Benefits and Risks of Clopidogrel vs. Aspirin Monotherapy after Recent Ischemic Stroke: A Systematic Review and Meta-Analysis by Maurizio Paciaroni, Birsen Ince, Bo Hu, Jiann-Shing Jeng, Kursad Kutluk, Liping Liu, Min Lou, Vladimir Parfenov, Ka Sing Lawrence Wong, Babak Zamani, Dara Paek, Jung Min Han, Michael del Aguila, Shalini Girotra

“…Conclusions. The analysis showed lower risks of major adverse cardiovascular or cerebrovascular events, recurrent stroke, and bleeding events for clopidogrel monotherapy compared to aspirin. …”
Get full text

-Tyrosine Confers Residualizing Properties to a -Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies by Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD

“…High-resolution immuno-PET/magnetic resonance imaging of tumors showed good correlation with biodistribution data. …”
Get full text

Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study by Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Jani Sofia Almeida, Luana Madalena Sousa, Luana Madalena Sousa, Luana Madalena Sousa, Patrícia Couceiro, Patrícia Couceiro, Patrícia Couceiro, Patrícia Couceiro, António Martinho, Joana Rodrigues, Ruben Fonseca, Manuel Santos-Rosa, Manuel Santos-Rosa, Manuel Santos-Rosa, Manuel Santos-Rosa, Manuel Santos-Rosa, Paulo Freitas-Tavares, José Manuel Casanova, José Manuel Casanova, José Manuel Casanova, José Manuel Casanova, José Manuel Casanova

“…A significant PFS improvement was observed in SD versus PD patients (p=0.0154), while therapy duration showed no effect (p=0.5433). PD patients showed reduced eosinophils (p<0.05) and Th2 cells (p<0.05). …”
Get full text

A Comprehensive Analysis of Moist Versus Non‐Moist Dressings for Split‐Thickness Skin Graft Donor Sites: A Systematic Review and Meta‐Analysis by Chun‐Yee Ho, Hsuan‐Yu Chou, Szu‐Han Wang, Ching‐Yu Lan, Victor Bong‐Hang Shyu, Chih‐Hao Chen, Chia‐Hsuan Tsai

“…Moist dressings such as Tegaderm, Hydrocolloid, Alginate, polyurethane, and hydrofiber showed a faster mean time to healing compared to non‐moist dressings like Mepitel and paraffin‐impregnated gauze. …”
Get full text

Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical... by António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira

“…Although its use has been extensively studied in clinical trials, real-world evidence regarding FCM treatment is scarce. …”
Get full text

Targeted Therapies Compared to Dacarbazine for Treatment of BRAFV600E Metastatic Melanoma: A Cost-Effectiveness Analysis by Vanessa Shih, Renske M. ten Ham, Christine T. Bui, Dan N. Tran, Jie Ting, Leslie Wilson

“…Transition probabilities were derived from two Phase III registration trials comparing each BRAF inhibitor against dacarbazine. …”
Get full text

Feasibility and potential effect of a pilot blended digital behavior change intervention promoting sustainable diets over a year by Ujué Fresán, Miguel López-Moreno, Sergi Fàbregues, Paquito Bernard, Anna Boronat, Vera Araújo-Soares, Laura M. König, Joren Buekers, Guillaume Chevance

“…We conducted a series of ABA n-of-1 trials with baseline, intervention, and follow-up phases over the course of a year, involving twelve participants. …”
Get full text

How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience by Gustavo Hideki Kawanami, Leopoldo Katsuda, Thiara Barcelos Rocha, Fabio da Silva Yamashiro, Leonardo Pelafsky, Xingshun Qi, Fernando Gomes Romeiro

“…The knowledge of the main adverse events described in the pilot clinical trials can avoid unnecessary withdrawal of regorafenib. …”
Get full text

Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat by Tamara Zenz, Robert Jenke, Denys Oliinyk, Sandra Noske, René Thieme, Tim Kahl, Ines Gockel, Florian Meier-Rosar, Achim Aigner, Thomas RH Büch

“…Introduction: Histone deacetylase inhibitors (HDACi) have shown promising preclinical activity in gastric cancer cells; unfortunately, however, these could not be confirmed in clinical trials. This highlights the need for the identification of underlying reasons, which may also provide the basis for possible combination therapies. …”
Get full text

Identification of reproductive performance in Bali-polled bulls using computer-assisted semen analysis and plasma seminal proteomics by Athhar Manabi Diansyah, Sanstoso Santoso, Herdis Herdis, Muhammad Yusuf, Tri Puji Priyatno, Tulus Maulana, Abdul Latief Toleng, Muhammad Ihsan Andi Dagong, Syahruddin Said, Hikmayani Iskandar, Aeni Nurlatifah, Puji Lestari, Lukman Affandy, Abdullah Baharun

“…Results: Post-thaw sperm kinematics showed satisfactory results, with a mean S/C of 1.52. …”
Get full text

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…Herein, we developed and identified a non‐nucleotide STING agonist called DW18343. DW18343 showed robust activation across different STING isoforms. …”
Get full text

Stemness Maintenance Properties in Human Oral Stem Cells after Long-Term Passage by Francesca Diomede, Thangavelu Soundara Rajan, Valentina Gatta, Marco D’Aurora, Ilaria Merciaro, Marco Marchisio, Aurelio Muttini, Sergio Caputi, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani

“…Cell proliferation assay showed no difference between early and late passages while senescence markers p16 and p21 were considerably increased in late passage. …”
Get full text

Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis by Donna Pratiwi, Miko Sidartha, Elvan Wiyarta, Elvan Wiyarta, I Wayan Agustinus Harimawan, Ni Made Dwi Asti Lestari, Bonglee Kim, Nurpudji Astuti Taslim, Trina Ekawati Tallei, Fahrul Nurkolis, Rony Abdi Syahputra

“…Review Manager (RevMan) 5.4.1 were used to analyze the data.ResultsFrom 18 studies, the results of the dominant genetic model AA vs. TT showed POR 95%Cl = 1.95 (1.36–2.80); p < 0.00001, in AA vs. …”
Get full text

Which combination of medical expulsive therapy is more effective for treatment of distal ureteral stone in adults? A systematic review and network meta-analysis by Maryam Taheri, Nasrin Borumandnia, Hamidreza Abdi, Amir H Kashi, Setareh Nourani, Sogand Sheikholeslami, Yasamin Maleki Gilvaei, Pardis Ziaeefar, Abbas Basiri

“…The combination MET of α-blockers with PDE-5 inhibitors (MD: -3.8, CI=-7.0, -0.5) showed significantly lower SET compared to α-blockers alone. …”
Get full text

Using Health Utility Index (HUI) for Measuring the Impact on Health-Related Quality of Life (HRQL) Among Individuals with Chronic Diseases by Frank Mo, Bernard C.K. Choi, Felix C.K. Li, Joav Merrick

“…Logistic Regression results showed a strong relationship between low HUI scores (≤ 0.5 and 0.06–1.0) and certain chronic conditions. …”
Get full text

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair by Mahmoud Balata, Mohamed Ibrahim Gbreel, Mohamed Hamouda Elkasaby, Marwa Hassan, Marc Ulrich Becher

“…Conclusion MitraClip and PASCAL devices showed comparable safety profiles and procedural success rates. …”
Get full text

Movement Competency Screens Can Be Reliable In Clinical Practice By A Single Rater Using The Composite Score by Kerry J. Mann, Nicholas O'Dwyer, Michaela R. Bruton, Stephen P. Bird, Suzi Edwards

“…While athletes did not display a familiarization effect after performing the novel tasks within the MCS for the first time, raters showed improved error detection on repeated viewing of the same movement…”
Get full text

Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration through IL-1 and BMP-2... by Asdar Gani, Risfah Yulianty, Supiaty Supiaty, Machirah Rusdy, Gustivanny Dwipa Asri, Dian Eka Satya, Ayu Rahayu Feblina, Harun Achmad

“…The group added with chitosan gel and crab shell HA showed a faster decrease in IL-1 expression than the control group. …”
Get full text

Artificial Taste: Advances and Innovative Applications in Healthcare by Letao Wang, Yuzhang Li, Yao Zhang, Bin Zheng

“…Only six studies reported verification results, showing that most participants perceived sour and salty tastes, mild bitter responses, and unreliable sweet evocation. …”
Get full text

Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy: A Meta-Analysis by Dong Wu, Shu-Mei Wu, Jie Lu, Ying-Qun Zhou, Ling Xu, Chuan-Yong Guo

“…A total of 8 randomized controlled trials including 407 patients were included. The efficacy of rifaximin was equivalent to nonabsorbable disaccharides according to the statistical data (risk ratio (RR): 1.06, 95% CI: 0.94–1.19; P=0.34). …”
Get full text