Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Pr... by V. T. Ivashkin, O. S. Lyashenko, O. M. Drapkina, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, A. Yu. Baranovsky, O. V. Goloshchapov, N. V. Zheleznova, O. Yu. Zolnikova, I. L. Kliaritskaia, N. V. Korochanskaya, T. L. Lapina, I. V. Maev, R. V. Maslennikov, R. G. Myazin, P. V. Pavlov, M. V. Perekalina, N. A. Pisarenko, A. V. Povtoreyko, E. A. Poluektova, L. A. Sekretareva, A. V. Tkachev, Yu. M. Troshkina, A. S. Trukhmanov, A. I. Ulyanin, S. G. Filatova, V. V. Tsukanov, O. S. Shifrin

“…Additional diagnostic methods that are used according to indications and contribute to the assessment of severity include endoscopy of the colon and abdominal cavity imaging methods. Treatment should be initiated in cases of characteristic clinical presentation of C. difficile-associated disease and positive laboratory stool testing. …”
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Exploring the Role of Radiosurgery for Atypical Meningiomas: Addressing Suboptimal Local Control in High-Risk Patients by Sanjeev Sreenivasan, MD, MCh, Salem Najjar, BA, Daniel Ma, MD, Sabrina L. Begley, BS, Yen-Ruh Wuu, MD, Zaker Rana, MD, Emile Gogineni, DO, Michael Schulder, MD, Anuj Goenka, MD

“…We defined local failure as tumor recurrence wthin the prescription isodose line, marginal failure as recurrence within 5 mm but outside the prescription isodose line, and distant/regional failure as recurrence beyond 5 mm of the prescription isodose line but within 2 cm of the surgical cavity. Results: We identified 45 pathologically confirmed atypical meningiomas in 25 patients. …”
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First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems by Charlotte J. Neumann, Rokhsareh Mohammadzadeh, Pei Yee Woh, Tanja Kobal, Manuela-Raluca Pausan, Tejus Shinde, Victoria Haid, Polona Mertelj, Eva-Christine Weiss, Vassiliki Kolovetsiou-Kreiner, Alexander Mahnert, Christina Kumpitsch, Evelyn Jantscher-Krenn, Christine Moissl-Eichinger

“…We demonstrated the presence of archaea in the infant oral cavity and GIT microbiome from early infancy, with Methanobrevibacter being the predominant genus. …”
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Experimental Study of Modified Videman Method to Replicate Knee Osteoarthritis in Rabbits by Jing LIU, Qiaoxuan LIN, Liming LU, Zexing GUO, Hong LIU, Liangzhi ZHANG, Zhongbiao XIU

“…MRI showed increased fluid accumulation in the articular cavity, less smooth femoral condyle cartilage, and MOAKS score increased significantly (<italic>P</italic>&lt;0.05). …”
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Alterations in physicochemical parameters of water and the growth performance of juvenile beluga Huso huso in earthen ponds by Hashem Noferesti, Hojatollah Jafaryan, Rahman Patimar, Hossein Adineh

“…Introduction: Sturgeon, renowned for its prized caviar, plays a vital role in aquatic ecosystems and holds significant economic value. …”
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Testicular cell transplantation of neon tetra Paracheirodon innesi into common carp fry by , Alimuddin, Odang Carman, Sri Setyo Wulandari

“…The testicular cells were labeled with PKH-26 fluorescent dye, and then transplanted into the peritoneal cavity of seven, ten, and 14 days post hatching common carp fry. …”
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Effect of Electroacupuncture Preconditioning on Inflammatory Factors of Rabbits after Spinal Cord Ischemia-Reperfusion Injury by Mengli YAO, Xianghua CHEN, Zhaohui CHEN, Hai WANG

“…Objective:To observe the effects of electroacupuncture preconditioning on the pathological changes of spinal cord tissue and the expression of inflammatory cytokines such as interleukin-1β(IL-1β), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), interleukin-1 receptor antagonist(IL-1Rα)after spinal cord ischemia-reperfusion injury, and to explore the protective mechanism of electroacupuncture on spinal cord ischemia-reperfusion injury in rabbits.Methods:A total of twenty-four New Zealand white rabbits were randomly divided into the sham operation group, the model group and the electroacupuncture group according to the random number table method, with eight cases in each group.The model was made by Zivin method in the model group and the electroacupuncture group, the abdominal cavity was opened after intravenous anesthesia at ear margin, the abdominal aorta was exposed and temporarily clamped, and the rabbit model of spinal cord ischemia-reperfusion injury was established after ischemia for thirty minutes.The model preparation and experimental animal treatment of the sham operation group were the same as those of the model group, however, the dissection was fully exposed without clamping the abdominal aorta.At thirty minutes before the induction of rabbit spinal cord ischemia-reperfusion model, SDZ-II electroacupuncture instrument was used to acupuncture bilateral"Xuanzhong"and"Yanglingquan"acupoints in the electroacupuncture group, intervention for thirty minutes.All rabbits were killed after intervention for twelve hours, and the L2-5 segments of spinal cord tissue were captured.HE staining method was used to observe the pathological changes of spinal cord tissues in the three groups; Immunohistochemical method was used to observe the localization and content changes of IL-1β, IL-6 and TNF-α; Enzyme-linked immunosorbent assay(ELISA)was used to detect the contents of IL-1β, IL-6, TNF-α and IL-1Rα in serum before modeling and 4, 8, 12 hours after ischemia-reperfusion.Results:①HE staining results: compared with the sham operation group, the number of neurons in spinal cord tissue in the model group decreased, the color of nucleus and cytoplasm of cells became lighter, and the boundary of nuclear membrane was not clear.In severe cases, the nucleus dissolved or even nucleolus disappeared, there were transparent areas around cells, and axons showed different degrees of degeneration such as enlargement, swelling and disappearance; compared with the model group, the number of neurons in the electroacupuncture group increased, the structure of most neurons was clear, the atrophy degree of nucleolus and nucleus was light, only a small amount of cells became deformed and necrosis, the damage degree of cells were lighter, and the density of surviving neurons increased.②Immunohistochemistry results: compared with the sham operation group, the expressions of IL-1β, IL-6 and TNF-α of spinal cord tissue in the model group were significantly increased(<italic>P</italic>&lt;0.05);compared with the model group, the contents of IL-1β, IL-6 and TNF-α in the spinal cord of rabbits in the electroacupuncture group were significantly decreased(<italic>P</italic>&lt;0.05).③ELISA results: Before modeling, there was no significant difference in the three groups(<italic>P</italic>&gt;0.05);compared with before modeling, the expressions of IL-1β, IL-6, TNF-α, IL-1Rα in serum of the three groups increased in different degrees at 4, 8 and 12 h after ischemia-reperfusion, with significantly significance(<italic>P</italic>&lt;0.05);compared with the sham operation group at the same time, the expressions of IL-1β, IL-6, TNF-α and IL-1Rα in the model group increased significantly at 4, 8 and 12 h after reperfusion(<italic>P</italic>&lt;0.05);compared with the model group at the same time, the expression of IL-1β and TNF-α in the electroacupuncture group decreased significantly at 4, 8, 12 h after reperfusion(<italic>P</italic>&lt;0.05).Conclusion:Electroacupuncture pretreatment can effectively alleviate the pathological injury of spinal cord and has a good protective effect on spinal cord ischemia-reperfusion injury, which may be related to inhibit the expression of IL-1β, IL-6 and TNF-α and promote the expression of IL-1Rα.…”
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Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the SEER Database and an Institutional Registry by Wenjie Huang, Yu Zhang, Hao Li, Zhiying Liang, Shumin Zhou, Jie Pan, Hui Xie, Chao Luo, Shuqi Li, Guangying Ruan, Fei Ai, Yanfeng Chen

“…Conclusion The number of PLNs is a better predictor of overall tumor burden for OTSCC and could be a more accurate metric for survival estimation, which should be considered in future simplified pathological nodal staging for better risk stratification and decision‐making in subsites of the oral cavity.…”
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Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation by Yuri Lourenco-Gonzalez, Victor Fattori, Talita P. Domiciano, Ana C. Rossaneis, Sergio M. Borghi, Tiago H. Zaninelli, Catia C. F. Bernardy, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri

“…In the KO2 model, vinpocetine dose-dependently reduced pain-like behaviors (spontaneous pain and hyperalgesia), paw edema, and neutrophil and mononuclear cell recruitment to the paw skin (assessed by H&E staining, fluorescence, and enzymatic assays) and to the peritoneal cavity. Vinpocetine also restored tissue endogenous antioxidant ability and Nrf2 and Ho-1 mRNA expression and reduced superoxide anion production and gp91phox mRNA expression. …”
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Computational Fluid Dynamics Analysis of Nasal Airway Changes after Treatment with C-Expander by Wang Xiao, Siling Liu, Yanqin Lu, Lei Lei, Ning Liu, Xiaoping Shen, Yuhong He, Ousheng Liu

“…After expansion, the mean and standard deviation values of intercanine maxillary width (CMW) and intermolar maxillary width (MMW) increased from 35.75±2.48 mm and 54.20±3.17 mm to 37.87±2.26 mm (P<0.05) and 56.65±3.10 mm (P<0.05), respectively. The nasal cavity volume increased from 20320.00±3468.25 mm3 to 23134.70±3918.84 mm3 (P<0.05). …”
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Kajian patogenisitas bakteri Edwardsiella ictaluri pada ikan patin Pangasionodon hypophthalmus by Wiwik Susanti, Agustin Indrawati, Fachriyan H Pasaribu

“…Clinical signs and pathology anatomy of co-infection fish showed vertical swim, petechial hemorrhage in the skin, dropsy, ascites in the abdominal cavity, pale liver and the kidney was dark red. Histopathology showed hydropic degeneration, fatty degeneration, hemorrhage and necrosis in the liver, melano macrophage center (MMC) and necrosis in the kidneys, hemorrhage, and inflammatory cell infiltrates were also found in the kidneys and brain. …”
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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Materials and methods: Tumors from 16 patients with appendiceal neoplasms (15 AAs and 1 high-grade appendiceal neoplasm) were implanted into the flank and the peritoneal cavity of immunodeficient mice leading to the successful establishment of three AAPDX models. …”
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Application of gastrointestinal decompression method in determining tip position of the triple-lumen nasointestinal tube in critically ill patients (胃肠减压法在危重症患者三腔鼻肠管位置判断中的应用)... by WANG Zhimin (王志民), LI Xuejing (李雪晶), QIAO Shouang (乔首昂)

“…The patients were divided into an experimental group and a control group, where the experimental group used a gastrointestinal decompression device to connect the suction cavity with the opening in the stomach, and combined with auscultation and liquid reflux to measure pH value to determine whether the tip of the catheter passed through the pylorus; The control group only used auscultation and pH measurement with liquid reflux to determine whether the catheter position passed through the pylorus. …”
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Alleviating effect of intranasal zinc on symptoms of allergic rhinitis by Huadong Xu, PhD, Keming Tong, BS, Naruhito Iwasaki, MD, PhD, Nobutaka Ohgami, PhD, Akira Tazaki, PhD, Takumi Kagawa, MMSc, Yanjun Gao, MMSc, Delgama A.S.M. Nishadhi, MMSc, Akihito Harusato, MD, PhD, Masafumi Sakashita, MD, PhD, Kazuhiro Ogi, MD, PhD, Shigeharu Fujieda, MD, PhD, Shogo Sumiya, MD, Shinichi Iwasaki, MD, PhD, Masashi Kato, MD, PhD

“…Background: There is no information about the clinical implications and kinetics of zinc (Zn) in the nasal cavity, a center of allergic inflammation, and serum in subjects with allergic rhinitis (AR). …”
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Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factor... by Heloisa Arantes, Diego Chaves Rezende Morais, Maria Aparecida do Carmo Rego, Paula de Mendonça Batista, Cicera Pimenta Marcelino, Milena Falcão Almeida, Marion Coting Braga, Paula Cristina Pungartnik, Angelica Carreira dos Santos, Juliana Ominelli, Tharcísio Machado Coelho, Fernanda Bohns Pruski Ramos, Marcelo Salgado, Marina Kelner, Cristiano Guedes Duque, Daniel Oliveira Brito, Carlos Gil Moreira Ferreira, Pedro Rafael Martins De Marchi

“…The main site of the primary tumor was the oropharynx in the private sector and oral cavity in the public sector. Among patients with oropharyngeal cancer, only those in the private sector were tested for HPV, with the majority being positive. …”
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Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus‐enhanced Adhesive Hydrogels by Xiaotong Peng, Tao Wang, Bo Dai, Yiping Zhu, Mei Ji, Pusheng Yang, Jiaxin Zhang, Wenwen Liu, Yaxin Miao, Yonghang Liu, Shuo Wang, Jing Sun

“…Upon injection of FA‐EVs hybrid GS hydrogel into the uterine cavity, a protective hydrogel layer forms on the surface of injury sites and sustains the release of STAT1‐siRNA‐loaded FA‐EVs to curtail M1 macrophages generation through inhibiting STAT1 phosphorylation, resulting in reduction of myofibroblasts activation and collagen deposition. …”
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Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma by Amir Hossein Alizadeh Bahmani, Mahmoud I. Abdel-Aziz, Simone Hashimoto, Corinna Bang, Susanne Brandstetter, Paula Corcuera-Elosegui, Andre Franke, Mario Gorenjak, Susanne Harner, Parastoo Kheiroddin, Leyre López-Fernández, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Antoaneta A. Toncheva, Christine Wolff, Michael Kabesch, Aletta D. Kraneveld, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee, on behalf of the SysPharmPediA consortium

“…The difference in formulation and administration technique of these devices may influence oral cavity microbiota composition. We aimed to compare the saliva microbiome in children with moderate-to-severe asthma using ICS via MDIs versus DPIs. …”
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Preservation of cfRNA in cytological supernatants for cfDNA & cfRNA double detection in non‐small cell lung cancer patients by Yidan Ma, Yifei Wang, Lei He, Jun Du, Lin Li, Zhixin Bie, Yuanming Li, Xiaomao Xu, Wei Zhou, Xiaonan Wu, Li Yang, Jing Di, Chenyang Li, Xiaoguang Li, Dongge Liu, Zheng Wang

“…Abstract Backgroud Supernatants from various cytological samples, including body cavity effusion, sputum, bronchoalveolar lavage fluid (BALF), and needle aspiration, have been validated for detecting genetic alterations using cell‐free DNA (cfDNA) in patients with non‐small cell lung cancer (NSCLC). …”
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A Fully Integrated Orthodontic Aligner With Force Sensing Ability for Machine Learning‐Assisted Diagnosis by Hao Feng, Wenhao Song, Ruyi Li, Linxin Yang, Xiaoxuan Chen, Jiajun Guo, Xuan Liao, Lei Ni, Zhou Zhu, Junyu Chen, Xibo Pei, Yijun Li, Jian Wang

“…Nevertheless, continuous wireless monitoring within the oral cavity is challenging due to limitations in sampling and device size. …”
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Multidisciplinary, multicenter consensus for the care of patients affected with Sturge–Weber syndrome by May El Hachem, Andrea Diociaiuti, Angela Galeotti, Francesca Grussu, Elena Gusson, Alessandro Ferretti, Carlo Efisio Marras, Davide Vecchio, Simona Cappelletti, Mariasavina Severino, Carlo Gandolfo, Simone Reali, Rosa Longo, Carmen D’Amore, Lodovica Gariazzo, Federica Marraffa, Marta Luisa Ciofi Degli Atti, Maria Margherita Mancardi, and the Sturge-Weber Syndrome Multidisciplinary Group

“…Results Through a Delphi consensus methodology, 28 recommendations have been developed concerning (i) dermatological SWS manifestations and related treatment timing and modalities, (ii) neurological referral, diagnosis, pharmacological treatment of neurological signs and symptoms, neurosurgical indications, neurocognitive evaluation and related treatment, psychosocial support and patient follow-up, (iii) diagnosis of ophthalmological manifestations, medical and surgical treatment, and follow-up, (iv) maxillofacial surgical treatment, (v) oral cavity assessment, care and follow-up, and (vi) primary care paediatrician/general practitioner involvement. …”
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