The Modification Effect of Influenza Vaccine on Prognostic Indicators for Cardiovascular Events after Acute Coronary Syndrome: Observations from an Influenza Vaccination Trial by Apirak Sribhutorn, Arintaya Phrommintikul, Wanwarang Wongcharoen, Usa Chaikledkaew, Suntara Eakanunkul, Apichard Sukonthasarn

Get full text

Evaluating the effects of chlorhexidine and vitamin c mouthwash on oral health in non-surgical periodontal therapy: a randomized controlled clinical trial by Nurdan Ozmeric, Ayaz Enver, Sila Cagri Isler, Ceren Gökmenoğlu, Merve Topaloğlu, Hilal Selamet, Gökçen Altun, Selin Aykol Sayar

Get full text

Comparison of three cryotherapy techniques for early post-TKA pain control in terms of efficacy and patient satisfaction: a randomized controlled trial by Keerati Chareancholvanich, Worawut Keesukpunt, Chaturong Pornrattanamaneewong, Rapeepat Narkbunnam, Atthakorn Jarusriwanna

“…MCCD has shown superior efficacy in pain reduction during the earliest postoperative period, and achieved high patient satisfaction. Trial registration This study was registered in the Thai Clinical Trials Registry database (no. …”
Get full text

Effect of power training on physical functional performance of patients with Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials. by Samuel Brito de Almeida, Emmanuelle Silva Tavares Sobreira, Charles Phillipe de Lucena Alves, Danielle Pessoa Lima, Janine de Carvalho Bonfadini, Manoel Alves Sobreira-Neto, Thiago Holanda Freitas, Simony Lira do Nascimento, Pedro Braga-Neto

“…Inclusion criteria were randomized controlled trials comparing PT to a control group or another PA intervention in PD patients. …”
Get full text

Macrophages Phenotype Regulated by IL-6 Are Associated with the Prognosis of Platinum-Resistant Serous Ovarian Cancer: Integrated Analysis of Clinical Trial and Omics by Xiaoqing Wu, Wenping Lu, Chaojie Xu, Cuihong Jiang, Zhili Zhuo, Ruipeng Wang, Dongni Zhang, Yongjia Cui, Lei Chang, Xi Zuo, Ya’nan Wang, Heting Mei, Weixuan Zhang, Mengfan Zhang, Chen Li

Get full text

Effect of a Multistage Educational Skill-Based Program on Nurse’s Stress and Anxiety in the Intensive Care Setting: A Randomized Controlled Trial by Mohsen Saffari, Farshid Rahimi Bashar, Amir Vahedian-Azimi, Mohamad Amin Pourhoseingholi, Leila Karimi, Morteza Shamsizadeh, Keivan Gohari-moghadam, Amirhossein Sahebkar

“…There was no significant change in the control group in terms of study variables during follow-up assessments, whereas measures of stress and anxiety were reduced after intervention in the trial groups except trait anxiety. Nurses in the mixed-method group (booklet+oral presentation+clinical teaching) showed less stress and anxiety during follow-ups. …”
Get full text

High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial by Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Angelika Terbuch, Barbara Obermayer-Pietsch, Erika Richtig, Stefan Pilz

“…The primary outcome was the frequency of hormonal axes recovery.Results Between 17th April 2019 and 16th September 2022, 18 out of the 20 randomised patients finished the trial; eight completed high-dose, 10 glucocorticoid replacement. …”
Get full text

Differences in catheter-related complications to insertion site selection for long peripheral intravenous catheters in antimicrobial therapy: a randomized controlled trial by Linfang Zhao, Xianghong Jin, Xiangyun Li, Chang Liu, Jie Wang, Xiuzhu Cao, Xufen Zeng, Yiyu Zhuang

“…Methods This randomized controlled trial included 90 participants randomly assigned to either the control or experimental group, with 45 patients in each group. …”
Get full text

Visual, clinical and quality of life outcomes of a new multifocal IOL with optimized diffractive grating: a non-randomized clinical trial by João Marcelo de Almeida Gusmão Lyra, Mariana Silva Gois de Almeida, Lucila de Albuquerque Barbosa Lira, Laís Oliveira dos Santos, Mateus Lins dos Santos, Jorge Artur Peçanha de Miranda Coelho

“…Conclusions The BIOS Trifocal IOL presented satisfactory effectivity in the treatment of cataract and presbyopia, providing functional vision across near, intermediate and far distances and maintaining good patient satisfaction. Trial Registration This trial was registered at the ReBEC (Registro Brasileiro de Ensaios Clínicos – Brazilian Registry of Clinical Trials)database under the registration code RBR-772s6y at April 6th, 2020.…”
Get full text

Effectiveness and safety of human placenta hydrolysate injection into subacromial space in patients with shoulder impingement syndrome: a single-blind, randomized trial by Du Hwan Kim, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Don-Kyu Kim, Chul-Hyun Cho, Ye-Ji Kim

“…Therefore, hPH can be used as an alternative treatment for shoulder impingement syndrome. Trial registration The trial was registered on www.Clinicaltrials.gov (NCT05528705, Registration Date: 06/09/2022).…”
Get full text

Multiple Sessions of Antimicrobial Photodynamic Therapy Improve Periodontal Outcomes in Patients with Down Syndrome: A 12-Month Randomized Clinical Trial by Rafael Ferreira, Sebastião Luiz Aguiar Greghi, Adriana Campos Passanezi Sant’Ana, Mariana Schutzer Ragghianti Zangrando, Carla Andreotti Damante

“…A randomized, double-blind, parallel trial was conducted with 37 individuals with DS. …”
Get full text

The effect of Camellia sinensis ointment on perineal pain and episiotomy wound healing in primiparous women: A triple-blind randomized clinical trial. by Masoumeh Sayahi, Azam Jahangirimehr, Zahra Hatami Manesh, Faraz Mojab, Maryam Nikbina

“…<h4>Trial registration</h4>This trial was registered in the Iranian Registry of Clinical Trials on 04/10/2019 with the IRCT ID: IRCT20190804044428N1. …”
Get full text

Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial by Francesca Colombo, Stefano Alfano, Massimo Milani

Get full text

Impact of cooling diabetic patients’ fingertips compared to vibrating stimulation on pain from the glucometer needle: A cross-over trial study by Vahid Vejdanihemmat, Hiva Azami, Leili Tapak, Shiva Borzouei, khodayar Oshvandi

Get full text

Results from the PROmoting Early Childhood Outside cluster randomized trial evaluating an outdoor play intervention in early childhood education centres by Rachel Ramsden, Dawn Mount, Yingyi Lin, Emily Fox, Susan Herrington, Janet Loebach, Adina Cox, Anita Bundy, Amber Fyfe-Johnson, Ellen Beate Hansen Sandseter, Michelle Stone, Mark S. Tremblay, Mariana Brussoni

“…The PROmoting Early Childhood Outside (PRO-ECO) study is a pilot randomized trial that evaluates the PRO-ECO intervention on children’s outdoor play participation. …”
Get full text

The Role of Butirprost^® as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial by Felice Crocetto, Armando Calogero, Michele Santangelo, Agostino Fernicola, Filippo Varlese, Benito Fabio Mirto, Fabio Machiella, Alfonso Falcone, Giovanni Pagano, Fabrizio Dinacci, Gaetano Giampaglia, Domenico Varriale, Francesco Trama, Salvatore Iaconis, Francesco Del Giudice, Gian Maria Busetto, Matteo Ferro, Francesco Lasorsa, Giuseppe Lucarelli, Ciro Imbimbo, Biagio Barone

Get full text

Acupuncture Dosage and Its Correlation with Effectiveness in Patients with Chronic Stable Angina: A Systematic Review and Meta-Analysis of Randomized Controlled Trial by Huang D, Li Y, Zheng X, Hu J, Tang H, Yin Y, Wu Z, Kong L

“…Acupuncture significantly reduced angina attacks compared to placebo (SMD, − 0.51; 95% CI [− 0.77, − 0.25], P = 0.0001, I2=62%), and standard care (SMD, − 1.25, 95% CI [− 1.89, − 0.61], P = 0.00001, I2=92%) without increasing adverse events. MDG showed a notable difference in reducing angina attacks (SMD, − 0.60, 95% CI [− 0.91, − 0.29], P = 0.001, I2=60%) while LDG and HDG did not. …”
Get full text

Non‐invasive telemedical care in heart failure patients and stroke: post hoc analysis of TIM‐HF and TIM‐HF2 trials by Serdar Tütüncü, Marcus Honold, Kerstin Koehler, Oliver Deckwart, Friedrich Koehler, Karl Georg Haeusler

Get full text

Effects of exercise dose based on the ACSM recommendations on depression in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials by Yang Fang, Yang Fang, Bai Xiaoling, Li Huan, Li Huan, Guan Yaping, Zhang Binying, Wang Man, Wu Juan, Liu Xinyu

“…The high ACSM adherence group showed greater improvement relative to the low/uncertain adherence group (SMD: −0.66 vs. −0.56). …”
Get full text

A systematic review and meta-analysis of randomized controlled trials for physical activity among colorectal cancer survivors: directions for future research by Jiayu Mao, Xiaoke Qiu, Yi Zhang, Can Wang, Xueli Yang, Qiuping Li

“…However, further high-quality clinical trials are needed to determine the optimal timing, duration, and delivery methods of PA interventions to maximize their effectiveness in this population.…”
Get full text