Lung and blood early biomarkers for host-directed tuberculosis therapies: Secondary outcome measures from a randomized controlled trial. by Robert S Wallis, Sibuse Ginindza, Trevor Beattie, Nishanee Arjun, Morongwe Likoti, Modulakgotla Sebe, Vinodh A Edward, Mohammed Rassool, Khatija Ahmed, Katherine Fielding, Bintou A Ahidjo, Mboyo D T Vangu, Gavin Churchyard

“…Two of the 4 arms (CC-11050 and everolimus) showed superior recovery of lung function at day 180 compared to control; none showed accelerated eradication of MTB infection. …”
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Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…<h4>Trial registration</h4>Clinicaltrials.gov-NCT04359901; https://clinicaltrials.gov/ct2/show/NCT04359901?…”
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Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients by Kyle Gouveia, Sheila Sprague, Jodi L. Gallant, Sarah MacRae, Gina Del Fabbro, Sofia Bzovsky, Paula McKay, Herman Johal, Jason W. Busse, on behalf of the COPE Investigators

“…Trial registration ClincialTrials.gov (NCT04274530). …”
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DAILY – A personalized circadian Zeitgeber therapy as an adjunctive treatment for alcohol use disorder patients: results of a pilot trial by Naomi Springer, Naomi Springer, Lisa Echtler, Lisa Echtler, Paul Volkmann, Anisja Hühne-Landgraf, Anisja Hühne-Landgraf, Jasmin Hochenbleicher, Eva Hoch, Eva Hoch, Gabi Koller, Dominic Landgraf

“…Abstinent participants showed significantly less variability in the times of their daily activities than relapsed participants. …”
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Evaluation of Efficacy and Safety of Transdermal Electrical Stimulation in Treatment of Knee Osteoarthritis by Kaiming LI, Shangquan WANG, Linghui LI, Qing ZHANG, Long LIANG, Ming CHEN, Jiawen ZHAN, Jing YIN, Zhuo WANG

“…Objective:To systematically evaluate the efficacy and safety of transdermal electrical stimulation (TES) in the treatment of knee osteoarthritis (KOA).Methods:A computerized systematic search of randomized controlled trials published in CNKI, Wanfang, VIP, Embase, PubMed, CBM, Cochrane libraries on the treatment of KOA by TES prior to October 2019. …”
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Systematic Evaluation and Trial Sequential Analysis of Therapeutic Effect of Needle Knife <italic>Versus</italic> Acupuncture on Cervical Spondylosis of Cervical Type by HUANG Bowei, CHEN Bin, CHEN Yinzhu, ZHAO Yingrong, ZHAO Hongjia

“…TSA V 0.9 software was used for trial sequential analysis.ResultsA total of 10 RCTs were included with 750 cases. …”
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Beta-Blockers After PCI for Stable Coronary Artery Disease and Preserved Left Ventricular Ejection Fraction by Safi U. Khan, MD, MS, Usman Ali Akbar, MD, Muhammad Shahzeb Khan, MD, Kershaw V. Patel, MD, Amna Nadeem, MBBS, Samarth Thakkar, MD, Hassaan B. Arshad, MD, Salim S. Virani, MD, PhD, Khurram Nasir, MD, MPH, Sachin S. Goel, MD, Alpesh R. Shah, MD, William Zoghbi, MD, Neal S. Kleiman, MD

“…Hospitalization for bone fracture (HR: 1.02 [95% CI: 0.85-1.22]) and acute appendicitis (HR: 1.17 [95% CI: 0.95-1.45]) showed no significant associations. Several sensitivity analyses showed consistent results. …”
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Effectiveness of a Comprehensive School-Based Oral Health Intervention Program on Periodontal Disease Outcomes: A Randomized Controlled Trial by Anuj Singh Parihar, M. S. Kalpana, Pooja Dwivedi, Meena Jain, Padmaja Swain, Fazil A. Nasyam

“…Materials and Methods: A randomized controlled trial was conducted among 5000 children (10-15 years) in rural Bhopal. …”
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3D Modeling of Geomagnetically Induced Currents in Sweden—Validation and Extreme Event Analysis by L. Rosenqvist, T. Fristedt, A. P. Dimmock, P. Davidsson, R. Fridström, J. O. Hall, L. Hesslow, J. Kjäll, M. Yu Smirnov, D. Welling, P. Wintoft

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Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-bli... by Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama Dabbagh

“…Bosentan has shown benefits in affected neonates. However, trials reported the association with unwanted effects. …”
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Providing an e-cigarette starter kit for smoking cessation and reduction as adjunct to usual care to smokers with a mental health condition: findings from the ESCAPE feasibility st... by Dimitra Kale, Emma Beard, Anna-Marie Marshall, Jodi Pervin, Qi Wu, Elena Ratschen, Lion Shahab

“…Qualitative analysis of participant interviews (N = 5) showed the intervention was broadly acceptable, but they also highlighted areas of improvements for the intervention and trial delivery. …”
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Effect of Mind Sound Resonance Technique on Pulmonary Function and Smoking Behavior among Smokers – A Prospective Randomized Control Trial by K. S. Moodala Girishankara, Shivaprasad Shetty, Krithika A. Ramaswamy, Prashanth Shetty

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The effects of Garcinia cambogia on glycaemic control and liver enzymes in adults: a systematic review and meta-analysis of randomised controlled trials by Sogand Tavakoli, Mohammad Reza Amini, Reyhaneh Rabiee, Marieh Salavatizadeh, Mostafa Afsharianfar, Moein Askarpour, Azita Hekmatdoost

“…Subgroup analysis showed that Garcinia cambogia significantly increased insulin levels in females and also increased insulin and FBS levels in those with a BMI ≥30 kg/m2. …”
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Nurse Participation in Colonoscopy Observation versus the Colonoscopist Alone for Polyp and Adenoma Detection: A Meta-Analysis of Randomized, Controlled Trials by Lei Xu, Yu Zhang, Haojun Song, Weihong Wang, Sijie Zhang, Xiaoyun Ding

“…And it showed no significant difference in the PDR and advanced lesions detection rate between the two groups (RR: 1.14, 95% CI: 0.95–1.37; RR: 1.35, 95% CI: 0.91–2.00; resp.). …”
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Evaluation of the Effectiveness of a Psychoeducational Intervention in Treatment-Naïve Patients with Antidepressant Medication in Primary Care: A Randomized Controlled Trial by R. Casañas, R. Catalán, R. Penadés, J. Real, S. Valero, MA. Muñoz, LL. Lalucat-Jo, M. Casas

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Short-term WB-EMS in Cancer Patients: Positive Effects After 2 Weeks of Exercise—A Single-arm Trial by Jane Kersten MSc, Timo Niels PhD, Annika Tomanek MSc, Freerk T. Baumann PD/ Habil

“…The body composition analyses showed significant reductions in body lean mass and extracellular water. …”
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The inter-trial and inter-session reliability of Theia3D-derived markerless gait analysis in tight versus loose clothing by Sylvia Augustine, Richard Foster, Gabor Barton, Mark J. Lake, Raihana Sharir, Mark A. Robinson

“…Results Reliability results showed average inter-trial variation of <2°, inter-session variation of <3° and inter-session-clothing variation <3.5°. …”
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Strengthening the success rate of suprapubic aspiration in infants by integrating point-of-care ultrasonography guidance: A parallel-randomized clinical trial. by Sadroddin Mahdipour, Seyedeh Nastaran Seyed Saadat, Hamidreza Badeli, Afagh Hassanzadeh Rad

“…<h4>Results</h4>Results showed that the POCUS-SPA had the highest success rate in urine sampling, and a statistically significant relation was noted among the three groups (P = 0.0001). …”
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The risks of adverse events with mirtazapine for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis by Caroline Barkholt Kamp, Johanne Juul Petersen, Pascal Faltermeier, Sophie Juul, Christina Dam Bjerregaard Sillassen, Faiza Siddiqui, Rebecca Kjaer Andersen, Joanna Moncrieff, Mark Abie Horowitz, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen

“…Meta-analysis and Trial Sequential Analysis showed insufficient information to determine the effects of mirtazapine on the risks of suicides or suicide attempts and serious adverse events. …”
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Functional Remediation Improves Serum BDNF and TrkB Levels in Euthymic Patients with Bipolar Disorder: A Randomized Trial Study by Li R, Li J, Ji SS, Li D, Chu L, Zhang J, Sun X, Luo X, Zhang Y

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