Optimising a multi-strategy implementation intervention to improve the delivery of a school physical activity policy at scale: findings from a randomised noninferiority trial by Cassandra Lane, Luke Wolfenden, Alix Hall, Rachel Sutherland, Patti-Jean Naylor, Chris Oldmeadow, Lucy Leigh, Adam Shoesmith, Adrian Bauman, Nicole McCarthy, Nicole Nathan

“…It is a cost-efficient alternative also likely to be a more suitable approach to supporting large scale implementation of school physical activity policies. …”
Get full text

Molecular Crosstalk Between SIRT1, Wnt/β-Catenin Signaling, and Inflammatory Pathways in Renal Transplant Rejection: Role of miRNAs, lncRNAs, IL-1, IL-6, and Tubulointerstitial Inf... by Nurhak Aksungur, Murat Kizilkaya, Necip Altundaş, Eda Balkan, Salih Kara, Elif Demirci, Abdullah Uyanik

“…<i>Background/Objectives</i>: This study aimed to evaluate the relationship between sirtuin family members (SIRT1, SIRT3, and SIRT6) and Wnt/β-catenin pathways with inflammation during the rejection process following kidney transplantation, as well as to explore their potential roles as candidate biomarkers. <i>Materials and Methods</i>: Blood samples were collected from 35 kidney transplant rejection patients and 30 healthy controls. …”
Get full text

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial. by Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Dilip Patel, Will Mungall, Timothy J Kendall, Adrian Thomson, Ross J Lennen, Maurits A Jansen, Carmel M Moran, Antonella Pellicoro, Prakash Ramachandran, Isaac Shaw, Rebecca L Aucott, Thomas Severin, Rajnish Saini, Judy Pak, Denise Yates, Neelesh Dongre, Jeremy S Duffield, David J Webb, John P Iredale, Peter C Hayes, Jonathan A Fallowfield

“…The clinical study's main limitations were the relatively small sample size and stable, well-compensated population.…”
Get full text

Metabolic syndrome and the risk of cardiovascular and all-cause mortality: data of 14-year prospective cohort study in Siberia by G I Simonova, S V Mustafina, O D Rymar, L V Scherbacova, T I Nikitenko, M Bobak, S K Malyutina

“…Among men, already 1 component of MS increased the risk of cardiovascular and all-cause mortality by 2,0 or more times; among women, 2-4 components of MS increased the risk of death by 3 times, and 5 components — by 4.Conclusion. …”
Get full text

Usefulness of the Magnetodynamic Mallet in Tooth Extraction: A Case Series by Domenico Baldi, Francesca Baldi, Federica Giordano, Luisa De Giorgis, Francesco Bagnasco, Andrea Tancredi Lugas, Maria Menini, Jacopo Colombo

“…A recently introduced extraction method involves the use of the Magnetic Mallet^®, which allows clinicians to be more precise and perform extractions faster. …”
Get full text

Effects of Pomegranate Seed Oil on Lower Extremity Ischemia-Reperfusion Damage: Insights into Oxidative Stress, Inflammation, and Cell Death by Ümmü Gülşen Bozok, Aydan İremnur Ergörün, Ayşegül Küçük, Zeynep Yığman, Ali Doğan Dursun, Mustafa Arslan

“…<i>Aim</i>: This study sought to clarify the therapeutic benefits and mechanisms of action of pomegranate seed oil (PSO) in instances of ischemia–reperfusion (IR) damage in the lower extremities. <i>Materials and Methods</i>: The sample size was determined, then 32 rats were randomly allocated to four groups: Control (C), ischemia–reperfusion (IR), low-dose PSO (IR + LD, 0.15 mL/kg), and high-dose PSO (IR + HD, 0.30 mL/kg). …”
Get full text

Association between ERCC2 Lys751Gln, Asp312Asn, and Arg156Arg polymorphisms and gynecological cancer susceptibility: a meta-analysis by Fen Chen, Jiayang Yu, Chun-Guang Wang

“…Therefore, we performed this meta-analysis to estimate these associations more precisely.ObjectIn this paper, we summarized a larger sample for meta-analysis to explored the relationship between the polymorphisms of the ERCC2 Lys751Gln, Asp312Asn, and Arg156Arg and gynecological tumors.MethodsWe conducted a systematic search for relevant case-control studies in PubMed, the Cochrane Library, Embase, and the Web of Science databases, covering studies up to October 2024. …”
Get full text

Sociodemographic disparities in diabetic retinopathy: Analysis of the 2021 behavioral risk factor surveillance system by Dawsyn Smith, S. Mackenzee Hester, Ryan Emmert, Juliana Bryant, Micah Hartwell

“…Design: We conducted a cross-sectional study using data from the Behavioral Risk Factor Surveillance System, a phone-based survey conducted in the United States and surrounding territories by the Centers for Disease Control, and assessed the prevalence of DR by various sociodemographic factors. Methods: A sample of 21,905 individuals was drawn from survey data based on self-reported diabetes status. …”
Get full text

A novel cross-validated machine learning based Alertix-Cancer Risk Index for early detection of canine malignancies by Hanan Sharif, Hanan Sharif, Reza Arabi Belaghi, Kiran Kumar Jagarlamudi, Sara Saellström, Liya Wang, Henrik Rönnberg, Staffan Eriksson, Staffan Eriksson

“…., Alertix-Cancer Risk Index (Alertix-CRI) which incorporates canine TK1 protein, CRP levels in conjunction with an age factor.MethodsA total of 287 serum samples were included in this study, consisting of 67 healthy dogs and dogs with different tumors (i.e., T-cell lymphoma n = 24, B-cell lymphoma n = 29, histiocytic sarcoma n = 47, hemangiosarcoma n = 26, osteosarcoma n = 26, mastocytoma n = 40, and mammary tumors n = 28). …”
Get full text

Examining perinatal health inequities: The role of disability and risk of adverse outcomes through the U.S. Pregnancy Risk Assessment Monitoring System. by Jeanne L Alhusen, Genevieve R Lyons, Rosemary B Hughes, Kathryn Laughon, Maria McDonald, Casey L Johnson

“…<h4>Objective</h4>To examine pre-pregnancy characteristics, pregnancy complications, and birth outcomes among respondents with self-reported disability compared to those without disability.<h4>Methods</h4>A cross-sectional weighted sample of 2,006,700 respondents with singleton live births who participated in the United States Pregnancy Risk Assessment Monitoring System (PRAMS) between 2018 and 2021 provided data on disability, including difficulty in vision, hearing, ambulation, cognition, communication, and self-care. …”
Get full text

Interpretable Machine Learning for Serum-Based Metabolomics in Breast Cancer Diagnostics: Insights from Multi-Objective Feature Selection-Driven LightGBM-SHAP Models by Emek Guldogan, Fatma Hilal Yagin, Hasan Ucuzal, Sarah A. Alzakari, Amel Ali Alhussan, Luca Paolo Ardigò

“…<i>Results:</i> Compared to other feature selection approaches, the MOFS approach was more robust in terms of predictive performance, and metabolites identified by this method were used in subsequent analyses for biomarker discovery. …”
Get full text

Clinical and morphological myocardial changes in patients with post-COVID-19 syndrome by S. V. Mayrina, I. A. Makarov, L. B. Mitrofanova, M. S. Vonsky, A. L. Runov, K. A. Papko, O. M. Moiseeva

“…To characterize the clinical manifestations and myocardial morphological changes in patients with cardiovascular complications of post-Covid syndrome.Material and methods. A total of 38 patients (Group I) with cardiac symptoms in the post-COVID-19 period underwent endomyocardial biopsy (EMB). …”
Get full text

The Effects of a Nursing Program Applying Zinc Oxide Mixed with Petroleum Jelly and Centella Asiatica Mixed with Aloe Vera on Skin Indicators Among Older Patients in Semi-Intensive... by Chaisomsee S, Banharak S, Sommana C, Tuntiyasawasdikul S, Sim-im S, Ransinyo K, Limpawattana P, Deesui W, Pimpun P, Somkamsri T, Seeharach O

“…However, further studies with larger sample sizes and more rigorous research designs are needed to validate these findings comprehensively. …”
Get full text

Ambulance Commanders’ Reluctance to Enter Road Tunnels in Simulated Incidents and the Effects of a Tunnel-Specific e-Learning Course on Decision-Making: Web-Based Randomized Contro... by Johan Hylander, Lina Gyllencreutz, Michael Haney, Anton Westman

“…There were no significant differences between the groups (P=.59; 2-sample test of proportions) in the second assessment. …”
Get full text

Health insurance non-enrollment among women in Sierra Leone: A cross-sectional analysis of the 2019 Demographic and Health Survey. by Augustus Osborne, Mainprice Akuoko Essuman, Peter Bai James, Camilla Bangura, Richard Gyan Aboagye, Comfort Z Olorunsaiye, Abdul-Aziz Seidu, Bright Opoku Ahinkorah

“…This study examines the factors associated with health insurance non-enrollment among women aged 15-49 in Sierra Leone.<h4>Methods</h4>We analysed data from a weighted sample of 15,574 women aged 15-49 years from the 2019 Sierra Leone Demographic and Health Survey. …”
Get full text

Influence of perceived influenza-like symptoms on intention to receive seasonal influenza vaccination by Renske Eilers, Fleur H. Groenendijk, Birthe A. Lehman, Nynke Y. Rots, Hester E. de Melker, Liesbeth Mollema, Josine van Beek

“…During home visits, throat/nose swabs, a blood sample and a questionnaire on demographics and general health were collected. …”
Get full text

What are the radiographic prevalence and anatomical patterns of maxillary sinus septa in a Turkish cohort? by Ibrahim Burak Yuksel, Sumeyye Celik Ozsoy, Muhammet Emin Arslan, Fatma Altiparmak, Hatice Yilmaz, Ali Altindag, Guldane Magat

“…Methods Panoramic radiographs of 1000 patients (587 females and 413 males), aged between 18 and 70 years, were retrospectively analyzed. …”
Get full text

Rearing system and immune status influence the small intestinal microbiota of IPB-D3 chickens: A full-length 16S rRNA metagenomic approach by Wawan Kuswandi, Cahyo Budiman, Isyana Khaerunnisa, Cece Sumantri

“…FR systems promoted richer, more beneficial microbial communities, while IN systems, especially with HL levels, were associated with opportunistic pathogens. …”
Get full text

Jian-Pi-Yi-Shen formula improves kidney function by regulating gut microbiome in rats with chronic kidney disease by Yuzhi Wang, Jiandong Lu, Wenkui Dai, Shudong Yang, Shudong Yang

“…Fecal samples were collected at three timepoints (T1: post-acclimation; T2: after three weeks on respective diets; T3: after three weeks of JPYSF treatment) for metagenomic sequencing. …”
Get full text

Long-term effects of combining anaerobic digestate with other organic waste products on soil microbial communities by Daniela Mora-Salguero, Denis Montenach, Manon Gilles, Vincent Jean-Baptiste, Sophie Sadet-Bourgeteau, Sophie Sadet-Bourgeteau

“…Notably, fungal communities responded more strongly to treatment variations than prokaryotic communities.DiscussionThis study provides new insights into the cumulative effects of substituting mineral fertilizers with digestates on soil microbial communities and soil physicochemical parameters. …”
Get full text