Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…Finally, RNA sequencing analysis showed that in the presence of rapamycin, AD-MSCs displayed improved chondroprotective regenerative effects on co-cultured OA chondrocytes. …”
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Efficacy and safety of pharmacotherapy for cancer cachexia: A systematic review and network meta‐analysis by Hao Chen, Masashi Ishihara, Hiroki Kazahari, Ryusuke Ochiai, Shigeru Tanzawa, Takeshi Honda, Yasuko Ichikawa, Nobuyuki Horita, Hisashi Nagai, Kiyotaka Watanabe, Nobuhiko Seki

“…Results Seven placebo‐controlled randomized trials involving 1421 patients were analyzed. Pairwise analysis showed that body weight increases were 4.6 kg (95% confidence interval [CI] 0.83–8.37 kg) for olanzapine, 3.82 kg (95% CI 0.73–6.91 kg) for espindolol (20 mg), 2.36 kg (95% CI 1.84–2.89 kg) for anamorelin (100 mg), and 1.31 kg (95% CI 0.42–2.19 kg) for anamorelin (50 mg). …”
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Unconventional use of injectable long-acting cabotegravir and rilpivirine against HIV-1 in PWH in clinical need: 52 weeks real-world data by Valentina Iannone, Roberto Rossotti, Nicholas Brian Bana, Gabriele Cavazza, Federico D’Amico, Francesca Lombardi, Pierluigi Francesco Salvo, Gianmaria Baldin, Simona Di Giambenedetto, Dario Bernacchia, Gabriele Pagani, Alberto Borghetti, Stefano Rusconi

“…Abstract Background Long-acting Cabotegravir and Rilpivirine (LA CAB + RPV) shows potential advantages in heavily comorbid and even in viremic people with HIV (PWH). …”
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Dufulin Impacts Plant Defense Against Tomato Yellow Leaf Curl Virus Infecting Tomato by Liping Huang, Yingying Tang, Shuaixin Wang, Jianbin Chen, Jiao Du, Shuo Yan, Deyong Zhang, Xiaobin Shi, Yong Liu, Fan Li

“…Plants treated with dufulin showed reduced symptomatology and lower viral titers compared to the controls. …”
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Beyond averaging: A transformer approach to decoding event related brain potentials by Philipp Zelger, Manuel Arnold, Sonja Rossi, Josef Seebacher, Franz Muigg, Simone Graf, Antonio Rodríguez-Sánchez

“…Traditional methods involve averaging the EEG signal of multiple trials to extract valuable neural signals from the high noise content of EEG data. …”
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Evaluation of ChatGPT-4 for the detection of surgical site infections from electronic health records after colorectal surgery: A pilot diagnostic accuracy study by Josep M. Badia, Daniel Casanova-Portoles, Estela Membrilla, Carles Rubiés, Miquel Pujol, Joan Sancho

“…Minor differences in outcomes were observed between colon and rectal surgeries, as well as between the hospitals participating in the study. Conclusions: ChatGPT shows high sensitivity and good overall accuracy for detecting SSI. …”
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Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2 by Brett A. Clementz, Ishanu Chattopadhyay, S. Kristian Hill, Jennifer E. McDowell, Sarah K. Keedy, David A. Parker, Rebekah L. Trotti, Elena I. Ivleva, Matcheri S. Keshavan, Elliot S. Gershon, Godfrey D. Pearlson, Carol A. Tamminga, Robert D. Gibbons

“…It may be especially useful for clinical trials.…”
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Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis by Tieci Yi, Min Li, Fangfang Fan, Lin Qiu, Zhi Wang, Haoyu Weng, Xiaoke Shang, Changdong Zhang, Wei Ma, Yan Zhang, Yong Huo

“…After a literature search and detailed evaluation, six trials enrolling a total of 203 individuals were included in the quantitative analysis. …”
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The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

“…Methods: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched up to December 2023 and 78 publications were included, covering treatment outcomes and adverse events. …”
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A cost–benefit analysis of the production system with improved and climate-resilient sorghum varieties in southern Mali by Adama B. Coulibaly, Félix Badolo, Félix Badolo, Jummai O. Yila, Jummai O. Yila, Bourema Koné, Baloua Nebié, Baloua Nebié, Nadine Worou, Nadine Worou, Macdonald Bright Jumbo, Kimseyinga Savadogo

“…A final sample of 31 farmers’ on-farm trials under the fertiliser package of “100 kg complex cereal and 50 kg urea” per hectare was held as the agronomic package. …”
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The Effect of Combining mHealth and Health Professional–Led Intervention for Improving Health-Related Outcomes in Chronic Diseases: Systematic Review and Meta-Analysis by Masashi Kanai, Takahiro Miki, Toshiya Sakoda, Yuta Hagiwara

“…In the short term, subjective outcomes showed significant improvement (SMD 0.31; 95% CI 0.12-0.50; I2=0%), while objective outcomes did not (SMD 0.11; 95% CI –0.05 to 0.27; I2=0%). …”
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Comparisons of open surgical repair, thoracic endovascular aortic repair, and optimal medical therapy for acute and subacute type B aortic dissection: a systematic review and meta-... by Jianping Liu, Xiaohong Chen, Juan Xia, Long Tang, Yongheng Zhang, Lin Cao, Yong Zheng

“…The results require further large-scale randomized controlled trials.…”
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Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis [version 2; peer review: 2 approved] by Nayak Snehasis, Karshe Haji Ali, Pendyala Siri, Ngabo Herve, Sayed Zafar

“…Conclusion This study showed that combination therapy is very effective for plaque psoriasis, with promising combinations of pioglitazone. …”
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Identification of QTL for Plant Height Traits in Single-segment Substitution Lines of Wild Rice by Xingxin DAI, Yanjie LIU, Chengxia LI, Rui TANG, Jiamei MU, Xuelin FU

“…Both qPHb1-4 and qPHb10-1 showed the phenotype contributions of more than 18.00%, and qPHb10-1 might be a novel QTL controlling plant height traits in BAR-SSSLs from O. barthii.…”
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The Application of Incretin-Based Pharmacotherapy in the Contemporary Management of Type 2 Diabetes: A Review of the Literature by Jakub Waszczyński, Wojciech Kulej, Wiktor Biesiada, Piotr Kulej, Justyna Woźniak, Justyna Weronika Kmieć, Anna Mariia Chernysh, Aleksandra Dusińska, Kamila Fuczyło, Karolina Stankević

“…Materials and Methods Data was sourced from recent clinical trials and literature (post-2020) from PubMed, Google Scholar, Lancet, New England Journal of Medicine, Nature, American Diabetes Association, Research Gate. …”
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The Role of SGLT2 Inhibitors in Heart Failure: A Systematic Review and Meta-Analysis by Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou

“…Recent randomised controlled trials (RCTs) have shown a significant prognostic benefit of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the cardiovascular (CV) profile of patients with diabetes. …”
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Factors determining first influenza vaccination among individuals with type 2 diabetes in the CONSTANCES cohort by age group (younger than 65 years or 65 and older) by Sylvain Paquet, Virginie Ringa, Henri Panjo, Jeanne Sassenou, Marie Zins, Laurent Rigal

“…The only factor related to first influenza vaccination significantly different between individuals aged at least 65 years with and without diabetes was age (OR = 0.83/OR = 1.05—P-interaction<0.001). This study shows that trials are now needed to test the effectiveness of age- and sex-specific messages to increase influenza vaccination coverage among people with diabetes.…”
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A comprehensive comparison of PARP inhibitors as maintenance therapy in platinum-sensitive recurrent ovarian cancer: a systematic review and network meta-analysis by Shiya Ji, Lu Chen, Yebo Yu, Xupeng Chen, Liwen Wei, Lili Gou, Cheng Shi, Susu Zhuang

“…Conclusion All included PARPis showed various degrees of benefit in survival outcomes and safety profile was acceptable for PSROC patients. …”
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A Comprehensive Review on Current Knowledge and Future Potential of Topical Therapies in Breast Cancer Treatment by N. Bharathi Sai Thilagam, V.P. Karthik, R. Gnanasambandan, C. Sowmya

“…Studies and clinical trials were evaluated that have investigated these treatments, focusing on their safety, ease of application, and patient acceptance. …”
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The blood pressure lowering effect of beetroot juice is impaired in periodontitis and recovered after periodontal treatment by Nydia Y. Sanchez-Orozco, Bob T. Rosier, Alondra Ruiz-Gutierrez, Fabiola Marquez-Sandoval, Alejandro Artacho, Lucrecia Carrera-Quintanar, Alex Mira

“…This is the first study showing that periodontitis could limit the blood-pressure lowering effects of nitrate reduction by the oral microbiota. …”
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