A Two-Stage Optimization Method for Multi-Runway Departure Sequencing Based on Continuous-Time Markov Chain by Guan Lian, Yingzi Wu, Weizhen Luo, Wenyong Li, Yaping Zhang, Xiaoyue Zhang

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Noise Reduction in LED-Based Photoacoustic Imaging by Takahiro Kono, Kazuma Hashimoto, Keisuke Fukuda, Uma Maheswari Rajagopalan, Kae Nakamura, Jun Yamada

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Taxonomic diversity in the global wheat phyllosphere mycobiome – a meta analysis by Marie Højmark Fischer, Agnieszka Rzepczynska, Agnieszka Rzepczynska, Rasmus Kjøller

“…Furthermore, we identified that while community composition differed between wheat growing regions, the identification method used was the most significant factor determining the depiction of community composition. …”
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Social policy of the early 1990^s in the conditions of economic reform: directions and ways of solution (Southern Ural). by N. V. Baryshnikova, O. V. Kuznetsova

“…The relevance of the problem is based on the lack of a comprehensive study of social transformations in the Southern Urals, which is the purpose of the study.   Materials and Methods. To achieve this goal, comparative-historical and problem-chronological methods were used, as well as the principles of objectivity, consistency and historicism were applied, allowing to reveal the problem in its logical factual sequence, based on documentary sources. …”
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Genetic diversity of the KIR/HLA system and susceptibility to hepatitis C virus-related diseases. by Valli De Re, Laura Caggiari, Mariangela De Zorzi, Ombretta Repetto, Anna Linda Zignego, Francesco Izzo, Maria Lina Tornesello, Franco Maria Buonaguro, Alessandra Mangia, Domenico Sansonno, Vito Racanelli, Salvatore De Vita, Pietro Pioltelli, Emanuela Vaccher, Massimiliano Berretta, Cesare Mazzaro, Massimo Libra, Andrea Gini, Antonella Zucchetto, Renato Cannizzaro, Paolo De Paoli

“…<h4>Background</h4>The variability in the association of host innate immune response to Hepatitis C virus (HCV) infection requires ruling out the possible role of host KIR and HLA genotypes in HCV-related disorders: therefore, we therefore explored the relationships between KIR/HLA genotypes and chronic HCV infection (CHC) as they relate to the risk of HCV-related hepatocarcinoma (HCC) or lymphoproliferative disease progression.<h4>Methods and findings</h4>We analyzed data from 396 HCV-positive patients with CHC (n = 125), HCC (118), and lymphoproliferative diseases (153), and 501 HCV-negative patients. …”
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Radiomic Features of Mesorectal Fat as Indicators of Response in Rectal Cancer Patients Undergoing Neoadjuvant Therapy by Francesca Treballi, Ginevra Danti, Sofia Boccioli, Sebastiano Paolucci, Simone Busoni, Linda Calistri, Vittorio Miele

“…The aim was to assess the potential presence of predictive factors for favorable or unfavorable responses to neoadjuvant chemoradiotherapy, thereby optimizing treatment management and improving personalized clinical decision-making. Methods: We conducted a retrospective analysis of adult patients with LARC who underwent pre- and post-nCRT MRI scans. …”
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Comparing the efficacy of topical interventions for pain management in oral lichen planus: a time-stratified bayesian network analysis of randomized controlled trials by Yuanmei Zhang, Chenhao Mao, Juanfang Zhu, Wenli Yang, Yanli Wang, Weiwei Yu, Jing Wang, Na Li, Jia Guo, Qi Zhang, Yi Zhou, Mengdong Peng, Yining Wang

“…The primary aim of this study was to establish a clinically relevant hierarchy among different treatments in terms of their effectiveness for short-term pain control. Methods EMBASE, Scopus, PubMed, WanFang database, and Cochrane databases were searched up to January 2025. …”
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Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients. by Ilze Elbere, Ivars Silamikelis, Ilze Izabella Dindune, Ineta Kalnina, Monta Briviba, Linda Zaharenko, Laila Silamikele, Vita Rovite, Dita Gudra, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins

“…<h4>Background</h4>The study was conducted to investigate the effects of metformin treatment on the human gut microbiome's taxonomic and functional profile in the Latvian population, and to evaluate the correlation of these changes with therapeutic efficacy and tolerance.<h4>Methods</h4>In this longitudinal observational study, stool samples for shotgun metagenomic sequencing-based analysis were collected in two cohorts. …”
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Optimizing fungal DNA extraction and purification for Oxford Nanopore untargeted shotgun metagenomic sequencing from simulated hemoculture specimens by Nattapong Langsiri, Wieland Meyer, Laszlo Irinyi, Navaporn Worasilchai, Nuttapon Pombubpa, Thidathip Wongsurawat, Piroon Jenjaroenpun, J. Jennifer Luangsa-ard, Ariya Chindamporn

“…Comparing different lysis methods showed that chemical lysis with CTAB/SDS generated DNA from pure fungal cultures with high yields (ranging from 11.20 ± 0.17 µg to 22.99 ± 2.22 µg depending on the species) while preserving integrity. …”
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High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy by Xin Sun, Yao Chen, Feifei Hu, Yumeng Qiao, He Wu, Yao Su, Yue Hu, Jie Wu, Jie Wu, Mingli Huang

“…Our goal is to establish mechanistic and functional links between altered gene expression and perinatal complications.MethodsPlacental pathology from 129 cases was analyzed to identify risk factors for maternal vascular malperfusion (MVM), a key pathological condition known to impair placental function. …”
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Remarkable response to crizotinib in a patient with advanced lung adenocarcinoma harboring the MPRIP-ROS1 fusion gene: A case report by Yasuyuki Kishikawa, Kohei Otsubo, Daisuke Shibahara, Yoshimasa Shiraishi, Yasuto Yoneshima, Eiji Iwama, Isamu Okamoto

“…This case also underscores the importance of comprehensive genomic profiling using hybrid capture-based next-generation sequencing to identify rare driver gene alterations that may not be detected by conventional target sequencing-based methods.…”
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