Acceptability and efficacy of the culturally adapted problem management plus intervention for people with disability in Pakistan: a pilot cluster randomized controlled trial by Basharat Hussain, Basharat Hussain, Muhammad Tahir Khalily, Muhammad Tahir Khalily, Ahmed Waqas, Atif Rahman, Ioannis Angelakis, Anum Nisar, Sabir Zaman, Tanveer Akhtar

“…Participants reported that this cultural alignment made the coping strategies more relatable and easier to adopt, contributing to improvements in both their mental health and somatic symptoms.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT04981522, identifier NCT04981522.…”
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Clinical Comparison of MEBO and Hyaluronic Acid Gel in the Management of Pain after Free Gingival Graft Harvesting: A Randomized Clinical Trial by Ahmed Hassan, Enji Ahmed, Dalia Ghalwash, Azza Ezz Elarab

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Sleep Promotion among Critically Ill Patients: Earplugs/Eye Mask versus Ocean Sound—A Randomized Controlled Trial Study by Abhilasha Chaudhary, Vinay Kumari, Neetu Neetu

“…Fisher’s LSD post hoc comparison showed a significant difference (p=0.001). Conclusion. …”
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Psychological counselling interventions to improve perceived quality of life and counter anxiety and depression in pulmonary-arterial-hypertension patients: A clinical trial by Emilia TARANTINO, Pietro CRESCENZO, Maria CAMPOBASSO, Francesca D’ALESSANDRO, Paola ARGIENTO, Emanuele ROMEO, Stefano GHIO, Patrizio VITULO, Francesco PARISI, Massimiliano MULÈ, Carlo ALBERA, Carmine Dario VIZZA, Michele D’ALTO

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The Effect of Free Weight Resistance Training on Cognitive Function Explored Through Eye Tracking: A Randomized Double-Blind Clinical Trial by Cristián Mateluna-Núñez, Romualdo Ibáñez-Orellana, César Campos-Rojas, Andrea Santana-Covarrubias, Rodrigo Fuentes Figueroa, Ricardo Martínez-Flores

“…In this randomized controlled trial, 18 participants were assigned to either an experimental or control group. …”
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Peritoneal instillation of magnesium sulfate and bupivacaine improves postoperative pain in laparoscopic cholecystectomy: A prospective, double-blind, randomized clinical trial by Santosh Kumar Sahu, Prerna Biswal, Madhusmita Patro, Sushree Das

“…Materials and Methods: We carried out this prospective, double-blind, randomized trial in 90 patients aged between 20 and 60 years who were randomly divided into three groups. …”
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Improved early postoperative cognition in elderly gastrointestinal patients: a randomized controlled trial on the role of ultrasound-guided stellate ganglion block by Ruyue Xue, Yuexian Li, Mei Zhan, Lin Yang, Defeng Sun

“…MDA levels were notably lower on postoperative day three in the SGB group (p < 0.05). Both groups showed significant changes in IL-6, SOD and MDA levels, when compared to preoperative values. …”
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Efficacy and safety of ciprofol versus propofol for induction of general anaesthesia or sedation: A systematic review and meta-analysis of randomised controlled trials by Abdallah Saeed, Mariam Elewidi, Ahmad Nawlo, Amr Elzahaby, Asmaa Khaled, Abdalla Othman, Mohamed Abuelazm, Basel Abdelazeem

“…Results: Nineteen randomised controlled trials were included in our analysis, with 2841 participants. …”
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Analgesic Effect of Passive Range-of-Motion Exercise on the Healthy Side for Pain after Total Knee Arthroplasty: A Prospective Randomized Trial by Shuichi Eto, Motoki Sonohata, Yasuo Takei, Masaya Ueno, Norio Fukumori, Masaaki Mawatari

“…Comparison of VAS scores before and after CPM showed no significant intergroup differences on all measurement dates. …”
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First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries by Masakazu Ishikawa, Shunya Tsuji, Goki Kamei, Kyohei Nakata, Akinori Nekomoto, Naofumi Hashiguchi, Tomoyuki Nakasa, Atsuo Nakamae, Naosuke Kamei, Keiichiro Inoue, Shingo Kawabata, Keiko Ueda, Nobuo Adachi

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The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials by Mitra Hariri, Masoudreza Sohrabi, Ali Gholami

“…Conclusion In conclusion, our study showed that magnesium significantly increased HDL-C levels. …”
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Peri-implant soft tissue conditioning of immediate posterior implants by CAD-CAM socket sealing abutments: a randomized clinical trial by Mai Mohamed Elgendi, Iman Salah Eldin Hamdy, Hanaa Ibraheem Sallam

“…Results At base line, after six as well as 12 months, SSA group showed statistically significant higher total modified PES scores than SHA group (P-value < 0.001). …”
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Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial by Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

“…Future research is needed to test the effects of the stress recovery intervention supplemented by goal setting and tailored prompts. Trial RegistrationClinicalTrials.gov NCT05553210; https://clinicaltrials.gov/study/NCT05553210…”
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A Randomized Clinical Trial of a Functional Electrical Stimulation Mimic to Gait Promotes Motor Recovery and Brain Remodeling in Acute Stroke by Xiuyuan Zheng, Danfeng Chen, Tiebin Yan, Dongmei Jin, Zhiqiang Zhuang, Zhimei Tan, Wei Wu

“…In conclusion, when four-channel FES induces cycling movement of the lower extremities based on a gait pattern, it may be more effective in promoting motor recovery and induce more plastic changes and brain remodeling than two-channel stimulation. This trial is registered with clinical trial registration unique identifier ChiCTR-TRC-11001615.…”
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Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trials by Fenglan Pu, Tianli Li, Chen Shen, Yingqiao Wang, Chunmei Tang, Xiaowen Zhang, Lijiao Yan, Qihe Xu, Jianping Liu

“…For the risk of bias, all trials were rated as some concerns. Compared with routine preventive procedure (RPP) (saline hydration and alprostadil), FOSM products plus RPP showed beneficial effects in reducing the incidence of CA-AKI (14.62% and 5.35%, respectively; RD −0.06, 95% CI −0.09 to −0.03). …”
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Comparative Evaluation of Implant-Protected Occlusion in Partially Edentulous Fixed Restoration Using Qualitative and Quantitative Assessment – A Prospective Clinical Trial by Ramesh Chowdhary, S Bukkapatnam

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Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, Riikka Havunen, Kristian Taipale, Dafne C A Quixabeira, Jorma Sormunen, Katriina Peltola, Suvi Sorsa, Santeri A Pakola, Elise Jirovec, Lyna Haybout, Claudia Kistler, Tatiana V Kudling, Victor Arias, James H A Clubb, Mirte van der Heijden, Teijo Pellinen, Joao M Santos

“…TUNIMO (NCT04695327) was a phase I clinical trial using TILT-123 in patients with advanced solid tumors aiming to assess the safety, efficacy, and immunological effects of TILT-123. …”
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Electroacupuncture combined with cognitive rehabilitation outperforms cognitive rehabilitation alone in treating post-stroke cognitive impairment: a randomized controlled trial by Yisha Guo, Tingting Sun, Fengxi Qiu, Xueyi Li, Weiwei Cui, Zhenhua Liao, Jiajia Yao

“…Secondary outcomes measured brain network global and nodal properties. The EA + CR group showed significant improvements in MoCA (p &lt; 0.001), AVLT-H (p = 0.004), and in areas like naming (p = 0.022), attention (p &lt; 0.001), and delayed recall (p &lt; 0.001). …”
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Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees in Delhi, India by Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra

“…This multicomponent worksite trial showed a reduction in weight, excess subcutaneous fat, and cardiometabolic risk factors after 6 months of active intervention in overweight Asian Indians. …”
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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury by Ji Cheol Shin, Keung Nyun Kim, Jeehyun Yoo, Il-Sun Kim, Seokhwan Yun, Hyejin Lee, Kwangsoo Jung, Kyujin Hwang, Miri Kim, Il-Shin Lee, Jeong Eun Shin, Kook In Park

“…In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). …”
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