Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade by Pedro Rocha, Rafael Bach, Laura Masfarré, Sharia Hernandez, Nil Navarro-Gorro, Adrià Rossell, Xavier Villanueva, Mario Giner, Ignacio Sanchéz, Miguel Galindo, Raúl Del Rey-Vergara, Albert Iñañez, Beatriz Sanchéz-Espiridion, Wei Lu, Ariadna Acedo-Terrades, Pau Berenguer-Molins, Albert Sánchez-Font, Roberto Chalela, Victor Curull, Álvaro Taus, Max Hardy-Werbin, Mark Sausen, Andrew Georgiadis, James White, Jennifer B Jackson, Laura Moliner, Sergi Clavé, Beatriz Bellosillo, Ana Rovira, Ignacio Wistuba, Luisa M Solis Soto, Júlia Perera-Bel, Edurne Arriola

“…Long-term (LTR) and short-term responders (STR) were defined as those with a response to ICB lasting more than 24 months or less than 6 months, respectively. …”
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Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series by Olav Dajani, Iain Philips, Ester Kristine Størkson, Trude R. Balstad, Leo R. Brown, Asta Bye, Ross Dolan, Christine Greil, Marianne Hjermstad, Gunnhild Jakobsen, Stein Kaasa, James McDonald, Inger Ottestad, Judith Sayers, Melanie Simpson, Mariana S. Sousa, Ola Magne Vagnildhaug, Michael S. Yule, Barry J. A. Laird, Richard J. E. Skipworth, Tora S. Solheim, Mark Stares, Jann Arends, the Cancer Cachexia Endpoints Working Group

“…This review examines oncological endpoints in CC clinical trials. Methods An electronic literature search of MEDLINE, Embase and Cochrane databases (1990–2023) was performed. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…To interrogate mechanisms of divergent immune responses in obese and non-obese patients, we examined the relationship among obesity status, clinical responses, and immune profiles from a diverse, pan-tumor cohort of patients treated with ICI-based therapy.Methods From June 2021 to March 2023, we prospectively collected serial peripheral blood samples from patients with advanced or metastatic solid tumors who received ICI as standard of care at Johns Hopkins. …”
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Coverage Estimation of Droplets Sprayed on Water-Sensitive Papers Based on Domain-Adaptive Segmentation by Dae-Hyun Lee, Baek-Gyeom Seong, Seung-Yun Baek, Chun-Gu Lee, Yeong-Ho Kang, Xiongzhe Han, Seung-Hwa Yu

“…Unmanned aerial spraying systems (UASSs) are widely used today for the effective control of pests affecting crops, and more advanced UASS techniques are now being developed. …”
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LC-Orbitrap-MS/MS Analysis of Chosen Glycation Products in Infant Formulas by Aleksandra Damasiewicz-Bodzek, Magdalena Szumska, Agnieszka Nowak, Sławomir Waligóra, Beata Pastuszka, Kamila Stopińska, Beata Janoszka

“…Therefore, the aim of this study was to develop a sensitive method to determine the content of AGEs in infant formulas. …”
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Unsupervised Cross-Regional and Cross-Year Adaptation by Climate Indicator Discrepancy for Crop Classification by Hengbin Wang, Yu Yao, Junyi Liu, Xindan Zhang, Yuanyuan Zhao, Shaoming Li, Zhe Liu, Xiaodong Zhang, Yelu Zeng

“…The experimental results show that ClimID-UDA achieves a more than 11% improvement in average accuracy and provides a viable option for large-scale cross-regional model transfer.…”
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Ribosome phenotypes for rapid classification of antibiotic-susceptible and resistant strains of Escherichia coli by Alison Farrar, Piers Turner, Hafez El Sayyed, Conor Feehily, Stelios Chatzimichail, Sammi Ta, Derrick Crook, Monique Andersson, Sarah Oakley, Lucinda Barrett, Christoffer Nellåker, Nicole Stoesser, Achillefs Kapanidis

“…Such accuracies correspond to the ability to differentiate susceptible and resistant samples with 99% confidence with just 2 cells, meaning that this method could eliminate lengthy culturing steps and could determine susceptibility with 30 min of antibiotic treatment. …”
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Synthesis and Characterization of Microcapsules as Fillers for Self-Healing Dental Composites by Maria Amalia Tăut, Marioara Moldovan, Miuţa Filip, Ioan Petean, Codruţa Saroşi, Stanca Cuc, Adrian Catalin Taut, Ioan Ardelean, Viorica Lazăr, Sorin Claudiu Man

“…HPLC demonstrates that the microcapsules formed at 800 rpm show a better control of liquid release than the heterogeneous ones obtained at a lower stirring speed. The centrifuged samples have rounded shapes, with dimensions between 80 and 800 nm, while the non-centrifuged samples are more uniform, with a spherical shape and dimensions of approximately 800 nm.…”
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Comparison Between the Wong Incision and Stromal Hydration of Corneal Incisions in Phacoemulsification by Raymond Nelson Regalado, MD, Jay Marianito Vicencio, MD, Ruben Lim Bon Siong, MD, Lee Verzosa, MD

“…Furthermore, the Wong incision showed a more stable wound seal against outward wound leakage in an in-vitro porcine model of clear corneal phacoemulsification.…”
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Soil water repellency of two disturbed soils contaminated with different agricultural microplastics tested under controlled laboratory conditions by Železnikar Špela, Drobne Damjana, Hočevar Matej, Noč Matic, Pintar Marina

“…The MP were milled to a uniform size range of some 10 to 300 μm and mixed with the soil samples. WDPT measurements were taken immediately after mixing and recorded for up to 60 s in order to find MP concentration levels at which strongly or more severely water repellency is inducted on soil samples. …”
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Recognition of Health Care Provider's Patient Safety Culture in Kurdistan/Iraq by Ismail Ahmed Ali, Shewaz Abdalrahman Hussein, Shelan Omar Ali, Fuaad Azad Muhamad

“…However, only two dimensions from 11 had reached positive response rate by respondents which include teamwork within Units (76.2%) and organizational learning (79%) dimensions, while the lowest dimension’s positivity include the frequency of reporting errors (4.6%). Furthermore, more than half (64.6%) of the study sample estimated the grade of patient safety as agreeable level, also only two of the respondents (1.5%) rated excellent grades for patient safety in their hospitals. …”
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Epidemiological Investigation, Isolation and Identification of Canine Distemper Virus in Parts of Henan and Hebei Provinces from 2019 to 2020 by Le ZHANG, Xiaohang YU, Yihe WANG, Jiamei YANG, Lili ZHAO, Ming DUAN

“…CDV occurs in animals of different ages, and young animals are more susceptible. A wild strain is isolated and identified from the diseased samples and named HB19-1. …”
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Examining predictors of perceived usefulness of learning management system from the perspectives of distance learning students: an application of the information success model by Amjid Khan, Arshad Hussain Afridi, Muhammad Kamal Khan, Pervaiz Ahmad

“…Next, a cross-sectional survey method was applied, and a close-ended 5-point Likert scale questionnaire was adopted to collect data from the target samples, yielding an 88.2% (n = 247) response rate. …”
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Utilization of Flaxseed Oil as Releasing For Some Natural Pigments and Antioxidants by Elsayed, A.A. Hendawy, Akram, M. M. Elanany, Ali, M. Bayomey

“…On the other hand, this feature causes a problem, making it susceptible to oxidation and rancidity more quickly. In this study, flaxseed oil obtained by the cold pressing method was enriched with dryer wastes of carrot, tomato, and olive leaves, where the oil was used directly as a releasing and diffusion medium for some bioactive compounds in these materials. …”
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Generation of Antigen Microarrays to Screen for Autoantibodies in Heart Failure and Heart Transplantation. by Andrzej Chruscinski, Flora Y Y Huang, Albert Nguyen, Jocelyn Lioe, Laura C Tumiati, Stella Kozuszko, Kathryn J Tinckam, Vivek Rao, Shannon E Dunn, Michael A Persinger, Gary A Levy, Heather J Ross

“…We first demonstrated that our antigen microarray technique displayed enhanced sensitivity to detect autoantibodies compared to the traditional ELISA method. We then piloted this technique using two sets of samples that were obtained at our institution. …”
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Ingenious wheat starch/Lepidium perfoliatum seed mucilage hybrid composite films: Synthesis, incorporating nanostructured Dy2Ce2O7 synthesized via an ultrasound-assisted approach a... by Sahar Zinatloo-Ajabshir, Alireza Yousefi, Mario Jekle, Fariborz Sharifianjazi

“…The composite films were produced through a casting method, combining these components to enhance the films' structural and functional properties. …”
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Further investigations into the accuracy of infrared radiofluorescence (IR-RF) and its inter-comparison with infrared photoluminescence (IRPL) dating by M. Sontag-González, M. K. Murari, M. Jain, M. Frouin, M. Fuchs

“…<p>Infrared radiofluorescence (IR-RF) is an alternative dating technique for potassium feldspar grains, offering a higher signal stability and based on a simpler underlying mechanism than more common luminescence dating approaches. However, its accuracy when tested on known-age samples has so far shown inconsistent results. …”
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Treatments of transarterial chemoembolization (TACE), stereotactic body radiotherapy (SBRT) and immunotherapy reshape the systemic tumor immune environment (STIE) in patients with... by Cai-Ning Zhao, Chi-Leung Chiang, Wan-Hang Keith Chiu, Sik-Kwan Kenneth Chan, Chun-Bong James Li, Wei-Wei Chen, Dan-Yang Zheng, Wen-Qi Chen, Ren Ji, Chung-Mau Lo, Salma K. Jabbour, Chi-Yan Albert Chan, Feng-Ming (Spring) Kong

“…This study aimed to exam the cells in the STIE, their changes after transarterial chemoembolisation (TACE), stereotactic body radiotherapy (SBRT), and immunotherapy (IO) and explore their significance in the treatment response of patients with unresectable HCC. Methods: This is a prospective biomarker study of patients with unresectable HCC. …”
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Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers by Katharina Remih, Franziska-Maria Hufnagel, Anna Sophie Karl, Valerie Durkalski-Mauldin, William Martens Lee, Constantine J. Karvellas, Zemin Su, Jody A. Rule, Petra Tomanová, Laura Krieg, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Frank Tacke, Sonja Luckhardt, Nicole Ziegler, Aimo Kannt, Bastian Engel, Richard Taubert, Robert John Fontana, Pavel Strnad

“…We performed untargeted and targeted serum proteomics to delineate processes occurring in adult patients with ALF and to identify potential biomarkers. Methods: Sera of 319 adult patients with ALF (∼50% acetaminophen [APAP]-related cases) were randomly selected from admission samples of the multicenter USA Acute Liver Failure Study Group consortium and subdivided into discovery/validation cohorts. …”
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Pre-assembled ECMO: Enhancing efficiency and reducing stress in refractory cardiac arrest care by Tharusan Thevathasan, Sonia Lech, Andreas Diefenbach, Elisa Bechthold, Tim Gaßmann, Sebastian Fester, Georg Girke, Wulf Knie, Benjamin T. Lukusa, Sebastian Kühn, Steffen Desch, Ulf Landmesser, Carsten Skurk

“…This pragmatic study thought to evaluate whether pre-assembled and pre-primed ECMO circuits (pre-primed group) maintain sterility over a 21-day period, expedite ECMO initiation in ECPR patients and alleviate the psychological burden on the ECPR team, compared to newly assembled and primed ECMO circuits (on-demand group). Methods: In a prospective manner, ECMO circuits were either pre-assembled and pre-primed under sterile conditions, maintained for 21 days with culture samples taken every seventh day, or newly assembled and primed during the acute emergency situation. …”
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