Significance of the peripheral blood Treg/Th17 ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma and its correlation with 1q21 gain/amplification by Jingjing Wen, Qiaolin Zhou, Fang Xu, Jing Yue, Ya Zhang, Yiping Liu, Jing Su, Xiaogong Liang

“…Despite advances in immunotherapy, current risk stratification lacks immune biomarkers.MethodsWe collected the peripheral blood and bone marrow samples from MM patients to investigate the relationships among 1q21 gain/amplification, the Treg/Th17 ratio, and MYC gene abnormalities at diagnosis, remission, and relapse. …”
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Effects of exercise intensity and diet on cardiac tissue structure and FGF21/β-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD + STZ induced type 2 dia... by Sevda Moharamzadeh, Majid Kashef, Mojtaba Salehpour, Meysam Torabi, Samira Vesali, Zakieh Samsonchi, Ensiyeh Hajizadeh-Saffar

“…Finally, the tissue and serum samples were collected and analyzed by two-way ANOVA. …”
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Morphological Changes Depending on the Contentof Clozapine and its Metabolites in the Lungs and Serum (Experimental Study) by O. L. Romanova, D. V. Sundukov, A. M. Golubev, M. I. Blagonravov

“…After euthanasia of the animals by decapitation, tissue samples of lungs were embedded in paraffin according to the standard technique. …”
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Structural Analysis of Wound Healing with Ehretia Laevis Roxb. Tincture Ointment versus Povidone-iodine Ointment in Wistar Rats: A Research Protocol by Pawan Banduji Itankar, Gaurav Rajendra Sawarkar, Punam Gaurav Sawarkar

“…This study aims to develop a tincture-based ointment, providing a more standardised and clinically applicable form. …”
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Geospatial analysis of limited access to drinking water services in East African countries: insights from recent demographic and health surveys by Gelila Yitageasu, Kassaw Chekole Adane, Amensisa Hailu Tesfaye, Amensisa Hailu Tesfaye, Zemichael Gizaw, Tigist Kifle, Lidetu Demoze

“…For this, understanding the spatial distribution of limited access to water source service is more pertinent. The purpose of this study is to analyze the spatial distribution of limited access to water source services in East Africa countries and seeks to inform the development and implementation of targeted interventions and policies in East Africa.MethodsThis study analyzed data from recent demographic and health surveys conducted in 12 East African nations between 2012 and 2023. …”
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Game Design, Effectiveness, and Implementation of Serious Games Promoting Aspects of Mental Health Literacy Among Children and Adolescents: Systematic Review by Michael Zeiler, Sandra Vögl, Ursula Prinz, Nino Werner, Gudrun Wagner, Andreas Karwautz, Natalie Zeller, Lorenz Ackermann, Karin Waldherr

“…However, the evidence was mostly based on small samples, and user adherence was sometimes low. …”
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Preliminary Investigation of a Novel Measure of Speech Recognition in Noise by Linda Thibodeau, Emma Freeman, Kristin Kronenberger, Emily Suarez, Hyun-Woong Kim, Shuang Qi, Yune Sang Lee

“…This interaction indicated that the effect of SNR on sentence comprehension was more pronounced in the continuous noise compared to the interrupted noise condition. …”
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Cardiometabolic risk factors and their relationship with the interleukin-6 receptor gene polymorphism (rs2228145) in patients with hypertrophic cardiomyopathy by T. G. Bezhanishvili, A. Ya. Gudkova, V. G. Davydova, S. E. Andreeva, A. N. Krutikov, E. N. Semernin, B. N. Kudryavtsev, S. A. Pyko, A. A. Kostareva, E. N. Shlyakhto

“…To analyze associations of interleukin-6 receptor gene (IL6R) polymorphism (rs2228145) with the clinical course characteristics of hypertrophic cardiomyopathy (HCM) in groups of patients with various cardiometabolic risk factorsMaterial and methods. The sample consisted of 123 patients with HCM. …”
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Associations between phthalate metabolites and two novel systemic inflammatory indexes: a cross-sectional analysis of NHANES data by Fangyu Cheng, Yueyuan Li, Kai Deng, Xinyu Zhang, Wenxue Sun, Xin Yang, Xiaofang Zhang, Chunping Wang

“…The study aimed to investigate the relationship between urine samples of nine mPAEs and levels of SII/SIRI in a single, nonlinear, and mixed relationship and explored the robustness of the findings under single and mixed effects using two sensitivity analyses for completeness. …”
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Effects of a Dietary Intervention with Lacto-Ovo Vegetarian and Mediterranean Diets on Apolipoproteins, Lipid Profile and Cardiovascular Risk: Results from the CARDIVEG Study by Giuditta Pagliai, Barbara Colombini, Marta Tristan Asensi, Monica Dinu, Sofia Lotti, Rossella Marcucci, Francesco Sofi

“…Anthropometric parameters and blood samples were obtained both at the beginning and at the end of the MD and VD periods. …”
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Exploring new mechanisms in cancer molecular pathways and pathogenic cell transformation: PIP4K2A as a prognostic marker and therapeutic target in cutaneous malignant melanoma by Wen-fei Luo, Ding-ming Song, Tong Shen, Yi-bo He, Hong-yang Du, Ming-jue Si, Lu-Wei Fang

“…This study aimed to investigate the role of the PIP4K2A gene in cutaneous malignant melanoma, with a focus on its influence on T cell-mediated immune responses. Methods Samples from cutaneous melanoma patients were analysed by single-cell transcriptome for differentially expressed genes and signalling pathways associated with cutaneous melanoma. …”
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Vancomycin levels for Bayesian dose-optimization in critical care: a prospective cohort study by Natalia Dreyse, Natalia Dreyse, Nicole Salazar, Jose M. Munita, Jordi Rello, Jordi Rello, Jordi Rello, René López, René López

“…Bland–Altman analysis indicated better agreement between AUC-3 and AUC-2 with AUCRef.ConclusionBayesian software using two vancomycin levels provides a more accurate and less biased AUC/MIC estimation in critically ill patients.…”
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Chronic Sleep Deprivation Causes Anxiety, Depression and Impaired Gut Barrier in Female Mice—Correlation Analysis from Fecal Microbiome and Metabolome by Lingyue Li, Zilin Meng, Yuebing Huang, Luyao Xu, Qianling Chen, Dongfang Qiao, Xia Yue

“…Due to the influence of endogenous hormone levels, females are more susceptible than males to negative emotions caused by sleep deprivation. …”
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Design, spectroscopic analysis, DFT calculations, adsorption evaluation, molecular docking, comprehensive in silico and in vitro bioactivity studies of thiocarbohydrazide grafted d... by Magda A. Akl, Aya G. Mostafa, Abdelrahman S. El-Zeny, El-Sayed R. H. El-Gharkawy

“…Drug-likeness rules like Lipinski’s, Veber’s and Egan’s were considered for a more comprehensive evaluation. The prepared DAC@TCH nanobiosorbent was investigated for its potential to adsorb metal ions (Ag+, Hg2+, and Cu2+) from diverse water samples. …”
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Association of HLA-C*07:359 with HLA-A, -B, and -DRB1 alleles in Taiwanese by Kuo-Liang Yang, Py-Yu Lin

“…Materials and Methods: The samples were peripheral whole blood, with dipotassium ethylenediaminetetraacetic acid and/or acid citrate dextrose anticoagulation additives. …”
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Epidemiology and genetic diversity of respiratory syncytial virus in adults 50 years and older with acute respiratory infections in Accra, Ghana by Comfort Nuamah Antwi, Bartholomew Dzudzor, James Odame Aboagye, Vishnu Nene Limon Abayateye, Joseph Ahia Quarcoo, Asantewa Sisi Yaa Anang, Gloria Gifty Whyte, John Kofi Odoom, Evangeline Obodai

“…RSV infection was confirmed in 11 (5.2%) participants. RSV infection was more prevalent among patients aged 65 years and older (8/11, 54.5%). …”
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Impact of Telemedicine Adoption on Hemiplegia in Patients With Stroke in Florida: Longitudinal Observational Study by Yao Li, Mingshan Zhang, Weiling Ke, Wenwen Li

“…The final sample includes 314,665 visits from patients with stroke. …”
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Midterm Outcomes Following Conversion of Failed Ankle Arthrodesis to Total Ankle Arthroplasty, Including Patients With a Deficient Fibula by George Lian MD, William Ip MD, Andrea Hankins, Michele Guillen, Carol Parise PhD

“…Background: Previous studies of conversion of failed ankle arthrodesis to total ankle arthroplasty showed failure in patients with an absent distal fibula, and more recently that has been considered a contraindication. …”
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The correlation between thyroid status parameters and prolactin levels in reproductive-age women with autoimmune thyroiditis and subclinical hypothyroidism by Yu.V. Buldygina, Yu.I. Beliakova, M.M. Vatsyk, H.M. Terekhova

“…A significant negative correlation between PRL and free T4 (Spearman R = –0.27; p = 0.043) indicates a more sensitive relationship compared to that between PRL and TSH.…”
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Investigating the impact of polymorphisms in the ANKK1 and DRD2 genes on oral health-related quality of life in male patients with temporomandibular disorders by Samantha Schaffer Pugsley Baratto, Allan Abuabara, Débora Cristina Cardozo Bueno, Thalita de Paris Matos, Camila Paiva Perin, Gisele Maria Correr, César Penazzo Lepri, Christian Kirschneck, Flares Baratto-Filho, Flares Baratto-Filho, Erika Calvano Küchler

“…The Mann–Whitney test was used in the recessive model (alpha = 0.05).ResultsThe sample included a total of 114 male patients. OHIP-14 total score ranged from 0 to 33. …”
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