Trastuzumab deruxtecan for the treatment of metastatic non-small cell lung cancer harboring HER2 non-exon 19/20 mutations: four case reports by Yan Meng, Yanping Du, Yanping Du, Xiaolin Liu, Jue Huang, Hanhan Chen, Chunxia He

“…The other two patients (one with HER2 exon 21 H878Y mutation and one with HER2 exon 17 V659E mutation) were continuing T-DXd treatment, both with a PFS of more than 6 months. No interstitial lung disease or grade ≥3 adverse events occurred in these four patients.ConclusionThe potential of T-DXd in patients with metastatic NSCLC harboring HER2 non-exon 19/20 mutations is considerable, which deserves to be validated in large-sample studies.…”
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Effects of hydration on the mechanical properties of deep shale under true triaxial stress: A case study of Fuling shale gas in Sichuan Basin, SW China by Jinzhou ZHAO, Zhihao YU, Lan REN, Ran LIN, Jianfa WU, Yi SONG, Cheng SHEN, Ying SUN

“…This study takes shale samples from the Jiaoshiba block in the Fuling shale gas field of the Sichuan Basin, and uses the true triaxial testing system to conduct a series of mechanical experiments under deep shale reservoir conditions after shale hydration. …”
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Evaluation of influenza-like illness sentinel surveillance system, Sunyani Municipality, Ghana by Abdul Gafaru Mohammed, Christopher Tamal, Magdalene Akos Odikro, Delia Akosua Bandoh, Donne Ameme, Ernest Kenu

“…The case detection quota of 260 suspected cases was not met in three of the five years. Sample collection to testing takes more than one week. …”
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Sexual health in female and male cancer survivors – compared with age-matched cancer-free controls in Norway by Emilie Åsberg, Guro F. Giskeødegård, Jarle Karlsen, Cecile E. Kiserud, Guro Aune, Marianne Nilsen, Randi J. Reidunsdatter

“…This study investigated sexual health in cancer survivors shortly after diagnosis and at long-term follow-up compared to the general population. Methods: A nationwide survey stratified by sex and age was distributed to a representative sample of the Norwegian population. …”
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Rotational Velocities and Radii Estimates of Low-mass Pre-main-sequence Stars in NGC 2264 by Laurin M. Gray, Katherine L. Rhode, Catrina M. Hamilton-Drager, Tiffany Picard, Luisa M. Rebull

“…We find that starspot-free models tend to underestimate the radii of the PMS stars at the age of the cluster, while models that incorporate starspots are more successful. We also observe a mass dependence in the degree of radius inflation, which may be a result of differences in the birth-line location on the HR diagram. …”
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Determinant Factors of Knowledge about Obesity among Workers in the Chemical Industry in Surabaya City, East Java Province by Ratih Damayanti, Indah Lutfiya, Nur Septia Handayani, Ratnaningtyas Wahyu Kusuma Wardani, Yunita Putri Linggarwati, Anya Indras Sweri

“…This study aims to analyze the factors associated with knowledge about obesity among workers. Methods: This study an analytical observational design with a cross-sectional approach conducted at PT XYZ in Surabaya City, East Java Province. …”
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Building bridges to operationalize One Health — A longitudinal two years’ AMR study in England using clinical and wastewater-based surveillance approaches by Like Xu, Nicola Ceolotto, Kishore Jagadeesan, Richard Standerwick, Megan Robertson, Ruth Barden, Helen Lambert, Barbara Kasprzyk-Hordern

“…Considering this, we evaluated community-wide AMR in the shadow of COVID-19, using wastewater-based epidemiology (WBE). Methods: Five hundred ninety wastewater samples were collected from 4 contrasting communities in England between April 2020 and March 2022 to test for antibiotics used, their metabolites, and persistent antibiotic resistance genes (ARGs). …”
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Magnetic anisotropy and GGG substrate stray field in YIG films down to millikelvin temperatures by Rostyslav O. Serha, Andrey A. Voronov, David Schmoll, Roman Verba, Khrystyna O. Levchenko, Sabri Koraltan, Kristýna Davídková, Barbora Budinská, Qi Wang, Oleksandr V. Dobrovolskiy, Michal Urbánek, Morris Lindner, Timmy Reimann, Carsten Dubs, Carlos Gonzalez-Ballestero, Claas Abert, Dieter Suess, Dmytro A. Bozhko, Sebastian Knauer, Andrii V. Chumak

“…We find that the total crystallographic anisotropy increases more than three times with the decrease in temperature down to 2 K. …”
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Differential Regulation of Morphology and Estrogen Receptor-Alpha Expression in the Vagina of Ovariectomized Adult Virgin Rats by Estrogen Replacement: A Histological Study by Ting Li, Yuanyuan Ma, Hong Zhang, Ping Yan, Lili Huo, Yongyan Hu, Xi Chen, Ting Li, Miao Zhang, Zhaohui Liu

“…Thereafter, vaginal samples were biopsied from the distal- and proximal-half portions. …”
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Effectiveness of traditional non-carbapenem β-lactams vs. novel β-lactams for the treatment of carbapenem-resistant Pseudomonas aeruginosa: a retrospective cohort study by Namareq F. Aldardeer, Hatun M. Labban, Raghad T. Alhuthil, Seham H. Aljahdali, Moataz H. Alharbi, Riham A. Alharbi, Mohammed I. Al Musawa, Abdulrahman A. Almalki, Thamer A. Almangour

“…Further studies with larger sample sizes are needed to confirm these findings.…”
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Permeability of the blood-CSF barrier in MOGAD: clinical correlation based on the 2023 diagnostic criteria by Yin-Xi Zhang, Qi-Lun Lai, Wei Fang, Bing-Qing Du, Chun-Hong Shen, Yong-Feng Xu, Mei-Ping Ding, Meng-Ting Cai

“…Serum and CSF samples were collected simultaneously prior to initiation of immunotherapies at admission. …”
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Type of menopause, age of menopause and cardiovascular disease: a cross-sectional study based on data from Rafsanjan cohort study by Zahra Jamali, Parvin Khalili, Fatemeh Ayoobi, Hajar Vatankhah, Ali Esmaeili-Nadimi, Faezeh Esmaeili Ranjbar, Mahboubeh Vatanparast

“…A sample of 1767 postmenopausal women were included. …”
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TRANSCRIPTOMIC ANALYSIS OF MELANOMA CELLS EXTRACTED FROM DIFFERENT SITES OF THE PRIMARY TUMOR by M. B. Aksenenko, A. V. Komina, N. V. Palkina, A. S. Averchuk, Yu. A. Rybnikov, Yu. A. Dyhno, T. G. Ruksha

“…Treatment of malignant tumors requires an individual approach to choose the most appropriate treatment regimen.The purpose of the study was to evaluate differences in melanoma tissue samples obtained from different parts of one patient’s primary tumor at the transcriptomic level.Material and Methods. …”
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Circulating Tfh cells and Tfr cells in papillary thyroid carcinoma and their diagnostic potential by Heng Zhang, Yiwen Yu, Minglei Jiang, Renquan Lu, Lin Guo

“…Objective: This study aim to explore the alterations of circulating T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in the peripheral blood of patients with papillary thyroid carcinoma (PTC), assess their association with PTC and the influence on B cells, and evaluate their diagnostic potential. Methods: Peripheral blood samples were collected from 76 newly diagnosed PTC patients and 21 matched healthy controls between June 2023 and June 2024. …”
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An Approach for Differential Diagnosis of Breast Tumors by ctDNA Methylation Sequencing by Xianyu Zhang, Yanling Yin, Zhujia Ye, Xingda Zhang, Wei Wei, Yi Hao, Liuhong Zeng, Ting Yang, Dalin Li, Jun Wang, Dezhi Zhao, Yanbo Chen, Shan Lei, Yongdong Jiang, Youxue Zhang, Shouping Xu, Abiyasi Nanding, Yajie Gong, Siwei Li, Yuanyuan Yu, Shilu Zhao, Siyu Liu, Yashuang Zhao, Zhiwei Chen, Shihui Yu, Jian‐Bing Fan, Da Pang

“…ABSTRACT Background Breast ultrasonography and mammography remain predominant in breast tumor evaluations, yet they often result in false positives, particularly for tumors classified as BI‐RADS 4a or those no more than 10 mm, which are not ideal for core needle biopsy (CNB). …”
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Preliminary results of a multidimensional approach to screen for frailty in community-dwelling older adults of eight Italian regions: the SUNFRAIL+ study by Vincenzo De Luca, Clara Donnoli, Valeria Formosa, Edoardo Carnevale, Michele Bisogno, Lola Patumi, Lisa Leonardini, Paola Obbia, Ernesto Palummeri, Manuela Ruatta, Anna Maddalena Basso, Marcello Minichini, Daniela Adamo, Dario Bruzzese, Lorenzo Mercurio, Michele Virgolesi, Stefano Toccoli, Simona Sforzin, Fortunata Denisi, Moira Borgioli, Marino Dell’Acqua, Valentina Cacciapuoti, Guido Iaccarino, Giuseppe Liotta, Maddalena Illario

“…Frailty can be prevented, reversed or mitigated by early screening for frailty risk in community-dwelling older adults, allowing for preventive interventions on clinical and social determinants.ObjectivesThe present article reports the preliminary results of the SUNFRAIL+ study multidimensional cascade assessment in a group of community-dwelling older adults of 8 Italian regions aimed to stratify the population according to the needs of care at the first administration, integrated with the quality of life (QoL) assessment to evaluate the impact of early, integrated care.MethodsThe SUNFRAIL+ study performed a multidimensional assessment of community-dwelling older adults by linking elements of the SUNFRAIL frailty assessment tool with an in-depth assessment of biopsychosocial domains of frailty, through validated questionnaires and physical tests.ResultsThe sample consisted of 743 participants (279 males and 464 females). …”
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A scoping review of antibiotic resistance through a One Health lens. Insights from the Nile Valley: Egypt, Sudan, and Ethiopia by Leena Al-Hassan, Leena Al-Hassan, Anya A. Nowbuth, Getachew Tesfaye Beyene, Biruk Yeshitela, Derbew Fikadu Berhe, Kassu Desta, Mistire Wolde, Thamarai Dorai-Schneiders, Amira Farouk, Mai Zafer, Rana ElShimy, Rana ElShimy, Hadir El-Mahallawy, Nagwa El-Amin, Anne Roemer-Mahler, Sarra Aizzeldin, Paul G. Higgins, Paul G. Higgins, Aalaa Moghith, Papreen Nahar, Einas A. Osman, Maowia Mukhtar

“…Data such as infection type, sample source, and observed resistance were recorded. …”
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Correcting for case-mix shift when developing clinical prediction models by Haya Elayan, Matthew Sperrin, Glen P. Martin, Niels Peek, Frieder Braunschweig, Jonas Faxén, Joakim Alfredsson, David A. Jenkins

“…This method uses a probabilistic similarity metric to re-weight data samples in the source set (before the case-mix shift) to more closely match the target set (after the case-mix shift), assuming the target set reflects the target population. …”
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A Comparative Study of Methyl-BEAMing and Droplet Digital PCR for <i>MGMT</i> Gene Promoter Hypermethylation Detection by Marco Macagno, Valeria Pessei, Noemi Congiusta, Luca Lazzari, Sara Erika Bellomo, Fariha Idrees, Alessandro Cavaliere, Filippo Pietrantonio, Alessandra Raimondi, Eleonora Gusmaroli, Maria Giulia Zampino, Lorenzo Gervaso, Davide Ciardiello, Giuseppe Mondello, Armando Santoro, Nicola Personeni, Emanuela Bonoldi, Maria Costanza Aquilano, Emanuele Valtorta, Salvatore Siena, Andrea Sartore-Bianchi, Alessio Amatu, Erica Francesca Bonazzina, Katia Bruna Bencardino, Guido Serini, Silvia Marsoni, Ludovic Barault, Federica Di Nicolantonio, Federica Maione

“…<b><i>Methods:</i></b> In this context, a subset of ARETHUSA metastatic colorectal cancer samples was used to compare two different techniques for assessing <i>O-6-methylguanine-DNA methyltransferase</i> hypermethylation: Methyl-BEAMing, a highly sensitive digital PCR approach that combines emulsion PCR and flow cytometry, and droplet digital PCR, a more automated procedure that enables the rapid, operator-independent analysis of a large number of samples. …”
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Development of a pan-genotypic monoclonal antibody-based competitive ELISA for the detection of antibodies against Bovine viral diarrhea virus by Shuhui Qi, Shuhui Qi, Jing Wang, Jing Wang, Ting Le, Chao Sun, Jitao Chang, Jitao Chang, Zhigang Jiang, Xin Yin, Quanhai Pang

“…IntroductionBovine viral diarrhea virus (BVDV), a positive-sense single-stranded RNA virus, causes significant economic losses in the cattle industry. Current diagnostic methods for BVDV exhibit variable sensitivity and specificity, underscoring the need for more rapid and accurate detection approaches. …”
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