Incidence, outcomes, and mortality risk factors of acute kidney injury in critically ill children: a tertiary care center study in Saudi Arabia by Tareq Alayed, Abdulaziz Alansary, Mohammed Al-Nahdi, Abdullah Alotaibi, Raghad Alhuthil, Moath Al Abdulsalam, Fahad Aljofan, Abdullah Alturki, Tariq Alofisan

“…DESIGN: Retrospective cohort SETTING: A PICU PATIENTS AND METHODS: The study included children (aged 4 weeks to 14 years) who were admitted to the PICU from (2016 to 2019) and developed AKI at King Faisal Specialist Hopsital and Research Centre. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…This study examines how SIRT1 protein levels correlate with clinicopathological characteristics and survival outcomes in patients with breast cancer. Methods: A total of 407 BC formalin-fixed paraffin-embedded (FFPE) samples were collected from King Abdulaziz University Hospital, Saudi Arabia. …”
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Cytokine profiling identifies circulating IL-2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in non-small cell lung cancer patients undergoing anti-PD1 therapy by Kriti Jain, Anika Goel, Deepa Mehra, Deepak Kumar Rathore, Akshay Binayke, Shyam Aggarwal, Surajit Ganguly, Amit Awasthi, Evanka Madan, Nirmal Kumar Ganguly

“…Baseline serum samples were collected prior to ICI initiation and profiled using a multiplex cytokine panel. …”
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Computer adaptive testing to assess impairing behavioral health problems in emergency department patients with somatic complaints by Lauren M. O'Reilly, Azhar I. Dalal BS, Serena Maag MS, Matthew T. Perry BS, Alex Card DO, Max B. Bohrer BS, Jackson Hamersly BS, Setarah Mohammad Nader MD, Kelli Peterson RN, David G. Beiser, Robert D. Gibbons, Brian M. D'Onofrio, Paul I. Musey

“…Individuals who had 2 or more ED visits in the prior year had 62% increased odds of being in the intermediate‐high suicide risk category (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.07–2.44) compared to those with zero prior ED visits. …”
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Characterising developmental dynamics of adult epigenetic clock sitesResearch in context by Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil

“…This knowledge could be used to optimise healthy ageing well before the onset of age-related conditions. Methods: We leveraged results from two longitudinal population-based cohorts (N = 5019 samples from 2348 individuals) to characterise trajectories of adult clock sites from birth to early adulthood. …”
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Development of Low-Cost In-House Assays for Quantitative Detection of HBsAg, HBeAg, and HBV DNA to Enhance Hepatitis B Virus Diagnostics and Antiviral Screening in Resource-Limited... by Simmone D’souza, Layla Al-Yasiri, Annie Chen, Dan T. Boghici, Guido van Marle, Jennifer A. Corcoran, Trushar R. Patel, Carla S. Coffin

“…These assays were validated using known HBV-positive and HBV-negative plasma samples (genotypes A–F) and HepAD38 cells treated with tenofovir disoproxil fumarate (TDF). …”
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Safeguarding Patients, Relatives, and Nurses: A Screening Approach for Detecting 5-FU Residues on Elastomeric Infusion Pumps Using HPLC-DAD by Andreia Cardoso, Ângelo Jesus, Luísa Barreiros, Daniel Carvalho, Maria dos Anjos Sá, Susana Carvalho, Patrícia Correia, Fernando Moreira

“…A mobile phase containing 5% acetic acid was used to obtain more efficient separation of 5-FU and the detection was performed at 260 nm. …”
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Serum trihalomethanes and cognitive decline: investigating environmental risk factors for neurodegenerative diseases by Jianping Liu, Sufang Wang, Yuanying Song, Rong Luo, Lijian Han, Lijian Han

“…A final analytic sample of 743 participants aged 60 years or older was analyzed. …”
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Lipids, Apolipoproteins, Lipid‐Lowering Drugs, and the Risk of Cerebral Small Vessel Disease: A Mendelian Randomization Study by Yi Xie, Shuai Liu, Xinyue Wang, Hao Huang, Minghuan Wang, Wensheng Qu, Zhiyuan Yu, Wei Wang, Xiang Luo

“…Specifically, the genetically determined expressions of lipid fractions in various size‐defined lipoprotein particles were more closely related to the risk of SVS than WMH. …”
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Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study... by Anna Lena Platzbecker, Janine Gronewold, Sara Schramm, Susanne Moebus, Andreas Stang, Börge Schmidt, Christian Weimar, Martha Jokisch, the Heinz Nixdorf Recall Study Investigative Group

“…Abstract Introduction As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non‐amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex‐ and age‐specific effects of T2DM on incident MCI after five years in a population‐based sample. Methods A total of 145 participants with T2DM and 1322 without T2DM were included. …”
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Anopheles mosquitoes in Mondulkiri forest, Cambodia: abundance, distribution, seasonal patterns and Plasmodium prevalence by Sebastien Boyer, Bros Doeurk, Antsa Rakotonirina, Sophy Chy, Chantrea Vong, Eakpor Piv, Baura Tat, Malen Ea, Chansophea Chhin, Sreyvouch Phen, Nimol Kloeung, Sopheakvatey Ke, Jean Popovici, Patrice Piola, Benoit Witkowski, Pierre-Olivier Maquart, Amélie Vantaux

“…Anopheles species were more prevalent during the late rainy season (August to November), with year-round activity observed. …”
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Precise mycobacterial species and subspecies identification using the PEP-TORCH peptidome algorithm by Duran Bao, Sudipa Maity, Lingpeng Zhan, Seungyeon Seo, Qingbo Shu, Christopher J Lyon, Bo Ning, Adrian Zelazny, Tony Y Hu, Jia Fan

“…Furthermore, a targeted proteomics method was validated in 63 clinical samples using the taxa-specific peptides selected by PEP-TORCH, making them suitable as biomarkers in more clinically friendly settings. …”
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Análisis de equidad y sostenibilidad presupuestaria del sistema de copago farmacéutico en España by Jaime Pinilla, Christian González-Martel, Beatriz González López-Valcárcel, Félix Lobo, Jaume Puig-Junoy

“…Method: Data from a random sample of 4,505,483 individuals residing in Spain were used, matching pharmaceutical consumption information from the Ministry of Health with economic data from the Tax Agency. …”
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Using an Ultraviolet-Enabled Boat to Reduce Microcystin and Suppress Cyanobacterial Growth in Harmful Algal Bloom-Impacted Surface Waters by Taylor Rycroft, Brianna Fernando, Michael L. Mayo

“…Non-cyanobacteria were too scarce in this CyanoHAB to conclude whether the CyanoSTUN UV-C inhibits harmful phytoplankton species more readily than beneficial species. Further field studies with the CyanoSTUN^TM are required to validate performance under more severe cyanoHAB conditions, however the results reported herein from the first field trial with the CyanoSTUN^TM suggest that this treatment method may offer water managers confronted with a CyanoHAB the ability to rapidly and safely pause a bloom for multiple days and reduce the risks posed by its associated cyanotoxins without adding chemicals.…”
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Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMR... by Henry W. Chase, Danella M. Hafeman, Merage Ghane, Alexander Skeba, Tyler Brady, Haris A. Aslam, Richelle Stiffler, Lisa Bonar, Simona Graur, Genna Bebko, Michele Bertocci, Satish Iyengar, Mary L. Phillips

“…Findings Adopting a training/testing sample structure to the analysis, we found no evidence of reproducible brain/behavior relationships despite identifying regions and connections that reflect reliable between‐scan individual differences. …”
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Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer by Zhe Zhao, Kailun Fei, Hua Bai, Zhijie Wang, Jianchun Duan, Jie Wang

“…However, the relationship between the intestinal flora and chemotherapy outcomes remains unclear and was investigated in this study. Methods We analyzed baseline stool samples from patients with locally advanced and advanced lung cancer before chemotherapy treatment, through metagenomics of the gut microbiota. …”
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Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines by Mariana Leguia, Antón Vila-Sanjurjo, Diana Juarez, Alejandra Garcia-Glaessner, Ana I. Gil, Mayita Alvarez, Rubelio Cornejo, Sami Cherikh, Casey E. Gelber, Johannes B. Goll, Leigh M. Howard, Natalia Jimenez-Truque, Kathryn M. Edwards, C. Buddy Creech, Claudio F. Lanata

“…We also used standard serologic methods to assess immunogenicity, and correlated these results with transcriptional and translational signatures. …”
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A survey of pediatric dentists' caries-related treatment decisions and restorative modalities – A web-based survey by Hassan S. Halawany, Fouad Salama, Vimal Jacob, Nimmi Biju Abraham, Tarfa Nasser Bin Moharib, Abdulfatah Samih Alazmah, Jawaher Abdulaziz Al Harbi

“…Conclusion: The prevalence of use of composite resin to restore primary teeth was higher compared to glass ionomer cements and amalgam whereas a limited use of esthetic pediatric crowns was found among the sample surveyed. Esthetic pediatric crowns were more utilized by male compared to female participants. …”
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Intimate partner violence against women living with HIV in Lesotho: evidence from the 2023/24 DHS data set by Gebresilassie Tadesse, Girum Nakie, Gidey Rtbey, Techilo Tinsae, Setegn Fentahun, Mulualem Kelebie, Tigist Kifle Tsegaw, Getachew Muluye Gedef, Getasew Kibralew, Fantahun Andualem

“…A weighted sample of 467 women aged 15–49 years who were living with HIV was included. …”
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Chromosomal instability by low-coverage whole-genome sequencing assay predicts prognosis in bladder cancer patients underwent radical cystectomy by Qi Ding, Hailiang Zhu, Bo Fan, Lisheng Wang, Xiaohua Jin, Cheng Cao, Ying Shi, Zhijiang Fan, Wenjian Tu, Feng Li

“…Abstract Purpose To investigate chromosomal instability (CIN) in tumor tissue from radical bladder resection and to evaluate whether it can be used as a biomarker for the molecular typing of (BC). Methods DNA was extracted from formalin-fixed paraffin-embedded samples of 50 BC patients who were followed up to March 23 2023 using the Qiagen nucleic acid kits. …”
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