Effectiveness of Different Intervention Modes in Lifestyle Intervention for the Prevention of Type 2 Diabetes and the Reversion to Normoglycemia in Adults With Prediabetes: Systema... by Yachen Wang, Xin Chai, Yueqing Wang, Xuejun Yin, Xinying Huang, Qiuhong Gong, Juan Zhang, Ruitai Shao, Guangwei Li

“…This review included randomized controlled trials (RCTs) that studied the effectiveness of lifestyle interventions in adults with prediabetes. …”
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Factors influencing role preferences in decision-making of healthy women with BRCA1/2 pathogenic variants: subanalysis from a randomised controlled decision coaching trial by Sibylle Kautz-Freimuth, Arim Shukri, Claudia Stracke, Anna Isselhard, Birte Berger-Höger, Anke Steckelberg, Frank Vitinius, Nicola Dikow, Marion Kiechle, Cornelia Meisel, Achim Wöckel, Marion Tina von Mackelenbergh, Rita Schmutzler, Kerstin Rhiem, Stephanie Stock

“…With this profile, the DC programme expands the existing counselling and care concept to include a measure that can also specifically cover the support needs of younger women and those with a lower education level. Trial registration DRKS-ID: DRKS00015527. Registered 30/10/2019.…”
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PReventing Idiopathic SCOliosis PROgression (PRISCOPRO): A protocol for a quadruple-blinded, randomized controlled trial comparing 3D designed Boston brace to standard Boston brace... by Elias Diarbakerli, Anastasios Charalampidis, Allan Abbott, Paul Gerdhem

“…<h4>Trial registration</h4>The protocol has been registered on ClinicalTrials.gov, identifier: NCT04805437.…”
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Effectiveness of Contralaterally Controlled Functional Electrical Stimulation versus Neuromuscular Electrical Stimulation on Upper Limb Motor Functional Recovery in Subacute Stroke... by Songhua Huang, Peile Liu, Yinglun Chen, Beiyao Gao, Yingying Li, Chan Chen, Yulong Bai

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Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement to Promote Soft Tissue Granulation in the Treatment of Neuropathic Diabetic Foot Ulcers Complicated by Osteo... by Regis Ernest Mendame Ehya, Hao Zhang, Baiwen Qi, Aixi Yu

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Efficacy and safety of dexamethasone or triamcinolone in combination with anti-vascular endothelial growth factor therapy for diabetic macular edema: A systematic review and meta-a... by Bo Zhou, Hua Liu, Feng Xiong

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Raising awareness of alcohol as a modifiable risk factor for breast cancer: A randomized controlled trial comparing the efficacy of accessing an interactive website with a non-inte... by Claudia Sardu, Fabrizio Angius, Paolo Contu, Sofia Cosentino, Monica Deiana, Matteo Fraschini, Clelia Madeddu, Elena Massa, Alessandra Mereu, Luigi Minerba, Carola Politi, Silvia Puxeddu, Francesco Salis, Julia M.A. Sinclair, Roberta Agabio

“…Conclusion: Our results show that accessing an interactive website may increase the percentage of women who acquire the knowledge that alcohol is a BC risk factor especially among women of lower levels of education.…”
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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…Introduction A quarter of breast cancers show human epidermal growth factor-2 (HER2) overexpression, where targeted therapy dramatically improves survival. …”
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Effect of mechanical debridement with and without adjunct antimicrobial photodynamic therapy for the treatment of peri-implant disease in obese patients: A systematic review and me... by Sultan Albeshri, Raed AlRowis

“…Results: Three randomized controlled trials (RCTs) were included. The number of participants ranged between 49 and 80 individuals. …”
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Effectiveness of a resilience, gender equity and mental health group intervention for young people living in informal urban communities in North India: a cluster randomized control... by Varadharajan Srinivasan, Miguel San Sebastián, Samson Rana, Pooja Bhatt, Greg Armstrong, Smita Deshpande, Kaaren Mathias

“…Methods This cluster randomised controlled trial used an analytic sample of 476 adolescents and young adults aged 11–25 years from randomised clusters in urban Dehradun, India. …”
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Impact of Scleroderma‐Associated Autoantibodies on Clinical Outcome Assessments: Post Hoc Analysis From a Randomised, Double‐blind, Placebo‐controlled, Phase 3 Trial of Tocilizumab... by Basmah Al Dulaijan, Suiyuan Huang, Celia J. F. Lin, Christopher P. Denton, Dinesh Khanna

“…Our objective was to assess the influence of baseline SSc‐Abs on the trajectories of the clinical outcome assessments (COAs) in a phase III randomized controlled trial. Methods We used data on both the groups who received placebo (Pbo) and tocilizumab from the focuSSced trial. …”
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The effect of psychosocial stimulation on the development, nutrition, and treatment outcomes of hospitalised children with severe acute malnutrition in Southern Ethiopia: a cluster... by Tesfalem Teshome Tessema, Andamlak Gizaw Alamdo, Eyoel B. Mekonnen, Tewodros G. Yirtaw, Fanna A. Debele, Teklu Gemechu, Tefera Belachew

“…A cluster-randomised controlled trial was conducted among health facilities that provide inpatient care for children with SAM in Silti Zone, Ethiopia. …”
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Does the transfer of knowledge from the pioneer generation to the second‐generation speed‐up the learning curve of robot‐assisted partial nephrectomies? TRANSFER trial (UroCCR n°83... by Louis Vignot, Zine‐Eddine Khene, Adil Mellouki, Arnoult Morrone, Jean‐Christophe Bernhard, Karim Bensalah, Daniel Chevallier, Nicolas Doumerc, Morgan Roupret, Francois‐Xavier Nouhaud, Cédric Lebacle, Jean‐Alexandre Long, Pierre Pillot, Xavier Tillou, Brannwel Tibi, Matthieu Durand, Younes Ahallal, Imad Bentellis

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Division of the inferior pulmonary ligament during upper lobectomy does not improve postoperative pulmonary function: a systematic review and meta-analysis of observational studies... by Boyang Chen, Weifeng Tang, Junhai Chen, Mingqiang Kang, Jinbiao Xie, Wu Wang, Tianbao Yang, Shijie Huang

“…Results 9 studies were identified, including two randomized controlled trials and seven retrospective case-control studies involving 1,612 patients. …”
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SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized con... by Beverley Lim Høeg, Katrine Bjerre Løppenthin, Josée Savard, Christoffer Johansen, Jesper Frank Christensen, Mads Nordahl Svendsen, Niels Holländer, Pernille Envold Bidstrup

“…Patients/material and methods: We conducted a feasibility randomized trial in patients under treatment for castration resistant mPCa with insomnia (Insomnia Severity Index [ISI] score ≥ 8). …”
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Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, C... by Nattaphol Uransilp, Pannawat Chaiyawatthanananthn, Sombat Muengtaweepongsa

“…This trial is registered with ClinicalTrials.gov ID: NCT03402204.…”
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Effectiveness of a Novel Contralaterally Controlled Neuromuscular Electrical Stimulation for Restoring Lower Limb Motor Performance and Activities of Daily Living in Stroke Survivo... by Ying Shen, Lan Chen, Li Zhang, Shugang Hu, Bin Su, Huaide Qiu, Xingjun Xu, Guilan Huang, Zhifei Yin, Jinyu Yang, Chuan Guo, Tong Wang

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Comparative analysis of land-based vs. water-based balance training on quality of life and physical and psychological deficits in athletes with chronic ankle instability: a randomi... by Aynollah Naderi, Khadije Ahi

“…A flexible rehabilitation program combining both approaches can optimize recovery, addressing specific needs, even though no significant differences were found in ankle stability, kinesiophobia, psychological Quality of Life, and dynamic balance between the two methods. Trial registration This study was prospectively registered with the University Hospital Medical Information Network Clinical Trial Registry under Clinical Trials UMIN000051746 on July 29, 2023.…”
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Efficacy and safety of sublingual immunotherapy using a combination of Dermatophagoides pteronyssinus and Blomia tropicalis extracts in patients with allergic rhinitis: A randomize... by Priscilla Rios Cordeiro Macedo, MD, MSc, Priscila Moraes, MD, Luísa Karla Arruda, MD, PhD, Fábio Fernandes Morato Castro, MD, PhD, Jorge Kalil, MD, PhD, Clóvis Eduardo Santos Galvão, MD, PhD

“…Methods: This was a double-blind, randomized, placebo-controlled trial of SLIT to treat house dust mite-induced Allergic Rhinitis (AR). …”
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Comparing physiological and psychological effects of virtual reality vs. traditional high-intensity interval training in healthy individuals: results from a preliminary pilot rando... by Jonathan Robinson, Mohammad Haziq Bin Abdul Razak

“…Conclusions This pilot study suggests that fully immersive VR can be an effective alternative to traditional HIIT, providing a high-flow experience and potentially enhancing motivation among physically active users. Trial registration ClinicalTrials.gov, NCT06420414. …”
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