The dosimetric value and safety evaluation of 3D printed bolus in adjuvant intensity-modulated radiotherapy after radical mastectomy for breast cancer: a prospective cohort study by Yaxue Wang, Hanzong Li, Wendie Hu, Bohan Li, Yujie Du, Fengyan Li

“…Conclusions The use of 3DPB in breast cancer radiotherapy is effective, achieving higher and more uniform dose distribution and better target conformity compared to without 3DPB. …”
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A surveillance study to determine the accuracy of mild traumatic brain injury diagnosis in an emergency department: protocol for a retrospective cohort study by Ian D Cameron, Ilaria Pozzato, Ashley Craig, Bamini Gopinath, Mark Gillett, Annette Kifley, Kim Van Vu, Susanne Meares, Anthony Liang

“…The WHO operational criteria for the clinical identification of mTBI cases is the presence of: (1) a Glasgow Coma Scale (GCS) of 13–15 after 30 min postinjury or on presentation to hospital; (2) one or more of the following: post-traumatic amnesia (PTA) of less than 24 hours’ duration, confusion or disorientation, a witnessed loss of consciousness for ≤30 min and/or a positive CT brain scan. …”
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The associations between gut microbiota and fecal metabolites with intelligence quotient in preschoolers by Jinghua Long, Jiehua Chen, Huishen Huang, Jun Liang, Lixiang Pang, Kaiqi Yang, Huanni Wei, Qian Liao, Junwang Gu, Xiaoyun Zeng, Dongping Huang, Xiaoqiang Qiu

“…However, due to limitations such as the small sample size, unclear causality, and the complexity of metabolites, more validation studies are still needed to further elucidate the mechanisms and stability of these associations.…”
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Procedure‐specific simulation for vaginal surgery training: A randomized controlled trial by Roxana Geoffrion, Nicole A. Koenig, Geoffrey W. Cundiff, Catherine Flood, Momoe T. Hyakutake, Jane Schulz, Erin A. Brennand, Terry Lee, Joel Singer, Nicole J. Todd

“…Baseline characteristics were similar, except for more fourth‐year control residents. After adjustment of confounders (age, level, baseline knowledge), GRS scores showed significant differences overall (mean difference 8.2; 95% confidence interval [CI]: 0.2–16.1; p = 0.044) and for VH (mean difference 12.0; 95% CI: 1.8–22.3; p = 0.02). …”
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Improvement of Nanopore sequencing provides access to high quality genomic data for multi-component CRESS-DNA plant viruses by Daniel H. Otron, Denis Filloux, Andy Brousse, Murielle Hoareau, Babbitha Fenelon, Cécile Hoareau, Emmanuel Fernandez, Fidèle Tiendrébéogo, Jean-Michel Lett, Justin S. Pita, Philippe Roumagnac, Pierre Lefeuvre

“…The effectiveness of the method was demonstrated on two plant samples, one infected with the bipartite begomovirus African cassava mosaic virus (ACMV) and the other infected with the nanovirus faba bean necrotic stunt virus (FBNSV), a virus with eight genomic segments. …”
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Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study by Chunxia Zhang, Yuchen Ying, Yuanhui Ru, Ziliang Wu, Yumeng Tian, Pingping Shen, Shiyuan Cao, Jing Zhang, Ri Liu

“…This suggests that further studies with larger sample sizes are needed to explore these relationships more comprehensively.…”
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Enhancing cognitive function through blood flow restriction: An effective resistance exercise modality for middle-aged women by Dohyeon Lee, Kyeongho Byun, Sewon Lee

“…Purpose: Cognitive decline progresses more rapidly in women than in men, with a higher prevalence of neurodegenerative diseases observed in females. …”
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The Group‐basEd Telehealth behavioral WEight Loss Program Among Breast Cancer Survivors: A Pilot and Feasibility Study by Kelly C. Allison, Courtney McCuen‐Wurst, Allie Raevsky, Nathaniel Holmes, Macy Goldbach, Carmen E. Guerra, Katharine A. Rendle, Tamara J. Cadet, Robert S. Krouse, Julia Tchou

“…Future studies should test this intervention in larger, more diverse samples. Trail Registration ClinicalTrials.gov identifier: NCT04855552, posted April 22, 2021…”
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Enhanced Recovery after Intensive Care (ERIC): study protocol for a German stepped wedge cluster randomised controlled trial to evaluate the effectiveness of a critical care telehe... by Ulrich Mansmann, Claudia Spies, Ursula Marschall, Reinhard Busse, Christine Adrion, Bjoern Weiss, Nicolas Paul, Elke Berger, Jörg Caumanns, Simone Rosseau

“…Besides, there is an increasing number of elderly patients with chronic diseases being treated in the intensive care unit (ICU). More than half of the survivors of critical illness suffer from medium-term or long-term cognitive, psychological and/or physical impairments after ICU discharge, which is recognised as post-intensive care syndrome (PICS). …”
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Immediate Diagnosis of Breast Carcinoma on Core Needle Biopsy Using Ex Vivo Fluorescence Confocal Microscopy: Feasibility in a One-Stop Breast Clinic Workflow by Marie-Christine Mathieu, Voichita Suciu, Marie-Laure Tanguy, Neila Ines Ben Romdhane, Salma Moalla, Sana Harguem-Zayani, Remy Barbe, Corinne Balleyguier, Angelica Conversano, Muriel Abbaci

“…Histopathological alterations were not more prevalent in FCM-imaged biopsies compared to conventionally treated biopsies. …”
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Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence by Ji‐Hua Shi, Wen‐Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pål‐Dag Line, Shui‐Jun Zhang

“…HER2 in HCC biology needs further explorations. Methods Clinical and mRNA data of HCC patients were obtained from TCGA HCC cohort, GSE89377 and GSE115018. …”
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Morphometric analysis of the fifth lumbar vertebra (L5): Anatomical dimensions and clinical implications in South Indian population by Nandini Bhat, Lakshmisha Rao, Ashwija Shetty, Souhardya Das, Nom Bhukya Kumar Naik, Vanishri Nayak, Sushma Prabhath, Kurian Alapatt, Suhani Sumalatha

“…Further research with larger and more diverse samples is recommended to validate and expand these findings.…”
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Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis by Ziv Shachar, Marlon V. Gatuz, Adam Folman, Maguli S. Barel, Rami Abu-Fanne, Dmitry Abramov, Mamas A. Mamas, Ariel Roguin, Ofer Kobo

“…This study aimed to investigate the impact of obesity on clinical outcomes in patients with high-risk PE. Methods: We conducted a retrospective analysis of US adult patients hospitalized with high-risk PE from 2016 to 2019 using the National Inpatient Sample database. …”
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Randomised placebo-controlled multicentre effectiveness trial of adjunct betamethasone therapy in hospitalised children with community-acquired pneumonia: a trial protocol for the... by Patrick M Meyer Sauteur, Julia Anna Bielicki, Malte Kohns Vasconcelos, Regina Santoro, Michael Coslovsky, Marco Lurà, Kristina Keitel, Tanja Wachinger, Svetlana Beglinger, Ulrich Heininger, Johannes van den Anker

“…Introduction Community-acquired pneumonia (CAP) causes around 10 hospitalisations per 1000 child-years, each associated with an average 13 non-routine days experienced and more than 4 parent workdays lost. In adults, steroid treatment shortens time to clinical stabilisation without an increase in complications in patients with CAP. …”
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The value of post radiotherapy prostate specific antigen dynamics for prostate cancer risk stratification models by Jane Shortall, Eliana Vasquez Osorio, Andrew Green, Kimberley Reeves, David Wong, Tanuj Puri, Peter Hoskin, Ananya Choudhury, Marcel van Herk, Alan McWilliam

“…Conclusion: PSA dynamics within the first three-years of post-radiotherapy follow-up for prostate cancer were more prognostic of BCR than pre-treatment risk-groups, suggesting PSA dynamics could be used to re-stratify BCR risk during early follow-up.…”
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Evidence Graph Analysis of Postoperative Pain Sensitization Induced by Perioperative Sleep Deprivation by XUE Jianjun, WANG Caihong, GUO Lingling, LI Xiuxia, ZHANG Jie, XU Ziqing, HOU Huaijing, YANG Kehu

“…Only 2 studies suggested that sleep disorders were not significantly associated with postoperative pain sensitization, and ten studies were uncertain whether sleep deprivation could induce postoperative pain sensitization.ConclusionsOverall evidence shows that sleep deprivation can induce postoperative pain sensitization, but the evaluation dimensions are limited and the methodological quality of the included literature needs to be improved. More high-quality, large-sample and standardized clinical studies should be carried out in the future to provide better scientific basis for clinical work.…”
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Pelvic osteotomies for correction of sagittal imbalance of the spine: An in-silico study comparing four different osteotomies by A.E.A. Ochtman, M.J. Claessens, F.C. Öner, T.P.C. Schlösser, K. Willemsen, J. Magré, H.C. Nguyen, M.C. Kruyt

“…BEPO is less demanding with minimal effect on the ligaments, however it requires more complex stabilization methods. Feasibility and safety tests are required as a next step.…”
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Hypothalamic atrophy and structural covariance in amnestic mild cognitive impairment and Alzheimer’s dementia by Hannah Pecher, Melanie Storch, Frauke Beyer, Veronica Witte, Christian-Frank Baasner, Peter Schönknecht, Christopher M. Weise

“…A number of studies have discussed hypothalamic involvement in AD with consecutive metabolic and/or autonomic disturbances yet only few studies have investigated hypothalamic atrophy in AD and its early stages in particular. Methods: We applied semi-automated volumetry of the hypothalamus (HTH) in 3 T MRI in a sample N = 175 participants [age 74.9 ± 7.22; gender 85 m/90f; cognitively normal controls (CN; N = 56); amnestic mild cognitive impairment (MCI; N = 78); AD (N = 41)] from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). …”
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Low Saturation Confidence Distribution-based Test-Time Adaptation for cross-domain remote sensing image classification by Yu Liang, Shilei Cao, Juepeng Zheng, Xiucheng Zhang, Jianxi Huang, Haohuan Fu

“…Firstly, weak-confidence softmax-entropy loss emphasizes categories that are more difficult to classify to address unbalanced class distribution. …”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…IntroductionCoeliac disease (CD) manifests more frequently in individuals with Down syndrome (DS) and its prevalence varies across different studies. …”
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