Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. by Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov

“…<h4>Principal findings</h4>High-throughput screening of a ∼236,000-member collection of diverse molecules arrayed as dilution series was used to identify inhibitors of the JMJD2 (KDM4) family of 2-oxoglutarate-dependent histone demethylases. …”
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Cortico-striatal action control inherent of opponent cognitive-motivational styles by Cassandra Avila, Martin Sarter

“…Turning on cue or stopping at a red light requires attending to such cues to select action sequences, or suppress action, in accordance with learned cue-associated action rules. …”
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Distribution of Genetic Determinants Associated with CRISPR-Cas Systems and Resistance to Antibiotics in the Genomes of Archaea and Bacteria by Laura Antequera-Zambrano, Ángel Parra-Sánchez, Lenin González-Paz, Eduardo Fernandez, Gema Martinez-Navarrete

“…Together, these results underscore the evolutionary and functional diversification of CRISPR-Cas systems in response to environmental and selective pressures.…”
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An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas. by Soraya Gaze, Patrick Driguez, Mark S Pearson, Tiago Mendes, Denise L Doolan, Angela Trieu, Donald P McManus, Geoffrey N Gobert, Maria Victoria Periago, Rodrigo Correa Oliveira, Fernanda C Cardoso, Guilherme Oliveira, Guilherme Oliveira, Rie Nakajima, Al Jasinskas, Chris Hung, Li Liang, Jozelyn Pablo, Jeffrey M Bethony, Philip L Felgner, Alex Loukas

“…Using well-established Brazilian cohorts of putatively resistant (PR) and chronically infected (CI) individuals stratified by the intensity of their S. mansoni infection, we probed arrays for IgG subclass and IgE responses to these antigens to detect antibody signatures that were reflective of protective vs. non-protective immune responses. …”
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TGFβ-signaling in Squamous Cell Carcinoma Occurring in Recessive Dystrophic Epidermolysis Bullosa by Julia Knaup, Christina Gruber, Barbara Krammer, Verena Ziegler, Johann Bauer, Thomas Verwanger

“…Selected results were verified by Real-time RT PCR. …”
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Recent Advances in Resistive Gas Sensors: Fundamentals, Material and Device Design, and Intelligent Applications by Peiqingfeng Wang, Shusheng Xu, Xuerong Shi, Jiaqing Zhu, Haichao Xiong, Huimin Wen

“…Device-level innovations—such as microheater integration, self-heated nanowires, and multi-sensor arrays—have further improved response speed and energy efficiency. …”
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Beam steerable MIMO antenna based on conformal passive reflective metasurface for 5G millimeter wave applications by Bilal Tariq Malik, Shahid Khan, Slawomir Koziel

“…The beam steering is accomplished by selecting a specific port of MIMO antenna. Each MIMO port is associated with a beam that points in a different direction due to a conformal reflective metasurface. …”
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Epothilone B from Aspergillus fumigatus with a strong antiproliferative and anti-tubulin polymerizing activities; apoptosis, and cell cycle analyses by Ashraf S. A. El-Sayed, Safa W. Aziz, Ahmed H. Moustafa, Noha M. Saad, Mohamed Ali

“…Abstract Epothilones were designated as one of the most recognized chemotherapeutic agents towards the drug-resistant tumors, for their higher potency to bind and stabilize the β-tubulin arrays, stopping the cell cycle. Epothilones were chemically resolved from Aspergillus fumigatus # MN744705.1, that being more affordable source than Sorangium cellulosum, for its rapid growth and unique biological behaviour. …”
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Photoelectrochemical CO2 reduction on CuO-Cu2O nanocomposites with noble metal co-catalysts enhances the production of C1 oxygenates and acetate by Tahereh Mokary Yazdely, Ricard Garcia-Valls, Alberto Puga

“…Multi-junction copper oxide nanocomposite photocathodes formed by CuO nanowire arrays coated with Cu2O nanopyramids or stacked nanoprisms, i.e. …”
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DNA methylation remodeling in temozolomide resistant recurrent glioblastoma: comparing epigenetic dynamics in vitro and in vivo by Michela Buonaiuto, Mariella Cuomo, Davide Costabile, Federica Trio, Sara Ferraro, Ornella Affinito, Alberto De Bellis, Maria Laura Del Basso De Caro, Roberta Visconti, Lorenzo Chiariotti, Giuseppe Catapano, Rosa Della Monica

“…We investigated epigenetic alterations in the cell model and in a cohort of patients with recurrent glioblastoma using genome-wide methylome approaches (Epic Arrays 850 k). Results We investigated the epigenetic changes associated with temozolomide exposure. …”
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Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling by Raquel Arantes Megid, Guilherme Gomes Ribeiro, Izabela Natalia Faria Gomes, Ana Carolina Laus, Letícia Ferro Leal, Letícia Ferro Leal, Luciane Sussuchi da Silva, Abu-Bakr Adetayo Ariwoola, Josiane Mourão Dias, Rui Manuel Reis, Rui Manuel Reis, Renato Jose da Silva-Oliveira, Renato Jose da Silva-Oliveira

“…Proliferation was analyzed in real-time by xCELLigence; protein profiles were quantified by protein arrays; and mRNA expression profile was measured using the PanCancer Pathways panel by NanoString. …”
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Spatiotemporal responses to a rural highway by four mammal species by Caitlin K. Brett, Anna R. Mehner, John H. Young, Sarah E. Lehnen, Richard J. Kline

“…This study used camera trap arrays to quantify activity surrounding FM106 for four mammal species. …”
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Bayesian inference towards the resolution of molecular evolution: application to the “Trichoderma harzianum sensu lato” clade by Druzhinina I S, Kubicek C P

“…The clear distinction between T. tomentosum and T. cerinum was not recognized in all trees, but was supported by multivariate analysis of phenotype micro arrays. In contrast, H. lixii/T. harzianum did not form a single phylogenetic species in this study, as its monophyly was not supported in any analysis. …”
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A novel method for estimating avian roost sizes using passive acoustic recordings by Malcolm C. K. Soh, Mandar A. Chitre, Matthias Hoffmann‐Kuhnt, Benjamin P. Y.‐H. Lee, Kenneth B. H. Er

“…Previous acoustic methods such as paired sampling, microphone arrays and use of call rate have been used to estimate bird abundances; however, these are less suited for estimating large roost populations where hundreds of individuals are calling in unison. …”
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The Political Economy of Crisis and the Crisis of Political Economy: The Challenge of Sustainability by Graham Murdock

“…At the same time, the political instabilities following the end of the Cold War have licenced a move from selective to saturation surveillance that has given the major capitalist states unprecedented entry into intimate life. …”
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Proteomics detection of S100A6 in tumor tissue interstitial fluid and evaluation of its potential as a biomarker of cholangiocarcinoma by Sudarat Onsurathum, Ornuma Haonon, Porntip Pinlaor, Chawalit Pairojkul, Narong Khuntikeo, Raynoo Thanan, Sittiruk Roytrakul, Somchai Pinlaor

“…Their potential as markers was evaluated in human cholangiocarcinoma tissue arrays, and in serum using enzyme-linked immunosorbent assay. …”
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. by Dan Su, Xuting Wang, Michelle R Campbell, Devin K Porter, Gary S Pittman, Brian D Bennett, Ma Wan, Neal A Englert, Christopher L Crowl, Ryan N Gimple, Kelly N Adamski, Zhiqing Huang, Susan K Murphy, Douglas A Bell

“…To better characterize smoking-associated methylation changes in whole blood and leukocyte subtypes, we used Illumina 450K arrays and Reduced Representation Bisulfite Sequencing (RRBS) to assess genome-wide DNA methylation. …”
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A portable biosensor for simultaneous diagnosis of TNF-<i>α</i> and IL-1<i>β</i> in saliva biomarkers using twin electronic devices by M. Monajjemi, F. Mollaamin, M. Dehghandar, S. Shahriari, P. Latifi, S. Mohammadi

“…This system works by arraying metal–oxide–semiconductor field-effect transistors (MOSFETs), with each targeting a biorecognition element (BRE) specific to one of these two important biomarkers. …”
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An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene by Zita Reisz, Rita Pereira, Smitha Nevis, Alan Mackay, Leena Bhaw, Yura Grabovska, Ross Laxton, Valeria Molinari, Anna Burford, Barnaby Clark, Cristina Bleil, Bassel Zebian, Erika Pace, Annette Weiser, Fernando Carceller, Lynley Marshall, Andrew King, Istvan Bodi, Safa Al-Sarraj, Chris Jones, Matthew Clarke

“…DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNP v12.5 R package)) classified the tumour as ‘DMG, H3 K27-altered’ (calibrated score = 0.99). …”
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Monitoring Livestock Health by Modeling Rumination Behavior According to Accelerometer-Based Information by E. Vahedi Tekmehdash, H. Navid, H. Ghasemzadeh, H. Karimi, M. Javani Holan

“…Finally, the performance of the final model and sensor was evaluated in the field for a few days.Results and DiscussionAfter calculating the evaluation criteria for different calculation factors, four optimal factors were finally selected from the 50 arrays. Muzzle mode was found to be the best place to install the sensor. …”
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