Germicidal Efficiency of 272 nm LED in Relation to the Hospital Strain of Klebsiella Pneumoniae by A. S. Kamrukov, T. V. Chernenkaya, L. Yu. Volodin, S. S. Petrikov, K. A. Popugaev, V. V. Bagrov, I. V. Bukhtiyarov, E. V. Zibarev, K. A. Semenov, V. I. Krylov

“…OF STUDY To evaluate the bactericidal efficacy of 272 nm LED radiation against hospital strains of Klebsiella pneumoniae bacteria characterized by multidrug resistance.Materials and Methods. The studies were carried out with an experimental sample of the LED apparatus for UV irradiation. …”
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Temporal Relationship Between Treatment Burden and Self-Care and Its Impact on Systolic Blood Pressure and Hypertension Control by Jia Z, Niu Z, Xie YJ, Su Z, Wang JJ, Hernandez J, Li YT, Wang HHX

“…The nature of such association opens the door for further primary care research on developing more sustainable hypertension management strategies.Keywords: treatment burden, self-care, systolic blood pressure, hypertension control, cross-lagged panel model, mediation analysis…”
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Dalpiciclib combined with pyrotinib and endocrine therapy in women with ER-positive, HER2-positive advanced breast cancer: A prospective, multicenter, single-arm, phase 2 trial. by Jian Zhang, Yanchun Meng, Biyun Wang, Xinhong Wu, Hongmei Zheng, Jing Hu, Wei Liu, Wenyan Chen, Leiping Wang, Jun Cao, Zhonghua Tao, Ting Li, Sujie Ni, Zhengyan Yu, Lichun Sun, Yun Wang, Qiang Peng, Song Wang, Xin Hu, Jianfei Wang, Yijia Wu, Xichun Hu

“…<h4>Background</h4>Combination of HER2-targeted therapy and endocrine therapy offers a more tolerable alternative to HER2-targeted chemotherapy regimens for estrogen receptor (ER)-positive, HER2-positive advanced breast cancer (ABC), but with compromised efficacy. …”
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Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1 by Jiali Wang, Yunlong Jia, Tianxu Liu, Xinyan Liu, Shuxian Yin, Jiaqi Chen, Xiaoqing Xu, Yi Zhang, Lihua Liu

“…This fundings lay a foundation for the development of BIN1-targeted therapies aimed at improving tumor immunogenicity and transforming immunologically “cold” NSCLC into a more responsive disease.…”
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Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial by Taylor B Thompson, Todd W Rice, Guy N Brock, Jonathan Peters, Elliott D Crouser, Matthew Exline, Sonal R Pannu, Jamie Zimmer, Jeffrey C Horowitz

“…Patients with an SpO2-SaO2 difference &gt;5% in either direction will be monitored but not assigned to either group. The sample size to determine efficacy is 1620 subjects, randomised over 60 weeks. …”
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Efficacy and safety of non-pharmacological therapies for primary insomnia: a network meta-analysis by Qin-hong Zhang, Qin-hong Zhang, Yong-jian Liu, Guanhu Yang, Guanhu Yang, Guanhu Yang, Mei-yi Zhu, Jia-hui Yang, Lun Li, Xiu-mei Yan, Qi-lin Liu, Jin-huan Yue, Xiao-ling Li, Yi-ming Li, Tian-cheng Xu, Fan Jiang

“…Future studies should use standardized measures for more specific insomnia assessment.…”
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Association between stroke and fracture and the mediating role of depression: a cross-sectional study from NHANES 2017 to 2020 by Yuqin Dan, Xuewen Pei, Danghan Xu, Zhaoxi Liu, Yuqi Wang, Meng Yin, Li Li, Gongchang Yu, Gongchang Yu

“…This study aims to clarify the intricate relationships among stroke, depressive symptoms, and fracture risk, potentially informing more holistic clinical strategies.MethodsUtilizing the most recent data from the National Health and Nutrition Examination Survey (NHANES, 2017 to 2020), this study encompassed 4,979 valid samples. …”
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Abstract 005: Outcomes of Heparin Induced Thrombocytopenia Type II in Aneurysmal Subarachnoid Hemorrhage Patients by Galadu Subah, Aiden K. Lui, Fangyi Lin, Rasheed Hosein‐Woodley, Anaz Uddin, Alexandria Naftchi, Sauson Soldozy, Chirag D. Gandhi, Fawaz Al‐Mufti

“…This study aims to investigate the incidence, complications, and outcomes of SAH patients who develop HIT. Methods ICD‐9‐CM and ICD‐10‐CM codes were used to query the National Inpatient Sample for patients with SAH between 2010 and 2019. …”
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Analysis of clinical features, prognosis and comprehensive therapeutic strategies in 261 patients with limited-stage esophageal small cell carcinoma by LIU Di, NI Jianjiao, ZHAO Kuaile, XIANG Jiaqing, ZHANG Zhen, ZHANG Junhua

“…Survival analysis was performed using the Kaplan-Meier method, and Cox regression was used to analyse factors related to prognosis. …”
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Oestrogen suppresses the adipogenesis of fibro/adipogenic progenitors through reactivating the METTL3–ESR1‐mediated loop in post‐menopausal females by Hao Zhou, Shujing Feng, Jinkui Cai, Xiexiang Shao, Siyuan Zhu, Han Zhou, Yongmin Cao, Ru Wang, Xingzuan Lin, Jianhua Wang

“…This study aimed to investigate the detailed mechanism underlying the excessive muscular fatty infiltration in postmenopausal females. Methods Supraspinatus muscle samples were collected from female patients with or without menopause, and from mice with or without ovariectomy (OVX), to evaluate muscular fatty infiltration and isolated FAPs. …”
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Diagnostic Performance of Clinical Metagenomic Next-Generation Sequencing for Suspected Central Nervous System Infections in a Municipal Hospital: A Retrospective Study in China by Wang H, Zhao J, Wang X, Li M, Hu T, Xu H, Dong M, He W, Che Z

“…With technical improvements for mNGS sample processing to increase throughput and reduce costs, clinicians may use mNGS more widely in municipal hospital laboratories.Keywords: CNS infections, mNGS, CSF, conventional microbiological tests, CMT…”
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Real-time blood gas management: evaluating quantum perfusion system’s accuracy against a standard blood gas analysis in CPB by Bahi Hyasat, Amjad Bani Hani, Ali Al Saraireh, Rana Al Kirmeen, Dina Sabha, Saif Yamin, Islam Massad, Ayman Hammoudeh

“…This non-inferiority study evaluates the Quantum Perfusion System by Spectrum Medical, which features continuous online blood gas monitoring through Quantum workstation (QWS) and Quantum ventilation module (QVM) without the use of cuvettes, against the standard blood gas analysis (BGA) analyzer to assess real-time clinical accuracy. Methods This retrospective study included a sample of 40 patients, monitored continuously with the QPS and compared at intervals against standard BGA measurements. …”
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Glomerular Filtration Rate, its Association with Risk Factors and Cardiovascular Diseases. The Results of the ESSE-RF-2 Study by S. A. Shalnova, S. A. Maksimov, Yu. A. Balanova, S. E. Evstifeeva, A. E. Imaeva, A. V. Kapustina, G. A. Muromtseva, V. I. Tarasov, I. A. Viktorova, A. N. Redko, N. N. Prishchepa, S. S. Yakushin, O. M. Drapkina

“…The average GFR level in the total sample was 97.8±16.6 ml/min/1.73 m2 ; 29.0% of individuals had an initial decrease in GFR, 1.6% had a reduced GFR. …”
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Metagenomic Analysis Identifies Sex‐Related Gut Microbial Functions and Bacterial Taxa Associated With Skeletal Muscle Mass by Hang A. Park, Joohon Sung, Yoosoo Chang, Seungho Ryu, Kyung Jae Yoon, Hyung‐Lae Kim, Han‐Na Kim

“…ABSTRACT Background This study aimed to explore the association between gut microbiota functional profiles and skeletal muscle mass, focusing on sex‐specific differences in a population under 65 years of age. Methods Stool samples from participants were analysed using metagenomic shotgun sequencing. …”
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Replacement of fetal calf serum by human serum as supplementation for human fibroblast culture Substituição de soro bovino fetal por soro humano como suplemento para cultura de fib... by César Isaac, Cristiana Nicoli de Mattos, Francinni Mambrine Pires do Rêgo, Larissa Nocchi Cardim, Silvana Cereijido Altran, André Oliveira Paggiaro, Rafael Mamoru Carneiro Tutihashi, Mônica Beatriz Mathor, Marcus Castro Ferreira

“…This supplementation is far from ideal as sample quality varies from batch to batch and the composition of FCS is not completely known. …”
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Mortality and Graft Failure With Medical Management Alone Versus Revascularization After Coronary Angiography Among Kidney Transplant Recipients: A Population-Based Study by Labib I. Faruque, Robert R. Quinn, Pietro Ravani, Tyrone G. Harrison, Brenda Hemmelgarn, Stephen Wilton, Alix Clarke, Matthew T. James, Ngan N. Lam

“…Conclusions: In kidney transplant recipients undergoing coronary angiography, the rate of mortality was more than double that of graft failure, regardless of post-angiography management of coronary artery disease. …”
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Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells by P. Zhou, X. Ma, S. Scalia, D. Toskic, X. Wu, T. Fogaren, Nancy Coady Lyons, Luis del Pozo-Yauner, R.L. Comenzo

“…With IP in vivo implants after 2 weeks more dimers were seen than in short term cultures in vitro. …”
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Efficacy and safety of acupuncture for the treatment of insomnia in breast cancer patients: A systematic review and meta-analysis by Yupeng Weng, Xuanrong Ren, Zheyan Zu, Lu Xiao, Min Chen

“…Owing to the limited number of studies included, potential biases of heterogeneous interventions, and methodological weaknesses of long-term follow-up, more high-quality RCTs with large sample sizes should be conducted to evaluate acupuncture treatment.…”
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M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer by Eva M Garrido-Martin, Toby W P Mellows, James Clarke, Anusha-Preethi Ganesan, Oliver Wood, Angelica Cazaly, Gregory Seumois, Serena J Chee, Aiman Alzetani, Emma V King, Gareth Thomas, Peter S Friedmann, Pandurangan Vijayanand, Tilman Sanchez-Elsner

“…We aimed to investigate the interrelationship of these TAM populations to establish how they modulate the efficacy of the adaptive immune system in early lung cancer.Methods Macrophages from matched lung (non-tumor-associated macrophages (NTAMs)) and tumor samples (TAMs) from resected lung cancers were assessed by bulk and single-cell transcriptomic analysis. …”
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Problems of adherence to therapy in patients with gout in real clinical practice by Elena V. Shchemeleva, Elena A. Skorodumova

“…To evaluate treatment adherence among patients with gout. Materials and methods. One hundred and thirty-eight patients with gout were examined in the Dzhanelidze Saint Petersburg Research Institute of Emergency Care; 89.9% of them are men and 10.1% are women. …”
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