Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…Emerging approaches, including adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) and oncolytic virotherapy, are showing promise. While CAR-T cell therapy has been less successful in melanoma compared to blood cancers, ongoing research is addressing challenges like the tumor microenvironment and antigen specificity. …”
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Direct-acting oral anticoagulant removal by intraoperative hemoadsorption in CABG and/or single valve surgery: interim analysis of the International Safe and Timely Antithrombotic... by Michael Schmoeckel, Matthias Thielmann, Keti Vitanova, Thomas Eberle, Nandor Marczin, Kambiz Hassan, Andreas Liebold, Sandra Lindstedt, Georg Mächler, Marijana Matejic-Spasic, Daniel Wendt, Efthymios N. Deliargyris, Robert F. Storey

“…Clinical registration number ClinicalTrials.gov identifier: NCT05077124.…”
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Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia by Fouzul Kansul, Deborah Vela, MD, Judit Csore, MD, Bright Benfor, MD, Sasha Suarez, MD, Anahita Dua, MD, MBA, MSC, Trisha L. Roy, MD, PhD

“…Objective: With the growing incidence of peripheral arterial disease (PAD) and the historic under-representation of female patients in cardiovascular trials, a comprehensive evaluation of sex-based variances in PAD presentation and treatment outcomes is needed. …”
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Efficacy and safety of laser acupuncture on osteoarthritis: a systematic review and meta-analysis by Xiangdong Wen, Guojiang Zhang, Jinquan Cui, Yuzhe Tang, Qi Meng, Yang Su, Senbo An, Shui Sun, Shui Sun

“…After identifying 11 studies, we used Stata 15.0 to analyze the data.ResultsIn the 11 studies identified, 931 patients were analyzed. Results showed that laser acupuncture significantly improved patients’ pain and function compared to the placebo laser group. …”
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Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers by Daehwan Kim, Heekyung Chung, Wen Liu, Kangjin Jeong, Tugba Y. Ozmen, Furkan Ozmen, Matthew J. Rames, Sangyub Kim, Xiao Guo, Nathan Jameson, Petrus R. de Jong, Steven Yea, Laurie Harford, Jiali Li, Cara A. Mathews, Deborah B. Doroshow, Vincent J. Charles, Doris Kim, Kimberlee Fischer, Ahmed A. Samatar, Adrian Jubb, Kevin D. Bunker, Kimberly Blackwell, Fiona Simpkins, Funda Meric-Bernstam, Gordon B. Mills, Olivier Harismendy, Jianhui Ma, Mark R. Lackner

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HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders by Qin Wang, Xinyi Zhu, Jing Li, Sanjia Xu, Ali Wang, Xinwen Zhang, Xingxing Wang, Xiaopeng Cai, Haimei Xing, Ye Liu, Xuesong Liu, Zhiwei Wang, Lai Wang, Lai Wang, Xi Yuan

“…HPK1 K46E-knockin and K46*-knockin Jurkat cells showed comparable levels of enhanced TCR-induced activation compared with control HPK1-wildtype Jurkat cells. …”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Despite countless experimental researches for new therapeutic strategies and promising clinical trials, the prognosis remains extremely poor, with a mean survival of less than 14 months. …”
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A systematic review on the correlation between COVID-19 and lower urinary tract symptoms by Ashkan Shafigh, Amir Mohammadi-Garebagh, Kavous Shahsavarinia, Sona Tayebi, Ali Mostafaei, Hanieh Salehi-Pourmehr, Sakineh Hajebrahimi

“…The analysis of eligible studies showed a 3.3 % prevalence of LUTS in infected patients (95 % CI: 2.0 % - 5.3 %; Q-value: 1021.397, I2: 97.45 %). …”
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Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis by Vitor Engracia Valenti, André dos Santos Chagas, Peter Chedraui, Ingrid Soares de Souza, Andrey Alves Porto, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Júnior, Juliana Zangirolami-Raimundo, David M. Garner, Rodrigo Daminello Raimundo

“…This study included non-blinded, single or double-blinded randomized control trials and postmenopausal women diagnosed with T2DM. …”
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Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study by Chenyu Fan, Hanfei Li, Hanfei Li, Ke Chen, Ke Chen, Guohui Yang, Hongyu Xie, Haozheng Li, Yi Wu, Meng Li, Meng Li, Meng Li

“…The MCI group displayed longer response latencies compared to the HC group while demonstrating comparable accuracy performance across both congruent and incongruent Stroop trials. The MCI group showed compensatory activation in the VLPFC, and PL regions compared to the HC group during the late stage of the Stroop task (q < 0.05, FDR-corrected). …”
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Latarjet procedure versus iliac crest autograft transfer for anterior shoulder instability: a systematic review and meta-analysis of comparative studies by Lang Li, Bofang Zeng, Meng Ding, Sha Wan, Kefu Lin, Zhen Tian

“…Randomized controlled trials (RCTs) and cohort studies directly comparing the Latarjet and ICBGT procedures were included. …”
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Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study by Mingqiang Wang, Mingqiang Wang, Yue Jin, Yue Jin, Wenxiao Zhang, Wenxiao Zhang, Ling Ye, Ling Ye, Huanzhang Shao, Huanzhang Shao

“…The rapid identification of these phenotypes could facilitate the screening of sCAP patients responsive to corticosteroid in future prospective clinical trials.…”
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Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis by Alisha Puri, Anita M. Lloyd, Aminu K. Bello, Marcello Tonelli, Sandra M. Campbell, Karthik Tennankore, Sara N. Davison, Stephanie Thompson

“…Selection Criteria for Studies: Observational studies and randomized trials. Data Extraction: Risk and precision measurements; measurement properties. …”
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Fecal Microbiota Transplantation as Therapy for Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis by Xiaolei Liu, Yan Li, Kaichun Wu, Yongquan Shi, Min Chen

“…Randomized controlled trials (RCTs) recruiting adults with active UC, which compared FMT with controls, were eligible. …”
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Adverse events in different administration routes of amiodarone: a pharmacovigilance study based on the FDA adverse event reporting system by Jingrong Yang, Mengfan You, Jingxin Wang, Rongfei Sun, Lili Han, Xiaonan Liu, Kaibin Niu, Kaidi Xing, Juanping Sun, Wenge Su, Yifei Wang

“…The Weibull distribution analysis showed a median onset time of 5 days for intravenous administration compared to 74 days for oral administration. …”
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Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis by Qianyu Lv, Qian Wu, Yingtian Yang, Lanlan Li, Xuejiao Ye, Shihan Wang, Yanfei Lv, Manshi Wang, Yushan Li

“…ObjectiveThis network meta-analysis was to compare the efficacy of different drugs on cardiac function, renal function, and clinical outcomes in patients with acute heart failure (AHF) accompanied by renal dysfunction.MethodsPubMed, EMBASE, Cochrane Library, and Web of Science were searched to screen all clinical trials of AHF between January 1st 2001 and March 31th 2024. …”
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Crocin Monotherapy in Non-Central Diabetic Macular Edema by Mojtaba Mojtahedzadeh, Masoud Reza Manaviat, Seyed Reza Mirjalili, Adeleh Sahebnasagh, Mohammad Khan Ardani, Farahnaz Hoseinzadeh, Fatemeh Saghafi

“…It may also improve the glycemic profile of diabetic patients; however, more high-quality randomized clinical trials with larger sample sizes and longer durations are needed for validation. …”
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Diagnostic Accuracy of Procalcitonin for Bacterial Infection in Liver Failure: A Meta-Analysis by Xinchun He, Liang Chen, Haiou Chen, Yuqing Feng, Baining Zhu, Caixia Yang

“…In this study, we included prospective observational studies or randomized controlled trials on PCT. The quality of the studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. …”
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Effects of isometric contraction training on hypertensive patients: A Systematic Review by Yuan Hao Dong

“…The National Cardiovascular Disease Center's "China Cardiovascular Health and Disease Report 2023" data shows that the prevalence of hypertension in adults has reached 31.6%, with a total of 245 million patients. …”
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Comparison of the effects of different teaching methods on the effectiveness of teaching neurology in China: a bayesian network meta-analysis and systematic review by Xiangyu Li, Longsheng Zhang, Wenjun Sun, Min Lei, Ying Li, Jiacheng Zhang, Xing Huang

“…In theoretical examinations, a statistically significant difference was noted among the teaching methods, with CBL, PBL, TBL, FCM, and EBM showing superior performance over the LBL method. …”
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