Evaluation and DFT Analysis of In Vitro Anticancer Activity of <i>Consolida orientalis</i>, <i>Smyrnium rotundifolium</i>, and <i>Euphorbia virgata</i> Plant Extracts in Colorectal... by Eda Sönmez Gürer, Zuhal Tunçbilek, Cemile Zontul, Ahu Kutlay, Amrendra Kumar, Gaurav Jhaa

“…In this context, natural compounds of plant origin play an important role in the development of new anticancer drugs. <b>Methods</b>: In this study, the effects of <i>Consolida orientalis</i> ethanol extract (flower parts), <i>Smyrnium rotundifolium</i> ethanol extract (aerial parts), and <i>Euphorbia virgata</i> ethanol extract (aerial parts) samples on HT-29 (human colorectal adenocarcinoma cell line) and healthy CCD-18Co (human normal colon fibroblast cell line) were investigated for the first time in the literature by applying 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test within the scope of in vitro cytotoxicity analysis. …”
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Gas Chromatography-Mass Spectrometry of Volatile Organic Impurities in Whiskey by Nataliya V. Shelekhova, Tamara M. Shelekhova, Liubov I. Skvortsova, Natalya V. Poltavskaya

“…Their quality and safety control is a serious analytical task that requires new, more accurate instrumental methods, e.g., chromatography-mass spectrometry. …”
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Putting the pieces of the puzzle together in modeling gendered educational choices by Jakob Schwerter, Fani Lauermann, Philipp Doebler, Marjolein Fokkema

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Digital Phenotyping for Detecting Depression Severity in a Large Payor-Provider System: Retrospective Study of Speech and Language Model Performance by Bradley Karlin, Doug Henry, Ryan Anderson, Salvatore Cieri, Michael Aratow, Elizabeth Shriberg, Michelle Hoy

“…ObjectiveThis study evaluated the performance of a machine learning (ML) model examining both semantic and acoustic properties of speech in predicting depression across more than 2000 real-world interactions between health plan members and case managers. …”
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Shear and flexural performance of reinforced geopolymer concrete beams cured under ambient and oven conditions with environmentally friendly waste steel tire wire additives by Yasin Onuralp Özkılıç, Ali İhsan Çelik, Ceyhun Aksoylu, Memduh Karalar, Md Azree Othuman Mydin, Essam Althaqafi, Fatih Yılmaz, Osman Ahmed Umiye

“…In addition, AS3600 predicted beam damage more correctly in different conventional computations. …”
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Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period by V. N. Timchenko, V. F. Sukhovetskaya, T. M. Chernova, T. A. Kaplina, M. D. Subbotina, O. V. Bulina, М. М. Pisareva

“…Coronaviruses can cause damage to various parts of the respiratory system, gastrointestinal tract, and other organs and systems.The aim of the study: to monitor the circulation of seasonal coronaviruses in hospitalized children in the pre-pandemic period.Materials and methods: real-time multiplex PCR was used to test samples of nasopharyngeal mucus from 2188 patients aged 1 monthto 17 years, hospitalized with acute respiratory infection in 2014—2018. …”
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Use of the 22C3 anti-PD-L1 antibody to determine PD-L1 expression in multiple automated immunohistochemistry platforms. by Marius Ilie, Shirin Khambata-Ford, Christiane Copie-Bergman, Lingkang Huang, Jonathan Juco, Veronique Hofman, Paul Hofman

“…Optimised protocols are urgently needed for use of the 22C3 antibody concentrate to test PD-L1 expression on more widely available IHC autostainers.<h4>Methods</h4>We evaluated PD-L1 expression using the 22C3 antibody concentrate in the three main commercially available autostainers Dako ASL48, BenchMark ULTRA (Ventana Medical Systems, Inc.), and Bond-III (Leica Biosystems) and compared the staining results with the PD-L1 IHC 22C3 pharmDx kit on the Dako ASL48 platform. …”
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Willingness to use pre-exposure prophylaxis for HIV prevention among men who have sex with men in Malaysia: Findings from an online survey. by Sin How Lim, Gitau Mburu, Adam Bourne, Joselyn Pang, Jeffrey A Wickersham, Clayton Koh Thuan Wei, Ilias Adam Yee, Bangyuan Wang, Matteo Cassolato, Iskandar Azwa

“…<h4>Results</h4>Fewer than half of participants (44%) knew about PrEP before completing the survey. Overall, 39% of the sample were willing to take PrEP. Multivariate logistic regression indicated that Malay men (AOR: 1.73, 95% CI:1.12, 2.70), having 2 or more male anal sex partners in the past 6 months (AOR: 1.98, 95% CI: 1.29, 3.05), previous knowledge of PrEP (AOR: 1.40, 95%CI: 1.06, 1.86), lack of confidence in practising safer sex (AOR: 1.36, 95% CI: 1.02, 1.81), and having ever paid for sex with a male partner (AOR: 1.39, 95% CI: 1.01, 1.91) were independently associated with greater willingness to use PrEP, while men who identified as heterosexual were less willing to use PrEP (AOR, 0.36, 95% CI: 0.13, 0.97). …”
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Surgical managements for rhegmatogenous retinal detachment: A network meta-analysis of randomized controlled trial. by Xinyu Yan, Meng Xu, Fengjun Su

“…In view of the small sample sizes of the included studies and the low certainty of evidence, these findings must be interpreted with caution. …”
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Derivation of a novel multi-gene prognostic model based on regulated cell death pathways in acute myeloid leukemia: A comprehensive bioinformatic analysis integrating gene expressi... by Ali Ahmadi, Amir Abas Navidinia, Davood Bashash, Behzad Poopak, Shadi Esmaeili

“…<h4>Background</h4>Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy with dismal survival outcomes, where dysregulation of regulated cell death (RCD) pathways plays a pivotal role in leukemogenesis and therapeutic resistance.<h4>Methods</h4>Differential expression analyses were performed comparing AML samples with healthy bone marrow. …”
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Mucosal microbiota signatures reveal diagnostic insights in chronic liver disease by Sadık Dinçer, Yakup Ülger, Anıl Delik

“…We analyzed gut microbiota by 16 S rRNA metagenomic next-generation sequencing (NGS) method from colonic mucosal biopsy samples in CLD and healthy individuals. …”
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The effect of resistant dextrin on glucose regulation markers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials by Mohammad Rudiansyah, Dina Akeel Salman, Hardik Doshi, Renuka Jyothi S., Debasish Shit, Swati Sharma, Mehran Nouri

“…However, it is crucial to conduct more clinical studies with adequate sample sizes and rigorous methodologies to develop evidence-based treatment guidelines.…”
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Epidemiology of age-related macular degeneration among elderly in geriatric homes, East Cairo, Egypt by Dina Hussien Edarous, Hoda I. Fahim, Mohamed Momen, Ashraf Abd El-Salam Shaat, Ayat F. Manzour

“…Methods A cross-sectional study was conducted on 283 elderly people in thirty geriatric homes in East Cairo. …”
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Development of Telepresence Among Patients and Psychotherapists in the Actor-Partner Interdependence Model: Longitudinal Observational Study of 20 Dyads From a Randomized Trial on... by Markus W Haun, Deborah van Eickels, Isabella Stephan, Justus Tönnies, Mechthild Hartmann, Michel Wensing, Joachim Szecsenyi, Andrea Icks, Hans-Christoph Friederich

“…Future studies with larger samples and more sessions are necessary to enhance the generalizability of these findings and to optimize the use of video consultations in mental health care.…”
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Experimental paradigm to test the effects of providing social support: study protocol of the PROSPECT trial (Study 2) by Vivien Hajak, Simone Grimm, Ewa Gruszczyńska, Aleksandra Kroemeke, Natalia Józefacka, Lisa Marie Warner

“…The paradigm allows for the manipulation of the provider's levels of competence (feedback on the effectiveness of their support to the other person) and relatedness (feedback on the alleged level of relatedness perceived by the partner person following the provision of support). Methods A priori power analyses resulted in a planned sample size of 250 participants randomized to four conditions: 1) no support provision, 2) support provision without feedback, 3) support provision with feedback on competence, 4) support provision with feedback on relatedness. …”
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A pilot study protocol of a relational coordination training intervention among healthcare professionals in an Army medical center by Sherita House, Susan M. Perkins, Melissa Miller, Tanekkia Taylor-Clark, Robin Newhouse

“…Abstract Background As patient care becomes more complex, high-quality communication and relationships among healthcare professionals are critical to coordinating care. …”
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Changes of Physical Function and Quality of Life in Patients with Type 2 Diabetes after Exercise Training in a Municipality or a Hospital Setting by Stig Molsted, Trine Munk Jensen, Jane Sedum Larsen, Louise Bockhoff Olesen, Sofie Bjerre Milling Eriksen, Thomas Rehling, Signe Sætre Rasmussen, Mette Aadahl

“…The QOL scales physical function and general health increased more in the municipality group than in the hospital group (10.5 [2.8; 18.2] vs. -1.2 [-7.9; 5.5], respectively, p=0.031, and 8.3 [2.3; 14.4] vs. -0.2 [-5.6; 5.1], respectively, p=0.042). …”
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Investigation of the histoarchitecture of bovine pericardium as the primary material used in reconstructive surgery and bioprosthesis by A. I. Zvyagina, K. V. Pyatina, V. V. Minaiychev, M. I. Kobyakova, Ya. V. Lomovskaya, A. S. Senotov, A. Yu. Teterina, I. S. Fadeeva

“…Objective: to study the composition and topology of the extracellular matrix (ECM) of bovine pericardium and to identify the best tissue areas suitable for the fabrication of bioprosthetic heart valves (BHVs). Materials and methods. The pericardium samples of healthy sexually mature bulls were studied; the native pericardium was divided into three experimental groups: core tissue (BP-CT group), heart base (BP-HB) and connective ligament base (BP-CL). …”
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Paediatric asthma prevalence and environmental factors: A community-based cross-sectional study. by Dr . Nalla Krishna, Dr. Pandala Paramesh, Dr . Kavitha Vislavath, Dr. Ravinaik Nunavath, Dr. I Sridhar

“…Materials and methods This cross-sectional analysis involved 100 children and adolescents aged 0-18 years. …”
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Executive function at baseline and follow-up in opioid maintenance patients and its relation to psychiatric comorbidity and substance use patterns by John Hanson Högberg, Björn Philips, Jonas Nielsen, Stina Richter Simsek, Kristina Berglund

“…Conclusions Executive function impairment is common in patients starting OMT, with specific functions more affected. The varied results of correlations between psychiatric comorbidity, substance use, and executive function indicate patient heterogeneity. …”
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