Beyond first-line therapy: efficacy and safety outcomes of continuing immunotherapy in extensive stage small cell lung cancer after PD-L1 inhibitor progression by Jianfeng Peng, Xueying Zhai, Xiaomei Liu, Zhaoqin Huang, Yimeng Wang, Peizhu Wu, Ran Gao, Xiangjiao Meng

“…Patients were divided into two groups according to whether to continue second-line immunotherapy. Results: In a cohort of 150 ES-SCLC patients evaluated post-progression following first-line PD-L1 inhibitors, second-line treatment regimens varied: 86 patients received immunotherapy beyond progression (IBP) and 64 did not proceed to second-line immunotherapy (non-IBP). …”
Get full text

Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the l... by Cinzia Marchica, Faisal Zawawi, Dania Basodan, Rosie Scuccimarri, Sam J. Daniel

Get full text

Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication by Kerstin Schweyer, Bastian Fatke, Kornelia Kreiser, Christian Rabe, Christian Seifert, Benno Ikenberg

Get full text

Understanding the implementation of interventions to improve the management of frailty in primary care: a rapid realist review by David Reeves, Thomas Blakeman, Harm Van Marwijk, Khulud Alharbi, Jung Yin Tsang

Get full text

Risk Balancing of Cold Ischemic Time against Night Shift Surgery Possibly Reduces Rates of Reoperation and Perioperative Graft Loss by Nikos Emmanouilidis, Julius Boeckler, Bastian P. Ringe, Alexander Kaltenborn, Frank Lehner, Hans Friedrich Koch, Jürgen Klempnauer, Harald Schrem

Get full text

The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma by Lianne M. Haveman, Andreas Ranft, Henk vd Berg, Anne Smets, Jarmila Kruseova, Ruth Ladenstein, Benedicte Brichard, Michael Paulussen, Thomas Kuehne, Heribert Juergens, Stephanie Klco‐Brosius, Uta Dirksen, Johannes H.M. Merks

Get full text

Construction of functional tissue-engineered microvasculatures using circulating fibrocytes as mural cells by Xiaolin Wang, Hong Tan, Harsha P Gunawardena, Jin Cao, Lu Dang, Hongbing Deng, Xueyong Li, Hongjun Wang, Jinqing Li, Caibin Cui, David A Gerber

Get full text

Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal Fibrosis by Jing Sun, Yangwei Wang, Wenpeng Cui, Yan Lou, Guangdong Sun, Dongmei Zhang, Lining Miao

Get full text

Constraints of S–Pb–Sr Isotope Compositions and Rb–Sr Isotopic Age on the Origin of the Laoyingqing Noncarbonate-Hosted Pb–Zn Deposit in the Kunyang Group, SW China by Hongsheng Gong, Runsheng Han, Peng Wu, Gang Chen, Lingjie Li

“…In addition, Pb isotopic ratios were consistent with the age-corrected Pb isotopic ratios of basement rocks, consequently suggesting that the source of mixed crustal Pb is mainly derived from basement rocks. …”
Get full text

Devletlerarası İlişkilerde Kurumsallaşma Örneği Olarak Şanghay İşbirliği Örgütü by Tamer KAŞIKCI

“…After the Second World War, in order not to experience the great wars that shook the fundamental basement of international relations and disrupted the political, economic and cultural relations between states and to ensure the continuity of these relations, multilateral institutional arrangements were established. …”
Get full text

A Rare Case of Cyclophosphamide-Induced Posterior Reversible Encephalopathy Syndrome in a Patient with Anti-GBM Vasculitis, and Review of Current Literature by Taha Nisar, Abdul R. Alchaki, Erin Feinstein

“…Precipitating factors for PRES are multifactorial and include autoregulatory failure due to changes in blood pressure, metabolic derangements, and cytotoxic medications. We report the second case of cyclophosphamide-induced PRES in a patient with anti-glomerular basement membrane (Anti-GBM) positive vasculitis. …”
Get full text

Water–rock interaction in the geothermal systems related to post-collision zone volcanism: A case study based on multivariate statistical analysis from the Kavak geothermal field (... by Gündüz, Mesut, Bozdağ, Ayla, Bayram, Ali Ferat, Bozdağ, Ali, Asan, Kürşad, Sardini, Paul

“…Multivariate statistical analysis confirms that first type and second type thermal waters identified based on their hydrochemistry formed two separate statistical groups, and suggests that the chemistry of the KGF waters was mainly controlled by the composition of the ErAVC rather than those of the basement metamorphic rocks as a result of water–rock interaction.…”
Get full text

Benidipine Protects Kidney through Inhibiting ROCK1 Activity and Reducing the Epithelium-Mesenchymal Transdifferentiation in Type 1 Diabetic Rats by Ganlin Wu, Meirong Xu, Kui Xu, Yilan Hu

Get full text

Fluid flow in crustal fault zones with varying lengthwise thickness: application to the Margeride fault zone (French Massif Central) by Emmy Penhoët, Laurent Arbaret, Laurent Guillou-Frottier, Hugo Duwiquet, Charles Gumiaux, Mathieu Bellanger

“…Our numerical models will increase understanding of how fault width and geometry impact the geothermal potential of the Margeride fault zone and similar areas in crystalline basement.…”
Get full text

Genesis of the Daping Gold Deposit in the Middle Xuefeng Mountain Area, Southern China: Constraints from Geochemistry, Fluid Inclusion, and H-O-S Isotope by Xu Kong, Wen-Tian Mi, Xue-Yuan Qi, Shu-Jun Lǚ, Yu-Jun Dong, Jie Xin

“…Among them, the first stage and the second stage are the main gold mineralization stages. …”
Get full text

Effects of Self-Made Prescription Compound Rhodiola on the Ultrastructure of Podocytes in Rats with Type 2 Diabetic Nephropathy by Shaojing Yuan, Jie Liu, Zhenhua Sun, Lihua Meng, Jiying Zhu, Min Wang, Jie Su

Get full text

Study on the Genetic Differences in Reservoir Characteristics Based on the Bidirectional Provenance of the Yanchang Formation in the Jiyuan Area, Ordos Basin, China by Qiang Tong, Zhaohui Xia, Jixin Huang, Junchang Wu, Yusheng Wang, Zheng Meng, Chaoqian Zhang

“…Combined with the nature of the basement of the basin and the characteristics of the present structure, it is believed that the Jiyuan area is located in the central and western parts of the basin, spanning two first-level structural units, the Tianhuan Depression and the Yishan Ramp. …”
Get full text

Insights on the Permian tuff beds from the Saint-Affrique Basin (Massif Central, France): an integrated geochemical and geochronological study by Poujol, Marc, Mercuzot, Mathilde, Lopez, Michel, Bourquin, Sylvie, Bruguier, Olivier, Hallot, Erwan, Beccaletto, Laurent

“…The elemental geochemistry, the presence of inherited detrital zircons and the Hf signatures of the volcanic ones indicate the involvement of an old (Proterozoic and older) basement in the magma genesis; this crustal contribution becomes more prominent towards the top of the sedimentary succession.…”
Get full text

Explainable machine learning model for predicting decline in platelet count after interventional closure in children with patent ductus arteriosus by Song-Yue Zhang, Yi-Dong Zhang, Hao Li, Qiao-Yu Wang, Qiao-Fang Ye, Xun-Min Wang, Tian-He Xia, Yue-E He, Xing Rong, Ting-Ting Wu, Rong-Zhou Wu

“…DPC following the intervention is defined as a percentage DPC ≥25% [(baseline platelet count−nadir platelet count)/baseline platelet count]. …”
Get full text

Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial by Ling Zhao, Qifu Li, Yanan Wang, Jialei Feng, Xinghe Zhang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Taipin Guo

Get full text