Efficient delivery of anlotinib and radioiodine by long circulating nano-capsules for active enhanced suppression of anaplastic thyroid carcinoma by Linlin Zhang, Chuanying Zhu, Shuo Huang, Miaomiao Xu, Chao Li, Hongliang Fu, Yafu Yin, Sheng Liang, Hui Wang, Zhilei Cui, Lei Huang

“…The Anlotinib-BSA nano-capsule (nBSA) showed a mostly uniform size distribution centering at 21–23 nm, and the nano-drug had a characteristic absorption peak at the wavelength of 325 nm. …”
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Multi-objective Optimal Scheduling of Water-Carbon in Cascade Reservoirs during Impoundment for Carbon Emission Reduction by ZHOU Yan-lai, NING Zhi-hao, HE Jun-tao

“…In the wet year, the selected scheme with the minimum flood risk increased power generation by 3.341 billion kW·h/a and reduced direct GHG emissions by 39.53 Gg CO2 e/a without increasing flood risk compared to the current scheme. …”
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Evaluation of Simulated Weightlessness Model of Hindlimb Unloading Miniature Pigs and Their Tissue Damage by TU Yingxin, JI Yilan, WANG Fei, YANG Dongming, WANG Dongdong, SUN Zhixin, DAI Yuexin, WANG Yanji, KAN Guanghan, WU Bin, ZHAO Deming, YANG Lifeng

“…Objective To establish a weightlessness simulation animal model using miniature pigs, leveraging the characteristic of multiple systems’ tissue structures and functions similar to those of humans, and to observe pathophysiological changes, providing a new method for aerospace research. …”
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Formulation Optimization of Liquid Rapid-Freezing Cryopreservation Solution and Its Application Effectiveness on Tilapia by Ting DUNA, Lanqing PENG, Fanwei DAI, Feiping CHEN, Zheng LUO, Qiongyao WANG, Hailin Yue, Jijun Gong, Mingqiang YE

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Genome-wide identification and analysis of ERF transcription factors related to abiotic stress responses in Nelumbo nucifera by Yingchun Xu, Junnan Jiang, Lihong Zeng, Huan Liu, Qijiang Jin, Ping Zhou, Yanjie Wang

“…Abstract Background Ethylene-responsive factor (ERF) transcription factors belong to the APETALA2/ERF (AP2/ERF) superfamily, and play crucial roles in plant development process and stress responses. However, the function of ERF proteins (especially for their role in response to abiotic stresses) remains scarce in Nelumbo nucifera, which is an important aquatic plant with high ornamental, economic, and ecological values. …”
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CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells by Elena Gurrieri, Giulia Carradori, Michela Roccuzzo, Michael Pancher, Daniele Peroni, Romina Belli, Caterina Trevisan, Michela Notarangelo, Wen-Qiu Huang, Agata S. A. Carreira, Alessandro Quattrone, Guido Jenster, Timo L. M. Ten Hagen, Vito Giuseppe D’Agostino

“…The capacity to entrap heterogeneous molecular cargoes and target specific cell populations through EV functionalization promises advancements in biomedical applications. …”
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Development and Optimization of a Novel Deep Learning Model for Diagnosis of Quince Leaf Diseases by A. Naderi Beni, H. Bagherpour, J. Amiri Parian

“…Our proposed CNN model consists of an architecture with four convolutional layers, with 224 × 224 RGB images as input to the first layer, which has 16 filters, followed by additional convolutional layers with 32, 64, and 128 filters respectively. Activation functions of ReLU combined with max-pooling were used at each convolutional layer, and Softmax activation was applied in the last layer of the neural network to convert the output into a probability distribution.Results and DiscussionThree confusion matrices based on the test dataset were constructed for all the CNN models to compare and evaluate the performance of the classifiers. …”
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A neural network-based method for input parameter optimization of edge transport modeling utilizing experimental diagnostics by Y. Luo, S. Xu, Y. Liang, E. Wang, J. Cai, Y. Feng, D. Reiter, A. Knieps, S. Brezinsek, D. Harting, M. Krychowiak, D. Gradic, P. Ren, D. Zhang, Y. Gao, G. Fuchert, A. Pandey, M. Jakubowski, the W7-X Team

“…Subsequently, the trained surrogate model is incorporated into a Bayesian inference framework with Dynamic Nested Sampling to infer posterior distributions of the EMC3-EIRENE input parameters. In this step, the FNN-predicted synthetic data are compared with the experimental data, and the likelihood function explicitly accounts for the measurement uncertainties of the selected diagnostics. …”
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Phosphate transporter gene families in rye (Secale cereale L.) – genome-wide identification, characterization and sequence diversity assessment via DArTreseq by David Chan-Rodriguez, Brian Wakimwayi Koboyi, Sirine Werghi, Bradley J. Till, Julia Maksymiuk, Fatemeh Shoormij, Abuya Hilderlith, Anna Hawliczek, Maksymilian Królik, Hanna Bolibok-Brągoszewska

“…Collectively our findings provide the foundation for selecting most promising candidates for further functional characterization.…”
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Impact of Urban Waterfront Green Space Landscape Elements on Public Health Behaviors Based on Restorative Perception by Yi WU, Hongfei QIU, Xinyue LUO, Yaping HU

“…Therefore, this research aims to delve into how landscape elements in urban waterfront green spaces influence public health behaviors from an internal spatial perspective, with restorative perception as a mediator.MethodsThis research takes Wuhan Shahu Park as an example and selects 93 landscape nodes within the park as the research objects. …”
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Evaluating the level of digitalization of the innovation process with artificial intelligence approach in the digital transformation of knowledge-based companies by ali Bagheri, reza radfar, sepehr ghazinoory

“…In this method, the number of membership functions is 5 functions representing very low, low, medium, high and very high. …”
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Strategy for Construction and Improvement of 4R Resilience Evaluation Model for Coastal Cities by Qixiang QIN, Weiping ZHANG, Yasen YIN

“…The reasons leading to the aforesaid results are mainly summarized in the following three aspects. 1) Due to dense population and land shortage, city samples with high development intensity pay more attention to spatial redundancy and resource acquisition during disasters, and their urban core functional areas have achieved full coverage of public services and emergency service facilities to a large extent through encrypted road networks, mixed land use, vertical functional layout and other ways. …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…The miR-6894-3p mimic regulated the activity of lnc-MAP3K13-3:1. Functional assays showed that lnc-MAP3K13-3:1 overexpression inhibited proliferation in HuH-7 and Li-7 cells, promoted apoptosis, reduced migration in Li-7 cells, but enhanced migration in HuH-7 cells. …”
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An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment by Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng, Xue-Kui Liu

“…Methods We developed a new combination strategy for the synthesis of penetrating peptides functionalized with targeting of integrin α6. The linear peptide S5 was multimerized with 4 copies in linear sequential order spaced by GSG between each copy to yield the 4S5 peptide. …”
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Roles of A- and C-weighted kurtosis adjustment for equivalent sound level in evaluating occupational hearing loss by Haiying LIU, Linjie WU, Yang LI, Jinzhe LI, Jiarui XIN, Hua ZOU, Wei QIU, Tong SHEN, Meibian ZHANG

“…However, few studies have considered the function of frequency weighting (A- or C-weighted) kurtosis on NIHL.ObjectiveTo study the significance of A- and C-weighted kurtosis adjustment for equivalent sound level (L'EX,8 h) in evaluating occupational hearing loss.MethodsA cross-sectional survey was used to select 973 noise-exposed workers in seven industries as the subjects. …”
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Genome-wide identification and expression of the HB gene family during overwintering in Korla pear (Pyrus sinkiangensis) by LIU Xiaoyan, WANG Lijuan, YANG Shenghui, LUO Guanghong, ZHU Jianbo

“…On chromosome 15, the highest number of HB members was distributed, totaling 12, while the other chromosomes contained 2 to 9 members each. …”
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Development of a Consensus-based Agenda to Identify Priorities for Clinical Research in Pediatric Orthopaedic Surgery by A. Noelle Larson, MD, Ria Paradkar, Matthew Schmitz, MD, Raymond Liu, MD, Neeraj M. Patel, MD, MPH, MBS, Henry Ellis, MD, Todd A. Milbrandt, MD, Dan Sucato, MD, Kevin Shea, MD, Jennifer Laine, MD

“…Final scores were used to select the top 16 research questions distributed by subspecialty area. …”
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High-Throughput Indirect Monitoring of TORC1 Activation Using the pTOMAN-G Plasmid in Yeast by Melissa Gómez, Guilherme Rocha, Diego Ruiz, Claudio Martínez, Francisco Salinas, Eduardo Kessi-Pérez

“…The target of rapamycin complex 1 (TORC1) is a highly conserved protein complex whose primary function is to link nutrient availability to cell growth in eukaryotes, particularly nitrogen sources. …”
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Genomic insights into population dynamics and adaptive strategies of the endangered dipterocarp, Hopea chinensis by Wei-Min Xiang, Yu-Ting Jiang, Jie Zou, Yan Deng, Kai Jiang, Kai-Jian Zhang, Xin-Yu Zhou, Kai-Xi Quan, Zi-Wen Han, Wei-Chao Liu, Liang Tang, Yuan-Yuan Li, Simon T. Segar, Yuan-Ye Zhang, Xing-Hua Hu, Rong Wang, Xiao-Yong Chen

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Association mapping of lignin response to Verticillium wilt through an eight-way MAGIC population in Upland cotton by Xiao-min TIAN, Peng HAN, Jing WANG, Pan-xia SHAO, Qiu-shuang AN, Nurimanguli AINI, Qing-yong YANG, Chun-yuan YOU, Hai-rong LIN, Long-fu ZHU, Zhen-yuan PAN, Xin-hui NIE

“…Two key candidate genes, Ghi_D05G01046 and Ghi_D05G01221, were selected within the QTLs through the combination of variations in the coding sequence, induced expression patterns, and function annotations. …”
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