Impact of strict IGF1 control on quality-of-life scores in patients with acromegaly by Chaitanya Gandhi, Marie-Claire Denis, Daniel Holmes, Juan Rivera, Stan van Uum, Shereen Ezzat, Constance Chik

“…These findings prompt larger prospective trials.…”
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Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial by Peter U. Amadi, Justice O. Osuoha, Chidi N. Ekweogu, Suha J. Jarad, Esienanwan E. Efiong, Prince C. Odika, Chioma Ejiofor, Oluchi Aloy-Amadi, Govind S. Gill, Chiamaka W. Adumekwe, Ailun Gaowa, Dawei Zhang, Barbora de Courten, Emmanuel N. Agomuo

“…Supported by the preclinical trial, eighty-five patients with type 2 diabetes (T2D) receiving first-line medications were enrolled in a double-blind, randomized, placebo-controlled trial with a 90 % power level. …”
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Phenotypic plasticity vs. local genetic adaptation: essential oil diversity of natural immortelle (Helichrysum italicum (Roth.) G.Don) populations along eastern Adriatic coast by Tonka Ninčević Runjić, Dejan Pljevljakušić, Marko Runjić, Martina Grdiša, Martina Grdiša, Zlatko Šatović, Zlatko Šatović

“…Three chemotypes were identified within which the populations were grouped. Results showed a significant and strong correlation between biochemical and bioclimatic distance, with 22.4% of biochemical differentiation between populations explained by bioclimatic distance. …”
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Efficacy of brain-computer interface training with motor imagery-contingent feedback in improving upper limb function and neuroplasticity among persons with chronic stroke: a doubl... by Myeong Sun Kim, Hyunju Park, Ilho Kwon, Kwang-Ok An, Hayeon Kim, Gyulee Park, Wooseok Hyung, Chang-Hwan Im, Joon-Ho Shin

“…Methods This randomized controlled trial included persons with chronic stroke who underwent BCI training involving functional electrical stimulation feedback on the affected wrist extensor. …”
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Efficacy of Ma'aljobon Aftimouni (Cuscuta Reflexa and whey) on HbA1c and blood glucose levels in patients with Type 2 Diabetes: A randomized triple-blind clinical trial by Fatemeh Mehrabi, Ali Safdari, Azam Moslemi, Mehdi Salehi, Ali Agharazi, Mohammad Reza Rezvanfar

“…Method: This randomized, controlled, and triple-blind trial study was conducted from November 2021 to August 2022 on 102 diabetic patients referred to the diabetes clinic in Iran. …”
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Combination Treatment with Thread-Embedding Acupuncture and Electroacupuncture for Knee Osteoarthritis Patients with Postoperative Pain: A Randomized Controlled Feasibility Study by Lee YJ, Han CH, Jeon JH, Kim E, Park KH, Kim AR, Kim YI

“…Large-scale clinical trials are needed to confirm the long-term effects of combination treatment.Keywords: thread-embedding acupuncture, electroacupuncture, osteoarthritis, knee, randomized controlled trial…”
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60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

“…Methods We undertook a prospective double-blinded randomised controlled parallel group clinical trial across two sites in London. Participants were randomly assigned (1 : 1) to Long Limb or Standard Limb Roux-en-Y gastric bypass with a fixed alimentary limb of 100 cm. …”
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The efficacy and safety of fluvoxamine in patients with COVID-19: A systematic review and meta-analysis from randomized controlled trials. by Qiufeng Zhou, Guozheng Zhao, Yu Pan, Ying Zhang, Yuehua Ni

“…<h4>Background</h4>Recently, several randomized controlled trials (RCTs) of fluvoxamine have been successfully conducted for the treatment of patients with coronavirus disease 2019 (COVID-19). …”
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Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial by Ana Belén Fernández-Serrano, Francisco José Moya-Faz, Cesar Augusto Giner Alegría, Juan Carlos Fernández Rodríguez, Jose Francisco Soriano Guilabert, Martín del Toro Mellado

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Dexmedetomidine Attenuates Inflammation in Elderly Patients Following Major Hepatobiliary and Pancreatic Surgery: A Randomized Clinical Trial [Corrigendum] by Chen X, Chen Q, Qin Z, Alam A, Zhao H, West R, Liu X, Li J, Li X, Yi B, Ma D, Gu J

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Comparison of the Effects of Hugo’s Point Massage and Play on IV-Line Placement Pain in Children: A Randomized Clinical Trial by Shahnaz Salawati Ghasemi, Mehdi Beyramijam, Fatemeh Yarahmadi, Taban Nematifard, Seyed Shahabeddin Bahrani, Masoomeh Khaleghverdi

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Comparative Effectiveness of Simulation versus Serious Game for Training Nursing Students in Cardiopulmonary Resuscitation: A Randomized Control Trial by Zahra Farsi, Mahdieh Yazdani, Samantha Butler, Maryam Nezamzadeh, Jila Mirlashari

“…However, the simulation group and the serious game group showed no significant difference in knowledge (9.55±2.81 vs. 7.77±2.46; p=0.065) or CPR skill demonstration (27.17±2.81 vs. 25.72±3.98; p=0.988). …”
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Factors associated with vaccine default in Southern Ghana based on data from the RTSS malaria vaccine trial in Cape Coast by Vincent Bio Bediako, Josephine Akua Ackah, Theophilus Junior Yankey, Joshua Okyere, Emmanuella Acheampong, Bernard Afriyie Owusu, Wonder Agbemavi, Adanna Uloaku Nwameme, Edward Mberu Kamau, Emmanuel Asampong

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The Short-Term Effects of Transcranial Direct Current Stimulation on Electroencephalography in Children with Autism: A Randomized Crossover Controlled Trial by Anuwat Amatachaya, Mark P. Jensen, Niramol Patjanasoontorn, Narong Auvichayapat, Chanyut Suphakunpinyo, Suparerk Janjarasjitt, Niran Ngernyam, Benchaporn Aree-uea, Paradee Auvichayapat

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Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial by Abdolkhalegh Keshavarzi, Rahimeh Akrami, Mohammad M. Zarshenas, Saeid Zareie, Tayyeb Ghadimi, Ali Najafi, Mahsa Rostami Chijan, Azizallah Dehghan, Elham Zarenezhad

“…This trial is registered with IRCT20180609040016N1.…”
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A benchmark of deep learning approaches to predict lung cancer risk using national lung screening trial cohort by Yifan Jiang, Leyla Ebrahimpour, Philippe Després, Venkata SK. Manem

“…Furthermore, pretraining on large-scale radiological image datasets did not show the expected performance advantage over pretraining on general-purpose datasets. …”
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Implementing injury prevention training in youth handball (I-PROTECT) in Sweden: study protocol for a cluster randomised trial by Per Nilsen, Alex Donaldson, Eva Ageberg, Sofia Bunke, Jennie Linnéll, Karin Moesch, Karolina Lucander, Axel Ström, Robert Wedberg, Per Ekberg

“…Introduction Efficacy trials show that evidence-based injury prevention training reduces injuries in youth athletes but effectiveness, that is, outside the controlled setting, is lower and, consequently this training has had limited public health impact. …”
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Efficacy and Safety of Prophylactic Agents in Prevention of Retinopathy of Prematurity: A Systematic Review and Meta-analysis of Randomised Controlled Trials by Waleed T Batais, Nada O Taher, Abeer K Alhindi, Abdullah A Ghaddaf, Anas Alamoudi, Sarah A Al-Ghamdi, Jumanah J Homsi, Hashem S Almarzouki, Mansour A Qurashi

“…Eight randomised controlled trials involving 1101 preterm infants were included. …”
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Efficacy and safety of intermittent fasting for type 2 diabetes mellitus: A systematic review and meta-analysis of randomized trials by Joshua Chadwick, Lavanya Ayyasamy, Madhanraj Kalyanasundaram, Ganeshkumar Parasuraman, Bhavani Shankara Bagepally, Jeyashree Kathiresan, Lokesh Shanmugam

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Evaluating the Effectiveness of a Multimodal Psychotherapy Training Program for Medical Students in China: Protocol for a Randomized Controlled Trial by Tao Pei, Yinan Ding, Jinsong Tang, Yanhui Liao

“…If this brief, cognitive behavioral therapy–based psychotherapy skill training proves effective, the potential mental health impact of its nationwide expansion could be significant. Trial RegistrationClinicalTrials.gov NCT06258460; https://clinicaltrials.gov/ct2/show/NCT06258460 International Registered Report Identifier (IRRID)DERR1-10.2196/58037…”
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