Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia by Bingxin Zhang, Shuxia Zhu, Dong Zheng, Xinyi Zhang, Wenxia Xie, Shujuan Zhou, Sisi Zheng, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Zixing Chen, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma

“…Furthermore, we explored that subtype A and high-scoring groups were more sensitive to immunotherapy. Multiple drugs with higher sensitivity among high-risk subgroups have been predicted. …”
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Machine learning-assisted assessment of extracellular vesicles can monitor cellular rejection after heart transplant by Jacopo Burrello, Stefano Panella, Ilaria Barison, Chiara Castellani, Alessio Burrello, Lorenzo Airale, Jessica Goi, Veronica Dusi, Roberto Frigerio, Gino Gerosa, Chiara Tessari, Nicola Pradegan, Giuseppe Toscano, Giovanni Pedrazzini, Mattia Corianò, Francesco Tona, Sara Bolis, Alessandro Gori, Marina Cretich, Marny Fedrigo, Annalisa Angelini, Lucio Barile

“…This approach holds the potential to reduce reliance on biopsies and tailor immunosuppressive strategies more precisely.…”
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Impact of a massive earthquake on adherence to antiretroviral therapy, mental health, and treatment failure among people living with HIV in Nepal. by Bharat Singh Negi, Sunil Kumar Joshi, Minato Nakazawa, Tomohiro Kotaki, Anup Bastola, Masanori Kameoka

“…Therefore, the objectives of this study were i) to assess the association of antiretroviral therapy (ART) adherence with mental health problems, and social behaviors, ii) to examine factors affecting treatment failure, and iii) to investigate changes in ART adherence and post-traumatic stress disorder (PTSD) among people living with HIV 6 and 12 months after the disaster.<h4>Methods</h4>Study was conducted 6 months after the earthquake in 2015 with a sample size of 305 earthquake victims with HIV and followed after 12 months of the earthquake. …”
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Ertapenem+meropenem including double carbapenem therapy (EMDCT) versus meropenem+imipenem including double carbapenem therapy (MIDCT) in the therapy of carbapenem-resistant Klebsie... by Merve Mert Vahabi, Deniz Akyol, Deniz Dağ, Gamze Şanlıdağ, Şevket Yeniyol, Arda Kaya, Dilşah Başkol, Seichan Ketentzi, Buğra Özkara, Şükrü Dirik, Gökhan Vatansever, Derya Kaya, Meltem Tüğdür, Hüseyin Aytaç Erdem, Feriha Çilli, Hilal Sipahi, Hüsnü Pullukçu, Meltem Taşbakan, Bilgin Arda, Oğuz Reşat Sipahi

“…BACKGROUND-AIM: In this retrospective matched cohort study, we aimed to compare the clinical outcomes of EMDCT including therapy receiving cases with MIDCT receiving CRKPI cases. MATERIALS/METHODS: This study was performed at a 1800+ bedded tertiary-care hospital.Adult patients with culture proven CRKPI(bacteremia,pneumonia,UTI,other)treated with EMDCT or MIDCT including regimens between August 2016 and October 2023 were included in the study.Matching was performed as one MIDCT matched to minimum 1 or 2 EMDCT when n is possible i)according to the sample infecting strain was yielded (bacteremia vs.bacteremia etc.)ii)being in the clinic or intensive care unit at the time of the first Infectious Diseases consultation. …”
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Serum glial fibrillary acidic protein in acute stroke: feasibility to determine stroke-type, timeline and tissue-impact by Julien F. Paul, Julien F. Paul, Julien F. Paul, Célina Ducroux, Célina Ducroux, Célina Ducroux, Célina Ducroux, Pamela Correia, Pamela Correia, Pamela Correia, Audrey Daigneault, Catherine Larochelle, Catherine Larochelle, Catherine Larochelle, Christian Stapf, Christian Stapf, Christian Stapf, Laura C. Gioia, Laura C. Gioia, Laura C. Gioia

“…The aim of this pilot study was to determine the feasibility of biomarker acquisition in suspected acute stroke, using modern ultrasensitive immunoassay techniques, and explore their potential usefulness for stroke diagnosis and management.MethodsIn 62 patients with suspected acute stroke, blood samples were prospectively obtained upon arrival and prior to neuroimaging. …”
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Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target by Sara Patrizi, Silvia Vallese, Sabina Barresi, Matteo Cassandri, Isabella Giovannoni, Lucia Pedace, Luana Abballe, Flavia Vinciarelli, Celeste Antonacci, Alessandra Stracuzzi, Barbara Mancini, Ida Russo, Angela Di Giannatale, Rossella Rota, Rita Alaggio, Franco Locatelli, Giuseppe Maria Milano, Evelina Miele

“…Methods: We conducted whole-genome DNAm and transcriptome analyses on 10 parameningeal head and neck ARMS patients, including 4 patients under 1 year old and 6 over 10 years old. …”
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Updates from a single-center phase 2 study of PD-1 inhibitor combined with hypomethylating agent plus CAG regimen in patients with relapsed/refractory acute myeloid leukemia by Hui-Sheng Zhou, Hui-Sheng Zhou, Yong-Feng Su, Jun Wang, Ya-Lei Hu, Ya-Lei Hu, An Wang, Lei Xu, Yi-Zhi Wang, Xuan Zheng, Yu-Qing Li, Yu-Qing Li, Kai-Li Min, Kai-Li Min, Chun-Ji Gao, Dai-Hong Liu, Dai-Hong Liu, Xiao-Ning Gao, Xiao-Ning Gao

“…Our study aimed to analyze the effectiveness and safety of combining tislelizumab with a hypomethylating agent (HMA) plus CAG regimen in treating patients with r/r AML, with an increased sample size and in comparison, with a historical control group for more reliable data support (ClinicalTrials.gov identifier NCT04541277).MethodsThe study included a total of 37 patients with r/r AML who received the tislelizumab + HMA + CAG regimen.ResultsThe overall response rate was 69.4%, with a median overall survival of 12.1 months and event-free survival of 6.2 months. …”
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High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1 by Roberta Lucianò, Maurizio Colecchia, Maurizio Colecchia, Francesca Sanvito, Irene Locatelli, Chiara Venegoni, Alessia Di Coste, Davide Danilo Zani, Angelica Stranieri, Chiara Giudice, Antonella Rigillo, Matteo Gambini, Francesco Montorsi, Francesco Montorsi, Andrea Salonia, Andrea Salonia, Marco Moschini, Massimo Alfano

“…The aim of this study was to investigate the expression of the α5β1 integrin and its specificity in high-grade UC in humans and dogs, a marker recently reported in the human bladder in situ carcinoma and murine model of orthotopic bladder cancer.MethodsExpression of integrin α5β1 was established by immunohistochemistry in 67 human bladder samples [four non-tumor tissues, 10 low-grade, 10 intermediate-grade, and 43 high-grade non-muscle invasive bladder cancer (NMIBC)] and 12 canine bladder tumor specimens.ResultsThe α5β1 integrin was not expressed by urothelial cells in the conditions of inflammatory cystitis, actinic cystitis, benign hyperplasia, and low/intermediate grade NMIBC; it was identified as a specific marker expressed only by the malignant cells in the urothelium in 81% of human and all canine high-grade NMIBC.ConclusionsThe expression of α5β1 integrin is a specific marker of high-grade UC located in the urothelium of humans and dogs and might be tested for targeted delivery of contrast agents or drugs. …”
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High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array by Hannah Viola, Liang-Hsin Chen, Seongbin Jo, Kendra Washington, Cauviya Selva, Andrea Li, Daniel Feng, Vincent Giacalone, Susan T. Stephenson, Kirsten Cottrill, Ahmad Mohammad, Evelyn Williams, Xianggui Qu, Wilbur Lam, Nga L. Ng, Anne Fitzpatrick, Jocelyn Grunwell, Rabindra Tirouvanziam, Shuichi Takayama

“…Dysregulated neutrophil recruitment drives many pulmonary diseases, but most preclinical screening methods are unsuited to evaluate pulmonary neutrophilia, limiting progress toward therapeutics. …”
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Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal B... by Nigel Curtis, Susan Donath, Dan Casalaz, Petra Zimmermann, Anne-Louise Ponsonby, Nicole L Messina, Kaya Gardiner, Katie Flanagan, Frank Shann, Roy Robins-Browne, Bridget Freyne, Veronica Abruzzo, Clare Morison, Lianne Cox, Susie Germano, Christel Zufferey, Katie J Allen, Peter Vuillermin, Mike South

“…Introduction BCG vaccination reduces all-cause infant mortality in high-mortality settings by more than can be attributed to protection against tuberculosis. …”
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Epidemiology and genetic diversity of common human coronaviruses in Beijing, 2015-2023: A prospective multicenter study by Qi Huang, Lu Kang, Xiaofeng Wei, Cheng Gong, Hui Xie, Maozhong Li, Yiting Wang, Mei Dong, Fang Huang

“…ABSTRACT: Objectives: To investigate the epidemiological and genetic features of common human coronaviruses (HCoVs) in Beijing in the context of the COVID-19 pandemic. Methods: We collected clinical samples from patients with acute respiratory tract infections (ARTIs) in 35 sentinel hospitals from 2015 to 2023. …”
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Electromagnetic shocking treatment induced grain bridging improved the impact toughness of 6082 aluminum alloys by Qian Sun, Qi Xiang, Guojing Ren, Lin Hua, Yi Yang

“…Stripy GBs are more commonly observed in HEST samples, indicating that nonlinear interface pre-melting and wetting are promoted by EST. …”
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Analyzing the Influence of Company's Business Strategy and Its Components as a Factor of Information Risk on Excess Stock Returns by Alireza Rahrovi Dastjerdi, Daryoosh Forooghi, Zahra Moradi

“…The sample comprised 236 companies listed on the TSE over the period from 2011 to 2022. …”
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Improved tumor-type informed compared to tumor-informed mutation tracking for ctDNA detection and microscopic residual disease assessment in epithelial ovarian cancer by Mehdi Ben Sassi, Henri Azais, Charles Marcaillou, Sylvain Guibert, Emmanuel Martin, Jérôme Alexandre, Louise Benoit, Aurélien de Reynies, Emilie Laude, Cam Duong, Jacques Medioni, Bruno Borghese, Anne-Sophie Bats, Valerie Taly, Pierre Laurent-Puig

“…Plasma samples from 47 advanced-stage EOC patients receiving chemotherapy and 54 healthy subjects were analyzed. …”
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High prevalence of resistance to macrolides and fluoroquinolones in Mycoplasma genitalium isolated from patients in two Russian megalopolises – Moscow and St. Petersburg in 2021– 2... by Edelstein I.A., Gushchin A.E., Gladin D.P., Romanov A.V., Negasheva E.S., Frigo N.V., Kozlov R.S., Potekaev N.N., Kozlova N.S., Borukhovich D.G.

“…Petersburg in 2021–2024. Materials and Methods. A total of 530 M. genitalium DNA-positive specimens (urethral and cervical swabs) obtained from men and women from the STD clinic in St. …”
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Local Similarity-Based Fuzzy Multiple Kernel One-Class Support Vector Machine by Qiang He, Qingshuo Zhang, Hengyou Wang, Changlun Zhang

“…The combined kernel is used to measure the local similarity between samples, and then, the importance of samples is determined based on the local similarity between training samples, so as to determine the membership degree and reduce the impact of noise. …”
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Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities by Qing-shan Chen, Rui-zhao Cai, Yan Wang, Ge-hao Liang, Kai-ming Zhang, Xiao-Yu Yang, Dong Yang, De-Chang Zhao, Xiao-Feng Zhu, Rong Deng, Jun Tang

“…This study aims to investigate SE heterogeneity in TNBC and its influence on BETi effectiveness, with the goal of advancing BETi precision treatment strategies and enhancing therapeutic efficacy. Methods We conducted a comprehensive analysis of H3K27ac ChIP-Seq data from TNBC cell lines and clinical samples, integrating multiple bulk RNA-Seq, scRNA-Seq, and stRNA-Seq datasets to characterize the SE landscape and heterogeneity in TNBC. …”
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How firearm legislation impacts firearm mortality internationally: A scoping review by Brianna Greenberg, Alexandria Bennett, Asad Naveed, Raluca Petrut, Sabrina M. Wang, Niyati Vyas, Amir Bachari, Shawn Khan, Tea Christine Sue, Nicole Dryburgh, Faris Almoli, Becky Skidmore, Nicole Shaver, Evan Chung Bui, Melissa Brouwers, David Moher, Julian Little, Julie Maggi, Najma Ahmed

“…Numerous legislative approaches were identified including preventative, prohibitive, and more tailored strategies focused on identifying high risk individuals. …”
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Emergence of plasmid-mediated tigecycline resistance tet(X4) gene in Enterobacterales isolated from wild animals in captivity by Lei Lei, Panfeng Xiong, Zelin Yan, Yanyan Zhang, Yuchen Wu, Gongxiang Chen, Houhui Song, Rong Zhang

“…However, the presence and molecular characteristics of tet(X)-carrying bacteria in these animals remain unknown. Methods: Eighty-four samples were collected from captive wild animals. tet(X) variants were detected using polymerase chain reaction and the isolates were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. …”
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Proteomic Profiling of Human Peripheral Blood Cell Targets of IgG Induced by SARS-CoV-2: Insights into Vaccine Safety by Nicolle Rakanidis Machado, Lais Alves do Nascimento, Beatriz Oliveira Fagundes, João Vitor da Silva Borges, Fabio da Ressureição Sgnotto, Isabella Siuffi Bergamasco, Juliana Ruiz Fernandes, Thalyta Nery Carvalho Pinto, Anna Julia Pietrobon, Gil Benard, Maria Notomi Sato, Jefferson Russo Victor

“…This study investigates the IgG autoantibody responses in patients with varying severities of COVID-19 infection and compares these responses with vaccinated individuals. Methods: We utilized proteomic profiling to analyze autoantibody reactivity against a broad spectrum of proteins expressed in lymphoid and myeloid cell subsets in serum samples from severe and moderate COVID-19 patients, as well as vaccinated individuals who received the inactivated CoronaVac (Sinovac) vaccine. …”
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