Chinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial by Nicola Robinson, Mei Han, Ling Yan, Vincent Chi Ho Chung, Jian-Ping Liu, Hui-Juan Cao, Shi-Bing Liang, Hong-Jie Cheng, Qiao-Yan Zhang, Yu-Fei Li, Ze-Yu Yu, Ling-Yao Kong, Yan-Mei Cai, Li-Bao An, Bao-Tuan Zhao, Shan-Shan Xu, Nai-Wei Zhang, Bo-Yi Jia, Wei-Fang Liu, Fang Niu, Ba-Teer Wu, Jin-Ming Song, Shu-Xin Jia, Meng-Meng Shi, Xiao-Na Zhang

“…Future large-scale, rigorously designed trials with longer treatment and follow-up periods are essential to evaluate the therapeutic effects and safety of TXYF, and to explore the psychological factors.Trial registration number ISRCTN12453166.…”
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Effect of an “Autogenous Leukocyte Platelet-Rich Fibrin Tooth Graft” Combination around Immediately Placed Implants in Periodontally Compromised Sites: A Randomized Clinical Trial... by Walid ElAmrousy, Dalia Rasheed Issa

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Enhancing postoperative analgesia in carotid endarterectomy patients: The potential of ultrasound-guided carotid sheath block combined with superficial cervical plexus block: A ran... by Anamarija Kruc, Lada Lijovic, Matteo Skrtic, Iva Pazur, Nikola Perisa, Tomislav Radocaj

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Effect of Vaginal Cream with the Combination of Honey, Olive, and Propolis on the Symptoms of Uterine Cervicitis Symptoms in Women: A Double-Blind Randomized Controlled Clinical Tr... by Hamideh Parsapour, Arezoo Shayan, Mehrnoosh Hosseinpoor, Seyedeh Zahra Masoumi, Farideh Kazemi, Shirin Moradkhani, Seyed Mohammad Hossein Oliaei, Zeinab Assareh, Mohammad Kazem Rashidi

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Role of adductor canal block and genicular nerve block on postoperative pain and enhanced recovery in patients undergoing total knee arthroplasty: A randomized clinical trial by Bassel Mohammed Elfokery, Mustafa Seet, Tareef Ashour, Hatem Alharbi, Mujeeb Ashraf, Hatim Alshareef, Mohammad Nyaz, Rayan Bakhreba, Atif Sait

“…Patients and Methods: This randomized trial was conducted on 50 subjects aged 40–75 years who underwent TKA under spinal anesthesia. …”
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Impact of ELKa, the Electronic Device for Prandial Insulin Dose Calculation, on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled... by Agnieszka Kowalska, Katarzyna Piechowiak, Anna Ramotowska, Agnieszka Szypowska

“…The ELKa system improves metabolic control in children with T1DM under regular usage. The trial is registered at ClinicalTrials.gov, number NCT02194517.…”
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Clinical Comparison between HD-tDCS and tDCS for Improving Upper Limb Motor Function: A Randomized, Double-Blinded, Sham-Controlled Trial by Yaqin Zeng, Ruidong Cheng, Li Zhang, Shan Fang, Shaomin Zhang, Minmin Wang, Qian Lv, Yunlan Dai, Xinyi Gong, Feng Liang

“…This randomized, sham-controlled clinical trial included 69 patients with subcortical stroke. …”
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Cardiopulmonary fitness in children/adolescents with chronic kidney disease and the impact of exercise training: a systematic review and meta-analysis of observational study and ra... by Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong

“…The results of a meta-analysis based on a pre-post single-arm trial showed that compared to baseline, exercise training improved the 6MWD by approximately 58.17 m (95% CI 16.27–100.06), with very low evidence.Conclusions This systematic review and meta-analysis of observational studies and clinical trials that included children/adolescents with CKD found that cardiorespiratory fitness is severely reduced in this population and that exercise training may be an effective strategy for improvement. …”
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Effect of Oral Vasopressors Used for Liberation from Intravenous Vasopressors in Intensive Care Unit Patients Recovering from Spinal Shock: A Randomized Controlled Trial by Ahmed Talaat Ahmed Ali, Mervat Anwar Abd EL-Aziz, Ahmed Mohamed Abdelhafez, Amr Mohamed Ahmed Thabet

“…A randomized controlled trial was conducted in the trauma ICU at the Assiut University Hospital in Egypt in patients with spinal shock who required intravenous vasopressor for ≥24 h. …”
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Achillea millefolium capsule improved liver enzymes and lipid profile compared to placebo in patients with type 2 diabetes: a double-blind randomized clinical trial by Shole Daneshvar-Ghahfarokhi, Hassan Ahmadinia, Tabandeh Sadeghi, Elham Basirat, Vahid Mohammadi-Shahrokhi

“…Trial registration Iranian Registry of Clinical Trials IRCT20230612058459N1 Registered on 2023–06–24.…”
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Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial by Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop

“…Objective To assess the long-term (3 year) efficacy and safety of secukinumab in patients with active psoriatic arthritis (PsA) in the extension phase of the FUTURE 1 study (NCT01892436).Methods Following the 2-year core trial, eligible patients receiving subcutaneous secukinumab 150 or 75 mg entered a 3-year extension phase. …”
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Comparative efficacy of lumbar and pelvic support on pain, disability, and motor control in women with postpartum pelvic girdle pain: a three-armed randomized controlled trial by Fahimeh-Sadat Jafarian, Mahmonir Jafari-Harandi, Gillian Yeowell, Ebrahim Sadeghi-Demneh

“…Clinical trial registration Iranian Registry of Clinical Trials IRCT20150210021034N11. …”
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A prospective randomized controlled trial comparing biphasic cartilage repair implant with microfracture in small chondral lesions of knee: findings at five-year-follow-up by Yao-Yi Kuo, Si-Qi Chiu, Wen-Pei Chang, Chih-Yu Chen, Chih-Hwa Chen, Chen-Kun Liaw, Cheng-Aun Tan, Pei-Wei Weng

“…Methods This randomized controlled clinical trial enrolled patients with symptomatic knee chondral lesions smaller than 3 cm2. …”
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Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Tria... by Joseph Studer, John A Cunningham, Elodie Schmutz, Jacques Gaume, Angéline Adam, Jean-Bernard Daeppen, Nicolas Bertholet

“…This study is a follow-up mediation analysis of the primary and secondary outcomes of a randomized controlled trial testing the effect of a smartphone-based intervention to reduce alcohol use. …”
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Evaluating the Impact of Pharmacotherapy in Augmenting Quit Rates Among Hispanic Adults in an App-Delivered Smoking Cessation Intervention: Secondary Analysis of a Randomized Contr... by Margarita Santiago-Torres, Kristin E Mull, Brianna M Sullivan, Ana Paula Cupertino, Ramzi G Salloum, Matthew Triplette, Michael J Zvolensky, Jonathan B Bricker

“…However, this combined approach was not effective with the US clinical guideline–based app (QuitGuide). Trial RegistrationClinicalTrials.gov NCT02724462; https://clinicaltrials.gov/study/NCT02724462 International Registered Report Identifier (IRRID)RR2-10.1001/jamainternmed.2020.4055…”
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CONTROVERSY AND CONFLICTS DUE TO IMPROPER MEDICAL CARE AND LEGAL PRACTICE OF THEIR RESOLVING by I. O. Perepechina, D. V. Perepechin, D. V. Smirnova

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Comparative Evaluation of the Safety and Efficacy of Long-Term Use of Imidafenacin and Solifenacin in Patients with Overactive Bladder: A Prospective, Open, Randomized, Parallel-Gr... by Masayoshi Zaitsu, Koji Mikami, Noriko Ishida, Takumi Takeuchi

“…This study is the first long-term trial to show differences in the properties of anticholinergics that were not detected in short-term studies. …”
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Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid... by Clifton O. Bingham, Emily Molina, Amy Praestgaard, Stefano Fiore, David Cella

“…Methods Data from three phase 3 randomized controlled trials of patients with RA who received sarilumab—MOBILITY, TARGET, and MONARCH—were evaluated. …”
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Cognitive behavioural therapy plus Kiesler Circle Training (CBT+) versus CBT only for patients with interpersonal problems: study protocol for a randomised controlled feasibility t... by Stephan Köhler, Philipp Sterzer, Eva-Lotta Brakemeier, Karen Ollrogge, Daniel Schulze, Eva Friedel, Nina Romanczuk-Seiferth, Anna-Lena Siegerist, Anne Guhn

“…It is hypothesised that the experimental group will show (a) greater reduction in interpersonal problems from pre-assessment to post-assessment and (b) greater symptomatic improvement regarding the primary diagnosis. …”
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Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. by Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki

“…<h4>Results</h4>Eighty-six percent completed the trial, with 82% of weekly study follow-up visits completed. …”
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