Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for delirium in intensive care units (ICU) and postoperative settings. …”
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Exploration of the quantitative-effectiveness association between acupuncture temporal parameters and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response... by Hao Tian, Qin Luo, Liuyang Huang, Liuyang Huang, Liuyang Huang, Guang Chen, Mingsheng Sun, Fanrong Liang

“…Future high-quality studies and large-scale multicenter clinical trials are needed to validate these findings.…”
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Anemia, Thrombocytopenia, and Changes in Biochemical Parameters Occurring in Patients with Uncomplicated Plasmodium falciparum Malaria: Data Analysis from Antimalarial Efficacy-Ran... by Khadime Sylla, Roger Tine, Doudou Sow, Souleye Lelo, Annie Abiola, Jean Louis NDiaye, Magatte NDiaye, Kuaku Folly, Léon Amath NDiaye, Oumar Gaye, Babacar Faye

“…Results from this analysis showed that subjects with high parasitaemia had a greater risk of anemia and thrombocytopenia. …”
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Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled... by Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Maede Hosseinpoor, Reza Heidari, Ida Mohammadi, Mohsen Chamanara, Melika Hosseinpour, Alireza Zali, Reza Mosaed, Saeed Oraee-Yazdani

“…This study was a parallel-group, randomized, open-label, active-controlled phase II trial with two arms, including treatment and control groups. …”
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Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) tri... by Hina Raheel, Sheela Sinharoy, Anaité Diaz-Artiga, Sarada S. Garg, Ajay Pillarisetti, Kalpana Balakrishnan, Marilu Chiang, Amy Lovvorn, Miles Kirby, Usha Ramakrishnan, Shirin Jabbarzadeh, Alexie Mukeshimana, Michael Johnson, John P. McCracken, Luke P. Naeher, Ghislaine Rosa, Jiantong Wang, Joshua Rosenthal, William Checkley, Thomas F. Clasen, Jennifer L. Peel, Lisa M. Thompson

“…Birth length-for-gestational age was only associated with BC.Clinical Trial Registration: The study has been registered with ClinicalTrials.gov (Identifier NCT02944682).…”
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IoC2 monitoring versus standard practice in reducing opioid consumption in elderly patients undergoing laparoscopic colorectal surgery: a study protocol for a randomised controlled... by Zhe Li, Jing Zhao, Xiaowen Liu, Huamei Cai, Yun Yan

“…While these technologies show promise in initial applications, the effectiveness of IoC2 in guiding pain management during anaesthesia, particularly in elderly patients who require precise opioid use, remains unclear. …”
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Erratum to ‘Efficacy and safety of local fibrinolytic therapy in intracranial hemorrhages: A systematic review and meta-analysis of randomised controlled trials’ [World Neurosurger... by Arun Babu Rajeswaran, Arshad Ali, Saleh Safi, Ahmed Eid Abdulghani Saleh

“…Methods: Medline, Embase, CINAHL Plus, Cochrane, Scopus, Web of science, clinical trials.gov, WHO and EU Clinical Trials Register were searched for RCTs only, on intra-clot fibrinolytics vs standard treatments for ICH and IVH. …”
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The Effect of Breathing Exercise Using Bubble Blower on Anxiety and Pain during Inferior Alveolar Nerve Block in Children Aged 7 to 10 Years: A Crossover Randomized Clinical Trial by Zahra Bahrololoomi, Tahereh Sadeghiyeh, Maedeh Rezaei, Nahid Maghsoudi

“…In this randomized crossover clinical trial, thirty-five children with moderate to severe anxiety requiring bilateral pulp therapy of mandibular primary molars were enrolled. …”
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Proseal laryngeal mask airway and endotracheal intubation in lower abdominal gynecological surgeries for perioperative gastric volume assessment and assessing postoperative recover... by Ranjay Mahaseth, Bhavna Gupta, Gaurav Jain, Anupama Bahadur, Deepak Singla, Debendra K. Tripathy

“…Results: Our results showed that there was no statistically significant difference between the two groups in antral CSA at various time intervals. …”
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Ultrasound-guided deep versus superficial continuous serratus anterior plane block for pain management in patients with multiple rib fractures: A prospective randomized double-blin... by Mohamed F. Mostafa, Mohamed Abdel-Moniem Bakr, Mohamed Ismail Seddik, Mohammed Mamdouh Mohammed Mahmoud, Gamal M.A. Ibrahim, Ahmed Talaat Ahmed

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Efficacy of Curcumin on Treating Cancer Anorexia-Cachexia Syndrome in Locally or Advanced Head and Neck Cancer: A Double-Blind, Placebo-Controlled Randomised Phase IIa Trial (CurCh... by Tawasapon Thambamroong, Kasan Seetalarom, Siriwimon Saichaemchan, Yanisa Pumsutas, Naiyarat Prasongsook

“…This constitutes an unmet need for clinical trials. This trial is registered with NCT04208334.…”
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Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Adverse events were monitored. This trial was registered with ClinicalTrials.gov (NCT04709952). …”
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Exploring the benefits and prescribing informations of combining East Asian herbal medicine with conventional medicine in the treatment of rheumatoid arthritis: A systematic review... by Hee-Geun Jo, Jihye Seo, Eunhye Baek, Donghun Lee

“…These patterns were consistent across eight secondary outcomes measuring pain, inflammation, and disease activity in RA. Subgroup analyses showed that EACM's effects were independent of the control CM type. …”
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Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing non-laparoscopic surgery: A systematic re... by Babu Lal, Ragavi Alagarsamy, Jitendra Kumar, Anshul J. Rai, Vineeta Yadav, Rajnish Joshi, Md. Yunus

“…Conclusion: Palonosetron and ondansetron exhibited comparable efficacy in the early hours (0–6 h). Palonosetron showed superior efficacy beyond 6 hours, providing sustained PONV prophylaxis in patients undergoing various surgeries, excluding laparoscopic procedures.…”
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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty: a prospective, double-blind, pilot,... by Chunyan Li, Jie Yang, He Liu, Wen Tan, Song Zhang, Hongxing Zhang, Yuan Han, Mingshu Tao, Rongguang Liu, Jiaxing Fang, Dexian Chen, Qi Wei, Xingyu Xiong, Wenxin Zhao, Junli Cao

“…No significant adverse events were reported.Conclusion In older patients undergoing lower limb major arthroplasty, a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep measures. …”
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Optimizing Soft Tissue Emergence Profile Around One-Piece Dental Implants by Abduljaleel Azad Samad

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Active versus sham transcranial direct current stimulation (tDCS) as an adjunct to varenicline treatment for smoking cessation: Study protocol for a double-blind single dummy rando... by Laurie Zawertailo, Helena Zhang, Noreen Rahmani, Tarek K Rajji, Peter Selby

“…Furthermore, the addition of longitudinal neuroimaging can shed light on neural circuitry changes that might occur as a result of brain stimulation, furthering our understanding of tDCS in addiction treatment.<h4>Trial registration</h4>This trial has been registered with Clinicaltrials.gov: NCT03841292 since February 15th 2019 (https://clinicaltrials.gov/ct2/show/NCT03841292)-retrospectively registered.…”
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Improving Health Outcomes in Coronary Artery Disease Patients with Short-Term Protocols of High-Intensity Interval Training and Moderate-Intensity Continuous Training: A Community-... by Catarina Gonçalves, Jorge Bravo, João Pais, Ana Abreu, Armando Raimundo

“…Moreover, the control group showed poorer results. Conclusion. HIIT can improve health outcomes more positively than MICT and control. …”
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Effect of Dexmedetomidine Added to Lidocaine Cartridge on the Level of Patient Sedation, Cooperation, and Patient and Surgeon Satisfaction during Mandibular Third-Molar Extraction... by Milad Etemadi Sh, Nasser Kaviani, Kimia Salimian, Golnaz Tajmiri

“…It was inferred from the outcomes of the present study that the application of DEX added to the LIDO local anesthesia cartridge could significantly benefit anxious patients with previous unpleasant dental treatment experiences. Trial Registration. This trial is registered with the clinical trial registration number: IRCT20200406046966N.…”
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Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraep... by Fei Chen, Jinghe Lang, Peter Hillemanns, Youzhong Zhang, Zoltán Novák, Long Sui, Ling Han, Christian Dannecker, Ctirad Mokráš, Zhixue You

“…Findings will be disseminated through peer review publications and conference presentations.Trial registration number NCT04484415; clinicaltrials.gov.…”
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