Melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia: the MAGIC non-inferiority RCT by Christopher Deery, Robert Bolt, Diana Papaioannou, Matthew Wilson, Marie Hyslop, Esther Herbert, Nikki Totton, Zoe Marshman, Tracey Young, Jennifer Kettle, Sondos Albadri, Simon Atkins, Katie Biggs, Janet Clarkson, Chris Evans, Laura Flight, Jacqui Gath, Fiona Gilchrist, Kate Hutchence, Nicholas Ireland, Amanda Loban, Amy Norrington, Hamish Paton, Jaydip Ray, Helen Rodd, Elena Sheldon, Richard Simmonds, Christopher Vernazza

“…Future work There remains a need to develop or repurpose another drug with a more favourable side effects profile to midazolam. …”
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Assessment of the Prevalence of Markers of Monoinfection with Hepatitis C Virus and Coinfection with Hepatitis C and B Viruses among the Personnel of Medical Institutions of an End... by M. P. Kostinov, N. A. Magomedova, I. A. Khrapunova, A. V. Linok, E. Yu. Malinnikova, G. I. Alatortseva, L. N. Pritvorova, L. N. Nesterenko, I. I. Amiantova, V. V. Dotsenko, V. Yu. Kabargina, V. B. Polishchuk, M. N. Loktionova, A. A. Besshaposhnikova

“…For the period under review (2023-2024) In the structure of HCV cases, 5 % of the study sample (1,643) were young people (up to 44 years old), while elderly and middle-aged people (45-60 years old) were more susceptible to combined forms of HCV and HBV (1.7 %). …”
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Cell-Type-Specific Heat-Induced Changes in the Proteomes of Pollen Mother Cells and Microspores Provide New Insights into Tomato Pollen Production Under Elevated Temperature by Priya Thapa, Jun Guo, Kajol Pradhan, Dibya Thapa, Sudhakar Madhavarapu, Jing Zou, Jesse Potts, Hui Li, Joshua O’Hair, Chen Wang, Suping Zhou, Yong Yang, Tara Fish, Theodore W. Thannhauser

“…Homogeneous cell samples of meiotic PMCs (prior to the tetrad stage) and free microspores were collected using laser capture microdissection (LCM). …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Most carers were white, married, spoke English as their first language, were university educated and in paid employment. Overall, 68% of the sample provided primary outcome data with more missing values in the intervention arm [TAU, n = 143/186 (76%); ECHOMANTRA + TAU, n = 110/185 (59%)]. …”
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On the Evaluation of the Reaction of Urban Managers Facing Flood as an Environmental Hazard with Emphasis on Resiliency (Case Study: Jiroft city) by Hossein Ghazanfarpour, 1 Marzieh Sedaghat Kish, Mogtaba Soleymani Damaneh, Yasser Sabahi Goraghani

“…Statistical tests, one-sample t-test and stepwise regression were applied to analyze the data. …”
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Optimization and test of the heating parts of gas-fired tea fixation and shaping machine by Qilong Wu, Qilong Wu, Lei Yu, Chengmao Cao, Chengmao Cao, Kuan Qin, Kuan Qin, Yi Jing, Yuhao Dai, Yuhao Dai, Xinliang Guo, Xinliang Guo, Lili Fan, Lili Fan, Junhao Zhang, Junhao Zhang, Chaoyue Fan, Chaoyue Fan, Haijun Bi, Haijun Bi

“…With the use of ANSYS finite element software, the orthogonal experiment method was applied to analyze and optimize the design of the spacing arrangement, the shape of the heating parts, and the heat conduction temperature field.ResultsResults show that the optimized heating parts significantly reduce the temperature difference on the surface of the U-shaped multi-groove pot, and the surface temperature field of the multi-groove pot is more uniform, which greatly improves the efficiency and quality of fresh tea leaf fixation and shaping. …”
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Faster postnatal decline in hepatic erythropoiesis than granulopoiesis in human newborns by Petra Janovska, Kristina Bardova, Zuzana Prouzova, Zuzana Prouzova, Ilaria Irodenko, Tatyana Kobets, Eliska Haasova, Eliska Haasova, Lenka Steiner Mrazova, Lenka Steiner Mrazova, Viktor Stranecky, Stanislav Kmoch, Martin Rossmeisl, Petr Zouhar, Jan Kopecky

“…In humans, this postnatal decline is not well characterized due to the scarcity of appropriate samples.ObjectiveTo characterize the effect of (i) gestational age at birth and (ii) length of survival after birth on hepatic haematopoiesis across various cell lineages involved.MethodsLiver autopsy samples from 25 born-alive infants, predominantly extremely preterm newborns who died mainly between 1 day and 3 weeks after birth, were analysed. …”
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Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial by Jia-Chen Wang, Li Zhao, Xiang-Yang Yu, Ting-Ping Wu, Chang-Fa Xia, Ju-Fang Shi, Hui He, Zhi-Qi Chen, Dan Shi, Han Xue, Qi Ao, Shu-Ping Liao, Zhang-Qiang Zheng, Qiong-Fang Huang, Lin Li, Sui-Ling Lin, Ying-Xue Li, Wen-Long Hu, Ji Peng, Lin Lei, Mao-Mao Cao, Fan Yang, Xin-Xin Yan, Si-Yi He, Meng-Di Cao, Shao-Li Zhang, Yi Teng, Qian-Ru Li, Nuo-Pei Tan, Hao-Yang Yu, Hong-Hui Cheng, Xi-Mo Wang, Wei-Qing Wu, Wan-Qing Chen

“…Abstract Background More efficacious, noninvasive screening methods are needed for advanced colorectal neoplasia. miR-92a is a reliable and reproducible biomarker for early colorectal cancer detection in stool samples. …”
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Effectiveness of Motivational Interviewing with Justice-involved People: A Systematic Review and Meta-analysis by Teresa Pinto e Silva, Cláudia Gouveia, Faraj A. Santirso, Olga Cunha, Sónia Caridade

“…Results: Results indicated that MI is more effective in increasing session attendance and reducing dropout than interventions without MI. …”
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Optimisation and clinical validation of a metagenomic third-generation sequencing approach for aetiological diagnosis in bronchoalveolar lavage fluid of patients with pneumoniaRese... by Shanshan Zhang, Xi Li, Xia Li, Ying Fu, Long Chen, Wei Wang, Qinqing Lin, Hui Lou, Yake Yao, Wenyu Chen, Cheng Zhong, Jian Ye, Yinan Yao, Huimin Guo, Yunsong Yu, Hua Zhou

“…However, this technology currently lacks standardised technical protocols, quality control measures, and comprehensive performance evaluations for the simultaneous detection of bacteria, fungi, and viruses in clinical settings. Methods: We optimised the mTGS workflow by refining key parameters (cell wall lysis, fragment size selection, host DNA depletion, and sequencing depth) using reference samples and bronchoalveolar lavage fluid (BALF) from eight patients with pneumonia. …”
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Comparative Study of Different Extraction Solvents and Liquid Chromatography Separation Modes on Metabolomics Analysis of Mango Pulp by Nan ZHANG, Xue WANG, Kewen WANG, Lu MI, Shini YANG, Lei XU, Zhenzhen XU

“…Combining (H2O+A)+HILIC with (Me+A)+RPLC significantly enhanced metabolite coverage and annotation accuracy. It provides a more comprehensive analytical method for the analysis of components in fruit and vegetable products such as mango pulp.…”
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Subtropical forest macro-decomposers rapidly transfer litter carbon and nitrogen into soil mineral-associated organic matter by Guoxiang Niu, Tao Liu, Zhen Zhao, Xuebing Zhang, Huiling Guan, Xiaoxiang He, Xiankai Lu

“…MAOM) is a promising method for identifying how SOM contributes to reducing global warming. …”
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The impact of the COVID-19 pandemic on the physical activity environment in English primary schools: a multi-perspective qualitative analysis by Danielle House, Robert Walker, Ruth Salway, Lydia Emm-Collison, Katie Breheny, Kate Sansum, Sarah Churchward, Joanna G Williams, Frank de Vocht, Russell Jago

“…Additionally, pupil ability and needs are more polarised. These factors have shaped, but are also shaped by, the high pressure in schools. …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Currently, the most suitable method to control this disease is the use of commercial fungicides. …”
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Resistance exercise snacks as a workplace health intervention by Tom Brandt, Christian Thomas Lothar Schwandner, Annette Schmidt

“…Muscle mass improved significantly more in the IG (+.42 kg ± .54) compared to the CG (-.16 kg ± .51) (p = .01, ⴄ²p = .24). …”
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The Impact of Rotational Malalignment Following Intramedullary Nailing for Intertrochanteric Fractures on Patients’ Functional Outcomes: A Prospective Study by Michail Vavourakis, Athanasios Galanis, Dimitrios Zachariou, Evangelos Sakellariou, Christos Patilas, Panagiotis Karampinas, Angelos Kaspiris, Meletis Rozis, John Vlamis, Elias Vasiliadis, Spiros Pneumaticos

“…Future research should focus on creating a more detailed, functional evaluation system for the elderly and applying it to a larger sample to confirm these findings.…”
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Targeting a highly repetitive genomic sequence for sensitive and specific molecular detection of the filarial parasite Mansonella perstans from human blood and mosquitoes. by Nils Pilotte, Tamara Thomas, Michael F Zulch, Allison R Sirois, Corrado Minetti, Lisa J Reimer, Steven A Williams, Lori J Saunders

“…When testing both sample types, our repeat-targeting index assay outperformed a ribosomal sequence-targeting reference assay, facilitating the identification of additional M. perstans-positive samples falsely characterized as "negative" using the less sensitive detection method.…”
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Conceptual Research Model of Metropolis Residents’ Pro-Environmental Behavior by Anastasia Lukina, Sergey Mkhitaryan, Roman Sidorchuk, Petr Nevostruev, Ekaterina Lukina

“…An online survey was conducted using the CAWI method on a quota sample of 1,502 respondents living in the metropolis of Moscow. …”
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Assessment and Improvement of Avatar-Based Learning System: From Linguistic Structure Alignment to Sentiment-Driven Expressions by Aru Ukenova, Gulmira Bekmanova, Nazar Zaki, Meiram Kikimbayev, Mamyr Altaibek

“…Evaluation of effect size demonstrated that the traditional approach had an edge over the avatar-based method, with lessons recorded on video displaying more moderate distinctions. …”
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Identification of potential prognostic biomarkers of thymoma with myasthenia gravis based on serum proteomics by Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Peng Liu, Peng Liu, Peng Liu, Peng Liu, Guoyan Qi, Guoyan Qi, Guoyan Qi, Guoyan Qi

“…Through proteomic analysis, we examined preoperative serum samples from patients with TMG to identify key prognostic proteins that could serve as a foundation for clinically predicting postoperative efficacy and guiding treatment selection.MethodAccording to the Clinical Research Guidelines of the Myasthenia Gravis Foundation of America (MGFA) for Post-Intervention Status (PIS), 20 patients with TMG were divided into an effective group (T1) [the PIS was minimal manifestation status (MMS) and above] and an ineffective group (T2) (the PIS did not reach MMS and above), with 10 cases each, and a healthy control group (C) with nine cases. …”
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