Dietary Fatty Acids and Predementia Syndromes by Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D' Introno, Anna M. Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panza

“…However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non–Vapolipoprotein E (APOE) ε4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE ε4 carriers. …”
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Incidence of postoperative pain after single-visit and multiple-visit root canal therapy: a systematic review by Gunjan Kumar, Samikshya Jena, Nisha Manila, Mohammad Fareed, Mohmed Isaqail Karobari

“…The majority of the studies (n-8) showed no difference between postoperative pain during single-sitting endodontic treatment or multiple-sitting endodontic treatment. …”
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Comparative analysis of Oreochromis niloticus responses to Chlorella vulgaris and Lactobacillus-fermented Azolla economic feed supplements in biofloc and green systems: An in silic... by Ahmed M. Aboseif, Nasser S. Flefil, Mostafa K.S. Taha, Asmaa Negm El-Dein, Mingchun Ren, Hualiang Liang, Abd-Ellatif M. Hussian

“…The fermentation process, involving Lactobacillus plantarum KU985433 and L. rhamnosus KU985437, enhances Azolla’s protein, phenolic, and antioxidant content while reducing carbohydrates and lipids. Comparative trials in biofloc and green water systems showed that fish fed with fermented Azolla exhibited improved growth, feed utilization, and immune response, demonstrating the potential of fermented plant-based feed as a sustainable alternative to conventional soybean meal. …”
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Combining two parasitoids (Asecodes hispinarum and Tetrastichus brontispae) for biological control of coconut leaf beetle by Qikai Zhang, Bin Jiao, Hui Lu, Jihong Tang, Xu Zhang, Baoqian Lyu

“…Our laboratory studies showed that the concurrent release of the two parasitoid species did not reduce either species lifespan or reproductive output, and it significantly enhanced the impact on CLB. …”
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Autologous Bone Marrow Mononuclear Cells in Ischemic Cerebrovascular Accident Paves Way for Neurorestoration: A Case Report by Alok Sharma, Hemangi Sane, Anjana Nagrajan, Nandini Gokulchandran, Prerna Badhe, Amruta Paranjape, Hema Biju

“…The striking fact was that the hand functions, which are the most challenging deficits, showed significant recovery. Functional Independence Measure scores and quality of life improved. …”
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The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series by Giuseppina Malcangi, Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Laura Ferrante, Giulia Latini, Irma Trilli, Paola Nardelli, Marialuisa Longo, Andrea Palermo, Francesco Inchingolo, Gianna Dipalma

“…The case series that goes with it shows real-world examples of how to improve skin elasticity, texture, and general facial appearance with little negative side effects. …”
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The oncological and reproductive outcomes of fertility-preserving treatments for stage 1 grade 1 endometrial carcinoma: a systematic review and meta-analysis by M. Olabisi Ogunbiyi, Samuel Oxley, Radha Graham, Adeola Olaitan

“…Further high-quality prospective multi-centre trials are warranted to determine the optimal treatment regimen and dosage and risk stratification for these patients.…”
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The Role of Angiotensin Antagonism in Coronary Plaque Regression: Insights from the Glagovian Model by Abdul H. Alkatiri, Doni Firman, Amir A. Alkatiri, Paskalis I. Suryajaya, Albert Sudharsono

“…Analysis from various trials utilizing ARB showed a significant plaque regression using olmesartan and telmisartan as evaluated by IVUS studies. …”
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Accuracy of Automatically Identifying the American Conference of Governmental Industrial Hygienists Threshold Limit Values Twelve Lifting Zones over Three Simplified Zones Using Co... by Menekse S. Barim, Ming-Lun Lu, Shuo Feng, Marie A. Hayden, Dwight Werren

“…The models were evaluated using data from 360 lifting trials performed by 10 subjects (5 males and 5 females) with an average age of 51.50 (±9.83) years. …”
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The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation by Guoli Huai, Yong Wang, Jiaxiang Du, Zhenhui Cheng, Yuxuan Xie, Jia Zhou, Hongmei Tang, Yanyan Jiang, Xiangyang Xing, Shaoping Deng, Dengke Pan, Dengke Pan, Dengke Pan

“…However, the optimal combination of genetic modifications and their expression levels for initial clinical trials remains unclear. This study investigates the generation of TKO/hCD55/hTM/hEPCR (6GE) pigs and evaluates their compatibility with human immune and coagulation systems.MethodsThe 6GE pigs were generated through iterative genome editing and F1 generation breeding. …”
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The Antiobesity Effect of GLP-1 Receptor Agonists Alone or in Combination with Metformin in Overweight /Obese Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Ana... by Xiaorui Lyu, Taibiao Lyu, Xue Wang, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Fengying Gong

“…All randomized controlled trials (RCTs) which reported the efficacy of GLP-1RAs and MET in overweight/obese PCOS patients in Medline (from Pubmed), Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus databases were independently searched by two reviewers. …”
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Combining an internal tension relieving technique with anterior cruciate ligament reconstruction (ACLR) reduces graft failure rate and improves functional outcomes: a systematic re... by Yixin Wen, Wei Huang, Minghui Li, Yong Jiang, Yibo Tong, Hongjun Mei, Junfeng Tan

“…However, given the limitations of short-term follow-up and reliance on retrospective studies, more randomized controlled trials and longer follow-up periods are needed to further evaluate the long-term graft failure rates and functional outcomes.…”
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Effects of virtual reality technology on early mobility in critically ill adult patients: a systematic review and meta-analysis by Yansha He, Yansha He, Qin Yang, Xiaoxia Dai, Tian Chen, Huan Wu, Kunjie Li, Shiqiong Zhu, Yanlin Liu, Hua Lei

“…To evaluate the quality of the included studies, the risk of bias was assessed using the RevMan 5.4 tool.ResultsA total of 11 randomized controlled trials (RCTs) published over 10 years were included, involving 880 critically ill adult patients: 435 in the experimental group and 445 in the control group. …”
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Meta Analysis on Rehabilitation Effect of Proprioception Training on Ankle Sprainof Athletes by Yuxiao CHEN, Jiaojiao LIU, Changsong Yi, Mengguang CHAI, Qing WANG, Lei JIANG

“…Objective:To explore the effects of proprioception training on the incidence of athletes' ankle sprains, dynamic neuromuscular control, postural stability and joint position perception.Methods:Data were searched from the databases of PubMed, Cochrane Library, EMbase, China National Knowledge Infrastructure(CNKI), Wanfang Database(Wangfang Data), Chinese Journal Full-text Database(VIP), China Biomedical Literature Database(CBMdisc).Athletes were included in the randomized controlled trials(RCTs)who were treated with proprioception training to improve the function of athlete's ankle joint.The retrieval time for each database was from the establishment of the database to December 31, 2019, and the references of related documents were traced.Two researchers independently searchered the literature, extracted data, and evaluated the quality of the literature.RevMan5.3 software was used to analyze the data.According to the systematic review manual provided by the Cochrane Collaboration Network, the continuous variables use mean difference(<italic>MD</italic>)and 95%confidence interval(<italic>CI</italic>)as indicators, and binary variables use risk ratio(RR)and 95%<italic>CI</italic> as indicators.The statistical heterogeneity was judged comprehensively by chi-square test(χ²test)and the Heterogeneity test(<italic>I</italic>²test).If <italic>P</italic>≥0.1 and <italic>I</italic>²≤50%, a fixed effects model would be used.In contrast, if <italic>P</italic>&lt;0.1 or <italic>I</italic>²&gt;50%, a random effects model would be used.Results:A total of 11 RCTs and 1 776 athletes were included.The results of Meta analysis showed that compared with the control group, the incidence of ankle sprains in the experimental group was significantly reduced after proprioceptive training[<italic>RR</italic>=0.61, 95%<italic>CI</italic>(0.41, 0.90), <italic>P</italic>=0.01]; compared with the control group, the posterolateral and posterior medical maximum extension distances of the experimental group increased significantly after proprioception training[<italic>MD</italic>=4.44, 95%<italic>CI</italic>(3.66, 5.23), <italic>P</italic>&lt;0.00 001;<italic>MD</italic>=4.21, 95%<italic>CI</italic>(3.18, 5.24), <italic>P</italic>&lt;0.00 001]and the difference was statistically significant;but there was no significant difference in the improvement effect of the anterior maximum extension distance, and the difference was not statistically significant(<italic>P</italic>&gt;0.05).The postural sway of the affected ankle joint in the experimental group was significantly lower than that in the control group;the athletes in the experimental group had better position perception ability in the ankle joint plantar flexion, dorsiflexion, middle and lateral directions than the control group.Conclusion:Proprioceptive training can effectively reduce the incidence of athletes' ankle sprains, improve dynamic neuromuscular control, improve postural stability, and enhance ankle joint position perception, which is worthy of clinical application.However, the absolute effect is not yet clear, so large samples and high-quality randomized controlled trials are still needed to further verify the efficacy of proprioception training, so as to provide more reliable evidence-based evidence for clinical rehabilitation.…”
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The efficacy of core decompression combined with regenerative therapy in early femoral head necrosis: a systematic review and meta-analysis involving 954 subjects by Haiwei Tang, Tingxian Ling, Enze Zhao, Mingke You, Xi Chen, Gang Chen, Kai Zhou, Zongke Zhou

“…Secondary outcomes (VAS, HHS, WOMAC score and Lequesne index) showed improved results when CD was combined with other regenerative agents, such as bone mesenchymal stem cells (BMSCs) and bone morphogenetic proteins (BMPs), etc. …”
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Design and Preparing a Topical Semi-solid Formulation of a Combination of Plantago ovata seeds and Rosehip oil to Provide an Analgesic and Anti-inflammatory Medicine by Amirhossein Zamani, Aida Alipour, Mohammad M. Zarshenas, Hajar Ashrafi

“…After passing the clinical trials, the mentioned product can be effective as a product derived from herbal compounds for pain control.…”
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Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinso... by Antonio Daniele, Francesco Panza, Antonio Greco, Giancarlo Logroscino, Davide Seripa

“…Zolpidem, an imidazopyridine widely used as sleep inducer, shows high affinity only for GABAA receptors containing the α-1 subunit and facilitates GABAergic neurotransmission through a positive allosteric modulation of GABAA receptors. …”
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Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study by Bernardino Clavo MD, PhD, Delvys Rodríguez-Abreu MD, PhD, Saray Galván-Ruiz MD, Mario Federico MD, PhD, Angeles Cánovas-Molina RN, Yolanda Ramallo-Fariña MSc, Carla Antonilli MD, Gretel Benítez MD, Himar Fabelo BEng MSc, PhD, Carla García-Lourve RN, MRes, Damián González-Beltrán CNS, MSc, Ignacio J. Jorge MD, PhD, Francisco Rodríguez-Esparragón BSc, PhD, Gustavo M. Callico MEng, PhD

“…This preliminary report shows the potential long-term effects of ozone treatment in the management of persistent numbness and tingling secondary to CIPN. …”
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CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors in non-small cell lung cancer by Carlos M Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot Blatt, Ganesh V. Raj, Yi Yin

“…Despite widespread deregulation of CDK4/6 activity in non-small cell lung cancer (NSCLC), clinical trials with CDK4/6 inhibitor (CDK4/6i) as a monotherapy have shown poor antitumor activity. …”
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Meta-analysis of Therapeutic Effect in Depression Treatment of Repetitive Transcranial Magnetic Stimulation Combined Paroxetine by Xinyi GUO, Guo YU, Xiaokuo HE

“…Objective:To evaluate the therapeutic effect of repetitive transcranial magnetic stimulation(TMS)combined with paroxetine in the treatment of depression, provide reference for the clinical treatment and related research of depression.Methods:We electronically searched databases, including CNKI Chinese Journal Full-text Database, Wanfang Database, VIP Database, PubMed, the Cochrane Library and EMbase, to collect randomized controlled trials(RCTs)about depression treated by repetitive TMS combined with paroxetine. …”
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