Comparative Evaluation of Ketoprofen Gel Alone and in Combination with Doxycycline Gel as Local Drug Delivery in the Treatment of Chronic Periodontitis among Smokers and Non-Smoker... by Krupali J. Gandhi, Priyadarshini P. Nadig, Shivlal Vishnoi, Bhumika S. Sheth, Jinal Desai, Kandarp Raj

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Effectiveness of a resilience, gender equity and mental health group intervention for young people living in informal urban communities in North India: a cluster randomized control... by Varadharajan Srinivasan, Miguel San Sebastián, Samson Rana, Pooja Bhatt, Greg Armstrong, Smita Deshpande, Kaaren Mathias

“…Methods This cluster randomised controlled trial used an analytic sample of 476 adolescents and young adults aged 11–25 years from randomised clusters in urban Dehradun, India. …”
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Impact of Scleroderma‐Associated Autoantibodies on Clinical Outcome Assessments: Post Hoc Analysis From a Randomised, Double‐blind, Placebo‐controlled, Phase 3 Trial of Tocilizumab... by Basmah Al Dulaijan, Suiyuan Huang, Celia J. F. Lin, Christopher P. Denton, Dinesh Khanna

“…Our objective was to assess the influence of baseline SSc‐Abs on the trajectories of the clinical outcome assessments (COAs) in a phase III randomized controlled trial. Methods We used data on both the groups who received placebo (Pbo) and tocilizumab from the focuSSced trial. …”
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The effect of psychosocial stimulation on the development, nutrition, and treatment outcomes of hospitalised children with severe acute malnutrition in Southern Ethiopia: a cluster... by Tesfalem Teshome Tessema, Andamlak Gizaw Alamdo, Eyoel B. Mekonnen, Tewodros G. Yirtaw, Fanna A. Debele, Teklu Gemechu, Tefera Belachew

“…A cluster-randomised controlled trial was conducted among health facilities that provide inpatient care for children with SAM in Silti Zone, Ethiopia. …”
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Does the transfer of knowledge from the pioneer generation to the second‐generation speed‐up the learning curve of robot‐assisted partial nephrectomies? TRANSFER trial (UroCCR n°83... by Louis Vignot, Zine‐Eddine Khene, Adil Mellouki, Arnoult Morrone, Jean‐Christophe Bernhard, Karim Bensalah, Daniel Chevallier, Nicolas Doumerc, Morgan Roupret, Francois‐Xavier Nouhaud, Cédric Lebacle, Jean‐Alexandre Long, Pierre Pillot, Xavier Tillou, Brannwel Tibi, Matthieu Durand, Younes Ahallal, Imad Bentellis

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Division of the inferior pulmonary ligament during upper lobectomy does not improve postoperative pulmonary function: a systematic review and meta-analysis of observational studies... by Boyang Chen, Weifeng Tang, Junhai Chen, Mingqiang Kang, Jinbiao Xie, Wu Wang, Tianbao Yang, Shijie Huang

“…Results 9 studies were identified, including two randomized controlled trials and seven retrospective case-control studies involving 1,612 patients. …”
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SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized con... by Beverley Lim Høeg, Katrine Bjerre Løppenthin, Josée Savard, Christoffer Johansen, Jesper Frank Christensen, Mads Nordahl Svendsen, Niels Holländer, Pernille Envold Bidstrup

“…Patients/material and methods: We conducted a feasibility randomized trial in patients under treatment for castration resistant mPCa with insomnia (Insomnia Severity Index [ISI] score ≥ 8). …”
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Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, C... by Nattaphol Uransilp, Pannawat Chaiyawatthanananthn, Sombat Muengtaweepongsa

“…This trial is registered with ClinicalTrials.gov ID: NCT03402204.…”
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Effectiveness of a Novel Contralaterally Controlled Neuromuscular Electrical Stimulation for Restoring Lower Limb Motor Performance and Activities of Daily Living in Stroke Survivo... by Ying Shen, Lan Chen, Li Zhang, Shugang Hu, Bin Su, Huaide Qiu, Xingjun Xu, Guilan Huang, Zhifei Yin, Jinyu Yang, Chuan Guo, Tong Wang

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Comparative analysis of land-based vs. water-based balance training on quality of life and physical and psychological deficits in athletes with chronic ankle instability: a randomi... by Aynollah Naderi, Khadije Ahi

“…A flexible rehabilitation program combining both approaches can optimize recovery, addressing specific needs, even though no significant differences were found in ankle stability, kinesiophobia, psychological Quality of Life, and dynamic balance between the two methods. Trial registration This study was prospectively registered with the University Hospital Medical Information Network Clinical Trial Registry under Clinical Trials UMIN000051746 on July 29, 2023.…”
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Efficacy and safety of sublingual immunotherapy using a combination of Dermatophagoides pteronyssinus and Blomia tropicalis extracts in patients with allergic rhinitis: A randomize... by Priscilla Rios Cordeiro Macedo, MD, MSc, Priscila Moraes, MD, Luísa Karla Arruda, MD, PhD, Fábio Fernandes Morato Castro, MD, PhD, Jorge Kalil, MD, PhD, Clóvis Eduardo Santos Galvão, MD, PhD

“…Methods: This was a double-blind, randomized, placebo-controlled trial of SLIT to treat house dust mite-induced Allergic Rhinitis (AR). …”
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Comparing physiological and psychological effects of virtual reality vs. traditional high-intensity interval training in healthy individuals: results from a preliminary pilot rando... by Jonathan Robinson, Mohammad Haziq Bin Abdul Razak

“…Conclusions This pilot study suggests that fully immersive VR can be an effective alternative to traditional HIIT, providing a high-flow experience and potentially enhancing motivation among physically active users. Trial registration ClinicalTrials.gov, NCT06420414. …”
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Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for delirium in intensive care units (ICU) and postoperative settings. …”
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Exploration of the quantitative-effectiveness association between acupuncture temporal parameters and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response... by Hao Tian, Qin Luo, Liuyang Huang, Liuyang Huang, Liuyang Huang, Guang Chen, Mingsheng Sun, Fanrong Liang

“…Future high-quality studies and large-scale multicenter clinical trials are needed to validate these findings.…”
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Anemia, Thrombocytopenia, and Changes in Biochemical Parameters Occurring in Patients with Uncomplicated Plasmodium falciparum Malaria: Data Analysis from Antimalarial Efficacy-Ran... by Khadime Sylla, Roger Tine, Doudou Sow, Souleye Lelo, Annie Abiola, Jean Louis NDiaye, Magatte NDiaye, Kuaku Folly, Léon Amath NDiaye, Oumar Gaye, Babacar Faye

“…Results from this analysis showed that subjects with high parasitaemia had a greater risk of anemia and thrombocytopenia. …”
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Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled... by Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Maede Hosseinpoor, Reza Heidari, Ida Mohammadi, Mohsen Chamanara, Melika Hosseinpour, Alireza Zali, Reza Mosaed, Saeed Oraee-Yazdani

“…This study was a parallel-group, randomized, open-label, active-controlled phase II trial with two arms, including treatment and control groups. …”
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Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) tri... by Hina Raheel, Sheela Sinharoy, Anaité Diaz-Artiga, Sarada S. Garg, Ajay Pillarisetti, Kalpana Balakrishnan, Marilu Chiang, Amy Lovvorn, Miles Kirby, Usha Ramakrishnan, Shirin Jabbarzadeh, Alexie Mukeshimana, Michael Johnson, John P. McCracken, Luke P. Naeher, Ghislaine Rosa, Jiantong Wang, Joshua Rosenthal, William Checkley, Thomas F. Clasen, Jennifer L. Peel, Lisa M. Thompson

“…Birth length-for-gestational age was only associated with BC.Clinical Trial Registration: The study has been registered with ClinicalTrials.gov (Identifier NCT02944682).…”
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First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer by Lini Pandite, Simon Metenou, Debra L Richardson, Erika Hamilton, Linda Van Le, Bo Ma, Fatima Rangwala, Nehal J Lakhani, Justin Call, Daphne Stewart, Lauren E Dockery, Guanfang Wang, Jade Huguet, Elliot Offman

“…A first-in-human phase I trial of SL-172154 was conducted in patients with platinum-resistant ovarian cancer.Methods SL-172154 was administered intravenously at 0.1, 0.3, 1.0, 3.0, and 10.0 mg/kg. …”
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IoC2 monitoring versus standard practice in reducing opioid consumption in elderly patients undergoing laparoscopic colorectal surgery: a study protocol for a randomised controlled... by Zhe Li, Jing Zhao, Xiaowen Liu, Huamei Cai, Yun Yan

“…While these technologies show promise in initial applications, the effectiveness of IoC2 in guiding pain management during anaesthesia, particularly in elderly patients who require precise opioid use, remains unclear. …”
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Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Place... by Supriya Shirodkar, Amit Vasani, Tanu Sahney, Meet Modi, Salini Pattnaik, P. Ravi Tejeshwar Reddy

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