The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey by Juan Yang, Mark Jit, Kathy S. Leung, Ya-ming Zheng, Lu-zhao Feng, Li-ping Wang, Eric H. Y. Lau, Joseph T. Wu, Hong-jie Yu

“…Conclusion The economic burden of influenza-associated outpatient and inpatient visits in China is substantial, particularly for young children, the elderly, and patients with underlying medical conditions. More widespread influenza vaccination would likely alleviate the economic burden of patients. …”
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Comprehensive analysis of single-cell and bulk RNA sequencing data unveils antigen-presenting and processing fibroblasts and establishes a predictive model in gastric cancer by Chenggang Zhang, Fangqi Chen, Jie Li, Yixuan He, Juan Sun, Zicheng Zheng, Guanmo Liu, Yihua Wang, Weiming Kang, Xin Ye

“…Results Compared to non-APPFs, APPFs exhibited more interactions with myeloid cells, endothelial cells, and lymphocytes via MHC-II signaling network. …”
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Rise and dine: unraveling breakfast habits among tenth graders - a cross-sectional study among 646 students in the City of Witten, Germany (GeWIT study) by Mohamed Salah Anwar Mohamed, Anwar Mohamed, Nessia Rachma Dianti, Anne-Lisa Heye, Klaus Völkel, Judith Tillmann, Oxana Klassen, Paul Wiesheu, Klaus Weckbecker, Eva Münster

“…Statistical analyses were conducted using SPSS, including chi-square tests and multivariable logistic regression to estimate odds ratios and identify predictors of breakfast skipping. Results In a sample of 646 students (response rate 98.3%), 50.6% (n = 327) reported skipping breakfast before school on the day of the survey. …”
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Sex differences in burnout and work-family conflict among Chinese emergency nurses: a cross-sectional study by Dongmei Diao, Dongmei Diao, Dongmei Diao, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Luying Zhong, Luying Zhong, Luying Zhong, Hao Zhang, Hao Zhang, Hao Zhang, Jianna Zhang, Jianna Zhang, Jianna Zhang

“…This study aimed to apply sex-specific analyses to investigate the associations between dimensions of burnout and work–family role behavior conflict among Chinese emergency department nurses.MethodsThis was a cross-sectional research. A questionnaire comprising items on demographic characteristics, work–family role behavior conflict, and burnout information, was distributed among emergency department nurses from 30 tertiary hospitals across mainland China, between December 26, 2023, and January 18, 2024.ResultsThis study's sample comprised 1,540 nurses. …”
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eCBT-I dialogue system: a comparative evaluation of large language models and adaptation strategies for insomnia treatment by Xueying Bao, Xingyu Zhu, Dongren Yang, Hao Lou, Ruoyun Wang, Yutong Wu, Wenhui Li, Yu Xia, Li Zeng, Yingying Pan, Xiqin Wang, Xian Zhang, Cheng Ling, Youhui Ling, Yan Zhang, Qi Zhao, Mei Yang

“…The systematic fine-tuning method selection process and the confirmation of the optimal model not only improve the adaptability of the large language model in the CBT-I task, but also provide a useful paradigm for AI applications in medical subfields with resource constraints and difficulties in data collection, laying a solid foundation for more accurate and efficient digital CBT-I clinical practice in the future.…”
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Comparison of treatment planning for stereotactic radiosurgery and stereotactic body radiation therapy techniques with 2.5mm and 5mm multileaf collimator (MLC): A pilot study [vers... by Senthil Manikandan, Krishna Sharan, Shirley Lewis, Suresh Sukumar, Umesh V, Srinidhi G Chandraguthi, Shreekripa Rao, Rechal Nisha Dsouza, Sneha Ravichandran

“…However, the study must be extended further with more samples and multiple comparison parameters. …”
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Changing trends in oral mucosal diseases in China (2016–2024): a cross-sectional study of 316,166 patients with focus on COVID-19 impact and use of chinese patent medicines by Peiru Zhou, Xu Zhang, Yifan Chen, Jiakun Fang, Yanhong Meng, Furong Yang, Pan Wei, Hong Hua

“…The study found significant differences in disease patterns among age groups, with oral potentially malignant disorders like oral lichen planus becoming more prevalent in older populations. CPMs were used by 52.29% of patients, with similar proportions using topical and systemic treatments. …”
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Prevalence and transmission of HIV-1 drug resistance mutations among patients with treatment failure and newly diagnosed people in Liangshan Prefecture, China, in 2021–2023 by Rong Pei, Rong Pei, Yulian Zhang, Chunnong Jike, Gang Yu, Ling Su, Ju Wang, Lin Xiao, Yubing Wang, Maogang Shen, Jiayi Liao, Yifei Zheng, Joris Hemelaar

“…A deeper understanding of HIV-1 drug resistance can lead to improvements in current treatment policies.MethodsWe conducted an analysis of HIV drug resistance mutations (DRMs) among patients with treatment failure and people newly diagnosed with HIV in Liangshan Prefecture. 8,523 blood samples were collected from people living with HIV with treatment failure and newly diagnosed individuals in all 15 counties and two cities in Liangshan Prefecture between 2021 and 2023.Results43.0% of patients with treatment failure acquired HIV through the heterosexual route, followed by injecting drug use (38.7%), while newly diagnosed individuals mainly acquired HIV through the heterosexual route (86.7%). 95.6% of patients with treatment failure were infected with HIV-1 variant CRF07_BC and 2.7% with CRF08_BC, and newly diagnosed individuals were also main infected with HIV-1 variant CRF07_BC (90.9), followed by CRF08_BC (4.0%) and CRF01_AE (2.5%). …”
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A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population by Arno R. Bourgonje, Martin F. Bourgonje, Sacha la Bastide-van Gemert, Tom Nilsen, Clara Hidden, Ron T. Gansevoort, Douwe J. Mulder, Jan-Luuk Hillebrands, Stephan J.L. Bakker, Robin P.F. Dullaart, Harry van Goor, Amaal E. Abdulle

“…This association is mitigated after adjustment for hs-CRP, and more pronounced with new-onset CKD defined by UAE.…”
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Molecular testing for cytologically suspicious and malignant (Bethesda V and VI) thyroid nodules to optimize the extent of surgical intervention: a retrospective chart review by Jessica Hier, Galit Avior, Marc Pusztaszeri, Joshua R. Krasner, Noura Alyouha, Veronique-Isabelle Forest, Michael P. Hier, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Tamilia, Richard J. Payne

“…Prospective studies with larger sample sizes are required to further investigate this finding. …”
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Hip fractures in Chinese TikTok (Douyin) short videos: an analysis of information quality, content and user comment attitudes by Zhuoxin Li, Zhuoxin Li, Yashi Lin, Yashi Lin, Kairou Zhang, Kairou Zhang, Ran Li, Ran Li, Mei Ju, Yanhua Chen, Jing Fu, Ruiyu Huang, Ling Zhu, Junjun Sun, Yanxia Guo, Min Gao, Yue Hu, Gang Liu, Baolu Zhang

“…While numerous Douyin videos address hip fracture, their information quality and factors affecting user comment attitudes remain uncertain.ObjectiveThis study aims to analyze the content, information quality, and user comment attitudes of videos depicting hip fractures on Chinese TikTok (Douyin).MethodsThe search term “hip fracture” was used on Douyin, which resulted in 170 samples being included. …”
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Characterization of intrahepatic B cells in acute-on-chronic liver failure by Yudong Zhao, Wei He, Chenchen Wang, Nana Cui, Changjie Yang, Zhengrui You, Bisheng Shi, Lei Xia, Xiaosong Chen

“…Previous reports were only based on immunophenotyping of peripheral blood samples. Here, we aim to dissect liver-infiltrating B-cell subpopulation in ACLF.MethodsPaired liver perfusate and peripheral blood were freshly collected from healthy living donors and recipients during liver transplantation. …”
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BRCA1 promoter hypermethylation is not associated with germline variants in Polish breast cancer patients by Karolina Prajzendanc, Paweł Domagała, Jolanta Hybiak, Wojciech Kluźniak, Cezary Cybulski, Katarzyna Białkowska, Alicja Ogrodniczak, Janusz Ryś, Aleksandra Sejda, Marek Szwiec, Joanna Tomiczek-Szwiec, Tomasz Kluz, Roksana Dwornik, Dagmara Cylwik, Jacek Gronwald, Jan Lubiński, Anna Jakubowska

“…Among BRCA1 PV carriers, the GG genotype was significantly more frequent, while the CC genotype was 10 times less common compared to non-carriers (p = 0.003). …”
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Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics by Alexander Tristancho-Baró, Ana Isabel López-Calleja, Ana Milagro, Mónica Ariza, Víctor Viñeta, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, David Badenas-Alzugaray, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…This study aims to investigate the genomic determinants associated with cefiderocol resistance in CPE isolates of human origin. <b>Methods</b>: Comparative genomic analyses were conducted between cefiderocol-susceptible and -resistant CPE isolates recovered from human clinical and epidemiological samples at a tertiary care hospital. …”
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Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism by Mai Han, Gang Cui, Yan Zhao, Xianbo Zuo, Xiaoxue Wang, Xin Zhang, Na Mi, Jiangli Jin, Chunyan Xiao, Jing Wang, Wei Wu, Yajuan Li, Jintong Li

“…Differences in system exposure were more pronounced during the terminal elimination phase than the early stage of GP1707D07 metabolism. …”
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Comparative Analysis of Long-Term Measles Immune Response After Natural Infection and Routine Vaccination in China by Sihong Zhao, Qianli Wang, Juan Yang, Qiaohong Liao, Juanjuan Zhang, Xiaoyu Zhou, Jiaxin Zhou, Zeyao Zhao, Yuxia Liang, Junteng Luo, Jingting Cai, Yanpeng Wu, Wei Wang, Hongjie Yu

“…In this study, we aimed to determine the distinct dynamics of vaccine-induced and naturally acquired antibodies, with specific focus on difference in vaccine-induced antibody responses across different birth cohorts. <b>Methods:</b> Based on two cohorts and one cross-sectional study conducted in Anhua County, Hunan Province, China, serum samples from children who followed China’s routine measles vaccination schedule (i.e., two-dose schedule at 8/18 months) and adults who acquired immunity through natural infection were tested for measles IgG antibodies using an enzyme-linked immunosorbent assay. …”
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Comparison of two combined drug therapy regimens for renal damage in patients with metastatic kidney cancer after previously performed unilateral nephrectomy by K. S. Titov, M. V. Epifanova, A. A. Alimov, O. Yu. Nesterova, E. V. Shutov, S. S. Lebedev, G. M. Zapirov

“…Combined immunotherapy with ipilimumab + nivolumab in patients with metastatic RCC in patients with a single kidney has a more pronounced deterioration in renal function compared with combined immunotherapy with pembrolizumab + axitinib.…”
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Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes by Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng

“…While these subtypes share clinical, genetic, and pathological features, their transcriptomic similarities and differences remain poorly understood. Methods We applied single-nucleus RNA-sequencing (snRNA-seq) to prefrontal cortex samples from individuals with non-cognitive impairment control (NCI), and dementia subtypes (AD, DLB, and PDD) to investigate cell type-specific gene expression patterns and pathways underlying pathological similarities and differences across dementia subtypes. …”
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HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study by Irma Wati Ngadimon, Devi Mohan, Mohd Farooq Shaikh, Ching Soong Khoo, Hui Jan Tan, Yu Mey Lee, Nor Syazwani Chamhuri, Farizal Fadzil, Nursyazwana Zolkafli, Alina Arulsamy, Jegan Thanabalan, Angel Aledo‐Serrano, Wing Loong Cheong

“…This prospective longitudinal study investigated whether serum HMGB1 levels are associated with PTE development and cognitive decline over 12 months post‐TBI. Methods Serum samples were collected from 41 TBI patients, including mild and moderate to severe, at baseline, 6, and 12 months following TBI. …”
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Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk by Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma

“…Plasma samples underwent untargeted metabolomic and lipidomic profiling using liquid chromatography–mass spectrometry (LC–MS). …”
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