Determining the effect of frailty on survival in advanced ovarian cancer: study protocol for a prospective multicentre national cohort study (FOLERO) by Daniel Hunde, Niklas Ekerstad, Mihaela Asp, Päivi Kannisto, Madelene Wedin, Charlotte Palmqvist, Pernilla Dahm-Kähler, Yvonne Brandberg, Mirna Abraham-Nordling, Kristina Åhlund, Vilhelm Mörlin, Nina Groes-Kofoed, Sahar Salehi

“…Study registration: ClinicalTrials.gov NCT06298877 …”
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Development and routine implementation of deep learning algorithm for automatic brain metastases segmentation on MRI for RANO-BM criteria follow-up by Loïse Dessoude, Raphaëlle Lemaire, Romain Andres, Thomas Leleu, Alexandre G. Leclercq, Alexis Desmonts, Typhaine Corroller, Amirath Fara Orou-Guidou, Luca Laduree, Loic Le Henaff, Joëlle Lacroix, Alexis Lechervy, Dinu Stefan, Aurélien Corroyer-Dulmont

“…Consequently, in clinical practice, monitoring patients in clinical trials in compliance with the RANO-BM criteria is rarely achieved. …”
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Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…Future researchers need to further explore the long-term efficacy and safety of wogonin in clinical trials and translate it for early application in the clinical treatment of true CNS disorders.…”
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Body composition changes and clinical outcomes in pediatric cystic fibrosis during 24 months of lumacaftor ivacaftor therapy based on real-world data by Marcell Imrei, Adrienn F. Kéri, Éva Gács, Ildikó Gönczi, Melinda Meláth, Éva Kosaras, Botond Demeter, Csaba Péterfia, Klára Vass, Gyöngyi Székely, Klementina Ocskay, Andrea Párniczky

“…Abstract Clinical trials demonstrate the short-term efficacy of dual CFTR modulators, but long-term real-world data is limited. …”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Also, though inflammation is as a result of adverse HF in patients, but despite the fact that broad immunosuppression therapeutic target has been used in various clinical trials, no positive results have showed up, but rather, the focus on proinflammatory cytokines has proved more benefits in patients with HF. …”
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Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis by Lizheng Wu, Shangwen Jing, Na Li, Dandan Cao, Fangli Pei, Yantong Luo, Xiaoxin Chen, Yingjie Huang, Cheng Zeng

“…The results of network meta-analysis showed that, Fufang Shajiziyou suppository combined with CT was more effective in improving the negative conversion rate and controlling the recurrence rate of Candida albicans. …”
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Janus kinase inhibitor treatment for inflammatory diseases: excess or no excess risk of venous thromboembolism? by Yachar Dawudi, Samuel Benarroch, Hélène Helfer, David M. Smadja, Isabelle Mahé

“…This literature review examines studies reporting the risk of VTEs associated with JAKis in patients with inflammatory diseases. Phase I to III trials showed no increased risk of VTEs. However, these studies were not designed to detect adverse events such as VTEs. …”
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Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice by Rose Hilal, Marine Poittevin, Adrien Pasteur-Rousseau, Adrien Cogo, Gabrielle Mangin, Marie Chevauché, Yasmine Ziat, José Vilar, Jean-Marie Launay, Jean-François Gautier, Dong Broquères-You, Bernard I. Levy, Tatyana Merkulova-Rainon, Nathalie Kubis

“…Clinical trials of cell therapy in stroke favor autologous cell transplantation. …”
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Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study by Gian Luca Erre, Matteo Piga, Anna Laura Fedele, Silvia Mura, Alessandra Piras, Maria Luisa Cadoni, Ignazio Cangemi, Martina Dessi, Gabriele Di Sante, Barbara Tolusso, Elisa Gremese, Alberto Cauli, Arduino Aleksander Mangoni, Pier Sergio Saba, Ciriaco Carru, Gianfranco Ferraccioli, Alessandro Mathieu, Giuseppe Passiu

“…Multiple regression analysis showed a positive correlation between Ln-RHI values and systolic blood pressure and HDL cholesterol levels; furthermore, higher values of Ln-RHI were associated with ACPA positivity, while smoking habit was associated with lower Ln-RHI values. …”
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SSVEP Enhancement in Mixed Reality Environment for Brain–Computer Interfaces by Jieyu Wu, Feng He, Xiaolin Xiao, Runyuan Gao, Lin Meng, Xiuyun Liu, Minpeng Xu, Dong Ming

“…Additionally, we proposed a cross-correlation task-related component analysis based on simulated annealing (SA-xTRCA), which can increase the signal-to-noise ratio (SNR) and detection accuracy by aligning SSVEP trials. The results of an offline experiment showed that the background and stimulus colors had a significant interaction effect that can impact system performance. …”
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Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis by Elizabete Priscila Costa Santana, Haidelucia Rodrigues Vieira Javarini, Dyego Carlos Souza Anacleto de Araújo, Sabrina Cerqueira-Santos, Tiago Marques Reis, Genival Araujo dos Santos-Junior, Kérilin Stancine Santos Rocha

“…Three studies were included in the meta-analysis, which showed moderate heterogeneity (I2 = 44%, p = 0.17). …”
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Glasswort as a Strategic Crop in Coastal Wetlands: Intercropping Results with Swiss Chard by Anna Rita Bernadette Cammerino, Michela Ingaramo, Vincenzo Rizzi, Maurizio Gioiosa, Massimo Monteleone

“…These were performed to test for possible interaction effects. The results showed that both glasswort and chard can be grown sustainably under slightly saline conditions (ECe range 4–8 dS m⁻¹). …”
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Short-term and long-term effect of non-pharmacotherapy for adults with ADHD: a systematic review and network meta-analysis by Xinyue Yang, Lin Zhang, Jing Yu, Meng Wang

“…Cognitive behavioral therapy (CBT) showed significantly greater effectiveness than the control group/condition in both the short-term (SMD: -4.43, 95%CI: -5.50 to -3.37) and long-term (SMD: -3.61, 95%CI: -4.66 to -2.56) core symptoms. …”
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Effectiveness of eHealth literacy interventions: a systematic review and meta-analysis of experimental studies by Chiara Barbati, Elvira Maranesi, Cinzia Giammarchi, Matteo Lenge, Manila Bonciani, Elisa Barbi, Giacomo Pietro Vigezzi, Mauro Dragoni, Tania Bailoni, Anna Odone, Roberta Bevilacqua

“…The meta-analysis included 10 studies that used the eHEALS. Participants showed a mean increase in eHEALS scores of 5.81 points (95% CI = 3.36–8.26, N = 1025) following the eHL interventions compared to the pre-intervention period. …”
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The effect of repetitive transcranial magnetic stimulation on sleep quality in patients with more than mild depressive mood: a systematic review and meta-analysis by Yu’ang Liu, Silang Huang, Xinxin Zhang, Huangying Liao, Weiguo Liu, Zhi Zhang, Xianhui Qu, Ziwen Wang

“…The results of the subgroup analyses showed that, in terms of stimulation frequency, compared with the 5-Hz and 10-Hz groups, the treatment effect of the 1-Hz group was better (I2 = 32%, MD = −2.69, 95%CI = −3.78 to −1.60, p < 0.00001). …”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…This new strategy may be a promising treatment for SCLC but needs to be confirmed in future clinical trials.…”
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Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study by Evgeny N. Mikhaylov, Tamara A. Lyubimtseva, Aleksandr D. Vakhrushev, Dmitry Stepanov, Dmitry S. Lebedev, Elena Yu. Vasilieva, Alexandra O. Konradi, Evgeny V. Shlyakhto

“…Although the study was underpowered, it showed that Bromhexine hydrochloride prophylaxis was associated with a reduced rate of symptomatic COVID-19. …”
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Effects of an 8-week pre-season targeted training on sprinting performance, agility and lower limb muscular asymmetries in elite soccer players by Artur Gołaś, Przemysław Pietraszewski, Robert Roczniok, Artur Terbalyan, Adam Maszczyk, Rafał Opaliński, Adam Zając

“…After the warm-up, participants performed two maximum 30 m sprints with a 5-minute rest interval between trials. After the linear sprint test, performed two repetitions of the COD randomized ZigZag test. …”
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Living through the psychological consequences of COVID-19 pandemic: a systematic review of effective mitigating interventions by Viroj Tangcharoensathien, Angkana Lekagul, Chawisa Suradom, Peeraya Piancharoen, Anamika Chattong

“…Cochrane risk-of-bias tool is applied to assess the quality of all randomised controlled trials (RCT).Results All studies were recently conducted in 2020. …”
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Enhancing Mandibular Reconstruction with Surgeon–Bioengineer Collaboration: A Protocol for Virtual Surgical Planning by Dong-Ho Shin, Hyo-Joon Kim, Ji-Su Oh, Seong-Yong Moon

“…Protocol efficiency was assessed through seven simulation trials measuring planning duration and required revisions. …”
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