An updated network meta-analysis of non-pharmacological interventions for primary hypertension in adults: insights from recent studies by Ziwen Chen, Qifu Li, Tao Xu, Xueli Zhou, Yunjie Shu, Taipin Guo, Fanrong Liang

“…We conducted a thorough search in eight databases, including PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, CNKI, WanFang Data, and Chongqing VIP, identifying potential randomized controlled trials (RCTs) from January 1, 2013, to August 1, 2024. …”
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Differences in immune-related toxicity between PD-1 and PD-L1 inhibitors: a retrospective cohort study in patients with advanced cancer by Cecilia Olsson Ladjevardi, Marcus Skribek, Anthoula Koliadi, Viktoria Rydén, Ali Inan El-Naggar, Evangelos Digkas, Antonios Valachis, Gustav J. Ullenhag

“…Pooled analyses based on clinical trials show a favorable toxicity profile for treatment with PD-L1 compared to PD-1 inhibitors. …”
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Spinal Cord Stimulation for Refractory Angina Pectoris: Current Status and Future Perspectives, a Narrative Review by Roberto Gazzeri, Jacopo Mosca, Felice Occhigrossi, Marco Mercieri, Marcelo Galarza, Matteo Luigi Giuseppe Leoni

“…Novel stimulation modalities, including high-frequency, Burst, and Differential Target Multiplexed (DTM), show potential advantages in enhancing patient comfort and clinical outcomes. …”
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Integrating Visible Light Communication and AI for Adaptive Traffic Management: A Focus on Reward Functions and Rerouting Coordination by Manuela Vieira, Gonçalo Galvão, Manuel A. Vieira, Mário Vestias, Paula Louro, Pedro Vieira

“…Results show significant reductions in vehicle and pedestrian waiting times, particularly in rerouting scenarios, demonstrating the system’s scalability and adaptability. …”
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A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens by Kaleb A. Reese, Christopher Lupfer, Rudd C. Johnson, Georgi M. Mitev, Valerie M. Mullen, Bruce L. Geller, Manoj Pastey

“…The results of these trials show that birds in both vaccinated groups had significantly (P<0.05) higher median survival times than non-vaccinated birds and that this protection could be due to M2e-specific serum IgG.…”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Tirzepatide and semaglutide are two pharmacological agents which show best results in terms of weight loss.   …”
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The mirror preference test: A reverse translational approach to study anomalous subjective experience in rats by Daria Chestnykh, Liubov S. Kalinichenko, Stephan von Hörsten, Johannes Kornhuber, Christian P. Müller

“…Here we demonstrate that naive rats show a preference for a mirror chamber, which was followed by significant habituation over a series of trials. …”
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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights by Mislav Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Andrea Gelemanović, Andrea Faour, Ivan Vlak, Josipa Radić

“…Overall, tetracyclines show promise as adjunct therapies in RA management due to their dual anti-inflammatory and immunomodulatory actions. …”
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Valorization of rice stubble through biodegradation using hydrolytic enzyme-producing Olivibacter oleidegradans CMB10 and Agrobacterium pusense SFMB9 by Milind Gajbhiye, Sushmita Patil, Sagar Awate, Supriya Kokare, Siddharth Terdale, Manish Kumar Dubey

“…There was an effective decrease in C/N ratio in all inoculated trials from 26.4 to 14.2 in 45 days of composting. …”
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Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective... by Yukitaka Ueki, Tom W J Huizinga, René E M Toes, Shoichi Fukui, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami, Tomohiro Koga, Naoki Matsuoka, Toshihiko Hidaka, Naoki Iwamoto, Mami Tamai, Shin-ya Kawashiri, Akitomo Okada, Ayako Nishino, Tamami Yoshitama, Takahisa Suzuki, Toshimasa Shimizu, Shimpei Morimoto, Tomomi Tsuru, Karin A J van Schie, Masahiro Ayano, Remi Sumiyoshi, Yushiro Endo, Tohru Michitsuji, Kaori Furukawa, Masataka Umeda, Nobutaka Eiraku, Hiroaki Hamada

“…Two distinct groups made of four clusters showed a significant difference in IgM-anti-CCP2 positivity. …”
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A cost-utility analysis of adding SGLT2 inhibitors for the management of type 2 diabetes with chronic kidney disease in Thailand by Natthakan Chitpim, Pattara Leelahavarong, Juthamas Prawjaeng, Sakditat Ittiphisit, Varalak Srinonprasert, Tanawan Kongmalai

“…While sodium glucose cotransporter-2 inhibitors (SGLT2i) show renal benefits in randomized controlled trials (RCTs), their cost-effectiveness in Thailand remains unclear. …”
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BRAIN CHANGER. Felice Jacka, 321 pages, Macmillan, 2019 (ISBN: 978-1-76055-651-8) by Cécil J.W. Meulenberg

“…These and other studies show that wherever the geographical area, plant-based Mediterranean-like diets improve the health outcomes of children, adolescents, adults and ageing individuals affected by mental health illnesses, in cost-effective ways. …”
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Update on Pulmonary Toxicity Induced by New Breast Cancer Treatments by Belluzzi L, Martinelli G, Medici B, Farina A, Martinelli E, Canino F, Caggia F, Molinaro A, Barbolini M, Tamburrano F, Moscetti L, Piacentini F, Dominici M, Omarini C

“…A literature search was performed between January and June 2024, considering papers, clinical trials, case reports, case series, meta-analyses, and systematic reviews published from January 2014 to June 2024. …”
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Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study by Martina Patone, Andrew JHL Snelling, Holly Tibble, Carol Coupland, Aziz Sheikh, Julia Hippisley-Cox

“…Abstract Background Sotrovimab is a neutralising monoclonal antibody (nMAB) currently available to treat extremely clinically vulnerable COVID-19 patients in England. Trials have shown it to have mild to moderate side effects, however, evidence regarding its safety in real-world settings remains insufficient. …”
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Vascular endothelial growth factor inhibitors for retinopathy of prematurity by O.V. Zhukova, I.A. Mal’tseva, A.V. Zolotarev

“…The results of multicenter clinical trials evaluating pegaptanib, bevacizumab, and ranibizumab are discussed. …”
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Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer by Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos, Wei Bo Li

“…Results The distribution of 223Ra after injection showed a rapid plasma clearance and a low urinary excretion. …”
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Safety and Efficacy of Combination Therapy with Anti-Vascular Endothelial Growth Factor and Laser for Retinopathy of Prematurity: A Systematic Review and Meta-Analysis by Alamoudi A, Alnabihi AN, Alsudais AS, Almufarriji N, Batais WT, Aldahlawi AK, Altalhi A, Al-Dhibi HA, Alakeely AG

“…The pooled analysis of favorable structural outcomes did not show a statistically significant difference between combination therapy with anti-VEGFs and laser therapy compared to the interventions in the control groups (P=0.25). …”
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Identification of musk compounds as inhibitors of the main SARS-CoV-2 protease by molecular docking and molecular dynamics studies by Belhassan Assia, Salgado Guillermo, Mendoza-Huizar Luis Humberto, Zaki Hanane, Chtita Samir, Lakhlifi Tahar, Bouachrine Mohammed, Gerli Candia Lorena, Cardona Wilson

“…The perspectives of this work are as follows: in vitro, in vivo and clinical trials to verify the computational findings.…”
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A dynamic optimization of soil phosphorus status approach could reduce phosphorus fertilizer use by half in China by Haiqing Gong, Yulong Yin, Zhong Chen, Qingsong Zhang, Xingshuai Tian, Zihan Wang, Yingcheng Wang, Zhenling Cui

“…We evaluate the DOP approach in 35,575 on-farm trials, and the results show that it is agronomically acceptable. …”
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Synthetic Hydrogel Dilutes <i>Serratia plymuthica</i> Growth— Promoting Effect on <i>Brassica napus</i> L. Under Drought Conditions by Grażyna B. Dąbrowska, Daniel Krauklis, Milena Kulasek, Magdalena Nocny, Marcel Antoszewski, Agnieszka Mierek-Adamska, Beata Kaliska

“…Moreover, the hydrogel did not show toxicity towards tested bacterial strains. Field trials during the drought demonstrated that inoculation with <i>S. plymuthica</i> significantly increased the number of siliques (16.48%) and yield (19.93%), compared to controls. …”
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