Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet by Jian Ma, Jian Ma, Zhongwen Gong, Hong Lu, Han Yang, Shengquan Wang, Qian Zhu, Hongya Liu, Yongjia Li, Yuemei Zhang, Xuemei Lian, Xuemei Lian

“…In CYP27A1(−/−) mice, hepatic lipid accumulation was more severe with further suppression of ABCA1, whereas ABCA1 expression in the lung remained elevated. …”
Get full text

Perspectives of nurses and patient representatives on the morally competent nurse: An international focus group study by Chris Gastmans, Evelyne Mertens, Alvisa Palese, Brian Keogh, Francesca Apolloni, Johanna Wiisak, Catherine Mc Cabe, Maria Dimitriadou, Alessandro Galazzi, Michael Igoumenidis, Nikos Stefanopoulos, Paraskevi Charitou, Evridiki Papastavrou, Riitta Suhonen, Stefania Chiappinotto

“…Data were analysed with a descriptive thematic method. Participants: A purposive sample of 38 nurses and 35 patient representatives was recruited. …”
Get full text

Meditation for subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials by Jiaxin Shi, Hao Tian, Jingwen Wei, Wenhan Xu, Qin Luo, Jin Peng, Jun Xia, Wenying Huai, Ying Xiong, Yunhui Chen

“…More large-scale and high-quality RCTs are needed to further substantiate these effects.…”
Get full text

Association Between Fixed-Dose Combination Use and Medication Adherence, Health Care Utilization, and Costs Among Medicaid Beneficiaries by Donglan Zhang, PhD, Jun Soo Lee, PhD, Nicole L. Therrien, PharmD, MPH, Lisa M. Pollack, PhD, MPH, MPT, Sandra L. Jackson, PhD, MPH, Xiaobei Dong, PhD, Anand Rajan, MS, Kai Hong, PhD, Andrew E. Moran, MD, MPH, Feijun Luo, PhD

“…Background: Fixed-dose combination (FDC) antihypertensives combine two or more agents. Compared with non-FDC antihypertensives of multiple classes (multi-pill therapy), combination-pill therapy using FDC antihypertensives may improve hypertension control. …”
Get full text

Changes in Alcohol Consumption During and After the Covid-19 Pandemic From 2020 to 2023 in a Prospective Cohort of Italian Adults by Sonia Cerrai, Giulia Carreras, Filippo Monti, Chiara Stival, Alessandra Lugo, Cristina Bosetti, Silvia Biagioni, Tiziana Fanucchi, Giuseppe Gorini, Andrea Amerio, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Sabrina Molinaro, Luc Smits, Silvano Gallus, the “Lost in Italy” and “Lost in Toscana” Study Investigators

“…Background: The lockdowns imposed by the government during coronavirus disease 2019 (COVID-19) pandemic have had a significant impact on the Italian population habits. Methods: LOckdown and lifeSTyles in Italy and in Tuscany studies collected data on a representative sample of the Italian adult population in 2020 (n = 6,003) followed up through 2023 via four additional surveys (3,000 ≤ n ≤ 6,600) through an online self-administered questionnaire. …”
Get full text

First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers by Aurélien Marabelle, Aung Naing, Funda Meric-Bernstam, Xingfeng Bao, Andrea Varga, David S Hong, Aparna Parikh, Geoffrey I Shapiro, Özlem Ataman, Larisa Reyderman, Terri A Binder, Min Ren, Mingjie Liu, Satish Dayal, Amy Y Siu, Pallavi Sachdev, Lucy Xu, Vijay Bhagawati-Prasad, Ilian Tchakov, Chean Eng Ooi

“…Paired tumor biopsies and blood samples, before and on treatment, were collected for pharmacokinetic and pharmacodynamic characterization of the treatment.Results No dose-limiting toxicities were observed, and the MTD was not reached. …”
Get full text

Mass development of a filamentous and likely nitrophilous aerophytic green alga on tree bark: Apatococcus ammoniophilus sp. nov. (Chlorophyta, Trebouxiophyceae) by Ulrik Søchting, Thomas Friedl, Øjvind Moestrup, Felix Grewe, Yukun Sun, Yağmur Tarhana Çakır, Markus Ganzera, Karin Glaser, Svenja Heesch, Fabian Hammerle, Daniel Nimptsch, Birgit Olberg, Ulf Karsten, Ulf Karsten

“…However, its species identity and taxonomy remained unknown.Material and methodsSelected algal samples from various substrates were analyzed for their ribosomal DNA sequences, metagenomic, and biochemical compounds [polyols and mycosporine-like amino acids (MAAs)].ResultsPhylogenetic analyses revealed the alga’s position within the Trebouxiophyceae (Chlorophyta), forming an independent lineage within Apatococcus. …”
Get full text

Comprehensive identification of pathogenic tandem repeat expansions in sporadic amyotrophic lateral sclerosis: advantages of long-read vs. short-read sequencing by Eleonora Sabetta, Karin Rallmann, Jonas Bergquist, Pille Taba, Pille Taba, Abigail L. Pfaff, Abigail L. Pfaff, Bal Hari Poudel, Davide Ferrari, Massimo Locatelli, Sulev Kõks, Sulev Kõks

“…In this paper we compare the investigation of pathological tandem repeat expansions on a group of ALS patients by comparing the standard short-read sequencing (SRS) technique with a long-read-sequencing (LRS) method which has recently become more accessible. …”
Get full text

One-year post lockdown trajectories of mental health and impact of COVID-19 lockdown-related factors by Mathilde Mongeau, Samantha Huo Yung Kai, Samantha Huo Yung Kai, Vanina Bongard, Vanina Bongard, Vanina Bongard, Nicola Coley, Nicola Coley, Nicola Coley, Emilie Bérard, Emilie Bérard, Jean Ferrières, Jean Ferrières, Jean Ferrières

“…IntroductionConcerns about the impact of restrictive measures on people’s wellbeing, especially mental health, were raised by the COVID-19 pandemic and related lockdown measures.MethodsIn this study, we examined longitudinal trajectories of mental health during the initial French lockdown period and up to one-year post-lockdown, among a representative sample of French adults aged over 50. …”
Get full text

Advancing Sustainable Textile Metrology: Reflectivity Measurement with Controlled Light Sources by Radostina A. Angelova, Elena Borisova, Daniela Sofronova

“…This study introduces an experimental method for evaluating the reflectivity of flexible textile materials under controlled lighting conditions. …”
Get full text

A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Methods Tumor, liver, and blood samples were obtained from patients undergoing resection for non-metastatic PDAC. …”
Get full text

A Comparative Study of the Perspectives of Long‐Stay Immigrants, Nurses and Cultural Mediators on Intercultural Communication: A Secondary Qualitative Analysis by Francesc Ramos‐Roure, Maria Feijoo‐Cid, Josep Maria Manresa‐Dominguez, Jordi Segura‐Bernal, Rosa García‐Sierra, Maria Isabel Fernández‐Cano, Antonia Arreciado Marañón, Eduard Moreno‐Gabriel, Clara Flamarich Gol, Pere Toran‐Monserrat

“…The sample was extended to include a focus group of cultural mediators. …”
Get full text

Improving contraceptive agency through peer social support: findings from a longitudinal qualitative evaluation of the I-CAN intervention in Uganda by Erica Sedlander, Beth Phillips, Isabelle Thapar, Catherine Birabwa, Lauren Suchman, Madeline Griffith, Dinah Amongin, Ronald Wasswa, Lynn Atuyambe, Jenny Liu, Peter Waiswa, Kelsey Holt

“…Women were purposefully sampled for diversity in contraceptive use, district, and age. …”
Get full text

Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Also notable is the presence of proliferative lymphocytes, the occurrence of which positively correlates with more aggressive tumor behavior in the bulk RNA-seq cohort. …”
Get full text

PIDLF+: A Novel Adaptive PIDLF for Forestry Height Mapping Based on Single-Baseline PolInSAR Data by Dandan Li, Hailiang Lu, Mercedes E. Paoletti, Juan M. Haut, Juntao Gu, Chao Li, Weipeng Jing

“…Meanwhile, the lack of training samples imposes additional constraints on the efficacy of supervised DL-based methods. …”
Get full text

Evaluation of perioperative care and drivers of cost in geriatric thoracolumbar trauma by Omar H. Tarawneh, Rajkishen Narayanan, Michael McCurdy, Tariq Z. Issa, Yunsoo Lee, Olivia Opara, Nicholas B. Pohl, Alexa Tomlak, Matthew Sherman, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Gregory D. Schroeder, Christopher K. Kepler

“…Secondarily, we examined the variability of cost across age groups by identifying drivers of cost of care. Materials and methods: We queried the United States Nationwide Inpatient Sample(NIS) for adult patients undergoing spinal fusion for thoracolumbar fractures between 2012 and 2017. …”
Get full text

Gestational diabetes-combined excess weight gain exacerbates gut microbiota dysbiosis in newborns, associated with reduced abundance of Clostridium, Coriobacteriaceae, and Collinse... by Yunshan Xiao, Yunshan Xiao, Yunshan Xiao, Yuan Shi, Yuan Shi, Yuan Shi, Yan Ni, Meilan Ni, Yuxin Yang, Xueqin Zhang, Xueqin Zhang, Xueqin Zhang

“…Further,LEfSe analysis identified 30 differential bacteria taxa between GDM-Total and healthy control groups, which increased to 38 between GDM+EGWG and non-GDM groups, highlighting more pronounced microbial shifts associated with EGWG. …”
Get full text

The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…While confirming the efficacy of the holistic approach, the results reveal the need for more efficient coordination between professionals and early involvement of rehabilitation specialists. …”
Get full text

Factors associated with head circumference and indices of cognitive development in early childhood by Matthew R Grigsby, William Checkley, Tahmeed Ahmed, Zulfiqar Ahmed Bhutta, Laura Nicolaou, Pascal Bessong, Margaret Kosek, Aldo A M Lima, Sanjaya Shrestha, Ram Chandyo, Estomih R Mduma, Laura Murray-Kolb, Brooks Morgan

“…Participating children were enrolled and followed up between 2009 and 2014. A final sample of 1210 children aged 0–24 months were included in the analyses. …”
Get full text

Metabolomic machine learning-based model predicts efficacy of chemoimmunotherapy for advanced lung squamous cell carcinoma by Liang Zheng, Wei Nie, Shuyuan Wang, Ling Yang, Fang Hu, Fang Hu, Meili Ma, Lei Cheng, Jun Lu, Bo Zhang, Jianlin Xu, Ying Li, Yinchen Shen, Wei Zhang, Runbo Zhong, Tianqing Chu, Baohui Han, Xiaoxuan Zheng, Xiaoxuan Zheng, Hua Zhong, Xueyan Zhang

“…The aim of our study was to establish a model that can predict the prognosis of chemoimmunotherapy in patients with advanced lung squamous cell carcinoma, integrating metabolomics with machine learning techniques.MethodsWe collected 79 serum samples from patients with advanced lung squamous cell carcinoma before receiving combined immunotherapy and performed untargeted metabolomics analysis. …”
Get full text