazar, Li Ding, Enrique Grande, Francisco X. Real, Manel Esteller, Matthew H. Bailey, Eduard Porta-Pardo, Enrique Grande, Teresa Alonso-Gordoa, Mario Álvarez-Maestro, Elena Andrada, Ainara Azueta, Raquel Benítez Javier Burgos, Daniel Castellano, M. Angel Climent, Mario Domínguez, Ignacio Durán Albert Font, Isabel Galante, Patricia Galván, Juan F. García, Xavier García del Muro, Félix Guerrero-Ramos, Núria Malats, Miriam Marqués, Pablo Maroto, Jaime Martínez de Villarreal, Ane Moreno-Oya, Jesús M. Paramio, Alvaro Pinto, Aleix Prat, Javier Puente, Oscar Reig, Francisco X. Real

“…Here, we explore the spatial distribution of cancer hallmarks across 63 primary untreated tumors from 10 cancer types using spatial transcriptomics. We show that hallmark activity is spatially organized, with the cancer compartment contributing to the activity of seven out of 13 hallmarks, while the tumor microenvironment (TME) contributes to the activity of the rest. …”
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Longitudinal Study on Low-Dose Aspirin versus Placebo Administration in Silent Brain Infarcts: The Silence Study by Ilaria Maestrini, Marta Altieri, Laura Di Clemente, Edoardo Vicenzini, Patrizia Pantano, Eytan Raz, Mauro Silvestrini, Leandro Provinciali, Isabella Paolino, Carmine Marini, Matteo Di Giuseppe, Tommasina Russo, Francesco Federico, Cristiana Coppola, Maria Pia Prontera, Domenico Maria Mezzapesa, Vincenzo Lucivero, Lucilla Parnetti, Paola Sarchielli, Maria Peducci, Domenico Inzitari, Giovanna Carlucci, Carlo Serrati, Carla Zat, Anna Cavallini, Alessandra Persico, Giuseppe Micieli, Stefano Bastianello, Vittorio Di Piero

“…Conclusions. These data show an increase of new CVD events in the untreated group. …”
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Sistem Kontrol Swarm untuk Flocking Wahana NR-Awak Quadrotor dengan Optimasi Algoritma Genetik by Endra Joelianto, Winarendra Satya Rajasa, Agus Samsi

“…In this paper, tuning with the optimization of GA is only done for the PD controller in order to produce the best swarm trajectory, while the weight matrices of the LQR are done on a trial error basis. Swarm simulation results of a quadrotor model system show the parameters , . , and  obtained using GA produce a good swarm movement with RMS error 0.0094 m of the objective function. …”
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Benefits, limits, and risks of ChatGPT in medicine by Jonathan A. Tangsrivimol, Jonathan A. Tangsrivimol, Erfan Darzidehkalani, Hafeez Ul Hassan Virk, Zhen Wang, Zhen Wang, Jan Egger, Michelle Wang, Sean Hacking, Benjamin S. Glicksberg, Markus Strauss, Markus Strauss, Chayakrit Krittanawong, Chayakrit Krittanawong

“…ChatGPT represents a transformative technology in healthcare, with demonstrated impacts across clinical practice, medical education, and research. Studies show significant efficiency gains, including 70% reduction in administrative time for discharge summaries and achievement of medical professional-level performance on standardized tests (60% accuracy on USMLE, 78.2% on PubMedQA). …”
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Learning Through Reflection: A Team’s Reflection on a Digital, Text-based Positive Health Coaching Intervention for Healthcare Professionals by Croia Loughnane, Róisín O’Donovan, Ashley P. Duggan, Pádraic Dunne

“…This article explores a coach’s reflections during a recent Randomised Controlled Trial (RCT) that examined the feasibility of text-based digital coaching for healthcare workers. …”
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Próba oceny rozwoju polskiej wsi pięć lat po przystąpieniu do Unii Europejskiej by Anna Marciniuk-Kluska, Antoni Bombik

“…The objective of this article is familiarisation with the issues relating to agricultural development in Poland and its perspectives for the future. A trial to assess the development of the Polish agricultural areas has been made five years after the accession to the European Union. …”
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Impact of the Project P.A.T.H.S. in the Junior Secondary School Years: Individual Growth Curve Analyses by Daniel T. L. Shek, Cecilia M. S. Ma

“…In the third year of the Full Implementation Phase, 19 experimental schools (n = 3,006 students) and 24 control schools (n = 3,727 students) participated in a randomized group trial. Analyses based on linear mixed models via SPSS showed that participants in the experimental schools displayed better positive youth development than did participants in the control schools based on different indicators derived from the Chinese Positive Youth Development Scale, including positive self-identity, prosocial behavior, and general positive youth development attributes. …”
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Development of PMRI Module in NTT Local Cultural Context to Improve Numeracy Literacy by Julindra Lesmana Baria, Agustin Fatmawati, Nia Kurniaty Rukman

“…Next is the disseminate stage, namely dissemination by conducting product trials. The trial was carried out on randomly selected grade VII students. …”
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The force of questioning and pragmatic strategies in courtroom interrogation: A conversation analysis by Anisah Anisah, Diana Fauzia Sari

“…Gibbons’ (2003) repetition and reformulation strategies were used to further investigate the pragmatic strategies. The finding shows pragmatic strategies, particularly repetition, and reformulation, were also evidenced in the lines of questioning. …”
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