PARP inhibitor‐based treatment in metastatic, castration‐resistant prostate cancer (mCRPC): A systematic review and meta‐analysis by Michela Roberto, Mattia Alberto Di Civita, Daniele Marinelli, Andrea Torchia, Nertila Cara, Giulia Maltese, Iolanda Speranza, Daniele Santini

“…Abstract Background We present a systematic review and meta‐analysis of randomized clinical trials (RCTs) with PARPi either as monotherapy or in combination with an androgen receptor‐targeted agent (ARTA) in first‐ and second‐line settings. …”
Get full text

Low-Dose Caffeine Supplementation Is a Valuable Strategy for Increasing Time to Exhaustion, Explosive Power, and Reducing Muscle Soreness in Professional Male Kickboxers by Maziar Saremi, Fatemeh Shahriari, Mohammad Hemmatinafar, Rasoul Rezaei, Alireza Niknam, Michael Nordvall, Alexei Wong, Reza Bagheri

“…A 1-wk washout period occurred between exercise trials. Caffeine was supplemented 60 min before each exercise session. …”
Get full text

Social Media Potential and Impact on Changing Behaviors and Actions in Skin Health Promotion: Systematic Review by Justyna Martyna Brzozowska, Joanna Gotlib

“…The analyzed research showed that social media is a source of information. …”
Get full text

DADmax/NADmax Ratio: Criterion for the Production and Selection of Demolition Aggregates with Low-Water Absorption by Kamel Akroum, Bouzidi Mezghiche

“…Similarly, DA fractions reconstituted from DA sub-fractions of the same PC showed a decrease in minimum values of 21% to 43% compared to average values and 31% to 58% compared to maximum values. …”
Get full text

Efficacy and retention rate of secukinumab in psoriatic arthritis across different clinical phenotypes: insights from the Italian GISEA Registry by Giuseppe Lopalco, Maria Morrone, Fabiola Atzeni, Chiara Bazzani, Francesco Paolo Bianchi, Francesco Paolo Cantatore, Roberto Caporali, Antonio Carletto, Alberto Cauli, Maria Sole Chimenti, Sergio Colella, Fabrizio Conti, Addolorata Corrado, Ennio Giulio Favalli, Alberto Floris, Marco Fornaro, Rosario Foti, Roberta Foti, Elena Fracassi, Bruno Frediani, Stefano Gentileschi, Roberto Gorla, Elisa Gremese, Emanuela Praino, Roberta Ramonda, Cinzia Rotondo, Marco Sebastiani, Angelo Semeraro, Gianfranco Ferraccioli, Giovanni Lapadula, Florenzo Iannone

“…Background: Randomized clinical trials have demonstrated the efficacy of secukinumab (SECU) in reducing disease activity in psoriatic arthritis (PsA), while real-world studies prove a broader perspective on SECU’s usefulness in everyday clinical practice. …”
Get full text

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis by Shixiao Jin, Liyan Sha, Jianli Dong, Jing Yi, Yang Liu, Zhongxian Guo, Bing Hu

“…We conducted a literature search using PubMed, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the differences between different nutritional strategies in women with GDM. …”
Get full text

Supervised vs. Self-Managed Exercise Therapy for Improving Shoulder Function After Traumatic Dislocation and Sprain: A Systematic Review and Meta-Analysis by Daniel Koska, Robert Zetzsche, Tobias A. Mayer, Christian Maiwald

“…Further high-quality trials with standardized protocols and improved adherence tracking are needed to establish more definitive conclusions and guide clinical decision-making.…”
Get full text

Safety and efficacy of anti-CD30 CAR-T cell therapy in relapsed/refractory classic Hodgkin lymphoma: a systematic review and meta-analysis by Fanqiao Meng, Maoyuan Xiang, Yu Liu, Dongfeng Zeng

“…Methods A systematic literature search of PubMed, Cochrane, Embase, ClinicalTrials.gov, and Web of Science databases was conducted until February 2024. …”
Get full text

Cytotoxic and cytostatic activity of five new imidazotetrazine derivatives on breast cancer cell cultures MDAMB231, BT474, and MCF-7 by Ahmed Hamid Al-Humairi, Svetlana E. Sitnikova, Valery V Novochadov

“…Imidazotetrazine 1 and iminothiotriazine 5 showed cytotoxic activity higher than that of the comparison drug and we classified these compounds as the ones with a moderate CTA. …”
Get full text

Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy by Mohammad Amin Manavi, Razieh Mohammad Jafari, Hamed Shafaroodi, Mohammad Sharifzadeh, Ahmad Reza Dehpour

“…However, there is a need for more randomized controlled trials specifically evaluating ivermectin's impact on seizures in O. volvulus‐infected epileptics on ASMs. …”
Get full text

Development and Evaluation of a Mental Health Chatbot Using ChatGPT 4.0: Mixed Methods User Experience Study With Korean Users by Boyoung Kang, Munpyo Hong

“…ConclusionsThe HoMemeTown Dr CareSam chatbot shows potential as a cross-lingual mental health support tool, achieving high user satisfaction and demonstrating comparative advantages over existing digital interventions. …”
Get full text

Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety by Víctor Mayoral, Rafael Galvez, Marta Ferrándiz, Xoán Miguéns Vázquez, Carlos Cordero-García, Antonio Alcántara Montero, Concepción Pérez, María Pérez-Páramo

“…Comparative studies (clinical trials and cohort studies) were included, with patients with neuropathic pain treated either with pregabalin or gabapentin. …”
Get full text

The Effect of Autologous Platelet Rich Plasma on Endometrial Receptivity: A Narrative Review by Milan Stefanović, Predrag Vukomanović, Ranko Kutlesic, Milan Trenkić, Vanja Dimitrov, Aleksa Stefanović, Vladimir Cvetanović

“…Obtained articles were screened, and suited studies (randomized controlled trials, case reports, case series, pilot studies, and reviews) were included in the present review. …”
Get full text

Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study by Liaoyi Lin, Yingbao Huang, Songzan Qian, Lifang Chen, Houzhang Sun

“…As for validation, 14 and 9 lipid species were correlated with acute and chronic pancreatitis of UK Biobank. Some lipid classes showed significant effects both in the FinnGen consortium and UK Biobank datasets.ConclusionsThe findings of this study indicate a potential genetic predisposition linking the plasma lipidome to pancreatic diseases and good prospects for future pancreatic disease clinical trials.…”
Get full text

Performance of 1-year-old camel calves fed a basal ration of alfalfa hay supplemented with different levels of concentrate by Ahmed R. Askar, Rawia Darwesh, Sabbah Allam, Galal M. Abdul Aziz, Afaf A. El Shereef, Ehab Y. Eid, Hamedi M. Kandil, Samir S. Abou El Ezz, Mohsen M. Shoukry

“…The experiment lasted for 6 months, in which digestibility trials took place at 14, 16, and 18 months of age, which corresponded to 2, 4, and 6 months of the experimental period. …”
Get full text

Aldosterone Blockade in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis by Qiao Chen, Die Zhao, Jie Sun, Chengzhi Lu

“…Articles were identified through PubMed, Embase, Cochrane Library, Ovid (Medline1946-2021), and ClinicalTrials.gov databases from their inception to December 31, 2020. …”
Get full text

Clinicopathological and Prognostic Significance of CD47 Expression in Lung Neuroendocrine Tumors by Mario Orozco-Morales, Alejandro Avilés-Salas, Norma Hernández-Pedro, Rodrigo Catalán, Graciela Cruz-Rico, Ana Laura Colín-González, Elsa Dosal-Mancilla, Pedro Barrios-Bernal, Oscar Arrieta

“…The mean age at diagnosis was 57.6 (±11.6) years; 30 patients were women (59%). 27.5% of patients were positive for CD47 expression, and 72.5% of patients showed a CD47 expression of less than 1% and were considered as negatives. …”
Get full text

Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication by E. L. Mishchenko, A. A. Makarova, E. A. Antropova, A. S. Venzel, T. V. Ivanisenko, P. S. Demenkov, V. A. Ivanisenko

“…Among the viral proteins, NS3 showed the  greatest number of regulatory linkages. …”
Get full text

Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study by I-Wen Chen, I-Wen Chen, Wei-Ting Wang, Yi-Chen Lai, Yi-Chen Lai, Ying-Jen Chang, Yao-Tsung Lin, Kuo-Chuan Hung, Kuo-Chuan Hung

“…These findings suggest that maintaining adequate vitamin D levels might be important for mental health in patients with CKD, although randomized trials are needed to confirm whether supplementation can prevent depression in this population.…”
Get full text

Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…Specifically, the combination of Enfortumab vedotin (EV) and pembrolizumab (Pembro) showed more effectiveness in treating patients compared to trials using the current standard treatment, suggesting that it could be a promising alternative treatment option.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024510152.…”
Get full text