A multidisciplinary pain management program for patients with chronic low back pain: a randomized, single-blind, controlled, feasibility study by Anna Dalmau-Roig, Christian Dürsteler, Mirari Ochandorena-Acha, Francisco Vilchez-Oya, Inés Martin-Villalba, Amadeu Obach, Marc Terradas-Monllor

“…Furthermore, the exploratory results of this study suggest that it could be an effective treatment to reduce pain intensity and improve on self-reported quality of life in these patients, although a future randomized clinical trial is needed to determine its effectiveness. Trial registration NCT05974072 (registration date July 11, 2023; retrospectively registered; ClinicalTrials.gov).…”
Get full text

Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…Physical activity data showed a positive trend towards increased activity overall, but no other changes in secondary outcomes were detected.Conclusions To make this intervention feasible for testing as a full trial, further research is required on (a) recruitment optimisation, (b) appropriate assessment tools, (c) protocols for phase 2 and 3, which can build in flexibility and (d) ways for NHS staff to facilitate the programme.Trial registration number ISRCTN52345929; Post-results.…”
Get full text

Efficacy and safety of everolimus for patients with focal cortical dysplasia type 2 by Se Hee Kim, Hoon‐Chul Kang, Yun Ho Roh, Jongsung Hahn, Kyung Lok Min, Seok‐Jin Lee, Donghwa Yang, Han Som Choi, Soyoung Park, Jeong Ho Lee, Sang‐Guk Lee, Se Hoon Kim, Min Jung Chang, Heung Dong Kim

“…Methods A prospective, crossover, placebo‐controlled clinical trial (ClinicalTrials.gov: NCT03198949) enrolled patients aged 4–40 years with pathologically confirmed FCD 2 and a history of ≥3 seizures per month for two out of the 3 months prior to screening. …”
Get full text

Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

Get full text

Swirling Flow and Wall Shear: Evaluating the BioMimics 3D Helical Centerline Stent for the Femoropopliteal Segment by Timothy M. Sullivan, Thomas Zeller, Masato Nakamura, Colin G. Caro, Michael Lichtenberg

“…A 271-patient multicenter international MIMICS-2 trial and a 500-patient real-world MIMICS-3D registry are underway.…”
Get full text

Pengembangan Instrumen Keterampilan Berpikir Kritis pada Pembelajaran Matematika SMA by Budi Harjo, Sudarmadi Putra, Kafin Jaladri, Joko Subando

“…The subsequent expanded trial evaluated construct validity and reliability using CFA. …”
Get full text

Drainage of Complex Walled-Off Pancreatic Fluid Collections in LAMS Era: A Multicenter Study by Thanawat Luangsukrerk, Kamin Harinwan, Stanley Khoo, Pradermchai Kongkam

“…Complex WOPFC had larger diameter of lesions, higher proportion of solid component, higher prevalence of pancreatic duct leakage, and higher number of DEN is required than group noncomplex lesions. Trial Registration. This trial is registered with TCTR20180223004.…”
Get full text

Comparative Effectiveness of Ultrasound-Guided Intratendinous Prolotherapy Injection with Conventional Treatment to Treat Focal Supraspinatus Tendinosis by John George, Shyan Ch’ng Li, Zulkarnain Jaafar, Mohamad Shariff A. Hamid

“…Ultrasound-guided intratendinous prolotherapy injection significantly improves patient’s range of abduction and improves sleep within 12 weeks of treatment compared to conventional physiotherapy management. Trial Registration. This study was registered under Current Controlled Trials (UK) and given International Standard Randomised Controlled Trial Number (ISRCTN) of 43520960.…”
Get full text

Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs by Jürgen Eichler, Björn Rulik, Alexander Abazid, Matthias B. Stope

“…Under NIPP treatment, patients showed no signs of pain, stress or discomfort, even after several applications. …”
Get full text

Assessment of Suspected Breast Lesions in Early-Stage Triple-Negative Breast Cancer during Follow-Up after Breast-Conserving Surgery Using Multiparametric MRI by Lamiss Mohamed Abd El Aziz Sad, Naglaa Lofty Dabees, Dareen Abd El-Aziz Mohamed, Amr Tageldin, Samar Galal Younis

“…Combination of DWI-MRI and DCE-MRI could have high diagnostic value for evaluating postoperative changes in patients with TNBC after BCS, followed by radiotherapy with/without chemotherapy. Trial Registrations. No trial to be registered.…”
Get full text

Causes and Clinical Impact of Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy by Hazem Abdelmotaal, Walid Ibrahim, Mohamed Sharaf, Khaled Abdelazeem

“…Possibly, patient-specific LTFU causes should be addressed before treatment in order to minimize the risk of LTFU. The clinical trial is registered with NCT04018326 (trial registration: ClinicalTrials.gov Identifier: NCT04018326, 10th of July 2019 “Retrospectively registered”).…”
Get full text

Acute effect of exercise with or without the integration of cooperative activities on inhibitory control in preadolescent school children by Melanie Berger, Markus Gerber, Sebastian Ludyga

“…Decomposition of the interaction showed that in contrast to CON and EX, EX+CO showed a greater increase of accuracy on incongruent relative to congruent trials. …”
Get full text

Intense Pulsed Light Therapy with Optimal Pulse Technology as an Adjunct Therapy for Moderate to Severe Blepharitis-Associated Keratoconjunctivitis by Fang Ruan, Yunxiao Zang, Ruti Sella, Hongshuang Lu, Shang Li, Ke Yang, Tao Jin, Natalie A. Afshari, Zhiqiang Pan, Ying Jie

“…This trial was initiated after a four-week pharmacotherapy for BKC in both groups and was scheduled at four-week intervals. …”
Get full text

Exploring Antibacterial Activity of Fish Protein Hydrolysate In Vitro Against Vibrio Strains and Disease Resistance to V. harveyi in Turbot (Scophthalmus maximus) by Yuliang Wei, Lu Wang, Yanlu Li, Qiang Ma, Mengqing Liang, Houguo Xu

“…Results of the feeding trial showed that FPH enhanced antioxidant and immune responses before V. harveyi challenge as modulating immunoglobulin M (IgM), catalase (CAT), and myeloperoxidase (MPO) activities in serum, as well as the number of goblet cells in the intestine. …”
Get full text

Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthe... by Emily Eisner, Sophie Faulkner, Stephanie Allan, Hannah Ball, Daniela Di Basilio, Jennifer Nicholas, Aansha Priyam, Paul Wilson, Xiaolong Zhang, Sandra Bucci

“… BackgroundDigital mental health interventions (DMHIs) to monitor and improve the health of people with psychosis or bipolar disorder show promise; however, user engagement is variable, and integrated clinical use is low. …”
Get full text

Effects of a Newly Developed Therapeutic Deep Heating Device Using High Frequency in Patients with Shoulder Pain and Disability: A Pilot Study by Gi-Wook Kim, Yu Hui Won, Sung-Hee Park, Jeong-Hwan Seo, Dae-hyun Kim, Hyung Nam Lee, Myoung-Hwan Ko

“…Methods. This noninferiority trial was designed to compare the treatment effect of HIPER-500® to that of SonoStim® (ultrasound) on shoulder pain and disability. …”
Get full text

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Preclinical and clinical trial data demonstrate the therapeutic potential of these tailored techniques. …”
Get full text

Psychometric Testing of the CHAMPS Questionnaire in French Canadians with COPD by Susanne Mak, Jean Bourbeau, Nancy E. Mayo, Sharon Wood-Dauphinee, Judith E. Soicher

“…The English and French versions of the CHAMPS did not show any substantial differences in reliability (frequency scores) or validity (frequency and caloric expenditure scores). …”
Get full text

Experiences of change following a blended intervention for adults with ADHD and emotion dysregulation: a qualitative interview study by Emilie S. Nordby, Viktor Schønning, Alice Barnes, Hayley Denyer, Jonna Kuntsi, Astri J. Lundervold, Frode Guribye

“…ClinicalTrials.gov ID: NCT05644028.…”
Get full text

Steroid use for established bronchopulmonary dysplasia: study protocol for a systematic review and meta-analysis by Roy K Philip, Joanna Seliga-Siwecka, Eduardo Villamor, Maria Pierro, Niazy Al Assaf, Sabina Strashun, Roberto Chioma, Kinga Zielińska, Krzysztof Włodarczyk

“…Moreover, a late timing for steroid treatment may show a more favourable safety profile in terms of neurodevelopment outcomes, considering the added postnatal brain maturation of these infants. …”
Get full text