First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries by Masakazu Ishikawa, Shunya Tsuji, Goki Kamei, Kyohei Nakata, Akinori Nekomoto, Naofumi Hashiguchi, Tomoyuki Nakasa, Atsuo Nakamae, Naosuke Kamei, Keiichiro Inoue, Shingo Kawabata, Keiko Ueda, Nobuo Adachi

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The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials by Mitra Hariri, Masoudreza Sohrabi, Ali Gholami

“…Conclusion In conclusion, our study showed that magnesium significantly increased HDL-C levels. …”
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Peri-implant soft tissue conditioning of immediate posterior implants by CAD-CAM socket sealing abutments: a randomized clinical trial by Mai Mohamed Elgendi, Iman Salah Eldin Hamdy, Hanaa Ibraheem Sallam

“…Results At base line, after six as well as 12 months, SSA group showed statistically significant higher total modified PES scores than SHA group (P-value < 0.001). …”
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Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial by Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

“…Future research is needed to test the effects of the stress recovery intervention supplemented by goal setting and tailored prompts. Trial RegistrationClinicalTrials.gov NCT05553210; https://clinicaltrials.gov/study/NCT05553210…”
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A Randomized Clinical Trial of a Functional Electrical Stimulation Mimic to Gait Promotes Motor Recovery and Brain Remodeling in Acute Stroke by Xiuyuan Zheng, Danfeng Chen, Tiebin Yan, Dongmei Jin, Zhiqiang Zhuang, Zhimei Tan, Wei Wu

“…In conclusion, when four-channel FES induces cycling movement of the lower extremities based on a gait pattern, it may be more effective in promoting motor recovery and induce more plastic changes and brain remodeling than two-channel stimulation. This trial is registered with clinical trial registration unique identifier ChiCTR-TRC-11001615.…”
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Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trials by Fenglan Pu, Tianli Li, Chen Shen, Yingqiao Wang, Chunmei Tang, Xiaowen Zhang, Lijiao Yan, Qihe Xu, Jianping Liu

“…For the risk of bias, all trials were rated as some concerns. Compared with routine preventive procedure (RPP) (saline hydration and alprostadil), FOSM products plus RPP showed beneficial effects in reducing the incidence of CA-AKI (14.62% and 5.35%, respectively; RD −0.06, 95% CI −0.09 to −0.03). …”
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Parallel randomised trial testing community fibrosis assessment for suspected non-alcoholic fatty liver disease: outcomes from LOCATE-NAFLD by Sanjeewa Kularatna, James O'Beirne, Adrian Barnett, Patricia C Valery, Elizabeth Powell, Ingrid J Hickman, Ruth Tulleners, David Brain, Katherine Stuart, Carolyn McIvor, Elen Witness, Melanie Aikebuse

“…Other clinical outcomes showed minimal changes.Conclusion The LOCATE model shows potential for impact, particularly in reducing waiting times for patients at high risk of developing severe liver disease due to NAFLD. …”
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Randomized controlled trial of cognitive behavioral therapy versus health education for sleep disturbance and fatigue following stroke and traumatic brain injury by Lucy Ymer, Adam McKay, Dana Wong, Kate Frencham, Natalie Grima, Monique Roper, Sylvia Nguyen, Jade Murray, Gershon Spitz, Jennie Ponsford

“…Design: Parallel groups randomized controlled trial. Subjects: 126 community dwelling adults with stroke or traumatic brain injury. …”
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Comparative Evaluation of Implant-Protected Occlusion in Partially Edentulous Fixed Restoration Using Qualitative and Quantitative Assessment – A Prospective Clinical Trial by Ramesh Chowdhary, S Bukkapatnam

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Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, Riikka Havunen, Kristian Taipale, Dafne C A Quixabeira, Jorma Sormunen, Katriina Peltola, Suvi Sorsa, Santeri A Pakola, Elise Jirovec, Lyna Haybout, Claudia Kistler, Tatiana V Kudling, Victor Arias, James H A Clubb, Mirte van der Heijden, Teijo Pellinen, Joao M Santos

“…TUNIMO (NCT04695327) was a phase I clinical trial using TILT-123 in patients with advanced solid tumors aiming to assess the safety, efficacy, and immunological effects of TILT-123. …”
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The effect of a physical activity program on chronic psychiatric patients' positive and negative symptoms and depression levels: A randomized controlled trial by Neslihan Lok, Kerime Bademlı, Sefa Lok

“…As a results; 1) this randomized-controlled trial investigated the effect of physical activity program on positive and negative symptoms depression levels among of patients with schizophrenia, 2) results of this study on 60 patients with schizophrenia showed that an 12-week group physical activity program was significantly effective in patients with schizophrenia’ positive and negative symptoms depression, 3) physical activity should be routinely included in plans of psychiatric nursing care.…”
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Electroacupuncture combined with cognitive rehabilitation outperforms cognitive rehabilitation alone in treating post-stroke cognitive impairment: a randomized controlled trial by Yisha Guo, Tingting Sun, Fengxi Qiu, Xueyi Li, Weiwei Cui, Zhenhua Liao, Jiajia Yao

“…Secondary outcomes measured brain network global and nodal properties. The EA + CR group showed significant improvements in MoCA (p &lt; 0.001), AVLT-H (p = 0.004), and in areas like naming (p = 0.022), attention (p &lt; 0.001), and delayed recall (p &lt; 0.001). …”
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Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees in Delhi, India by Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra

“…This multicomponent worksite trial showed a reduction in weight, excess subcutaneous fat, and cardiometabolic risk factors after 6 months of active intervention in overweight Asian Indians. …”
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Evaluation of the Efficacy of Oxygen-releasing Gel as an Adjunct to Scaling and Root Planing in Chronic Periodontitis: A Split-mouth Randomized Controlled Trial by Shristi Agarwal, Shweta Bali, Priyanka Aggarwal, Amit Garg, Aruna Nautiyal, Manish Sharma

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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury by Ji Cheol Shin, Keung Nyun Kim, Jeehyun Yoo, Il-Sun Kim, Seokhwan Yun, Hyejin Lee, Kwangsoo Jung, Kyujin Hwang, Miri Kim, Il-Shin Lee, Jeong Eun Shin, Kook In Park

“…In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). …”
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Effectiveness of physiological flexion swaddling and oromotor interventions in improving preterm infants' oral feeding ability in the NICU: a randomized controlled trial by Luh K. Wahyuni, Irawan Mangunatmadja, Risma K. Kaban, Elvie Zulka K. Rachmawati, Rizky K. Wardhani, Budiati Laksmitasari, Boya Nugraha

“…Methods: A randomized clinical trial in five Neonatal intensive care units (NICU) was performed involving 70 preterm infants born at 28–34 weeks gestational age. …”
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Binaural auditory beats vs music of choice as audio distraction behaviour guidance technique among children: A randomized controlled trial by Bhuvanesh N. Bhusari, Shivayogi M. Hugar, Niraj Gokhale, Shweta Kajjari, Sanika Karmarkar, Varunika Sahai

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The Effect of Exercise Interventions on Sleep Quality and Weight Loss in Individuals with Obesity: A Systematic Review and Meta-Analysis of Randomized Control Trials by Soonjo Ka, Yu Hyeon Choe, Young-Im Kim, Nahyun Kim, Minjae Seo, Youngju Choi, Jonghoon Park

“…The combined aerobic and resistance exercise regimen showed the most substantial effects on sleep quality. …”
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Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status in Women with Gestational Diabetes: A Randomized Controlled Clinical Trial by Sadegh Jafarnejad, Sadaf Saremi, Farzan Jafarnejad, Arman Arab

“…Objective. This trial aims to examine the effects of a Probiotic Mixture (VSL#3) on glycemic status and inflammatory markers, in women with GDM. …”
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Effects of functional strength training on pain, function, and lower extremity biomechanics in patients with patellofemoral pain syndrome: a randomized clinical trial by Zheyu Xiong, Wei Zheng, Haiwen Wang, Yuan Gao, Chengshuo Wang

“…Conclusion Interventions focused on functional adaptations result in differential kinematic and muscle activation changes that may result in greater improvements in pain and knee function than lower limb muscle strengthening alone. Trial registration chictr.org.cn. NO: ChiCTR2400087664. …”
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