A Pilot Randomized Crossover Trial of Wet Suction and Conventional Techniques of Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Upper Gastrointestinal Subepithelial Lesion... by Mika Takasumi, Takuto Hikichi, Minami Hashimoto, Jun Nakamura, Tsunetaka Kato, Hitomi Kikuchi, Yuichi Waragai, Ko Watanabe, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Manabu Hayashi, Yuki Sato, Hiroki Irie, Ryoichiro Kobashi, Yoshinori Okubo, Masao Kobayakawa, Hiromasa Ohira

“…The wet EUS-FNA technique failed to show a potential for improved cellularity of specimens compared to the dry technique for UGI-SELs.…”
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Development and effectiveness evaluation of an interactive e-learning environment to enhance digital health literacy in cancer patients: study protocol for a randomized controlled... by Lukas Lange-Drenth, Hellena Willemer, Mirjam Banse, Anke Ernst, Anne Daubmann, Anja Holz, Christiane Bleich, Susanne Weg-Remers, Holger Schulz

“…Additionally, patients’ often limited ability to find and evaluate cancer-related online information can lead to misinformation.ObjectiveAn interactive e-learning environment to promote digital health literacy will be developed and evaluated for effectiveness.Primary hypothesisCancer patients who use the e-learning environment (IG1.1–IG1.3) or the content of the environment as a non-interactive PDF file (IG2) will show greater improvement in their digital health literacy from baseline to 8 weeks after baseline compared to patients who receive no such intervention, but are referred to a standard information brochure.MethodsThe hypothesis will be tested in a stratified randomized controlled superiority trial with five parallel groups and the primary endpoint of digital health literacy. …”
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Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomiz... by Elke Kalbe, Ann-Kristin Folkerts, Anja Ophey, Carsten Eggers, Saskia Elben, Karina Dimenshteyn, Patricia Sulzer, Claudia Schulte, Nele Schmidt, Christian Schlenstedt, Daniela Berg, Karsten Witt, Lars Wojtecki, Inga Liepelt-Scarfone

“…This trial is registered with DRKS00010186.…”
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Efficacy of brain stimulation therapies across psychiatric, movement, and cognitive disorders: an umbrella review synthesizing meta-analyses of randomized controlled trialsResearch... by Zhenyue Zu, Fenglan Chen, Linxi Yang, Wenzhuo Wei, Mi Zhang, Limin Huang, Ni Li, Zihan Lv, He Du, Xinrong Xue, Lijun Ma, Huixue Wang, Kai Wang, Xiaoming Li

“…The largest meta-analysis showed a moderate standardized mean difference (SMD) of 0.56 (95% CI: 0.49, 0.64; I2 = 70%). …”
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Clinical Efficacy and Safety of Human Mesenchymal Stem Cell Therapy for Degenerative Disc Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Ruirong He, Shaobo Ding

“…We conducted a meta-analysis with randomized controlled trials (RCTs) to evaluate the clinical efficacy and safety of MSC transplantation in patients with DDD. …”
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The effects of gluteal stretching vs. Lightback® on hip rotation range of motion and posterior chain flexibility in healthy subjects: a cross-over clinical trial by Charles Cotteret, Jaime Almazán-Polo, Fabien Guérineau, Ángel González de-la-Flor

“…Methods A randomized cross-over trial was carried out in 31 physically active participants (62 lower limbs; n = 31 Lightback group (LBG) and n = 31 stretching group (SG)). …”
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Double-blind, randomized, placebo-controlled pilot clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenia refractory auditor... by Xiaojuan Wang, Xiaochen Zhang, Yuan Chang, Jingmeng Liao, Shuang Liu, Dong Ming

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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…Most safety analysis results showed no statistical difference.ConclusionThe results indicated that anti-tau protein monoclonal antibodies, such as Semorinemab and Tilavonemab, showed promise in terms of efficacy and safety for managing AD. …”
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Effects of Active Video Games Combined with Conventional Physical Therapy on Perceived Functionality in Older Adults with Knee or Hip Osteoarthritis: A Randomized Controlled Trial by Francisco Guede-Rojas, Cristhian Mendoza, Jorge Fuentes-Contreras, Cristian Alvarez, Bárbara Agurto Tarbes, Javiera Karina Muñoz-Gutiérrez, Adolfo Soto-Martínez, Claudio Carvajal-Parodi

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Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial by Thanapon Chobpenthai, Patcharapol Arunwatthanangkul, Wiriya Mahikul

“…All trial participants were trained to record their Numerical Rating Scale (NRS) pain score and Oxford Knee Score and were advised to undergo weekly follow-ups and assessment of the outcome at 4 weeks. …”
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Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…ClinicalTrials.gov registration: NCT04722718.…”
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Use of a bioresorbable polylactide sheet (OrthoWrap® Bioresorbable sheet) on tendon healing after extensor tendon repair: a controlled clinical trial by Abbas Abdoli Tafti, Hamidreza Mohammadi, Morteza Rezaei, Seyyed Hossein Saeed Bonadaki

“…Trial registration IRCT, IRCT20180627040252N3. Registered 20,220,617, Https//irct.behdasht.gov.ir/trial/56,652.…”
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Effects of Exercise Training Combined with Increased Physical Activity to Prevent Chronic Pain in Community-Dwelling Older Adults: A Preliminary Randomized Controlled Trial by Tatsuya Hirase, Hideki Kataoka, Shigeru Inokuchi, Jiro Nakano, Junya Sakamoto, Minoru Okita

“…A time-by-group interaction was found for physical activity, with the intervention group showing significant improvement p<0.05. The intervention group also showed greater improvement in pain intensity and total number of pain sites at 12 weeks after intervention than the control group p<0.05. …”
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To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Tri... by Laloo Phassang, Radhika Kapoor, Prashant Tyagi, Amit Wadhawan

“…Conclusion: The study found that both Group A and Group B showed better outcomes than Group C at the 3- and 6-month marks. …”
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Effect of Ropivacaine Combined with Nalbuphine in Erector Spinae Plane Block on Postoperative Analgesia in Lumbar Trauma Surgery: A Single-Center Randomized Controlled Trial by Zhang J, Zhang F, Zhang H, Yu L, Chen J, Wang S

“…The log-rank (Mantel–Cox) test showed that the hazard ratio (HR, Group N/Group R) was 0.225 (95% CI, 0.114 to 0.443). …”
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Intertransverse process block versus subcostal transversus abdominis plane block in patients undergoing laparoscopic radical gastrectomy: a prospective randomized controlled trial by Qian Chen, Xinyue Zhou, Fang Wang, Yang Zeng, Bin Qian, Haiyun Du

“…Conclusion This study showed that the double-shot bilateral ITPB could reduce opioids consumption and achieve longer and better pain relief. …”
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Efficacy of Simple Eye Ointment, Polyethylene Cover, and Eyelid Taping in Prevention of Ocular Surface Disorders in Critically Ill Patients: A Randomized Clinical Trial by Mehdi Ahmadinejad, Esmat Karbasi, Yunes Jahani, Maryam Ahmadipour, Maryam Soltaninejad, Zahra Karzari

“…This study was a double-blind clinical trial (IRCT: 201109225426N3, https://www.irct.ir/trial/5825), in which 152 patients were randomized into three groups and each group underwent a different eye care procedure. …”
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Safety and efficacy of oral administrated cepharanthine in non-hospitalized, asymptomatic or mild COVID-19 patients: a Double-blind, randomized, placebo-controlled trial by Jianyi Wei, Shupeng Liu, Yuexiang Bian, Lei Li, Biyun Qian, Zixuan Shen, Yan Zhang, Adila Abuduaini, Fuchen Dong, Xin Zhang, Jinhui Li, Yongpei Yu, Weituo Zhang, Jun Wang, Wei Zhai, Qixiang Song, Yu Zheng, Weihua Pan, Lanlan Yu, Qimin Zhan, Ning Zhang, Junhua Zheng, Shuming Pan, Chen Yao, Hai Li

“…However, 60 mg/day CEP showed a slight trend which needs future confirmatory trials to validate. …”
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Efficacy and safety of jaktinib hydrochloride tablets in active axial spondyloarthritis: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial by Xiaomei Li, Xiaoxia Wang, Jian Wu, Xiao Zhang, Chunde Bao, Shengqian Xu, Lingyun Sun, Juan Wang, Guixiu Shi, Xiaofei Wang, Qing Dai, Antao Xu, Huaxiang Wu, YongQing Wang, Yan Ye, Yongfu Wang, Huaxiang Liu, Chenyin Lv, Jun Miao, Weiqi Min, Kuanting Wang, Luan Xue, Shanhui Ye

“…No major adverse cardiovascular events, malignancy, thromboembolism or deaths were reported.Conclusions Jaktinib showed good efficacy and tolerability in the treatment of active r-axSpA, with the 100 mg two times per day showing a trend towards better efficacy.Trial registration number NCT04507659.…”
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Chest-to-Back Skin-to-Skin Contact to Regulate Body Temperature for Low Birth Weight and/or Premature Babies: A Crossover Randomized Controlled Clinical Trial by Sisay Gere, Yemane Berhane, Alemayehu Worku

“…We applied a noninferiority clinical trial among LBW and/or premature infants admitted to a referral hospital neonatal intensive care unit (NICU) in Ethiopia. …”
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