The Effect of Cognitive-Motor Dual Tasks on the Risk of Falls in Female Saudi Students: A Cross-Sectional Study by Alatawi SF, Mahmoud HM

“…ROF was measured using the Biodex balancing device for balance alone (no DT) and with DT (motor and two cognitive tasks). After three trials, the mean and average were calculated. The ICC calculation showed a reliable result of < 0.8. …”
Get full text

A Review on Bioactive Phytochemical Constituents and Pharmacological Activities of Aegiceras corniculatum: A Pharmaceutically Important Mangrove Plant by Pritam Sarkar, Tasfiya Rufaidah Ahnaf, Razina Rouf, Jamil Ahmad Shilpi, Shaikh Jamal Uddin

“…Despite numerous studies demonstrating various pharmacological advantages of this plant and its constituents, the number of clinical trials conducted on humans remains significantly limited.…”
Get full text

High-quality DNA extraction for Desmodium gangeticum: A medicinal shrub of Shivalik Himalayas by Shiwani Singh, Maneesh S. Bhandari, Neeraj Dwivedi

“…Results: With the standardised buffer conditions and protocol, high-quality DNA with purity indicated by a 260/280 nm absorbance ratio in a range of 1.8 to 2.0 with 250 ng/µL – 950 ng/µL concentration from 0.5 g of leaf sample and also validated by agarose gel electrophoresis showing reduced contaminations and intact DNA was isolated. …”
Get full text

Exploring digital health interventions for pregnant women at high risk for pre-eclampsia and eclampsia in low-income and-middle-income countries: a scoping review by Emily Seto, Anam Shahil Feroz, Noreen Afzal

“…Objective To explore digital health interventions that have been used to support pregnant women at high risk for pre-eclampsia/eclampsia (HRPE/E) in low-income and middle-income countries (LMICs).Design Scoping review.Data source EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and CINAHL were searched between 1 January 2000 and 20 October 2020.Eligibility criteria The review included original research studies that were published in English, involved pregnant women at HRPE/E and implemented digital health interventions for PE/E in LMICs.Data extraction and synthesis Two reviewers independently completed the data extraction for each of the 19 final articles. …”
Get full text

Cost-Minimization Analysis for Subcutaneous Daratumumab in the Treatment of Newly Diagnosed Multiple Myeloma in Three Gulf Countries by Anas Hamad, Shereen Elazzazy, Ruba Y. Taha, Hani Osman, Sana Alblooshi, Islam Elkonaissi, Mustaqeem A. Siddiqui, Khalil Al-Farsi, Mohammed Al Lamki, Sali Emara, Gihan H. Elsisi

“…**Results:** The model showed that the use of dara-SC in NDMM patients who were eligible or ineligible for ASCT resulted in lower non-drug costs, including premedication drug costs, adverse-effect costs, administration costs, medical staff costs, and indirect costs. …”
Get full text

Enhanced STag Marker System: Materials and Methods for Flexible Robot Localisation by James R. Heselden, Dimitris Paparas, Robert L. Stevenson, Gautham P. Das

“…They are assessed against the existing STag markers and each shows clear improvements. Further, we explore the viability of various materials for marker fabrication, for use in outdoor and low-light conditions. …”
Get full text

Clinical efficacy of various resuscitation fluids in the management of sepsis in postoperative surgical and trauma patients: a systematic review and meta‑analysis by Yongjie Wang, Kewu Chen, Xiaolu Li, Jianing Guan

“…Results: Our meta-analysis included 18 randomized controlled trials comparing the efficacy of different resuscitation fluids for sepsis management in 14 469 critically hypotensive patients. …”
Get full text

Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Anal... by Xiaojie Yuan, Jiping Wang, Shuo Yang, Mei Gao, Lingxia Cao, Xumei Li, Dongxu Hong, Suyan Tian, Chenglin Sun

“…This study systematically reviewed the relevant clinical trials to evaluate the effects of intermittent fasting diet on glucose and lipid metabolism and insulin sensitivity in patients with metabolic syndrome. …”
Get full text

Second-line systemic treatment for metastatic colorectal cancer: A systematic review and Bayesian network meta-analysis based on RCT. by Chengyu Sun, Enguo Fan, Luqiao Huang, Zhengguo Zhang

“…<h4>Results</h4>A total of 47 randomized controlled trials were included, involving 16,925 patients and 44 second-line systemic treatments. …”
Get full text

Radiomics for differentiating adenocarcinoma and squamous cell carcinoma in non-small cell lung cancer beyond nodule morphology in chest CT by Minmini Selvam, Abjasree Sadanandan, Anupama Chandrasekharan, Sidharth Ramesh, Arunan Murali, Ganapathy Krishnamurthi

“…However, widespread multicentre trials are required to realize the full potential of radiomics in lung nodules.…”
Get full text

A meta-analysis of the impact of TOE adoption on smart agriculture SMEs performance. by Adrian Nagy, Johan Tumiwa, Fitty Arie, Erdey László, Anas Ratib Alsoud, Main Al-Dalahmeh

“…<h4>Methods</h4>PRISMA technique was used to examine evidence from clinical trials, and clinical significance was determined using the GRADE approach. …”
Get full text

Safety and Efficacy of Bleb Needling with Antimetabolite after Trabeculectomy Failure in Glaucoma Patients: A Systemic Review and Meta-Analysis by Xuhao Chen, Lingge Suo, Ying Hong, Chun Zhang

“…However, IOP reduction effects, success rates, and complications occurrence for this procedure showed great inconsistency among the different studies. …”
Get full text

Effect of Yoga on Blood Pressure in Prehypertension: A Systematic Review and Meta-Analysis by Janhavi Sandeep Khandekar, Vanamala Lakshmi Vasavi, Vijay Pratap Singh, Stephen Rajan Samuel, S. G. Sudhan, Bidita Khandelwal

“…Databases such as PubMed, Embase, Scopus, and Web of Science were searched for randomised control trials only in the time duration of 2010–2021. The main outcome of interest was systolic and diastolic blood pressures. …”
Get full text

Linking winter wheat (Triticum aestivum L) root traits and root water uptake with electrical resistivity tomography by Huijie Gu, Yanzhe Wang, Luca Peruzzo, Baoru Li, Yang Lu, Xiuwei Liu

“…This study, therefore, utilized buried fresh root experiments, soil pots, and field-irrigation trials with different winter wheat (Triticum aestivum L.) cultivars to examine the influence of fresh crop roots on ER and assess ERT’s capability to characterize root uptake and the root system size. …”
Get full text

The impact of particle size of nanostructured lipid carriers on follicular drug delivery: A comprehensive analysis of mouse and human hair follicle penetration by Saman Heydari, Mohammad Barzegar-Jalali, Mostafa Heydari, Afsaneh Radmehr, Ana Cláudia Paiva-Santos, Maryam Kouhsoltani, Hamed Hamishehkar

“…Mouse models are mostly used in clinical trials for dermal, transdermal, and follicular delivery studies. …”
Get full text

Impaired arbitration between reward-related decision-making strategies in Alcohol Users compared to Alcohol Non-Users: a computational modeling study by Srinivasan A. Ramakrishnan, Riaz B. Shaik, Tamizharasan Kanagamani, Gopi Neppala, Jeffrey Chen, Vincenzo G. Fiore, Christopher J. Hammond, Shankar Srinivasan, Iliyan Ivanov, V. Srinivasa Chakravarthy, Wouter Kool, Muhammad A. Parvaz

“…Maximum a posteriori fitting of a dual-system reinforcement-learning model was used to assess the degree of model-based control, and a utility model was used to assess risk sensitivity for the low- and high-stakes trials separately. As expected, Alcohol Non-Users showed significantly higher model-based control in higher compared to lower reward conditions, whereas no such difference between the two conditions was observed for the Alcohol Users. …”
Get full text

Evaluation of intranasal TLR2/6 agonist INNA-051: safety, tolerability and proof of pharmacology by Francesca A. Mercuri, Scott White, Hayley A. McQuilten, Charlotte Lemech, Stephan Mynhardt, Rana Hari, Ping Zhang, Nicole Kruger, Grant McLachlan, Bruce E. Miller, Nicholas P. West, Ruth Tal-Singer, Christophe Demaison

“…Methods Two randomised, double-blind, placebo-controlled clinical trials were conducted in healthy adult participants. …”
Get full text

A real-world Pharmacovigilance study of brodalumab based on the FDA adverse event reporting system by Ke He, Kaidi Zhao, Tingyi Yin, Meng Liu, Jiashu Liu, Wenqian Du, Xinyi Liu, Baochen Cheng, Dewu Zhang, Yan Zheng

“…Although it has demonstrated favorable efficacy and safety in clinical trials, the strict inclusion and exclusion criteria may not fully reflect its safety profile in real-world settings. …”
Get full text

Cost-effectiveness of selective digestive decontamination (SDD) versus selective oropharyngeal decontamination (SOD) in intensive care units with low levels of antimicrobial resist... by Marc J M Bonten, Denise van Hout, Nienke L Plantinga, Patricia C Bruijning-Verhagen, Evelien A N Oostdijk, Anne Marie G A de Smet, G Ardine de Wit, Cornelis H van Werkhoven

“…A willingness-to-pay curve was plotted to reflect the probability of cost-effectiveness of SDD for a range of different values of maximum costs per prevented in-hospital death.Results The ICER resulting from the fixed-effect meta-analysis, adjusted for clustering and differences in baseline characteristics, showed that SDD significantly reduced in-hospital mortality (adjusted absolute risk reduction 0.0195, 95% CI 0.0050 to 0.0338) with no difference in costs (adjusted cost difference €62 in favour of SDD, 95% CI –€1079 to €935). …”
Get full text

Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation by Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Li-Li Peng, Yan Li, Ming-An Yu

“…However, progression-free survival rates in M-PTC patients showed convergence across all TSH levels by the 5-year follow-up.Conclusion Maintaining TSH levels within the normal range post-ablation may be appropriate for managing T1N0M0 PTC treated with MWA, but randomized controlled trials are needed to confirm optimal TSH targets and their impact on outcomes.…”
Get full text