The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study by Gustė Klimaitė, Arūnas Vasiliauskas, Pranas Grinkevičius, Dominyka Grinkevičienė, Deivydas Šapalas

“…Remineralization of enamel was the highest in samples from the P11-4 group (54.1%), followed by the nano-HA group (35.4%), FV group (17.8%), and control group (11.2%). …”
Get full text

Transcriptional regulatory network analysis of microglia in multiple sclerosis by CAI Qiangwei, SUN Feng, WU Wenyu, SHAO Fuming, GAO Zhengliang, JIN Shengkai

“…Objective·To investigate the differential gene expression of microglia in the gray and white matter of multiple sclerosis (MS) using single-nucleus transcriptomic analysis, aiming to explore their roles in disease progression, and identify key transcriptional regulatory networks associated with the disease.Methods·snRNA-seq data of frozen human brain tissue samples from MS patients and control individuals were obtained from the Gene Expression Omnibus (GEO) database. …”
Get full text

The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control study by Amjad Ahmadi, Leili Shokoohizadeh, Farshad Sheikhesmaili, Bahram Nikkhoo, Asadollah Mohammadi, Mohammadali Khan Mirzaei, Mohammad Yousef Alikhani, Rasoul Yousefimashouf

“…Future studies should aim for larger cohorts to provide more definitive insights into this important issue.…”
Get full text

Molecular Detection and Clinical Impact of <i>Helicobacter pylori</i> Virulence Genes in Gastric Diseases: A Study in Arequipa, Peru by Yuma Ita-Balta, Alice Zegarra-Adanaque, Johany Sanchez-Guillen, Miguel Farfán-Delgado, Carlos Ortiz-Castro, Alexis Germán Murillo Carrasco, Alejandro Miranda Pinto, Cecilia Manrique-Sam

“…Additionally, the presence of <i>cagA</i> was significantly linked to moderate inflammatory intensity in gastric body biopsies, indicating its association with more severe histopathological outcomes. Chronic gastritis was the most common histopathological finding, with moderate intensity correlating strongly with the presence of virulence genes. …”
Get full text

The influence of dietary choices: investigation of the relationship dietary inflammatory index and fetal growth restriction by Ayşe Gülçin Baştemur, İclal Sena Gezer, Burcu Kesikli, Atakan Tanaçan, Özgür Kara, Nuray Yazıhan, Dilek Şahin

“…Conclusion This study showed that a pro-inflammatory maternal diet increased dietary inflammatory index and increased maternal inflammatory markers, and this was more significant in fetuses with FGR than in normal weight fetuses.…”
Get full text

Healthcare under fire: quantifying the impact of violence on medical services in facilities supported by International Medical Corps in three prefectures of Central African Republi... by Natalya Kostandova, Jennifer OKeeffe, Audrey Mahieu, Blaise Bienvenu Ali, Christian Mulamba, Pierre Somsé, Odilon Guesset Bingou IV, Sebastien Dackpa, Gerard Mbonimpa, Thierry Fikiri, Larissa Fast, Leonard Rubenstein

“…Future research should build on these findings to provide more effective protection, mitigation, and recovery strategies for healthcare systems in conflict zones.…”
Get full text

Magnetic Nanoparticles with On-Site Azide and Alkyne Functionalized Polymer Coating in a Single Step through a Solvothermal Process by Romualdo Mora-Cabello, David Fuentes-Ríos, Lidia Gago, Laura Cabeza, Ana Moscoso, Consolación Melguizo, José Prados, Francisco Sarabia, Juan Manuel López-Romero

“…<b>Background/Objectives</b>: Magnetic Fe₃O₄ nanoparticles (MNPs) are becoming more important every day. We prepared MNPs in a simple one-step reaction by following the solvothermal method, assisted by azide and alkyne functionalized polyethylene glycol (PEG400) polymers, as well as by PEG6000 and the polyol β-cyclodextrin (βCD), which played a crucial role as electrostatic stabilizers, providing polymeric/polyol coatings around the magnetic cores. …”
Get full text

The Clinical Value of the Combined Detection of Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Prognostic Nutritional Index (PNI) in Ear... by Zheng J, Zheng L, Wang X, Mao X, Wang Q, Yang Y, Mo D

“…Besides, the combination of hematological indicators is more effective in diagnosing GC patients, especially for male patients (AUC=0.916, 95% CI: 0.901– 0.932, sensitivity: 84.98%, specificity: 84.29%). …”
Get full text

Association of Adenotonsillectomy with Vaso-occlusive Crisis Frequency in Sickle Cell Patients of Eastern Saudi Arabia: A Retrospective Study by Moath Alfaleh, Omar Alanzi, Ali Alaskari, Mohammed Alzamil, Hussain Al-Baharna

“…Vaso-occlusive Crisis (VOC), a defining symptom of SCD, is acute painful assaults caused by vaso-occlusion in the bone marrow. SCD is substantially more prevalent in some regions of Saudi Arabia than in others, with the Eastern Province having the highest incidence rates, followed by the Southern and Western provinces. …”
Get full text

Preoperative Talocalcaneal Distance and Subtalar Fusion are Not Associated with Worse Patient-Reported Outcomes in Progressive Collapsing Foot Deformity by Grace DiGiovanni BS, Agnes Jones MS, Seif El Masry, Jonathan T. Deland MD, Scott J. Ellis MD, Matthew S. Conti MD

“…Category: Hindfoot; Other Introduction/Purpose: As progressive collapsing foot deformity (PCFD) advances, narrowing between the lateral talar process and calcaneus at the angle of Gissane often occurs. This signifies more advanced peri-talar subluxation and may result in sinus tarsi impingement. …”
Get full text

Study of TRAF3IP3 for prognosis and immune infiltration in hepatocellular carcinoma by Xing Wang, Xin Gao, Airu Liu, Yan Qin, Zhi-Yu Ni, Xiao Lan Zhang

“…Results Analysis of public databases and immunohistochemical staining on 20 pairs of samples confirmed a decrease in TRAF3IP3 expression in HCC. …”
Get full text

Effect of Soft Rehabilitation Robot Gloves on Upper Limb and Hand Function of Stroke Patients：A Meta-Analysis by YU Tingting, SHEN Yuwei, WAN Guomeng, LI Jianan

“…Meta-analysis results showed that, compared with the control group, FMA-UE score [<italic>MD</italic>=8.05, 95% <italic>CI </italic>(7.01,9.09), <italic>Z</italic>=15.20, <italic>P</italic>&lt;0.000 01], MBI score [<italic>MD</italic>=9.91, 95% <italic>CI</italic> (2.65,17.17), <italic>Z</italic>=2.68, <italic>P</italic>=0.007], WMFT score [<italic>MD</italic>=8.39, 95% <italic>CI</italic> (6.99,9.78), <italic>Z</italic>=11.81，<italic>P</italic>&lt;0.000 01], grip strength [<italic>SMD</italic>=0.39, 95% <italic>CI</italic> (0.11,0.67), <italic>Z</italic>=2.75, <italic>P</italic>=0.006], and ARAT score [<italic>MD</italic>=11.18, 95% <italic>CI</italic> (9.10, 13.26), <italic>Z</italic>=10.53, <italic>P</italic>&lt;0.000 01] were significantly higher in the experimental group, but there was no significant difference in BBT score between two groups [<italic>MD</italic>=0.53, 95% <italic>CI</italic> (-1.47, 2.53), <italic>Z</italic>=0.52, <italic>P</italic>=0.60].ConclusionSRG can improve the upper limb and hand motor function and activities of daily living of stroke patients, but more large-sample and high-quality RCTs would be needed to further verify its efficacy.…”
Get full text

Exploring the Relationship Between Public Social Media Accounts, Adolescent Mental Health, and Parental Guidance in England: Large Cross-Sectional School Survey Study by Wakithi Siza Mabaso, Sascha Hein, Gabriela Pavarini, Mina Fazel

“…ObjectiveThis study aims to investigate the association between having a public social media account and anxiety and depression in school-going adolescents. MethodsOverall, 80 secondary schools and further education colleges in England were sampled using a cross-sectional web-based survey as part of the 2023 OxWell Student Survey. …”
Get full text

A Novel Oncogenic and Drug-Sensitive KIF5B-NTRK1 Fusion in Lung Adenocarcinoma by Hui Li, Huicong Liu, Lisha Xiao, Huabin Gao, Huiting Wei, Anjia Han, Gengpeng Lin

“…Moreover, <i>KIF5B</i>-<i>NTRK1</i> gene chimera has been shown to be an oncogene, activating both the MAPK and PI3K/AKT signaling pathways. The biopsy sample was analyzed using various methods such as hematoxylin–eosin staining (HE), immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS) based on a 1267-gene panel. …”
Get full text

Minimally invasive differential diagnosis of melanocytic intraocular neoplasms by A. Yu. Tsygankov, S. V. Saakyan, E. B. Myakoshina, A. M. Burdennyi, V. I. Loginov

“…Purpose: to analyze the mutation frequency of the GNAQ/GNA11 gene in circulating tumor DNA and genotypes of the polymorphic marker C3435T of the ABCB1 gene in a large sample of patients with intraocular melanocytic neoplasms (IMN).Material and methods. …”
Get full text

Potential liquid biopsy markers of exosomal microRNAs in renal interstitial fibrosis blood and urine by Chunyan Lv, Yuan Zhong, Yao Hu, Yan Tang

“…Objective: To explore more and better liquid biopsy markers of exosomal microRNAs (exo-miRNAs) in renal interstitial fibrosis (RIF) and to preliminary investigate the biological functions and signaling pathways involved in these markers. …”
Get full text

Comparative Study of Trans‐Axillary Approach and Delto‐Pectoral Approach to the Treatment of Ideberg Types I and II Scapular Glenoid Fractures by Xu Zhang, Zhen Jiang, Feng‐Long Chu, Dai‐Liang Jia, Xiu‐Guo Han, Xiao‐Yan Li, Yi‐Feng Zhao, Hai‐Bin Wang, Bin Wu

“…The objective of this study is to explore the clinical efficacy of both approaches in the treatment of Ideberg Types I and II scapular glenoid fractures. Methods The trans‐axillary approach is the surgical method of exposing a glenoid fracture along the anterior edge of the latissimus dorsi muscle through an axillary incision. …”
Get full text

Retrospective Analysis of Factors Associated with a Prolonged Nucleic Acid Conversion Time in Patients with COVID-19 at Fangcang Shelter Hospital by Li Y, Wei Y, Wang Y, Chen Q, Hou X

“…Nucleic acid amplification detection method was used to detect 2019-nCoV nucleic acid in nasopharyngeal swab samples. …”
Get full text

Dry needling as an adjunct treatment to multimodal rehabilitation protocol following rotator cuff repair surgery: a preliminary, randomized sham-controlled trial by Faeze Naseri, Mehdi Dadgoo, Mohammadreza Pourahmadi, Morteza Nakhaei Amroodi, Shirin Azizi, Amirhossein Shamsi

“…Future studies should consider different control groups, long-term follow ups, larger sample sizes, and more MTrP-DN sessions to better understand their potential impact. …”
Get full text

PO86 | Emicizumab in patients with moderate hemophilia A and severe bleeding phenotype: single-center real-world experience

“…The youngest patient experienced a great improvement of his social life, interacting more with his peers, and started to work out at the gym and play basketball. …”
Get full text