A phase I study of the CDK4/6 inhibitor ribociclib combined with gemcitabine in patients with advanced solid tumors by Aurora Norman, Mahesh Seetharam, Jacob Allred, Jianping Kong, Mateusz Opyrchal, Wen Wee Ma, Yanyan Lou, Grace K. Dy, Amit Mahipal, S. John Weroha, Andrea E. Wahner Hendrickson, Joel M. Reid, Alex A. Adjei

“…Abstract Background Based on preclinical data showing addition of CDK4/6 inhibitors to gemcitabine was synergistic, ribociclib was evaluated in combination with gemcitabine to determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLT). …”
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2013 Evaluation of Non-Irrigated Mid- to Full-Season Maturing Cotton Varieties in Jay, Florida by Darcy E. P. Telenko, Michael Donahoe

“… This report includes a summary of the 2013 mid- to full-season cotton Official Variety Trial in Jay, Florida. It shows the performance of 16 cotton varieties. …”
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2013 Evaluation of Non-Irrigated Mid- to Full-Season Maturing Cotton Varieties in Jay, Florida by Darcy E. P. Telenko, Michael Donahoe

“… This report includes a summary of the 2013 mid- to full-season cotton Official Variety Trial in Jay, Florida. It shows the performance of 16 cotton varieties. …”
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2013 Evaluation of Non-Irrigated Early-Maturing Cotton Varieties in Jay, Florida by Darcy E. P. Telenko, Michael Donahoe

“… This report includes a summary of the 2013 early-season cotton Official Variety Trial in Jay, Florida. It shows the performance of 11 cotton varieties. …”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…Metabolomic analysis showed some separation in the levels of ceramides and cardiolipins between those who survived and those who died. …”
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Improvement of cocoa-pod husk using sheep rumen liquor for tilapia diet by Dedi Jusadi, Julie Ekasari, Azis Kurniansyah

“…Tilapia with an average body weight of 3.86±0.44 g were stocked at a density of 15 fish/aquarium and were maintained for 15 days. In the first trial, CPHM hydrolyzed with 150 mL/kg and incubated for 12 and 24 hour showed the lowest crude fiber content (21.38% and 21.67%). …”
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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…However, clopidogrel responsiveness shows variability based on CYP2C19 polymorphism. …”
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Pollution Characteristics and Risk Assessment of Heavy Metal Elements in Sediment in the West Lake of Hengshui Lake by Zhongqiang Zhang, Shuzhen Wei, Jianxiao Liu

“…The degree of heavy metal pollution was evaluated by the geoaccumulation index (Igeo) method. The results showed that the concentrations of Cr, Zn, Pb, Cu, Cd, and Hg at in all sampling points of the fish ponds were lower than soil risk screening values of agricultural land in soil environmental quality: risk control standard for soil contamination of agricultural land (trial) (GB 15618-2018). …”
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Economic Evaluation of a Novel Treatment of Attention-Deficit/Hyperactivity Disorder in US Motor Vehicle Drivers by Jacie T. Cooper, John E. Schneider, Jim Potenziano, David S. Fam

“…A randomized controlled trial showed that DXR patients were 43% less likely to crash during a driving simulation than individuals taking placebo. …”
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Self-testing for pregnancy: a systematic review and meta-analysis by Ping Teresa Yeh, Caitlin E Kennedy, Manjulaa Narasimhan, Karima Gholbzouri

“…One additional trial of community health workers offering home pregnancy tests showed a significant increase in pregnancy knowledge and antenatal counselling among 506 clients. …”
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Reliability of nociceptive monitors vs. standard practice during general anesthesia: a prospective observational study by Daniel Widarsson Norbeck, Sophie Lindgren, Axel Wolf, Pether Jildenstål

“…Conclusion NOL and SCA demonstrated superior sensitivity and responsiveness to nociceptive stimuli compared to HR, effectively detecting significant changes in nociceptive thresholds across various stimuli, although responses during skin incision showed no such advantage. Trial registration Clinical trial - NCT05218551.…”
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The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia by Yukako Obata, Yushi U. Adachi, Katsumi Suzuki, Taiga Itagaki, Hiromi Kato, Maiko Satomoto, Yoshiki Nakajima

“…The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference. This trial is registered with UMIN Clinical Trial Registry: UMIN000019925.…”
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Collagen turnover biomarkers to predict outcome of patients with biliary cancer by Leonard Kaps, Muhammed A. Genc, Markus Moehler, Stephan Grabbe, Jörn M. Schattenberg, Detlef Schuppan, Rasmus Sund Pedersen, Morten A. Karsdal, Philipp Mildenberger, Annett Maderer, Nicholas Willumsen

“…Trial registration Trial registration number and date of registration NCT00661830 (NCT number) 15 April 2008 Trial registry The complete registry can found under: https://clinicaltrials.gov/study/NCT00661830?…”
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Effectiveness of the Modified WHO Labour Care Guide to Detect Prolonged and Obstructed Labour Among Women Admitted at Eight Publicly Funded, Midwife-Led Community Health Facilities... by Mugyenyi GR, Tumuhimbise W, Atukunda EC, Tibaijuka L, Ngonzi J, Kayondo M, Kanyesigye M, Musimenta A, Yarine FT, Byamugisha JK

“…More controlled and powered studies should evaluate the two tools in different facilities and sub-populations.Trial Registration: This trial registration was registered with clinical trials.gov number NCT05979194 on 2023-08-07, and the protocol was published by BMJ open, as 10.1136/bmjopen-2023-079216 on 15 April 2024.21 Trial registration number NCT05979194 clinical trials.gov.Keywords: modified WHO LCG, partograph, effectiveness, labour monitoring, ambispective cohort study, Uganda…”
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Optimasi Keamanan Web Server Terhadap Serangan Brute-Force Menggunakan Penetration Testing by Fahmi Fachri

“…The results of the study show that there are three categories of weaknesses, 5 vulnerabilities at the High level, 164 vulnerabilities at the Medium level, 52 vulnerabilities at the Low level. …”
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The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers by Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Carsten Watzl, Edmund Wascher, Stephan Getzmann

“…These parameters should be considered when assessing the risk for developing burnout and validating the diagnosis of burnout. Trial registration: ClinicalTrials.gov NCT05155397; https://clinicaltrials.gov/ct2/show/NCT05155397.…”
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Relationships between multiple patient safety outcomes and healthcare and hospital-related risk factors in colorectal resection cases: cross-sectional evidence from a nationwide sa... by Ralf Kuhlen, Jochen Schmitt, Felix Walther, Martin Roessler, Peter Scriba, Maria Eberlein-Gonska, Olaf Schoffer

“…Hospital variables like volume, ownership or localisation did not show consistent relationships to patient safety outcomes.Trial registration number ISRCTN10188560.…”
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Transcranial photobiomodulation for reducing symptoms of autism spectrum disorder and modulating brain electrophysiology in children aged 2–7: an open label study by Yuli Fradkin, Joaquin A. Anguera, Alexander J. Simon, Luis De Taboada, Eugenia Steingold

“…No moderate or severe side effects were reported.ConclusionThis study supports the potential of tPBM as a safe and effective treatment for ASD, and it suggests that EEG measurements may serve as a useful biomarker for future research. Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT04660552…”
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Low-Protein Diet Supplemented with Keto Acids Is Associated with Suppression of Small-Solute Peritoneal Transport Rate in Peritoneal Dialysis Patients by Na Jiang, Jiaqi Qian, Aiwu Lin, Wei Fang, Weiming Zhang, Liou Cao, Qin Wang, Zhaohui Ni, Qiang Yao

“…We investigate whether low-protein diet would show benefits in suppressing peritoneal transport rate in peritoneal dialysis (PD) patients. …”
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Development of a machine learning model related to explore the association between heavy metal exposure and alveolar bone loss among US adults utilizing SHAP: a study based on NHAN... by Jiayi Chen

“…Conclusion In this study, RF showed superior performance compared with the other five algorithms. …”
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