New developments in immunotherapy for SCLC by Zhonglin Hao, Tsering Dolkar, Christopher Gates, Reinhold Munker

“…Several phase II and phase III clinical trials for bispecific T cell engagers show promise. …”
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Vibration Frequencies Extraction of the Forth Road Bridge Using High Sampling GPS Data by Jian Wang, Xiaolin Meng, Changbiao Qin, Jiaohong Yi

“…To understand the change in the structural characteristics under different loadings, the deformation results from three different loading conditions are presented, that is, the ambient circulation loading, the strong wind under abrupt wind speed change, and the specific trial with two 40 t lorries passing the bridge. The results show that GPS not only can capture absolute 3D deflections reliably, but also can be used to extract the frequency response accurately. …”
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Reporting and interpreting statistical results in veterinary medicine: Calling for change by Hsin‐Yi Weng, Locksley L. McV. Messam

“…By providing practical guidance, we show that a change in reporting and interpreting statistical results is feasible and necessary. …”
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Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China by Shuang Zhao, Han Yang, Haijuan Zhao, Miao Miao, Qingqing Wang, Yaru Wang, Yuying Yin, Xin Wang

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Dynamic natural components and morphological changes in nonculprit subclinical atherosclerosis in patients with acute coronary syndrome and mild chronic kidney disease at the 1-yea... by Jia-Cong Nong, Wei You, Yi-Fei Wang, Yi Xu, Tian Xu, Pei-Na Meng, Xiang-Qi Wu, Zhi-Ming Wu, Xiao-Han Kong, Hai-Bo Jia, De-Lu Yin, Lang Li, Fei Ye

“…<h4>Trial registration</h4>Clinical Trial registration ClinicalTrials.gov. …”
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Beehive Fireworks Festival Effect on the Nearby Atmospheric PM2.5 Level by Chih-Chung Lin, Jen-Hsiung Tsai, Yi-Chin Hsieh, Shui-Jen Chen

“…The iso-concentration contour maps show that K+, Cl−, Mg2+, and NO3 − are related to firework release during the festival.…”
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A systematic review of the impact of artificial intelligence on educational outcomes in health professions education by Eva Feigerlova, Hind Hani, Ellie Hothersall-Davies

“…Clinical Trial number: not applicable.…”
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Black Soldier Fly Larvae’s Optimal Feed Intake and Rearing Density: A Welfare Perspective (Part II) by Arianna Cattaneo, Simona Belperio, Luca Sardi, Giovanna Martelli, Eleonora Nannoni, Sihem Dabbou, Marco Meneguz

“…In this study, Control (commercial laying hen feed) and Omnivorous substrates (vegetable and meat) were used as dietary regimes. In the first trial, three feeding rates were tested: 50, 100, and 200 mg feed/larva/day; in the second trial, three rearing densities were evaluated: 5, 10, and 15 larvae/cm². …”
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LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model by Po-Cheng Chang, Shien-Fong Lin, Yen Chu, Hung-Ta Wo, Hui-Ling Lee, Yu-Chang Huang, Ming-Shien Wen, Chung-Chuan Chou

“…LCZ696 (valsartan/sacubitril) therapy significantly reduced mortality in patients with heart failure (HF). Although a clinical trial (PARADISE-MI Trial) has been ongoing to examine the effects of LCZ696 in myocardial infarction (MI) patients, the effects of LCZ696 on remodeling of cardiac electrophysiology in animal models remain largely unclear. …”
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Prediction of post-contrast acute kidney injury by bedside ultrasonography by Mümin Murat Yazici, Enes Hamdioğlu, Nurullah Parça, Gürkan Altuntaş, Özcan Yavaşi, Özlem Bilir

“…Further studies are needed to confirm these findings. Trial registration Clinical trial number: not applicable.…”
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Effects of Long Distance Transportation on Honey Bee Physiology by Kiheung Ahn, Xianbing Xie, Joseph Riddle, Jeff Pettis, Zachary Y. Huang

“…Protein content in head showed no significant differences between S and T either in 7-day-old or 17-day-old bees of MI trial, but GA trial showed a significant reduction in bees experiencing transportation. …”
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Step-by-step causal analysis of EHRs to ground decision-making. by Matthieu Doutreligne, Tristan Struja, Judith Abecassis, Claire Morgand, Leo Anthony Celi, Gaël Varoquaux

“…We show that too large treatment-initiation times induce immortal time bias. …”
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The Interaction Between Dietary Fat Level, n-3 LC-PUFA, and Zinc on Their Postprandial Absorption Kinetics in Atlantic Salmon (Salmo salar) by HaoHang Fang, Nini H. Sissener, Øystein Sæle, Trygve Sigholt, Antony J. Prabhu Philip

“…After 4-week feeding interventions, samples were collected at different postprandial time points, ranging from 0 to 36/38 h after feeding. Results showed that increased Zn level in feed significantly increased the postprandial plasma Zn level in trial 1 (8–9°C). …”
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Harmonization of the fastest and densest responses reflects humanlike reaction time in mice by Chan Hee Kim

“…Unlike humans, whose RT usually reflects a one-to-one stimulus–response relationship, the RT of animals can show two peaks representing the fastest and densest responses in the response distribution due to multiple responses per trial and can be further delayed depending on stimulus duration.MethodsStimulus duration was controlled to investigate whether these two peak latencies align to form a single RT. …”
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Dopamine Appetite and Cognitive Impairment in Attention Deficit/Hyperactivity Disorder by Jonathan Williams, Eric Taylor

“…The TD model contains four parameters: the learning rate, discounting for future rewards, brittleness (randomness) of behavior, and action bias. The results show that the basic TD model accounts well for control performance in trials of 5 sec, 10 sec, and 15 sec duration; but not for the deficits in ADHD performance at 5 sec and 15 sec. …”
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VIRTUAL MANUFACTURING AND SIMULATION ANALYSIS OF SPIRAL BEVEL GEAR BASED ON CURVATURE ADJUSTMENT by WANG XueJun, WANG ZhongHou, LI Yan, DIAO XinWei, LIU XiaoFeng

“…In view of the blindness and contingency of the trial cutting method in traditional processing of spiral bevel gears, this paper proposes a processing adjustment method of designing grinding wheel section according to the curvature of the tooth surface. …”
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Deception defense method against intelligent penetration attack by Jinyin CHEN, Shulong HU, Changyou XING, Guomin ZHANG

“…The intelligent penetration attack based on reinforcement learning aims to model the penetration process as a Markov decision process, and train the attacker to optimize the penetration path in a trial-and-error manner, so as to achieve strong attack performance.In order to prevent intelligent penetration attacks from being maliciously exploited, a deception defense method for intelligent penetration attack based on reinforcement learning was proposed.Firstly, obtaining the necessary information for the attacker to construct the penetration model, which included state, action and reward.Secondly, conducting deception defense against the attacker through inverting the state dimension, disrupting the action generation, and flipping the reward value sign, respectively, which corresponded to the early, middle and final stages of the penetration attack.At last, the three-stage defense comparison experiments were carried out in the same network environment.The results show that the proposed method can effectively reduce the success rate of intelligent penetration attacks based on reinforcement learning.Besides, the deception method that disrupts the action generation of the attacker can reduce the penetration attack success rate to 0 when the interference ratio is 20%.…”
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A Rare Presentation of Hepatitis A Infection with Extrahepatic Manifestations by Geetika Bhatt, Varrinder S. Sandhu, Charlene K. Mitchell

“…A trial of prednisone resulted in improvement of his symptoms. …”
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Adaptive wavelet base selection for deep learning-based ECG diagnosis: A reinforcement learning approach. by Qiao Xiao, Chaofeng Wang

“…Traditional methods typically rely on fixed wavelet bases chosen heuristically or through trial-and-error, which can fail to cover the distinct characteristics of individual ECG signals, leading to suboptimal performance. …”
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Self-adaptive differential evolution algorithm based on population state information by Weijie MAI, Weili LIU, Jinghui ZHONG

“…The local optimum and stagnation state information of the population seriously affects the performance of differential evolution (DE) algorithm.An advanced DE algorithm with population state processing measures was proposed to address the above two issues.When the population falled into the local optimum, the individuals in the population were learned randomly by LBFGS method to improve the global quality of the solution, and Gaussian mutation was employed to trigger new individuals to jump out of local optimum.As for the stagnation state, the covariance matrix of the population was applied to reorganize the target individuals based on the rotation of the spatial coordinates to suppress the stagnation state of the population and enhance the global search ability of the algorithm.In addition, a new selection strategy was designed, which built an external archive to store abandoned individuals after greedy selection.When the trial individual was inferior to the target individual, the algorithm no longer generated the next generation with greedy selection strategy, but made reasonable intelligent selection around the external archive to ensure that the algorithm converges to the global optimum.Compared with eight state-of-the-art DE algorithms on 29 benchmark functions, the experimental results show that the proposed algorithm has better performance in terms of the solution accuracy and convergence speed.…”
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