Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial by Shinichiro Takiguchi, Shinichiro Takiguchi, Kai Makita, Takashi X. Fujisawa, Takashi X. Fujisawa, Shota Nishitani, Shota Nishitani, Akemi Tomoda, Akemi Tomoda, Akemi Tomoda

“…Children and adolescents with RAD show aberrant attachment behaviors, and existing psychotherapies are difficult to maintain; therefore, pharmacological interventions to aid and boost treatment responses are needed. …”
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Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers by Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Gina Mejía-Abril, Manuel Roman, Sergio Luquero-Bueno, David Piñeiro, Marc Ribó, Francisco Abad-Santos, Dolores Ochoa

“…Maximum concentration was detected at the end of the infusion/injection, and mean half-life was 9.5 h for both routes of administration. These results show that safety and pharmacokinetic profiles were comparable between intravenous infusion and bolus injection of ApTOLL, supporting a change of the route of administration for future clinical practice (ClinicalTrials.gov: NCT05569720).…”
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Effect of Genicular Nerve Block (GNB) on Pain in Lesions of the Knee Joint: A Meta-Analysis of Randomized Controlled Trials by Li W, Xu F, Chen F, Cao L, Bao X

“…In the comparison of GNB and non-GNB, the analysis results of analgesic effects at all visits showed [SMD=− 0.51, 95% CI (− 0.89, − 0.14)]. Analysis of analgesic effects at a visit at 1 month showed [SMD=− 0.79, 95% CI (− 1.55, − 0.02)]. …”
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Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Minyi Chen, Runkai Hu, Weichao Han, Shaobo Ding

“…Our aim is to evaluate the efficacy and safety of hMSC transplantation for children with CP using a meta-analysis of randomized controlled trials (RCTs). We conducted a systematic literature search including Embase, PubMed, ClinicalTrials.gov, Cochrane Controlled Trials Register databases, Chinese Clinical Trial Registry, and Web of Science from building database to February 2020. …”
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Masticatory Ability for a Single Implant Mandibular Overdenture Retained by Two Different Attachments: A Randomized Controlled Trial by Marwa Abdel AaL, Amr Naguib, Ahmed Salah, Karim Foda, Nora Sheta, Nouran Abdel Nabi

“…The aim of this randomized clinical trial was to compare the masticatory ability subjectively between ball and Cendres+Métaux Locator (CM-LOC) attachment for a single implant retained mandibular overdenture throughout a 24-month follow-up period. …”
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Economic evaluation of a randomized controlled trial comparing mifepristone and misoprostol with misoprostol alone in the treatment of early pregnancy loss. by Charlotte C Hamel, Marcus P L M Snijders, Sjors F P J Coppus, Frank P H A Vandenbussche, Didi D M Braat, Eddy M M Adang

“…Recently, a number of trials showed that prompt treatment with the sequential combination of mifepristone with misoprostol is superior to misoprostol alone in reaching complete evacuation. …”
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Acceptability and effectiveness of a study information video in improving the research consent process for youth: a non-inferiority trial by Sarah Bernays, Victoria Simms, Chido Dziva Chikwari, Katharina Kranzer, Tsitsi Bandason, Rashida Abbas Ferrand, Ethel Dauya, Constance R S Mackworth-Young, Mandikudza Tembo, Constancia Mavodza, Tinashe Cynthia Mwaturura, Som Kumar Shrestha, Salmaan Ferrand, Talent Shavani

“…Introduction Obtaining informed consent for research includes the use of information sheets, which are often long and may be difficult for participants to understand. We conducted a trial to investigate whether consent procedures using a study information video coupled with electronic consent were non-inferior to standard consent procedures using participant information sheets (PIS) among youth aged 18–24 years in Zimbabwe.Methods The trial was nested within an endline population-based survey for a cluster-randomised trial from October 2021 to June 2022. …”
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Quality of life in early breast cancer patients after adjuvant accelerated partial-breast irradiation (APBI) in randomized trial by Petr Burkon, Iveta Selingerova, Miroslav Vrzal, Milos Holanek, Oldrich Coufal, Katerina Polachova, Vera Andraskova, Sachin R. Jhawar, Pavel Slampa, Tomas Kazda, Marek Slavik

“…Other functional scales showed a decrease in the WBI arm at M0 (p = 0.027 for physical functioning). …”
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Measured Resection as Gap Balance Method in Mobile‐Bearing Medial Unicompartmental Knee Arthroplasty: A Randomized Controlled Trial by Qian Liu, Jianhua Ren, Wenhui Zhang, Tangzhao Liang, Zhe Wang, Siwei Xie, Yuhang Li, Jianfeng Hou, Kun Wang, Ronghan He

“…The prosthetic angles, ROM improvement, and GPE showed no significant difference between the groups (p > 0.05). …”
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An evidence-based tailored eHealth patient education tool for patients with knee osteoarthritis: A randomized controlled trial by Chong Li, Chuanmei Zhu, Kangping Song, Xiaona Xiang, Xiaoyi Wang, Jing Hu, Zhao Li, Yi Deng, Daoxin Jiang, Lixin Guo, Ting Ren, Luwen Zhu, Haibo Ai, Shaojun Zhang, Zhongliang Liu, Yonghong Yang, Siyi Zhu, Chengqi He

“…Methods A two-arm randomized controlled trial was performed, with 218 KOA patients allocated 1:1 to two groups by balanced block randomization. …”
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Cardiac function and quality of life improvement with fasudil hydrochloride in patients with diabetes post-PCI: a randomized controlled trial by Xuejia Yang, Qian Li, Yaning Liu, Ran Chen, Yanjing Liu, Chenghui Sun, Licha Kong, Qiuli Dong

“…Methods We conducted a randomized controlled trial including 100 patients with diabetes and CHD who underwent PCI. …”
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Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis by Agnieszka Starzyk, Piotr Charzewski

“…Materials and Methods: This study combined a literature review with clinical trial analysis to evaluate the role of selenium and vitamin D in HT. …”
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A Multicentre Randomized Controlled Trial of Recombinant Interferon-Alpha-2a in the Treatment of Patients with Chronic Hepatitis C by Masafumi Komatsu, Tsuyoshi Ono, Ko Nakajima, Itaru Toyoshima, Mitsuro Chiba, Osamu Masamune, Shunji Ohkubo, Tsukasa Yoshida, Hitoshi Yagisawa, Kanji Komatsu, Hideki Wakamatsu, Nobuo Yamada, Hiroyuki Watanabe, Tsuyoshi Mukojima, Mitsuo Goto

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Oral lactoferrin as a treatment of pediatrics’ anemia resulted from chronic kidney diseases: a randomized controlled trial by Sahar Kamal Hegazy, Mai Salah El-Din Koura, Mohamed Shokry Elharoun

“…In contrast, IV iron dextran showed significant changes within its group in iron, GFR, IL-6, GDF-15, and RDW-SD. …”
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Efficacy of Opioid-Free Anesthesia with Dexmedetomidine in Inhibiting Nociception during Laparoscopic Abdominal Procedures: A Randomized Clinical Trial by Anisa Olata, Susilo Chandra, Arif H. M. Marsaban, Aida Rosita Tantri

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Impact of an online mindfulness-based program on wellbeing and trait mindfulness for research postgraduate students: a randomized-controlled trial by Jia-Qi Xu, Yee-Man Jennifer Tang, Hoi Ying Katherine Chen

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Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial by R. M. Hazarbassanov, N. G. T. Queiroz-Hazarbassanov, J. N. Barros, J. A. P. Gomes

“…Double-masked randomised controlled trial. Methods. Twenty-two refractive surgery patients oriented to apply FreshTears (FT; n=13) or Optive (Op; n=9), topically, QID, for 3 months. …”
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A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients by Shayma Ghazi, Dilyar Ahmed Baban, Saif Monem Aziz

“…Patients and Methods: A randomized controlled clinical trial on 45 (T2DM) patients, both sexes with moderate gingivitis, age 40-55 years, (Hb1Ac) < 7%. …”
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Effect of labor analgesia using programmed intermittent epidural boluses on postpartum depression symptoms: A randomized controlled trial by Anmol Jindal, Sukanya Mitra, Jasveer Singh, Subodh Kumar, Poonam Goel, Subhash Das

“…Aim: In this randomized controlled trial, we studied the effect of pain relief by combined spinal epidural (CSE) and other factors influencing PPD. …”
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Judges versus artificial intelligence in juror decision-making in criminal trials: Evidence from two pre-registered experiments. by Eiichiro Watamura, Yichen Liu, Tomohiro Ioku

“…Participants reviewed two murder trial vignettes and made sentencing decisions (1 = suspended sentence; 8 = prison sentence) under two conditions: trials with and without mitigating circumstances.…”
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