Clinical and fertility outcomes in lynch syndrome patients with endometrial carcinoma or endometrial Intraepthelial neoplasia treated with fertility sparing management by Hadley W. Reid, Alexandria N. Young, Sophia H. Yin, Isabela Covelli Velez, Mary Kathryn Abel, David L. Kolin, Elizabeth S. Ginsburg, Matthew B. Yurgelun, Colleen Feltmate, Jessica D. St Laurent

“…Progesterone response rates appear to be lower than those in sporadic cases, though similar clinical and histologic factors (age, BMI, and p53 expression pattern) may predict disease regression and fertility outcomes. A larger sample and standardized treatment paradigm are needed to provide more evidence on fertility sparing management for LS patients.…”
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Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma by Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Miao Dang, Huanqin Zhang, Weizheng Zhou, Xu Guo, Jinliang Xing

“…Methods Capture-based mtDNA sequencing was carried out in plasma cell-free DNA samples from 1168 participants, including 571 patients with HCC, 301 patients with chronic hepatitis B or liver cirrhosis (CHB/LC) and 296 healthy controls (HC). …”
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Inflation expectations proprieties during the war: The case of Ukraine by Szyszko Magdalena, Rutkowska Aleksandra, Motuzka Olena

“…Its novel aspect also concerns the method applied—standard procedures cannot be used for this sample length.…”
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Endotracheal Intubation Done in Field Conditions of Restrained Space by S. Gavrilovic, S. Milic, F. Dujmovic, Z. Fiser

“…Maximum performing time for the sample was 15 seconds. We consider that, using this method, the endo-tracheal intubation can be realized in all conditions up to now thought untouchable. …”
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Socio-economic inequalities in minimum dietary diversity among Ethiopian children aged 6–23 months: a decomposition analysis by Nigusu Worku, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Mihret Getnet, Wubshet Debebe Negash, Wubshet Debebe Negash, Adina Yeshambel Belay, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Melak Jejaw, Kaleb Assegid Demissie, Misganaw Guadie Tiruneh, Asebe Hagos

“…BackgroundGlobally, inappropriate feeding practices account for more than two-thirds of all cases of child mortality during the first 2 years of a child’s life. …”
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Genetic Alterations in Chromatin Regulatory Genes in Upper Tract Urothelial Carcinoma and Urothelial Bladder Cancer by Shuo Wang, Xuzhi Yan, Weihua Lan, Yapeng Wang, Ze Wang, Dali Tong, Yao Zhang, Qiang Ran, Haoyang Li, Junhao Jin, Haiyang Xiao, Jing Xu, Qian Yan, Dianzheng Zhang, Qiang Ma, Hualiang Xiao, Jun Qin, Luofu Wang, Jun Jiang, Qiuli Liu

“…Results of tissue microarray of 78 muscle‐invasive bladder cancer (MIBC) samples were used as prognostic factors of different subtypes of MIBC. …”
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Randomized clinical trial of peer integrated collaborative care intervention after physical injury by Eileen M Bulger, Peter Thomas, Jin Wang, Lauren K Whiteside, Ronald Maier, Allison Engstrom, Douglas F Zatzick, Joan Russo, Patrick Heagerty, Khadija Abu, Tanya Knutzen, Jake Shoyer, Navneet Birk, Cristina Conde, Paige Ryan, Matt Iles-Shih, Lawrence Palinkas

“…Objectives The goal of the current study was to assess the effectiveness of a peer integrated collaborative care intervention for postinjury outcomes.Methods Injury survivors ≥18 years of age were screened for post-traumatic stress disorder (PTSD) symptoms and severe postinjury concerns; screen-positive patients were randomized to the intervention versus enhanced usual care control conditions. …”
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Multidrug-resistant Organisms Among Patients in COVID-19 Wards Compared to Non-COVID-19 Wards in Indonesian Hospitals by Shod A. Zulkarnain, Radhitya Abdullah, Ardellia G. Pradnyadevati, Muhammad FR Roesianto, Oktavia K. Putri, Raden BR Padmosudiro, Ryan M. Ramadhan, Susanthy Djajalaksana, Dewi Indiastari, Wiwi Jaya, Arie Z. Fathoni, Irene Ratridewi, Sofiana A. Sahara, Etty F. Ruliatna, Anne Voor in ’t holt, Juliette A. Severin, Nurima DP Hastuti, Sanarto Santoso, Dewi Santosaningsih

“…Patients with MDROs were more frequently detected in non-COVID-19 wards compared to COVID-19 wards in both hospitals (SAH: 19.8%/15.3%, p=0.001; NWH: 5%/2.2%, p=0.030). …”
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Changes in retail cigarette price after tax increase: Findings from the 2018–2020 ITC Vietnam surveys by Thi Phuong Thao Tran, Thi Ngoc Phuong Nguyen, Thu Trang Vu, Thai Uyen Tran, Don Nguyen, Thi Hai Phan, Son Dao The, Min Kyung Lim, Anne C. K. Quah, Jin-Kyoung Oh, Hoang Van Minh

“…International brands were substantially more expensive than domestic brands, but prices for both remained constant across all waves. …”
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Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis by Roman G. Vasyliev, Olga S. Gubar, Inna M. Gordiienko, Larisa S. Litvinova, Anzhela E. Rodnichenko, Valeria V. Shupletsova, Alona V. Zlatska, Kristina A. Yurova, Natalia M. Todosenko, Veronika E. Khadzhynova, Mariia V. Shulha, Svitlana N. Novikova, Dmytro O. Zubov

“…The aim of this study was to compare the biological properties of HF- and SD-derived NCSCs after their large-scale expansion. Methods. The conventional explant method was used to obtain HF NCSCs. …”
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Clinical research report on Chinese patent medicines and classic traditional Chinese medicine prescriptions (2023) by Xiaolei Wu, Haiyin Hu, Yuetong Wang, Alice Josephine Fauci, Yazi Zhang, Wenting Song, Fengwen Yang, Boli Zhang, Junhua Zhang, Zhaochen Ji

“…However, quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.…”
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Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, an... by Emma Naomi James, Muy-Teck Teh, Yufeng Li, Christine Wagner-Bock, Zahra Falah Al-Khateeb, Lee Peng Karen-Ng, Terry Roberts, Linnea Synchyshyn, Amy Lewis, Ana O’Loghlen, Andrew Silver, Adina Teodora Michael-Titus, Mark Bennett, Jacob Guy Bundy, Maria Elzbieta Mycielska, Eric Kenneth Parkinson

“…Membrane transporters in similar human fibroblasts cultures were measured by western blotting and more extensively by reverse transcription and quantitative polymerase chain reaction (qPCR) in human fibroblasts, keratinocytes, myoblasts, adipocytes and astrocytes. …”
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Loneliness among dementia caregivers: evaluation of the psychometric properties and cutoff score of the Three-item UCLA Loneliness Scale by Amira Mohammed Ali, Saeed A. Al-Dossary, Carlos Laranjeira, Carlos Laranjeira, Carlos Laranjeira, Abeer Selim, Abeer Selim, Abeer Selim, Souheil Hallit, Souheil Hallit, Souheil Hallit, Abdulmajeed A. Alkhamees, Aljawharah Fahad Aljubilah, Musheer A. Aljaberi, Ebtesam Abdullah Alzeiby, Annamaria Pakai, Haitham Khatatbeh

“…This instrumental study aimed to examine the factor structure, reliability, convergent validity, criterion validity, and cutoff scores of a short loneliness measure: the Three-Item version of the University of California, Los Angeles, Loneliness Scale (UCLALS3) in a convenience sample of dementia family caregivers (N = 571, mean age = 53 ±12 years, 81.6% females).MethodsExploratory and confirmatory factor analyses were used to examine the structure of the UCLALS3 while receiver-operating characteristic (ROC) curve, including caregiving burden and emotional distress as outcomes, was used to examine its cutoff.ResultsOne factor accounted for 79.0% of the variance in the UCLALS3; it was perfectly invariant across genders but variant at the metric level across countries. …”
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Changes in lymphocyte subsets pre- and post-particle radiotherapy in head and neck bone and soft tissue tumors by Haojiong Zhang, Haojiong Zhang, Haojiong Zhang, Jing Gao, Jing Gao, Jing Gao, Jiyi Hu, Jiyi Hu, Jiyi Hu, Weixu Hu, Weixu Hu, Weixu Hu, Qingting Huang, Qingting Huang, Qingting Huang, Lin Kong, Lin Kong, Lin Kong

“…Treatment modalities included proton or carbon-ion radiotherapy, with or without chemotherapy, targeted therapy, or immunotherapy. Peripheral blood samples were collected both before and after the completion of radiotherapy. …”
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Home blood pressure during night-time sleep – a feasible treatment target for patients with hypertension: a proof-of-concept randomised controlled trial by Eric Kam-Pui Lee, Shuqi Wang, Benjamin Hon-Kei Yip, Esther Yee-Tak Yu, Shuk-Yun Leung, Jinghao Han, Yue-Kwan Choi, Kam-Fai Chow, Wai-Ho Chung, Byran P. Yan, Anastasia S. Mihailidou, Richard J. McManus, Samuel Yeung-Shan Wong

“…Although titrating medications according to nighttime HBPM readings may improve nighttime BP, the small sample size limited statistical significance and the single-centre design restricted generalizability. …”
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Randomised controlled trial of perinatal vitamin D supplementation to prevent early-onset acute respiratory infections among Australian First Nations children: the ‘D-Kids’ study p... by Anne B Chang, Peter S Morris, Tom Snelling, Paul V Licciardi, Michael J Binks, David Simon, E Kim Mulholland, Adrienne Kirby, Heather D'Antoine, Amy S Bleakley, Susan J Pizzutto, Michelle Lamberth, Verity Powell, Jane Nelson, Geetha Rathnayake, Amanda J Leach

“…While ARI-related mortality is low in Australia, First Nations infants are hospitalised with ARIs up to nine times more often than their non-First Nations counterparts. …”
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Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol by Andreas Obermair, Monika Janda, Sandra C Hayes, Elizabeth Eakin, Marcelo Nascimento, Dimitrios Vagenas, Jermaine Coward, Louisa G Gordon, Catherine Shannon, James Nicklin, Jeffrey Goh, Vanessa L Beesley, Penny Webb, Merran Williams, Sheree Rye, Rosalind R Spence, Helene O’Neill, Melissa J Newton, Sara Baniahmadi, Andrea Garret

“…However, these recommendations are derived from research typically involving cohorts with more common cancers and relatively good prognosis, such as breast and prostate. …”
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Long-read sequencing identifies copy-specific markers of SMN gene conversion in spinal muscular atrophy by M. M. Zwartkruis, M. G. Elferink, D. Gommers, I. Signoria, L. Blasco-Pérez, M. Costa-Roger, J. van der Sel, I. J. Renkens, J. W. Green, J. V. Kortooms, C. Vermeulen, R. Straver, H. W. M. van Deutekom, J. H. Veldink, F. Asselman, E. F. Tizzano, R. I. Wadman, W. L. van der Pol, G. W. van Haaften, E. J. N. Groen

“…Progress has thus far been limited by methodological constraints. Methods To address this, we developed HapSMA, a method to perform polyploid phasing of the SMN locus to enable copy-specific analysis of SMN and its surrounding genes. …”
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Effect of a Pleuran-Based Supplement on Salivary IgA Secretion in Children With Recurrent Respiratory Infections by Peter Kunc, MD, PhD, Jaroslav Fabry, MD, PhD, Michaela Matiscakova, MD, Katarina Istvankova, DVM, Zuzana Diamant, MD, PhD, Juraj Majtan, PhD, DSc, Milos Jesenak, MD, PhD

“…This study aimed to evaluate the effects of a pleuran-based supplement (ß-glucan isolated from Pleurotus ostreatus in combination with vitamin D and zinc) on mucosal immunity –through modulating salivary secretory immunoglobulin A (sIgA) levels –in children with RRIs. Methods: This monocentric, prospective, open-label pilot study investigated the effect of an orally administered pleuran/vitamin D/zinc supplement (1–2 chewable tablets daily depending on body weight) on the dynamics of sIgA secretion measured in saliva samples collected at three timepoints: at baseline and after 4–6 and 8–10 days. …”
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Evaluation of statistical models of carriage to predict the impact of the 10-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in Nigeria by Aishatu L. Adamu, John. Ojal, Caroline Mburu, Katherine E. Gallagher, Stefan Flasche, Kofo Odeyemi, Christy A.N. Okoromah, Isa S. Abubakar, Musa M. Bello, Victor Inem, Angela Karani, Boniface Karia, Donald Akech, Ifedayo M.O. Adetifa, J. Anthony G. Scott

“…Relying entirely on indirect effects, Models 2 and 3 represent the minimum impact of PCV. Predictions would be more accurate if they accounted for direct effects among vaccinated VT carriers. …”
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