Extracellular Vesicles Derived from Human Umbilical Mesenchymal Stem Cells Transfected with miR-7704 Improved Damaged Cartilage and Reduced Matrix Metallopeptidase 13 by Kun-Chi Wu, Hui-I Yang, Yu-Hsun Chang, Raymond Yuh-Shyan Chiang, Dah-Ching Ding

“…Therefore, miR-7704-overexpressed EVs derived from HUCMSCs showed potential as an innovative therapeutic strategy for treating OA. …”
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A pilot study on the effects of olfactory stimulation with white musk aromatic oil on psychophysiological activity: a crossover study by Fadilla Zennifa, Taisuke Nakashima, Yanli Xu, Saki Koshio, Erika Tomimatsu, Akiko Isa, Katsuya Satake, Fumi Kishida, Kuniyoshi Shimizu

“…The proposed pilot study showed “gorgeous”, “sweet”, and “like” impression toward white musk aromatic oil under VAS evaluation. …”
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TraxVBF: A hybrid transformer-xLSTM framework for EMG signal processing and assistive technology development in rehabilitation by Seyyed Ali Zendehbad, Athena Sharifi Razavi, Marzieh Allami Sanjani, Zahra Sedaghat, Saleh Lashkari

“…The fact that people with mobility impairments often have great difficulties in performing essential Activities of Daily Living (ADL) shows the importance of developing effective rehabilitation strategies. …”
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Fibrin Glue Enhances Adipose-Derived Stromal Cell Cytokine Secretion and Survival Conferring Accelerated Diabetic Wound Healing by Ursula Hopfner, Matthias M. Aitzetmueller, Philipp Neßbach, Michael S. Hu, Hans-Guenther Machens, Zeshaan N. Maan, Dominik Duscher

“…Although several vehicles have shown to successfully act as cell carrier systems in preclinical trials, regulatory issues have prohibited clinical usage for chronic wounds. …”
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Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (H... by Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger

“…This approach can be used to optimize HT treatments, design clinical trials, and interpret patient data.…”
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Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study by Sara Angiulli, Aurora Merolla, Elisa Borgonovo, Rebecca De Lorenzo, Serena Spadoni, Barbara Fontana, Giuseppina Manganaro, Elena Rela, Alberto Bongiovanni, Rita Peracino, Chiara Bellino, Giulia Pata, Eleonora Bianconi, Sabina Martinenghi, Francesca Ulivi, Cristina Renzi, Cristina Renzi, Emanuele Bosi, Emanuele Bosi, UNISCREEN Study Group, Sara Angiulli, Aurora Merolla, Alberto Bongiovanni, Rebecca De Lorenzo, Elena Rela, Rita Peracino, Chiara Bellino, Giuseppina Manganaro, Elisa Borgonovo, Sara Critelli, Aldo Fici, Martina Mallus, Giulia Morocutti, Giulia Pata, Clara Soggetti, Chiara Calabrese, Alberico Di Resta, Maria Pia Ruggiero, Antonella Spano’, Francesca Biasco, Manuel Stocchi, Pietro Melodia, Giuseppe Ancona, Andrea Laurenzi

“…The study was registered as ClinicalTrials.gov NCT05841719.ResultsThe study included 1,535 participants (50.1% of local population). …”
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Determining the effect of frailty on survival in advanced ovarian cancer: study protocol for a prospective multicentre national cohort study (FOLERO) by Daniel Hunde, Niklas Ekerstad, Mihaela Asp, Päivi Kannisto, Madelene Wedin, Charlotte Palmqvist, Pernilla Dahm-Kähler, Yvonne Brandberg, Mirna Abraham-Nordling, Kristina Åhlund, Vilhelm Mörlin, Nina Groes-Kofoed, Sahar Salehi

“…Study registration: ClinicalTrials.gov NCT06298877 …”
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Development and routine implementation of deep learning algorithm for automatic brain metastases segmentation on MRI for RANO-BM criteria follow-up by Loïse Dessoude, Raphaëlle Lemaire, Romain Andres, Thomas Leleu, Alexandre G. Leclercq, Alexis Desmonts, Typhaine Corroller, Amirath Fara Orou-Guidou, Luca Laduree, Loic Le Henaff, Joëlle Lacroix, Alexis Lechervy, Dinu Stefan, Aurélien Corroyer-Dulmont

“…Consequently, in clinical practice, monitoring patients in clinical trials in compliance with the RANO-BM criteria is rarely achieved. …”
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Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…Future researchers need to further explore the long-term efficacy and safety of wogonin in clinical trials and translate it for early application in the clinical treatment of true CNS disorders.…”
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Body composition changes and clinical outcomes in pediatric cystic fibrosis during 24 months of lumacaftor ivacaftor therapy based on real-world data by Marcell Imrei, Adrienn F. Kéri, Éva Gács, Ildikó Gönczi, Melinda Meláth, Éva Kosaras, Botond Demeter, Csaba Péterfia, Klára Vass, Gyöngyi Székely, Klementina Ocskay, Andrea Párniczky

“…Abstract Clinical trials demonstrate the short-term efficacy of dual CFTR modulators, but long-term real-world data is limited. …”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Also, though inflammation is as a result of adverse HF in patients, but despite the fact that broad immunosuppression therapeutic target has been used in various clinical trials, no positive results have showed up, but rather, the focus on proinflammatory cytokines has proved more benefits in patients with HF. …”
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Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis by Lizheng Wu, Shangwen Jing, Na Li, Dandan Cao, Fangli Pei, Yantong Luo, Xiaoxin Chen, Yingjie Huang, Cheng Zeng

“…The results of network meta-analysis showed that, Fufang Shajiziyou suppository combined with CT was more effective in improving the negative conversion rate and controlling the recurrence rate of Candida albicans. …”
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Janus kinase inhibitor treatment for inflammatory diseases: excess or no excess risk of venous thromboembolism? by Yachar Dawudi, Samuel Benarroch, Hélène Helfer, David M. Smadja, Isabelle Mahé

“…This literature review examines studies reporting the risk of VTEs associated with JAKis in patients with inflammatory diseases. Phase I to III trials showed no increased risk of VTEs. However, these studies were not designed to detect adverse events such as VTEs. …”
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Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice by Rose Hilal, Marine Poittevin, Adrien Pasteur-Rousseau, Adrien Cogo, Gabrielle Mangin, Marie Chevauché, Yasmine Ziat, José Vilar, Jean-Marie Launay, Jean-François Gautier, Dong Broquères-You, Bernard I. Levy, Tatyana Merkulova-Rainon, Nathalie Kubis

“…Clinical trials of cell therapy in stroke favor autologous cell transplantation. …”
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Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study by Gian Luca Erre, Matteo Piga, Anna Laura Fedele, Silvia Mura, Alessandra Piras, Maria Luisa Cadoni, Ignazio Cangemi, Martina Dessi, Gabriele Di Sante, Barbara Tolusso, Elisa Gremese, Alberto Cauli, Arduino Aleksander Mangoni, Pier Sergio Saba, Ciriaco Carru, Gianfranco Ferraccioli, Alessandro Mathieu, Giuseppe Passiu

“…Multiple regression analysis showed a positive correlation between Ln-RHI values and systolic blood pressure and HDL cholesterol levels; furthermore, higher values of Ln-RHI were associated with ACPA positivity, while smoking habit was associated with lower Ln-RHI values. …”
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SSVEP Enhancement in Mixed Reality Environment for Brain–Computer Interfaces by Jieyu Wu, Feng He, Xiaolin Xiao, Runyuan Gao, Lin Meng, Xiuyun Liu, Minpeng Xu, Dong Ming

“…Additionally, we proposed a cross-correlation task-related component analysis based on simulated annealing (SA-xTRCA), which can increase the signal-to-noise ratio (SNR) and detection accuracy by aligning SSVEP trials. The results of an offline experiment showed that the background and stimulus colors had a significant interaction effect that can impact system performance. …”
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Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data by Zhihao Li, Daniel Aliseda, Owen Jones, Luckshi Rajendran, Christian Magyar, Robert Grant, Grainne M. O’Kane, Anna Saborowski, Gonzalo Sapisochin, Arndt Vogel

“…Following positive results from the TOPAZ-01 and KEYNOTE-966 trials, immune checkpoint inhibitors (ICIs) combined with chemotherapy are now the standard of care. …”
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Effect of Transcranial Direct Current Stimulation in the Treatment of Aphasia after Stroke：A Meta-Analysis by CUI Ying, LI Bo, TIAN Guang

“…The randomized controlled trials (RCTs) of tDCS in the treatment of aphasia after stroke were included, and the retrieval time for each database was from inception to August 2021. …”
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Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by E. D. Fedorov, V. V. Veselov, S. V. Kashin, E. V. Tikhomirova, A. V. Veselov, D. V. Zavyalov, A. Kornowski, T. E. Gorskaya, M. Volteau, T. Ponchon

“…Despite the higher incidence of nausea in the OSS group, the patients showed significantly higher compliance with the OSS mode as compared to that of Macrogol. …”
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Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis by Elizabete Priscila Costa Santana, Haidelucia Rodrigues Vieira Javarini, Dyego Carlos Souza Anacleto de Araújo, Sabrina Cerqueira-Santos, Tiago Marques Reis, Genival Araujo dos Santos-Junior, Kérilin Stancine Santos Rocha

“…Three studies were included in the meta-analysis, which showed moderate heterogeneity (I2 = 44%, p = 0.17). …”
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