Cytokine Reduction in the Treatment of Joint Conditions by J. D. Sipe, J. Martel-Pelletier, I. G. Otterness, J.-P. Pelletier

“…Pharmacologic regulation of IL-1 and TNFα remain primary targets for treatment of arthritis, and results of early clinical trials are promising. However, the results of long-term clinical trials will be required to support the value of anti-cytokine therapy in treatment of arthritis.…”
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A randomized, double‐blind, placebo‐controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease by Darren Bentley, Marie Mannino, Marianne Manchester, Priscila Camillo Teixeira, Bernhard Reis, Malcolm Boyce, Sandra Nagel

“…Few participants had an increase in gliadin‐specific, IFNγ‐secreting T cells, and the antigen‐specific responses (anti‐tTG and anti‐DGP antibodies) were weaker than expected in both arms. …”
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Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization by Yury A. Tyurin, Svetlana A. Lissovskaya, Rustem S. Fassahov, Ilshat G. Mustafin, Anton F. Shamsutdinov, Marina A. Shilova, Albert A. Rizvanov

“…Thus, along with other clinical trials, the study performed would clarify some aspects of molecular pathogenesis of human allergic rhinitis.…”
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Screening and Identification of Cold-Tolerant Phosphorus and Potassium Solubilizing Bacteria and Their Growth-Promoting Effects on Soybean in Cold Regions by Hao Yan, Tianyi Wang, Haocheng Wang, Nan Sun, Xuebing Wang, Xingbo Zhao, Zhongbao Yao, Hao Tian, Shengjie Chen, Songyan Tang, Chenyang Li

“…It was shown that P-2 secretes gluconic acid and P-5 secretes lactic acid to degrade insoluble phosphorus at low temperatures and that K-1 secretes citric acid to degrade insoluble potassium. …”
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Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence by Fuad Fares, Avri Havron, Eyal Fima

“…The therapeutic efficacy of EPO-CTP analog needs to be established in higher animals and in human clinical trials.…”
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GLP-1 Receptor Agonists’ Impact on Fertility - A Review by Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec, Silvia Ciraolo, Agnieszka Kulczycka-Rowicka

“…Research Materials and Methods: The study is built upon an analysis of current literature, clinical trials, meta-analyses, and systematic reviews as well as press reports from various sources. …”
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Effect of Recombinant Human Epidermal Growth Factor Associated with Conventional Drug Therapy on the Dry Eye Symptom Score in Patients with Dry Eyes after Cataract Surgery: A Syste... by Changce Sun, Xiaojun Zhang

“…The online database was searched for the clinical controlled trials of rhEGF associated with conventional drugs in the therapy of dry eyes after cataract surgery. …”
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Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review by Sarah Ezquerra, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, Flavio Carrion

“…They show great potential for cell therapy-based treatments, which is why they are being used in numerous clinical trials for a wide range of diseases. However, the success of placebo-controlled clinical trials has been limited, so new ways of improving the therapeutic effects of MSC are being developed, such as their assembly in a 3D conformation. …”
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Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune... by Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic

“…NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). …”
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Gastric Cytoprotection as Basis of Gastrointestinal Mucosa Protection and Repair in Erosive Ulcerative Lesions of Various Aetiologies by K. V. Ivashkin, E. A. Izatullaev, V. R. Korneeva

“…In experiment, MMSC prevented the ethanol-induced GM damage, stimulated mucin release and its redistribution on the GM surface; in clinical trials, MMSC effectively facilitated remission in duodenal ulcer.Conclusion. …”
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The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram, Obaid Ur Rehman, Eeshal Fatima, Zain Ali Nadeem, Omer Usman, Waqas Rasheed, Ramsha Ali, Khawaja Abdul Rehman, Abdulqadir J. Nashwan

“…Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. …”
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Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV by Anna K. Coussens, Adrian R. Martineau, Robert J. Wilkinson

“…Conversely, vitamin D can act to inhibit expression and secretion of a broad range of inflammatory mediators and matrix degrading enzymes driving immunopathology during active TB and antiretroviral- (ARV-) mediated immune reconstitution inflammatory syndrome (IRIS). …”
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Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice by Menglin Chen, Hong Yao, Huizi Tan, Wenqi Huang, Quanyong Wu, Shaoping Nie

“…Disorders in disease activity index (DAI), morphology and histology of colon tissue, intestinal permeability, and secretion of MPO, TNF-α and IL-6 were ameliorated by daily intake of live B. longum NSP001 cells in both conventional and humanised colitis mice. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

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Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade by Junjie Li, Yuandong Luo, Quanlan Fu, Shuxian Tang, Pingping Zhang, Ian H. Frazer, Xiaosong Liu, Tianfang Wang, Guoying Ni

“…These results indicate that F1/F3 may be effective to improve the efficacy of ICB and therapeutic vaccine-based immunotherapy for human epithelial cancers and warrants consideration for clinical trials.…”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Gastric emptying and insulin secretion are also affected by GLP-1 RAs. Clinical trials consistently demonstrate significant weight loss, positive action on cardiovascular risk and better glycemic control. …”
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Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders by Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang

“…The release of intracellular DNA into the extracellular area occurs via two pathways: cell death and active secretion by cells. The DNA, which is free in the extracellular space, is commonly known as Cell-Free DNA (cfDNA). …”
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Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation by S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I. Joosten, H. J. P. M. Koenen

“…Background. Recent clinical trials using regulatory T cells (Treg) support the therapeutic potential of Treg-based therapy in transplantation and autoinflammatory diseases. …”
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Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis by Chao Li, Didi Zuo, Tao Liu, Libin Yin, Chenyao Li, Lei Wang

“…Furthermore, randomized controlled trials (RCTs) of large patients are needed to confirm the results.…”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Key phenotypic and transcriptional changes occurred in a PD-1+CXCL13+CD4+ T cell subset, in response to all treatments, including increased interleukin-17 secretion and signaling toward plasma cells. Interestingly, LAG-3 protein upregulation was detected as a unique pharmacodynamic effect mediated by PD1-LAG3, but not by PD1-TIM3 or anti-PD-1.Conclusions Our in vitro system reliably assessed responses to bispecific antibodies co-targeting PD-1 together with LAG-3 or TIM-3 using patients’ tumor infiltrating immune cells and revealed transcriptional and phenotypic imprinting by bispecific antibody formats currently tested in early clinical trials.…”
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