Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome by Carlo Sorrentino, Paola Lanuti, Emma Di Carlo, Alice Turdo, Matilde Todaro, Stefania Livia Ciummo, Luigi D'Antonio, Cristiano Fieni

“…Both immunoregulatory mediators stimulated BCSC proliferation and self-renewal, while their selective blockade dramatically hindered IL30-dependent BCSC proliferation and mammosphere formation. …”
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Seroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021–2022 by Eilish Hart, John Tulloch, Daniel Bailey, Tim Brooks, Heli Harvala, Peter Simmonds, Roberto Vivancos, Neil French, Amanda Semper

“…Methods: The prevalence of Bbsl-specific antibodies in the English population was estimated in a cross-sectional cohort, selected from an archive of residual NHS blood donor plasma samples (age range 17 - 84, collected between 2021 - 2022). 10,000 samples were randomly selected proportionate to the population size of each of the nine English administrative regions. 9,994 samples were tested using a standard two-tiered testing strategy, with an IgG/IgM ELISA followed by an IgG immunoblot (array) test for any sera with positive or indeterminate reactivity in the ELISA. …”
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Quasars Can Signpost Supermassive Black Hole Binaries by J. Andrew Casey-Clyde, Chiara M. F. Mingarelli, Jenny E. Greene, Andy D. Goulding, Siyuan Chen, Jonathan R. Trump

“…We find at 95% confidence that quasars are at most 5 times as likely to host an SMBHB as a random galaxy. Pulsar timing arrays may therefore be more likely to find SMBHBs by prioritizing quasars over a random selection of galaxies in their searches.…”
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Deep Neural Emulation of the Supermassive Black Hole Binary Population by Nima Laal, Stephen R. Taylor, Luke Zoltan Kelley, Joseph Simon, Kayhan Gültekin, David Wright, Bence Bécsy, J. Andrew Casey-Clyde, Siyuan Chen, Alexander Cingoranelli, Daniel J. D’Orazio, Emiko C. Gardiner, William G. Lamb, Cayenne Matt, Magdalena S. Siwek, Jeremy M. Wachter

“…While supermassive black hole (SMBH) binaries are not the only viable source for the low-frequency gravitational wave background (GWB) signal evidenced by the most recent pulsar timing array (PTA) data sets, they are expected to be the most likely. …”
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Review of Luneburg Lens Antenna Designs Manufactured Using 3D Printing by D. V. Kusaykin, I. V. Grigoriev, D. V. Denisov, P. A. Turalchuk

“…The interest in multibeam dielectric lens antenna arrays has been growing in recent years due to the development of millimeter-wave telecommunication and radar systems. …”
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PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin by Blake Gilks, Martin Köbel, Diana Canals Hernaez, Michael R Hughes, Pamela Dean, Peter Bergqvist, Ismael Samudio, Ola Blixt, Katharina Wiedemeyer, Yicong Li, Chris Bond, Eric Cruz, Calvin D Roskelley, Kelly M McNagny

“…Mapping of the tumor-restricted epitope was performed using enzyme-treated human tumor cell lines and a glycan array.Results One mAb (PODO447) showed strong reactivity with a variety of Podxl+ tumor cell lines but not with normal primary human tissue including Podxl+ kidney podocytes and most vascular endothelia. …”
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Modeling Factors Influencing Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…Diving deeper into the realm of project financing, one finds a diverse array of financing mechanisms, each characterized by its unique set of risks and complex capital structures. …”
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Identifying Indicators and Themes of Leadership Evolution in the Framework on Theory of Being-Centered Leadership by Soraya Birami, Abolfazl Gaini, Iraj Roohi

“…Objective In today’s interconnected global business environment, companies face the challenge of engaging with diverse stakeholders, including suppliers, customers, government regulators, and employees who represent a wide array of multicultural, ethnic, and religious backgrounds. …”
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Impact of single nucleotide polymorphisms of immunomodulatory factors on treatment response and prognosis in acute myeloid leukemia by Mingying Li, Mingying Li, Tao Sun, Tao Sun, Mengyuan Chang, Mengyuan Chang, Tingting Liu, Tingting Liu, Lei Feng, Lei Feng, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Huixian Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Jingjing Ye, Jingjing Ye

“…SNP genotyping was conducted using the MassARRAY platform. Furthermore, we analyzed the relationship between AML susceptibility, bone marrow (BM) blast percentage, clinical characteristics, treatment response, and prognosis with the selected SNPs.ResultsThe study indicated that HMOX1 rs2071746 and TNFAIP2 rs1132339 are associated with BM blasts at the diagnosis of AML patients. …”
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Metabolism-associated marker gene-based predictive model for prognosis, targeted therapy, and immune landscape in ovarian cancer: an integrative analysis of single-cell and bulk RN... by Lele Ling, Bingrong Li, Boliang Ke, Yinjie Hu, Kaiyong Zhang, Siwen Li, Te Liu, Peng Liu, Bimeng Zhang

“…Genomic exploration of the prognostic model unveiled an array of biological functions linked with metabolism. …”
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Immune mediators as plasma biomarkers for identifying household contacts and classifying clinical forms and leprosy reactions by Jairo Campos Carvalho, Jairo Campos Carvalho, Marcelo Antônio Pascoal-Xavier, Marcelo Antônio Pascoal-Xavier, Marcelo Grossi Araújo, Júlia Pereira Martins, Andrea Teixeira-Carvalho, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Vanessa Peruhype-Magalhães, Jordana Grazziela Alves Coelho-dos-Reis, Olindo Assis Martins-Filho, Márcio Sobreira Silva Araújo

“…Quantitative measurements of these immune mediators were carried out using high-throughput multiplex microbead array. The results demonstrated that most of the plasma immune mediators were increased in all clinical groups compared with NI controls. …”
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Assessing Credit Risk in the Sphere of Commercial Lending to Organizations of the Kemerovo Region by Chernichenko S., Kotov R.

“…The analysis of most indicators revealed an unstable situation in the credit policy of metallurgical enterprises in the region, i.e. huge arrays and a high share of overdue debts, an irrational capital structure, a low level of liquidity of the balance sheet, and a significant proportion of unprofitable enterprises. …”
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Portable thermal scanners to detect and monitor small endotherms: A comparative assessment of available equipment to guide practitioners by Finella M. E. Dawlings, Claire Mackay, Morgan Humphrey, William F. Mitchell, Karina J. Sorrell, Sonia Sanchez, Benjamin M. Viola, Rohan H. Clarke

“…Here we seek to provide objective guidance on thermal tool selection to practitioners who wish to adopt such tools to detect and monitor small endotherms. …”
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96-Channel on-chip reconfigurable optical add-drop multiplexer for multidimensional multiplexing systems by Zhao Weike, Peng Yingying, Cao Xiaoping, Zhao Shi, Liu Ruoran, Wei Yihui, Liu Dajian, Yi Xiaolin, Han Shangtong, Wan Yuanjian, Li Kang, Wu Guangze, Wang Jian, Shi Yaocheng, Dai Daoxin

“…The present ROADM consists of a six-channel mode/polarization de-multiplexer, a 6 × 16 array of microring-resonator (MRR)-based wavelength-selective switches, and a six-channel mode/polarization multiplexer. …”
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Analysis of genetic diversity and phylogenetic relationships among Indonesian native cattle breeds using microsatellite markers: A review by Rini Hastarina, Agung Purnomoadi, Sutopo Sutopo, Dela Ayu Lestari, Fatmawati Mustofa, Putu Novia Gariri, Pupus Galau Prahara, Firda Tasya Kamila, Syaddad Verahry Philco, Maulida Arkaan Muhammad Da’i, Asep Setiaji

“…Background and Aim: Indonesia is home to a diverse array of native cattle breeds - such as Aceh, Bali, Madura, and Sumba Ongole - that are uniquely adapted to their regional environments and integral to the country’s agricultural and cultural heritage. …”
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Detection of [O iii]88 μm in JADES-GS-z14-0 at z = 14.1793 by Sander Schouws, Rychard J. Bouwens, Katherine Ormerod, Renske Smit, Hiddo Algera, Laura Sommovigo, Jacqueline Hodge, Andrea Ferrara, Pascal A. Oesch, Lucie E. Rowland, Ivana van Leeuwen, Mauro Stefanon, Thomas Herard-Demanche, Yoshinobu Fudamoto, Huub Röttgering, Paul van der Werf

“…We report the first successful Atacama Large Millimeter/submillimeter Array (ALMA) follow-up observations of a secure z > 10 JWST-selected galaxy, by robustly detecting (6.6 σ ) the [O iii ] _88 _μ _m line in JADES-GS-z14-0 (hereafter GS-z14). …”
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SAUNAS. II. Discovery of Cross-shaped X-Ray Emission and a Rotating Circumnuclear Disk in the Supermassive S0 Galaxy NGC 5084 by Alejandro S. Borlaff, Pamela M. Marcum, Pasquale Temi, Nushkia Chamba, S. Drew Chojnowski, Enrique Lopez-Rodriguez, Aneta Siemiginowska, Seppo Laine, Anton M. Koekemoer, Kelly N. Sanderson, Audrey F. Dijeau, Moire K. M. Prescott, Leslie Proudfit, Michael N. Fanelli

“…Combining Chandra, Atacama Large Millimeter/submillimeter Array, EVLA, and Hubble Space Telescope archival data and newly acquired data from the Apache Point Observatory/Dual Imaging Spectrograph, we detect a double-lobed 17 kpc X-ray emission with plumes oriented approximately perpendicular and parallel to the galactic plane of the massive lenticular galaxy NGC 5084 at 0.3–2.0 keV. …”
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Anisakis Sensitization in the Croatian fish processing workers: Behavioral instead of occupational risk factors? by Ana Jerončić, Diana Nonković, Anamarija Vrbatović, Jerko Hrabar, Ivana Bušelić, Victoria Martínez-Sernández, Santiago A Lojo Rocamonde, Florencio M Ubeira, Sonja Jaman, Esma Čečuk Jeličić, Marco Amati, Maria Angeles Gomez Morales, Boris Lukšić, Ivona Mladineo

“…The study exhaustively covered almost all marine fish processing workers in Croatia, reflecting real-time Anisakis sensitization status within the industry, already under the influence of wide array of allergens.…”
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Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart d... by Christian Torp-Pedersen, Lars Køber, Karina Banasik, Christian Erikstrup, David Westergaard, Mette Nyegaard, Erik Sørensen, Søren Brunak, Henrik Ullum, Kari Stefansson, Henning Bundgaard, Unnur Thorsteinsdottir, Ruth Frikke-Schmidt, Hreinn Stefánsson, Sisse R Ostrowski, Ina H Laursen, Amalie D Haue, Oscar Petersen, Peter C Holm, Hilma Holm, Lise W Thørner, Margit A H Larsen, Michael Schwinn, Arnaldur Gylfason, Florian Zink, G Bragi Walters, Asmundur Oddsson, Guðmar Þorleifsson, Gisli Másson, Daniel Gudbjartsson, Ole B Pedersen

“…All individuals are genotyped using the Infinium Global Screening Array from Illumina and imputed using a reference panel consisting of whole-genome sequence data from 8429 Danes along with 7146 samples from North-Western Europe. …”
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Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. by Mia M Gaudet, Karoline B Kuchenbaecker, Joseph Vijai, Robert J Klein, Tomas Kirchhoff, Lesley McGuffog, Daniel Barrowdale, Alison M Dunning, Andrew Lee, Joe Dennis, Sue Healey, Ed Dicks, Penny Soucy, Olga M Sinilnikova, Vernon S Pankratz, Xianshu Wang, Ronald C Eldridge, Daniel C Tessier, Daniel Vincent, Francois Bacot, Frans B L Hogervorst, Susan Peock, Dominique Stoppa-Lyonnet, KConFab Investigators, Paolo Peterlongo, Rita K Schmutzler, Katherine L Nathanson, Marion Piedmonte, Christian F Singer, Mads Thomassen, Ontario Cancer Genetics Network, Thomas v O Hansen, Susan L Neuhausen, Ignacio Blanco, Mark H Greene, Judith Garber, Jeffrey N Weitzel, Irene L Andrulis, David E Goldgar, Emma D'Andrea, Trinidad Caldes, Heli Nevanlinna, Ana Osorio, Elizabeth J van Rensburg, Adalgeir Arason, Gad Rennert, Ans M W van den Ouweland, Annemarie H van der Hout, Carolien M Kets, Cora M Aalfs, Juul T Wijnen, Margreet G E M Ausems, HEBON, EMBRACE, Debra Frost, Steve Ellis, Elena Fineberg, Radka Platte, D Gareth Evans, Chris Jacobs, Julian Adlard, Marc Tischkowitz, Mary E Porteous, Francesca Damiola, GEMO Study Collaborators, Lisa Golmard, Laure Barjhoux, Michel Longy, Muriel Belotti, Sandra Fert Ferrer, Sylvie Mazoyer, Amanda B Spurdle, Siranoush Manoukian, Monica Barile, Maurizio Genuardi, Norbert Arnold, Alfons Meindl, Christian Sutter, Barbara Wappenschmidt, Susan M Domchek, Georg Pfeiler, Eitan Friedman, Uffe Birk Jensen, Mark Robson, Sohela Shah, Conxi Lazaro, Phuong L Mai, Javier Benitez, Melissa C Southey, Marjanka K Schmidt, Peter A Fasching, Julian Peto, Manjeet K Humphreys, Qin Wang, Kyriaki Michailidou, Elinor J Sawyer, Barbara Burwinkel, Pascal Guénel, Stig E Bojesen, Roger L Milne, Hermann Brenner, Magdalena Lochmann, GENICA Network, Kristiina Aittomäki, Thilo Dörk, Sara Margolin, Arto Mannermaa, Diether Lambrechts, Jenny Chang-Claude, Paolo Radice, Graham G Giles, Christopher A Haiman, Robert Winqvist, Peter Devillee, Montserrat García-Closas, Nils Schoof, Maartje J Hooning, Angela Cox, Paul D P Pharoah, Anna Jakubowska, Nick Orr, Anna González-Neira, Guillermo Pita, M Rosario Alonso, Per Hall, Fergus J Couch, Jacques Simard, David Altshuler, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Kenneth Offit

“…Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. …”
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