hERGAT: predicting hERG blockers using graph attention mechanism through atom- and molecule-level interaction analyses by Dohyeon Lee, Sunyong Yoo

“…Abstract The human ether-a-go-go-related gene (hERG) channel plays a critical role in the electrical activity of the heart, and its blockers can cause serious cardiotoxic effects. Thus, screening for hERG channel blockers is a crucial step in the drug development process. …”
Get full text

Prevalence and associated factors of diabetes among adult populations of Hawassa town, southern Ethiopia: A community based cross-sectional study. by Getu Kassa Belete, Hlupheka Lawrence Sithole

“…This presents an opportunity to mitigate diabetes risk through public health measures, including avoiding khat chewing, promoting healthy diets, managing overweight and obesity, implementing community-based screening, enhancing health literacy, and integrating health information into daily life.…”
Get full text

The Validity Of 75gms OGTT For Detection Of GDM Keeping 100gms OGTT As Gold Standard by Shazia Mehreen, Muhammad Usman, Kashif Rauf, Saima Naz, Muhammad Abdul Rab Faisal Sultan, Muhammad Akram Randhawa

“…Conclusion: Results of this study showed that 75 gms OGTT is highly sensitive (83.02%) and specific (82.83%) for the detection/diagnosis of gestational DM. Advanced screening and diagnosis of gestational DM, and its effective treatment not only inhibit adverse perinatal and maternal outcomes but also save the lives of both child and mother from diabetes in future. …”
Get full text

A scoping review on U.S. undergraduate students with disabilities in STEM courses and STEM majors by Maura Borrego, Ariel Chasen, Hannah Chapman Tripp, Emily Landgren, Elisa Koolman

“…Results We considered extensive lists of disability types and diagnoses and concluded that “disability” as a search term best captured educational experiences rather than medical approaches. After screening nearly 9000 abstracts, we identified a final set of 409 dissertations, articles, conference papers, commentaries, briefs and news items. …”
Get full text

Central obesity is a burden even in normal weight adolescents of a non-metropolitan Indian City: A case for alarm and action for prevention and control by Tabassum Nawab, Zulfia Khan, Iqbal M. Khan, Mohammad A. Ansari

“…Conclusion: Central obesity among school-going adolescents of a non-metropolitan Indian city is alarmingly high and a burden even in one-fourth of normal weight adolescents. Screening for CO among adolescents by primary physicians, pediatricians, and through School Health Programme is recommended. …”
Get full text

The winding road to health: A systematic scoping review on the effect of geographical accessibility to health care on infectious diseases in low- and middle-income countries. by Fleur Hierink, Emelda A Okiro, Antoine Flahault, Nicolas Ray

“…After title and abstract screening 99 articles were read in full detail, from which 64 articles were selected, including 10 manually. …”
Get full text

Insulin Resistance Markers to Detect Nonalcoholic Fatty Liver Disease in a Male Hispanic Population by Maritza Pérez-Mayorga, Jose P. Lopez-Lopez, Maria A. Chacon-Manosalva, Maria G Castillo, Johanna Otero, Daniel Martinez-Bello, Diego Gomez-Arbelaez, Daniel D. Cohen, Patricio Lopez-Jaramillo

“…These markers should be used as the first step when screening patients for NAFLD.…”
Get full text

The COVID‐19 pandemic and associated declines in cancer incidence by race/ethnicity and census‐tract level SES, rurality, and persistent poverty status by Benmei Liu, Mandi Yu, Jeffrey Byrne, Katheen A. Cronin, Eric J. Feuer

“…Abstract Background The COVID‐19 pandemic had a significant impact on cancer screening and treatment, particularly in 2020. However, no single study has comprehensively analyzed its effects on cancer incidence and disparities among groups such as race/ethnicity, socioeconomic status (SES), persistent poverty (PP), and rurality. …”
Get full text

Predictors of Alcohol Use, Alcohol-Related Problems, and Substance Use Following Adolescent Metabolic and Bariatric Surgery by Gretchen E. White, PhD, Richard E. Boles, PhD, Anita P. Courcoulas, MD, MPH, Thomas H. Inge, MD, Susan Z. Yanovski, MD, Todd M. Jenkins, PhD, Meg H. Zeller, PhD

“…In this cohort, nearly half of those who underwent MBS as adolescents screened positive for alcohol use disorder, symptoms of alcohol-related harm, or alcohol-related problems within 8 years post-surgery. …”
Get full text

Integrating multiomics analysis and machine learning to refine the molecular subtyping and prognostic analysis of stomach adenocarcinoma by Miaodong Wang, Qin He, Zeshan Chen, Yijue Qin

“…In total, 10 hub genes (CES3, AHCYL2, APOD, EFEMP1, CYP1B1, ASPN, CPE, CLIP3, MAP1B, and DKK1) were screened and constructed the CMLS was significantly correlated with prognosis in patients with STAD and was an independent prognostic factor for patients with STAD. …”
Get full text

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling by Jennifer S. Ward, Karl J. Schreiber, John Tam, Ji-Young Youn, Roman A. Melnyk

“…Proximity-dependent biotinylation approaches offer an orthogonal approach to complement genetic screens. Here, we evaluate the potential of this method to identify host-toxin interactions on the cell surface and in the cytosol, where the toxin modifies essential host targets. …”
Get full text

Study on Clinicopathological Features and Risk Factors of Patients with Multiple Primary Breast Cancers and Thyroid Disease by Jie Li, Yonghong Liu, Jian Jin, Qingfeng Shi, Yanting Ji, Bo Zhang, Pengfei Hu

“…Therefore, clinical attention should be paid to the above factors in the process of clinical treatment, and early-risk screening should be performed to achieve the purpose of improving the prognosis to the greatest extent.…”
Get full text

Adherence to Dihydroartemisinin-Piperaquine Treatment among Patients with Uncomplicated Malaria in Northern Ghana by Abraham Rexford Oduro, Samuel Chatio, Paula Beeri, Thomas Anyorigiya, Rita Baiden, Philip Adongo, Patricia Akweongo

“…A total of 405 patients were screened; 299 were positive by rapid diagnostic testing and 216 by microscopy. …”
Get full text

Factors Influencing Background Parenchymal Enhancement in Breast Contrast-Enhanced Mammography: A Retrospective Study by Xue J, Qu T, Li Z, Shi B, Yang G, Rong X, Li Y, Lin G, Ping Y

“…Additionally, to characterize the dynamic changes in BPE during CEM.Methods: This retrospective study included 103 women who underwent CEM at a single institution between September 2019 and November 2021 for screening or diagnostic purposes. Menopausal status and menstrual cycle phase were recorded for all patients. …”
Get full text

Circulating miR-574–5p shows diagnostic and prognostic significance and regulates oxygen-glucose deprivation (OGD)-induced inflammatory activation of microglia by targeting ATP2B2... by Xia Yin, Chunlei Zhang

“…Background: Early screening is critical for the prevention of ischemic stroke. miR-574–5p was considered a promising biomarker for ischemic stroke but lacks direct confirmation. …”
Get full text

Acceptability of digital vending machines to improve access to sexual and reproductive health in Brighton, UK: a qualitative analysis by Jaime H Vera, Richard Cooper, Syra Dhillon, John Mear, Gillian Louise Dean, Rhys D Wenlock

“…Participants welcomed being able to access comprehensive sexual health screening through a VM. Five stakeholders completed the interview. …”
Get full text

Frontal Plane Knee Kinematics and Kinetics During Gait in Children and Youth with Achondroplasia—Correspondence with Static X-Ray Images and Relevance to Symptoms by Matthias Hösl, Antonia Thamm, Faik Kamel Afifi, Sean Nader

“…<b>Conclusions:</b> Three-dimensional gait analysis may be an objective screening method for dynamic knee alignment and stability and may complement radiography in monitoring ACH. …”
Get full text

HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis by Enhao Wang, Shazhou Li, Yang Li, Tao Zhou

“…Candidate genes were further screened using Gene Set Enrichment Analysis (GSEA) and Random Forest (RF) algorithms. …”
Get full text

Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial by Matthias Behrends, Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Aaron J Clark, Jacqueline M Leung

“…Lidocaine safety will be assessed with daily screening questionnaires and lidocaine plasma levels.Ethics and dissemination This study protocol has been approved by the ethics board at the University of California, San Francisco. …”
Get full text

Pretreatment attrition after rifampicin-resistant tuberculosis diagnosis with Xpert MTB/RIF or ultra in high TB burden countries: a systematic review and meta-analysis by Tom Decroo, Palmer Masumbe Netongo, Tinne Gils, Christelle Geneviève Jouego

“…Forest plots were generated using R software.Results Thirty eligible studies from 21 countries were identified after full-text screening and included in the meta-analysis. Most studies used routine programme data. …”
Get full text