Effects of aerobic exercise on cognitive function and quality of life in patients with Alzheimer’s disease: a systematic review and meta-analysis by Linlin Yang, Zhichao Yuan, Chenggen Peng

“…For the Minimum Mental State Examination (MMSE) (SMD=0.95, 95% CI 0.58 to 1.32, Z=5.06, p<0.00001), Alzheimer’s Disease Assessment Scale-Cognitive Section (ADAS-cog) (SMD=−0.67, 95% CI −1.15 to –0.2, Z=2.77, p=0.006) and quality of life (SMD=0.36, 95% CI 0.08 to 0.64, Z=2.51, p=0.01), but not statistically significant for depressive symptoms (SMD=−0.25, 95% CI −0.63 to 0.13, Z=1.27, p=0.21). Subgroup analysis showed that duration greater than 16 weeks and less than 50 min per intervention improved MMSE Scores. …”
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Effect of Task Oriented Training on Gross Motor Dysfunction for Children with Cerebral Palsy： A Meta-Analysis by LI Yang, CHEN Ying, ZHU Xiangyu, SHI Jiehong, FENG Yuan, WU Wenlei, FU Ruochen

“…ObjectiveTo evaluate the effect of task oriented training (TOT) on gross motor dysfunction for children with cerebral palsy (CP) by meta analysis.MethodsThe databases of PubMed, Embase, Cochrane Library, Web of Science, CINAHL, ProQuest, CNKI, VIP, Wanfang Data, CBMdisc and Electronic literature search database of Peking University Health Science Center were searched from inception to March 10, 2022 for randomized controlled trials (RCTs) on TOT for children with CP by manual and computer search. …”
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Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis by Chao Li, Didi Zuo, Tao Liu, Libin Yin, Chenyao Li, Lei Wang

“…Furthermore, randomized controlled trials (RCTs) of large patients are needed to confirm the results.…”
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Efficacy and safety of sequential therapy for primary osteoporosis with bone formation promoters followed by bone resorption inhibitors: a meta-analysis by Yuxin Liu, Xin Liu, Yuefeng Wu, Tao Luo

“…Randomized controlled trials (RCTs) on the sequential therapy of primary osteoporosis with bone formation promoters followed by bone resorption inhibitors were included. …”
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Clinical Efficacy of Extracorporeal Shock Wave in the Treatment of Knee Osteoarthritis： A Meta-analysis by GU Jinyu, LI Kaiming, ZHANG Qing, LI Linghui, BAI Zixing, WANG Shangquan

“…ObjectiveTo evaluate the efficacy and safety of extracorporeal shock wave therapy for knee osteoarthritis (KOA) by Meta analysis.MethodsThe CNKI database, Wanfang Data, China Science and Technology Journal Database (VIP), CBMdisc, PubMed and Cochrane Library were searched from inception to October 2020 for randomized controlled trials (RCTs) of extracorporeal shock wave therapy for KOA. …”
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Pharmacological Vitamin C-induced high H2O2 generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids by Ali Mussa, Mahasin Hamid, Khalid Hajissa, Ahmad Hafiz Murtadha, Mohammad A. I. Al-Hatamleh, Noor Fatmawati Mokhtar, Vuk Uskoković, Magdalena Plebanski, Rohimah Mohamud, Rosline Hassan

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A systematic review and meta-analysis of the impact of transcranial direct current stimulation on cognitive function in older adults with cognitive impairments: the influence of do... by Thatchaya Prathum, Thanwarat Chantanachai, Oranich Vimolratana, Chotica Laksanaphuk, Irin Apiworajirawit, Benchaporn Aneksan, Kanthika Latthirun, Cheng-Ta Yang, Wanalee Klomjai

“…Methods Randomized controlled trials (RCTs) published through November 2023 were retrieved from databases including PubMed, Scopus, EMBASE, EBSCO, and the Cochrane Library. …”
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A systematic review of impact of person-centred interventions for serious physical illness in terms of outcomes and costs by Richard Harding, Sridhar Venkatapuram, Alessandra Giusti, Ruwayda Petrus, Liz Gwyther, Lindsay Farrant, I Petersen, Amelia Cook, Kennedy Bashan Nkhoma

“…Most of these studies (n=47) were randomised controlled trials. Our search yielded two main types of interventions: (1) studies with self-management components and (2) technology-based interventions. …”
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Efficacy and Safety of Chemotherapy or EGFR‐TKIs as First‐Line Therapy in NSCLC Patients Harboring Non‐Ex 20 Ins Uncommon EGFR Mutations: A Retrospective Study in China by Chen Liao, Li Bai, Tingting He, Qingle Liang, Defeng Hu, Shipeng Lei, Yong He, Yubo Wang

“…ABSTRACT Background Uncommon EGFR mutations are a kind of heterogeneous group of mutations with various responses to EGFR‐TKIs and are often excluded from most prospective clinical trials. In this real‐world retrospective study, we retrospectively compared the efficacy and safety of chemotherapy or various generations of EGFR‐TKIs as first‐line therapy in NSCLC Chinese patients harboring non‐ex 20 ins uncommon EGFR mutations. …”
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Development of single-pin, un-barbed, pole-tagging of free-swimming dolphins and sharks with satellite-linked transmitters by Michael J. Moore, Thomas M. Lanagan, Randall S. Wells, Jason Kapit, Aaron A. Barleycorn, Jason B. Allen, Robin W. Baird, Camrin D. Braun, Gregory B. Skomal, Simon R. Thorrold

“…The latter showed very short touch/response intervals and highlighted the need for several iterative revisions of the pneumatic system. …”
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Observational cohort study of a group-based VR program to improve mental health and wellbeing in people with life-threatening illnesses by Hannes Kettner, Hannes Kettner, David R. Glowacki, David R. Glowacki, Justin Wall, Justin Wall, Justin Wall, Robin L. Carhart-Harris, Robin L. Carhart-Harris, Leor Roseman, Leor Roseman, Joseph L. Hardy, Joseph L. Hardy

“…While conclusions are presently limited by the lack of randomization or a comparison group, our findings strongly suggest further research is warranted, including randomized controlled trials.…”
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The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review by Yan Chen, Yan Chen, Jiaojiao Zhao, Jiaojiao Zhao, Yifei Wang, Yifei Wang, Long Ge, Long Ge, Joey Sum-wing Kwong, Junjie Lan, Rui Zhang, Huaye Zhao, Linfang Hu, Jiaxue Wang, Shuimei Sun, Songsong Tan, Xiaoqing Lin, Rui He, Wenyi Zheng, Xiaosi Li, Jiaxing Zhang

“…This study aims to evaluate the relative efficacy and safety of the first-line monotherapies in primary therapy of IA through network meta-analysis (NMA).MethodsWe systematically searched PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP database, Wanfang database, and China Biology Medicine for randomized controlled trials (RCTs) up to July 2023 that evaluated the efficacy and safety of monotherapies. …”
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Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients by Yongjie Xie, Xiaoran Feng, Youqun Gao, Xiaojiang Zhan, Fenfen Peng, Qian Zhou, Xianfeng Wu, Xiaoyang Wang, Na Tian, Qingdong Xu, Ning Su, Xingming Tang, Jianbo Liang, Jiao Li, Yueqiang Wen

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Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

“…We then performed biological experiments to validate that Etoposide suppresses the replication of the EV71 virus in a concentration-dependent manner with minimal cytotoxicity to various cell lines. Remarkably, it shows inhibitory activity against EV71 A, B, C, and CVA16, suggesting that Etoposide may be a potential broad-spectrum inhibitor. …”
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An Analysis of the Effectiveness and Safety of Upadacitinib in the Treatment of Inflammatory Bowel Disease: A Multicenter Real-World Study by Hongzhen Wu, Tingting Xie, Qiao Yu, Tao Su, Min Zhang, Luying Wu, Xiaoling Wang, Xiang Peng, Min Zhi, Jiayin Yao

“…Upadacitinib, a Janus kinase 1 (JAK1) inhibitor, has shown effectiveness in trials for Crohn’s disease (CD) and ulcerative colitis (UC). …”
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Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review of studies before and during the COVID-19 pandemic by Benjamin C. Pierson, Kyle Apilado, Kyle Apilado, M. Alaric Franzos, M. Alaric Franzos, Rhonda Allard, James D. Mancuso, David Tribble, David Tribble, David Saunders, Tracey Perez Koehlmoos, Tracey Perez Koehlmoos

“…Ivabradine and midodrine demonstrated the highest rate of symptomatic improvement, while beta-blockers showed the largest reduction in heart rate variability. …”
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Evaluation of the Therapeutic Effect of Traditional Chinese Medicine on Osteoarthritis: A Systematic Review and Meta-Analysis by Lin Wang, Xiao-Fei Zhang, Xue Zhang, Dong-Yan Guo, Yu-Wei Duan, Zhi-Chao Wang, Li-Shan Pei, Han Ru, Jiang-Xue Cheng, Ya-Jun Shi, Jun-Bo Zou

“…Some rigorous randomized controlled trials (RCTs) are needed to confirm these findings.…”
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The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a... by Xiaoting Gu, Xiaohe Li, Weixue Tian, Chaoyue Zheng, Chaoyue Zheng, Yutian Cai, Yutian Cai, Xiang Xu, Xiang Xu, Conglu Zhao, Conglu Zhao, Hongting Liu, Hongting Liu, Yao Sun, Yao Sun, Zhilin Luo, Zhilin Luo, Shuwen Zhu, Shuwen Zhu, Honggang Zhou, Honggang Zhou, Xiaoyu Ai, Cheng Yang, Cheng Yang

“…CYP3A4 was the major CYP isoform responsible for Deg-AZM metabolism. Deg-AZM showed moderate inhibition with CYP2B6 and CYP2D6. …”
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Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma by Wei Gao, Tong Ding, Beicheng Sun, Nan Li, Fang Gao, Meng Jia, Mitchell Ho, Na Li, Luan Sun, Zhanhui Gao, Lei Ao, Sujuan Ma, Peihua Lu, Shaochang Jia

“…Therefore, it would be worth investigating the potential influence of antigen shedding in anti-GPC3 CAR-T therapy for HCC.Methods In this study, we constructed two types of CAR-T cells targeting distinct epitopes of GPC3 to examine how sGPC3 influences the activation and cytotoxicity of CAR-T cells in vitro and in vivo by introducing sGPC3 positive patient serum or recombinant sGPC3 proteins into HCC cells or by using sGPC3-overexpressing HCC cell lines.Results Both humanized YP7 CAR-T cells and 32A9 CAR-T cells showed GPC3-specific antitumor functions in vitro and in vivo. …”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…In a repeat CEA antigen stimulation assay, M5A showed the best cell proliferation and cytokine secretion levels. …”
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